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Comparison of Residence Time Estimation Methods for Radioimmunotherapy Dosimetry and Treatment Planning—Monte Carlo Simulation Studies

Bin He, R.L. Wahl, Yong Du, G. Sgouros, H. Jacene, I. Flinn, E.C. Frey
2008 IEEE Transactions on Medical Imaging  
Estimating the residence times in tumor and normal organs is an essential part of treatment planning for radioimmunotherapy (RIT).  ...  In this study we compared the use of residence time estimation methods using QSPECT to planar methods.  ...  Wahl has licensed inventions regarding radioimmunotherapy through the University of Michigan to GlaxoSmithKline and Biogen-Idec related to RIT agents Bexxar and Zevalin.  ... 
doi:10.1109/tmi.2007.908131 pmid:18390348 pmcid:PMC2588667 fatcat:a5ixc3f6qfdrvjx4pqaloasuka

Comparison of I-131 Radioimmunotherapy Tumor Dosimetry: Unit Density Sphere Model Versus Patient-Specific Monte Carlo Calculations

David M. Howard, Kimberlee J. Kearfott, Scott J. Wilderman, Yuni K. Dewaraja
2011 Cancer Biotherapy and Radiopharmaceuticals  
The goal of this study was to compare mean tumor absorbed dose estimates using the unit density sphere model incorporated in OLINDA with previously reported dose estimates from Monte Carlo simulations  ...  High computational requirements restrict the use of Monte Carlo algorithms for dose estimation in a clinical setting, despite the fact that they are considered more accurate than traditional methods.  ...  Acknowledgments This work was supported by grant 2R01 EB001994 awarded by the National Institutes of Health, United States Department of Health and Human Services (Bethesda, MD).  ... 
doi:10.1089/cbr.2011.0965 pmid:21939358 pmcid:PMC3189007 fatcat:vz2dowc5zraidgaiwgztsdiqye

The Impact of PET and SPECT on Dosimetry for Targeted Radionuclide Therapy

Glenn Flux, Manuel Bardies, Myriam Monsieurs, Sauli Savolainen, Sven-Erik Strand, Michael Lassmann
2006 Zeitschrift für Medizinische Physik  
To date, few treatments have involved the use of dosimetry either to plan treatment or to retrospectively ascertain the absorbed dose delivered during treatment.  ...  Monte Carlo simulations are an appealing tool that can help to model interactions occurring in the patient or in the detector system.  ...  The residence times for Y-90 in blood and major organs were estimated from In-111 [14] .  ... 
doi:10.1078/0939-3889-00291 pmid:16696370 fatcat:uiemmk5tcjg23d75epvwz6kxl4

Use of Integrated SPECT/CT Imaging for Tumor Dosimetry in I-131 Radioimmunotherapy: A Pilot Patient Study

Yuni K. Dewaraja, Scott J. Wilderman, Kenneth F. Koral, Mark S. Kaminski, Anca M. Avram
2009 Cancer Biotherapy and Radiopharmaceuticals  
In summary, malignant lymphomas can have dramatic tumor regression within days of treatment, and advanced imaging methods allow for a highly patient-specific tumor-dosimetry calculation that accounts for  ...  In this article, we present the methodology for highly patient-specific tumor dosimetry by utilizing such a system and apply it to a pilot study of 4 follicular lymphoma patients treated with I-131 tositumomab  ...  ., and James Chapman, Ph.D., of Siemens Medical Solutions for helpful discussions about the SPECT=CT system. Disclosure Statement Dr.  ... 
doi:10.1089/cbr.2008.0568 pmid:19694576 pmcid:PMC2841975 fatcat:f3er72rj2fgelawjd3niio7bwa

Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy

Wietske Woliner-van der Weg, Rafke Schoffelen, Robert F Hobbs, Martin Gotthardt, David M Goldenberg, Robert M Sharkey, Cornelis H Slump, Winette TA van der Graaf, Wim JG Oyen, Otto C Boerman, George Sgouros, Eric P Visser
2015 EJNMMI Physics  
We developed a three-dimensional (3D) image-based RBM dosimetry approach using the Monte Carlo-based 3D radiobiological dosimetry (3D-RD) software and determined its additional value for predicting RBM  ...  Tumor-to-RBM dose ratios were calculated and compared for 177 Lu-based pretargeted RIT and simulated pretargeted RIT with 90 Y.  ...  KUN 2008-4038) and NCI R01CA116477. We thank Antoi P.W. Meeuwis for providing the essential assistance in preparing the data for the dosimetry.  ... 
doi:10.1186/s40658-014-0104-x pmid:26501807 pmcid:PMC4545615 fatcat:d7ty2r34fzd3pcvz3ojx43f7hi

A radionuclide therapy treatment planning and dose estimation system

A Liu, L E Williams, G Lopatin, D M Yamauchi, J Y Wong, A A Raubitschek
1999 Journal of Nuclear Medicine  
The system is called the Radionuclide Treatment Planning and Absorbed Dose Estimation System (RTDS).  ...  It is intended for radioimmunotherapy applications, although other forms of internal emitter therapy may also be considered.  ...  Absorbed Dose Estimation Module Two methods are available for absorbed dose estimation given the organ residence times.  ... 
pmid:10405136 fatcat:34ojq36pvzhi7pxpdikxr42rrm

131I-Tositumomab Radioimmunotherapy: Initial Tumor Dose-Response Results Using 3-Dimensional Dosimetry Including Radiobiologic Modeling

Y. K. Dewaraja, M. J. Schipper, P. L. Roberson, S. J. Wilderman, H. Amro, D. D. Regan, K. F. Koral, M. S. Kaminski, A. M. Avram
2010 Journal of Nuclear Medicine  
Methods: Twenty patients undergoing 131 I-tositumomab for the treatment of refractory B-cell lymphoma volunteered for the study. Sixty tumors were imaged.  ...  Here, fully 3-dimensional (3D) dosimetry was performed coupling SPECT/CT at multiple time points with Monte Carlo-based voxelby-voxel dosimetry to examine such correlations.  ...  ACKNOWLEDGMENTS This work was supported by grant 2R01 EB001994 awarded by the National Institute of Health, United States Department of Health and Human Services.  ... 
doi:10.2967/jnumed.110.075176 pmid:20554734 pmcid:PMC3302158 fatcat:kqpnerphyje5rnxf26vf3rnqf4

Radiological Technology for Targeted Radionuclide Therapy

Kohei Hanaoka, Noriaki Miyaji, Hiroto Yoneyama, Matsuyoshi Ogawa, Takamasa Maeda, Kenta Sakaguchi, Takashi Iimori, Hiroyuki Tsushima
2020 Japanese Journal of Radiological Technology  
Targeted radioisotope therapy (TRT) is a radiotherapy using radioisotope or drug incorporating it and has been used as a treatment for selectively irradiating cancer cells.  ...  In recent years, interest in TRT has increased due to improvements in radionuclide production technology, development of new drugs and imaging modalities, and improvements in radiation technology.  ...  Comparison of residence time estimation methods for radioimmunotherapy dosimetry and treatment planning-Monte Carlo simulation studies.  ... 
doi:10.6009/jjrt.2020_jsrt_76.12.1237 pmid:33342942 fatcat:h6bfb7bp6baubbiibdf4y7dwlq

Dosimetry of internal emitters

George Sgouros
2005 Journal of Nuclear Medicine  
A treatment planning approach to radionuclide therapy will eventually require incorporation of biologic and radiobiologic considerations.  ...  Ongoing efforts to improve the accuracy of dosimetry calculations are discussed, as well as studies examining the relationship between absorbed dose and response.  ...  ACKNOWLEDGMENTS Support from the National Institutes of Health (grants R01 CA62444, R01 CA 72683, and P01 CA33049) and from the U.S.  ... 
pmid:15653648 fatcat:3h6lqyxnazduvf4gwnvvvmgtmy

Crypt Cell Dosimetry for 99Tcm-Sestamibi in a New Small Intestinal Dosimetry Model

Lena Jönsson, Xiaowei Liu, Bo-Anders Jönsson, Michael Ljungberg, Sven-Erik Strand
2003 Cancer Biotherapy and Radiopharmaceuticals  
A novel approach is the generation of Monte Carlo simulated scintillation camera images of a computer patient using a radionuclide biodistribution obtained from an experimental animal study.  ...  The main focus was on the use of detailed biokinetic data from animals combined with Monte Carlo simulations using anthropomorphic phantoms on macro level, and applied in the development and refinement  ...  Acknowledgements During the course of the work described in this thesis several people have helped and supported me in many ways.  ... 
doi:10.1089/108497803765036382 pmid:12804047 fatcat:unf76km4unchdconty4lv4wwlm

EQPlanar: a maximum-likelihood method for accurate organ activity estimation from whole body planar projections

N Song, B He, R L Wahl, E C Frey
2011 Physics in Medicine and Biology  
We have validated this method using both Monte Carlo simulation and patient data.  ...  In the simulation study, we evaluated the precision and accuracy of the method in comparison to the original QPlanar method.  ...  . : EQPlanar method LKidney : left kidney, RKidney: right kidney.  ... 
doi:10.1088/0031-9155/56/17/004 pmid:21813961 pmcid:PMC3335261 fatcat:2zxyaxnnezharf4ujynpbr2wmu

State of the Art in Nuclear Medicine Dose Assessment

Michael G. Stabin, A. Bertrand Brill
2008 Seminars in nuclear medicine  
Methods for quantification of activity in clinical and preclinical studies also are discussed, and we show how to implement them in currently available dose calculational models.  ...  Some of the future challenges for dose assessment in nuclear medicine are discussed, including application of patient-specific dose calculational methods and the need for significant advances in radiation  ...  body in a way that allows Monte Carlo computer programs to simulate the creation and transport of photons through these various structures in the body.  ... 
doi:10.1053/j.semnuclmed.2008.05.005 pmid:18662553 fatcat:blemr5csvza5zdaddb3bkb7jvi

Radiolabeled Immunoglobulin Therapy for Patients with Solid Tumors

Nabil Khater, Marcel Kap, Rima Sayah, Dimor Elbers, Huib M Vriesendorp
2017 Journal of Nuclear Medicine & Radiation Therapy  
Monte-Carlo simulation and convolution calculations were used to determine the activity of Y-90 required for delivering 100Gy to a 50 × 50 × 50 mm 3 water-equivalent tumor model, assuming a homogeneous  ...  Materials and Methods: Using Immunohistochemistry (IHC), mouse anti-human TNC IgM and IgG clones were tested for the detection of TNC in formalin fixed biopsies of patients with Glioblastoma multiforme  ...  field of radioimmunotherapy.  ... 
doi:10.4172/2155-9619.1000338 fatcat:nqpsvzhpdfegja4w75xqby3ioi

Application of the 4-D XCAT Phantoms in Biomedical Imaging and Beyond

W. Paul Segars, B. M. W. Tsui, Jing Cai, Fang-Fang Yin, George S. K. Fung, Ehsan Samei
2018 IEEE Transactions on Medical Imaging  
The XCAT series encompasses a vast population of phantoms of varying ages from newborn to adult, each including parameterized models for the cardiac and respiratory motions.  ...  simulated.  ...  Acknowledgments This work was supported by the research grant R01 EB001838 from the National Institutes of Health.  ... 
doi:10.1109/tmi.2017.2738448 pmid:28809677 pmcid:PMC5809240 fatcat:tqw4jbctkjb4fhe4jtg2evei7y

Nuclear medicine dosimetry

Michael Stabin
2006 Physics in Medicine and Biology  
Basic methods of internal dosimetry and the systems that have been developed for use in nuclear medicine are described.  ...  The development of the MIRD system and the International Radiopharmaceutical Dosimetry Symposium series is outlined. The evolution of models and tools for calculating dose estimates is reviewed.  ...  The PEREGRINE code (Lehmann et al 2005) has also been proposed for three-dimensional, computational dosimetry and treatment planning in radioimmunotherapy.  ... 
doi:10.1088/0031-9155/51/13/r12 pmid:16790903 fatcat:i7wrnzkfyncm3owvtqf7wpda34
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