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Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping

Basavaraju G. Sanganahalli, Michelle R. Rebello, Peter Herman, Xenophon Papademetris, Gordon M. Shepherd, Justus V. Verhagen, Fahmeed Hyder
2016 NeuroImage  
We imaged odor-specific activity patterns of the dorsal OB in the same anesthetized rats with fMRI and OICa 2+ and then co-registered the respective maps to compare patterns in the same space.  ...  Comparison of maps generated by both methods for a given odor showed ~70% overlap, indicating similar odor-specific maps by each method.  ...  Acknowledgments Supported by NIH grants R01 DC-011286 (to JVV and FH), R01 MH-067528 (to FH), and P30 NS-052519 (to FH).  ... 
doi:10.1016/j.neuroimage.2015.11.048 pmid:26631819 pmcid:PMC4733588 fatcat:glaayqltaze7dl2s2rcxqlfz5q

Chemotopic odorant coding in a mammalian olfactory system

Brett A. Johnson, Michael Leon
2007 Journal of Comparative Neurology  
patterns of activity are the key factors underlying that aspect of the olfactory code.  ...  When glomerular activity patterns are viewed relative to the overall level of glomerular activation, the patterns accurately predict the perception of odor quality, thereby supporting the notion that spatial  ...  Acknowledgements Supported by United States Public Health Service Grants DC03545, DC006391, and DC006516  ... 
doi:10.1002/cne.21396 pmid:17480025 pmcid:PMC2213457 fatcat:ozxw65aefrecza27fr32rhyzom

Abstracts from the Thirty-fourth Annual Meeting of the Association for Chemoreception Sciences

2013 Chemical Senses  
Thus, non-promoter DNA methylation by Dnmt3a may be utilized for maintaining active chromatin states of genes critical for development.  ...  Here I will review data from our and other labs that have used functional neuroimaging to uncover context-dependent patterns of activity in both primary and secondary olfactory cortex.  ...  Using intrinsic optical signals imaging and local field potential recordings, we observed that odor maps and changes in oscillatory patterns of activity in the OB are present for both types of stimuli  ... 
doi:10.1093/chemse/bjs091 pmid:23300212 fatcat:or55rqfvszfqdmmdlusi5jfrbi

Abstracts from the Thirty-first Annual Meeting of the Association for Chemoreception Sciences

2009 Chemical Senses  
Recently, we have used fura-2 based calcium imaging to explore the ability of FFAs to elicit intracellular calcium ([Ca2+]i) rise in isolated C57BL/6 TBCs.  ...  Precision emerges in development as synaptic connections remodel, a process requiring neural activity and involving regression of some synapses and strengthening and stabilization of others.  ...  The idea that glomerular activation patterns underlie odor perception and recognition is analogous to claiming that the inverted image maps of photoreceptor activation identify visual objects; that is,  ... 
doi:10.1093/chemse/bjp032 fatcat:6xmofcx6xbcclhmogkxgybu5yu

XXVIIth Annual Meeting of the European Chemoreception Research Organization, ECRO 2017

2018 Chemical Senses  
I will take a look at the chemical, psychological, and computational approaches to combine flavours for maximal impact.  ...  I will argue that the psychological account (informed by an awareness of cultural differences), and to a lesser extent the chemical account, would appear to provide the most meaningful suggestions as far  ...  Acknowledgment: This work was supported by AMOREPACIFIC R&D unit (RI5A000002) P33-A systematic comparison of semiochemical signaling in the accessory olfactory system of wild and lab strain mice  ... 
doi:10.1093/chemse/bjx077 fatcat:7x7swc55ivhqbgcxv43qjuhfvi

Abstracts from the 35th Annual Meeting of AChemS

2013 Chemical Senses  
Acknowledgements: Supported by DK078779 Although the olfactory map facilitates the encoding of odor information, how its pattern is specified remains largely unknown.  ...  Recent work has shown that the Drosophila olfactory map is initially formed by spatial segregation of the projection neuron dendrites in the antennal lobe.  ...  we combined fMRI with intrinsic and calcium optical imaging to better characterize glomerular responses.  ... 
doi:10.1093/chemse/bjt036 fatcat:y46sw4p335epfkuraityepgpnm

List of Abstracts from the Twenty-ninth Annual Meeting of the Association for Chemoreception Sciences

2007 Chemical Senses  
By drawing on studies from behavioral biology, neuroscience, molecular biology and genomics, this lecture will explore the secrets of their success.  ...  of social behavior using the "evo-devo" paradigm, and a new perspective on the nature-nurture problem.  ...  software to include the mapping method specified by the Leon and Johnson lab and intend to add a method to import the odor maps available in their Glomerular Activity Response Database.  ... 
doi:10.1093/chemse/bjm024 fatcat:vvc2tltr6ff2jpjf5oexocyuyy

List of Abstracts of the Seventeenth Annual Meeting of the European Chemoreception Research Organisation

2006 Chemical Senses  
providing an initial step in the reconstruction of an odor image from its deconstructed features.  ...  Dade et al. compared working memory for odors and faces in a two-back samedifferent task and found similar levels of performance.  ...  To analyze the network activity underlying these computations, we measured odor responses across large numbers of neurons by 2-photon imaging after bolus loading of a calcium indicator.  ... 
doi:10.1093/chemse/bjl029 fatcat:bhjdee37fjbqtgolwpshbpes5y

An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction

Gordon M. Shepherd, Timothy B. Rowe, Charles A. Greer
2021 Frontiers in Cellular Neuroscience  
Parallel research provided strong evidence that processed odor information is spatial representations of odor molecules that constitute odor images in the olfactory bulb and odor objects in olfactory cortex  ...  We take a first step toward a fundamental understanding by identifying the sequence of local operations carried out by microcircuits in the pathway.  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ... 
doi:10.3389/fncel.2021.658480 pmid:33994949 pmcid:PMC8120314 fatcat:ttijyzsqgbcvplneg35qwmtpfy

Functional Connectivity of the Brain Across Rodents and Humans [article]

Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, Behnaz Yousefi, Yasmine Bassil, Gloria Perrin Clavijo, Vahid Khalilzad Sharghi, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+2 others)
2022 arXiv   pre-print
of the brain's physiological and pathological functional activity.  ...  Time-varying features of functional connectivity, obtained by sliding windowed approaches, quasi-periodic patterns, and coactivation patterns, are compared across species.  ...  Acknowledgments The authors would like to thank Harry Watters for helpful discussions, and acknowledge funding from 1R01MH111416, 1R01NS078095, and 1R01EB029857.  ... 
arXiv:2111.05912v5 fatcat:6vqseyf5qvgdjdbhy5esnpjrse

Functional Connectivity of the Brain Across Rodents and Humans

Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, Behnaz Yousefi, Yasmine Bassil, Gloria P. Clavijo, Vahid Khalilzad Sharghi, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+2 others)
2022 Frontiers in Neuroscience  
of the brain's physiological and pathological functional activity.  ...  Time-varying features of functional connectivity, obtained by sliding windowed approaches, quasi-periodic patterns, and coactivation patterns, are compared across species.  ...  For example, the default mode network is implicated in a wide variety of human behavior, and an analogous network has been proposed for rodents.  ... 
doi:10.3389/fnins.2022.816331 pmid:35350561 pmcid:PMC8957796 fatcat:kkfqmlxlyncbzinrgrqtu6p4ia

Twenty-first Annual Meeting of the Association for Chemoreception Sciences

1999 Chemical Senses  
It will be shown that the calcium-dependent processes best understood at the molecular level-the activation of guanylyl cyclase (GC) by calcium-sensing GCAPs and the CaCM-dependent shift in the K½ of the  ...  Tuning is effected by variations in the number of ion channels and in the kinetics of K + -channel activation, the latter adjustment brought about by alternative splicing of the mRNA encoding the K + channels  ...  Smith and J. Walker and D. Ahlgren for project assistance.  ... 
doi:10.1093/chemse/24.5.517 fatcat:bcmvg6zuenfqtlte5kww3srayy

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience: Eilat, Israel, November 25–27, 2007

2007 Neural Plasticity  
The Israel Society for Neuroscience—ISFN—was founded in 1993 by a group of Israeli leading scientists conducting research in the area of neurobiology.  ...  The primary goal of the society was to promote and disseminate the knowledge and understanding acquired by its members, and to strengthen interactions between them.  ...  The effects of music background on sleep efficiency, anxiety and depression in Schizophrenia patients  ... 
doi:10.1155/2007/30585 pmid:25148070 pmcid:PMC2366074 fatcat:u4tjfw6shnaxpnzwezieeiqnpm

Association for Chemoreception Sciences (AChemS), 37th Annual Meeting, Bonita Springs, Florida, 22–25 April 2015:

2015 Chemical Senses  
Active odor sampling behaviors shape spatiotemporal input patterns and thus also shape processing and perception.  ...  We found that odors activate sparse, dispersed patterns of piriform neurons, which exhibit considerable trial-to-trial variability.  ...  Abstracts are printed as submitted by the author(s).  ... 
doi:10.1093/chemse/bjv029 fatcat:nf3ixsnfwfd5zcig6j3aagrura

Abstracts from the 24th Annual Meeting of the European Chemoreception Research Organization (ECRO 2014), Dijon, France, September 10-13th, 2014

2015 Chemical Senses  
By combining Multi-Voxel Pattern Analysis and fMRI, we found distinct spatial activity patterns in piriform cortex (PC) as a function of chemical and perceptual similarity: whereas anterior PC activity  ...  We present here a brain imaging study aimed at relating neural activity in human olfactory cortex and chemical space of odorants on the one hand and perceptual space of odors on the other hand.  ...  Olfactory Performance Is Predicted by Individual Sex-Atypicality, but Not Sexual Orientation A Novel Semi Intact in Situ Nose-Olfactory Bulb-Brainstem Preparation (NOBBP) of Rat  ... 
doi:10.1093/chemse/bju073 fatcat:tcf6foce2ve6zn77aqjzywelcm
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