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Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants
2010
BMC Bioinformatics
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Motivated by a need for a deeper understanding of organ transplant rejection, we combine the data from five separate studies to compare acute rejection versus stability after solid organ transplantation ...
, and use this data to examine approaches to multiplex meta analysis. ...
Acknowledgements The work was supported by the Lucile Packard Foundation for Children's Health, National Library of Medicine (R01 LM009719 and T15 LM7033), the National Institute of Allergy and Infectious ...
doi:10.1186/1471-2105-11-s9-s6
pmid:21044364
pmcid:PMC2967747
fatcat:b3bv2hteqjatnmovv4ww3qgz3u
Donor-Derived Cell-Free DNA to Diagnose Graft Rejection Post-Transplant: Past, Present and Future
2021
Transplantology
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This review elucidates the evolution, physiology, techniques, limitations, and prospects of dd-cfDNA as a biomarker for post-transplant graft damage and rejection. ...
Due to its applicability over all transplanted organs irrespective of age, sex, race, ethnicity, and the non-requirement of a donor sample, it emerges as a new gold standard for graft health and rejection ...
it a late marker for acute rejection [66] . ...
doi:10.3390/transplantology2030034
fatcat:my6sdgnwujaa3bjcqhl4gf6uga
Advances of genomic science and systems biology in renal transplantation: a review
2011
Seminars in Immunopathology
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mechanistic understanding of the rejection process. ...
The diagnosis of rejection in kidney transplant patients is based on histologic classification of a graft biopsy. ...
This illustrated the importance of the statistical approach applied in a multiplex meta-analysis [25] . ...
doi:10.1007/s00281-011-0243-2
pmid:21318414
pmcid:PMC3082700
fatcat:thrm2xmd7rhvjfqgt5mexusvry
Gene signatures common to allograft rejection are associated with lymphocytic bronchitis
2019
Clinical Transplantation
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The relationships of LB (classified here as Endobronchial or E-grade rejection) to small airway (A- and B-grade) pathologies are unclear. ...
Differential expression using DESeq2 was used for pathway analysis and to define an LB-associated metagene. ...
Acknowledgements: We acknowledge the study participants and their families for their generous contributions, and Dr. George Caughey for his mentorship and input into prior versions of this manuscript. ...
doi:10.1111/ctr.13515
pmid:30849195
pmcid:PMC6545574
fatcat:45muly6rfva4xnne3drkerryem
An Approach to Fungal Diagnostics in Solid Organ Transplantation
2018
OBM Transplantation
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The approach to diagnosing fungal infections following solid organ transplantation (SOT) is patient-specific. ...
This review provides a cognitive framework for practitioners aiming to diagnose fungal infections in recipients of SOT, taking into consideration the benefits and limitations of currently available diagnostic ...
In a Cochrane meta-analysis that included patients with solid organ transplantation, the sensitivity and specificity of PCR for the diagnosis of invasive aspergillosis ranged from 58.0 to 80.5% and 78.5 ...
doi:10.21926/obm.transplant.1804037
fatcat:roz3an25dvc27ge7mdqx4bqlcq
A Changing Paradigm in Heart Transplantation: An Integrative Approach for Invasive and Non-Invasive Allograft Rejection Monitoring
2021
Biomolecules
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Cardiac allograft rejection following heart transplantation is challenging to diagnose. Tissue biopsies are the gold standard in monitoring the different types of rejection. ...
, thus representing an integrated approach for heart transplant patients monitoring. ...
The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. ...
doi:10.3390/biom11020201
pmid:33535640
fatcat:ojmr6r7y7ranhau6skp2zezvqi
Identifying biomarkers as diagnostic tools in kidney transplantation
2011
Expert Review of Molecular Diagnostics
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There is a critical need for biomarkers for early diagnosis, treatment response, and surrogate end point and outcome prediction in organ transplantation, leading to a tailored and individualized treatment ...
However, there is still no routine application of any of these markers in clinical transplantation. ...
In a recent publication, the authors combined the data from five separate studies to compare AR versus stability after solid organ transplantation, and used this data to examine approaches to multiplex ...
doi:10.1586/erm.10.119
pmid:21405969
pmcid:PMC3116652
fatcat:rivexgj3ojhxdakcaj7wyeuda4
In praise of arrays
2008
Pediatric nephrology (Berlin, West)
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and its applications, as well as the limitations and evolution of microarrays, in the field of organ transplantation. ...
Methods of applying microarrays to clinical practice 7. Limitations of using microarrays in clinical practice 8. The black-box of microarray data analysis ...
In the past few years, there has been an increasing number of publications on solid organ transplantation, with particular emphasis on the heart and kidney. ...
doi:10.1007/s00467-008-0808-z
pmid:18568367
pmcid:PMC2719727
fatcat:f3lebgcy5rh47k7e3ses2ybueq
Landscape of Immune Cells Heterogeneity in Liver Transplantation by Single-Cell RNA Sequencing Analysis
2022
Frontiers in Immunology
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Taken together, these findings have gained novel mechanistic insights for understanding the immune landscape in liver transplantation, and it outlines the characteristics of immune cells and provides potential ...
Rejection is still a critical barrier to the long-term survival of graft after liver transplantation, requiring clinicians to unveil the underlying mechanism of liver transplant rejection. ...
SL, SY, YZ, and XL contributed to the data management and statistical analyses. JC, SL, and XL wrote the manuscript. All authors contributed to the article and approved the submitted version. ...
doi:10.3389/fimmu.2022.890019
fatcat:d7iu47wwbnb25bcr3flcrnl2ei
A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring
2019
PLoS ONE
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A Common Rejection Module (CRM) consisting of 11 genes expressed in allograft biopsies was previously reported to serve as a biomarker for acute rejection (AR), correlate with the extent of graft injury ...
We investigated the use of this gene panel on the urine cell pellet of kidney transplant patients. ...
Acknowledgments We are grateful for the help from physicians, clinical coordinators, research personnel, patients, and patient families. ...
doi:10.1371/journal.pone.0220052
pmid:31365568
pmcid:PMC6668802
fatcat:oabawwdalvfnjh5xsg4s72muya
ABSTRACTS Joint 16th International HLA and Immunogenetics Workshop, 26th European Federation for Immunogenetics Conference and 23rd British Society of Histocompatibility and Immunogenetics Conference, Liverpool, U.K. May 31st - June 3rd, 2012
2012
Tissue Antigens
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The ImmuKnow assay measures the cellular immune function and is aimed at identifying solid organ transplant recipients at risk for acute rejection or infection. ...
solid organ transplantation. ...
:01 ( We performed a meta-analysis of the MHC diversity of 25 primate species by extracting DNA sequences available on IPD-MHC Database for catarrhines. ...
doi:10.1111/j.1399-0039.2012.01877.x
fatcat:q6k6fgfgwbhjdjd6qearg3mlnu
Community-Acquired Respiratory Viruses in Transplant Patients: Diversity, Impact, Unmet Clinical Needs
2019
Clinical Microbiology Reviews
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SUMMARY Patients undergoing solid-organ transplantation (SOT) or allogeneic hematopoietic cell transplantation (HCT) are at increased risk for infectious complications. ...
Here, we review the current knowledge about CARVs in SOT and allogeneic HCT patients to better define the magnitude of this unmet clinical need and to discuss some of the lessons learned from human influenza ...
ACKNOWLEDGMENTS We are very thankful to Patrick Lane of ScEYEnce Studios for working with us to prepare the graphically enhanced figures. ...
doi:10.1128/cmr.00042-19
pmid:31511250
fatcat:ggi6iplx3zcpziuc77yc6friz4
Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients
2020
Clinical Microbiology Reviews
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SUMMARY Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with ...
Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral signatures or genomes can be identified in the blood of these patients ...
We thank Florian Laubscher and Patrick Lane of ScEYEnce Studios for their contribution in designing the figure. ...
doi:10.1128/cmr.00027-20
pmid:32847820
fatcat:mj5huvyurbbnlhfprntxuo65ce
If at First You Don't Succeed: Stem-Cell Transplantation for Acute Myeloid Leukemia After First Relapse
2013
Journal of Clinical Oncology
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For a detailed description of the disclosure categories, or for more information about ASCO ...
Although all authors completed the disclosure declaration, the following author(s) and/or an author's immediate family member(s) indicated a financial or other interest that is relevant to the subject ...
Evens AM, David KA, Helenowski I, et al: Multicenter analysis of 80 solid organ transplantation recipients with post-transplantation lymphoproliferative disease: Outcomes and prognostic factors in the ...
doi:10.1200/jco.2012.43.4241
pmid:23439749
fatcat:znxb5vhupffedb77khsjkjxuuq
Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children
2014
Influenza and Other Respiratory Viruses
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(HSCT) and solid organ, particularly lung transplant recipients. ...
One or more of the following immunodeficiency states were included in the latter group: Hematopoietic stem cell transplant (HSCT) (allogeneic and autologous transplants) and solid-organ transplant (SOT ...
doi:10.1111/irv.12255
pmid:24801963
pmcid:PMC4181803
fatcat:tj5laoepubcm5fcnfgg6rzswqm
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