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ClinicalTrials.gov as a Data Source for Semi-Automated Point-Of-Care Trial Eligibility Screening

Pascal B. Pfiffner, JiWon Oh, Timothy A. Miller, Kenneth D. Mandl, Gajendra P. S. Raghava
2014 PLoS ONE  
Implementing semi-automated processes to efficiently match patients to clinical trials at the point of care requires both detailed patient data and authoritative information about open studies.  ...  Objective: To evaluate the utility of the ClinicalTrials.gov registry as a data source for semi-automated trial eligibility screening.  ...  Acknowledgments We thank Lee Nadler for his support and wisdom.  ... 
doi:10.1371/journal.pone.0111055 pmid:25334031 pmcid:PMC4205089 fatcat:mt7lkowh75gvrl6ehwlmgv6aui

Natural Language Processing for Mimicking Clinical Trial Recruitment in Critical Care: A Semi-automated Simulation Based on the LeoPARDS Trial [article]

Hegler Tissot, Anoop Shah, Ruth Agbakoba, Amos Folarin, David Brealey, Steve Harris, Richard Dobson, Folkert Asselbergs
2019 biorxiv/medrxiv   pre-print
We applied an algorithm to identify eligible patients using a moving 1-hour time window, and compared the set of patients identified by our approach with those actually screened and recruited for the trial  ...  Clinical trials often fail on recruiting an adequate number of appropriate patients.  ...  We demonstrate that even simple NLP techniques combined with a multi-contextualized searchable platform are able to support automatic or semi-automatic clinical trial screening. II. METHODS A.  ... 
doi:10.1101/19005603 fatcat:agloqpm3qrddxizrgy3yiynjse

Performances of a Solution to Semi-Automatically Fill eCRF with Data from the Electronic Health Record: Protocol for a Prospective Individual Participant Data Meta-Analysis

Nicolas Griffon, Helena Pereira, Juliette Djadi-Prat, María Teresa García, Sara Testoni, Manon Cariou, Jacques Hilbey, Aurèle N'Dja, Grégory Navarro, Nicola Gentili, Oriana Nanni, Massimo Raineri (+8 others)
2020 Studies in Health Technology and Informatics  
The present paper describes the design of the evaluation of a technology allowing EHR to act as eSource for clinical trials.  ...  The evaluation protocol consists in an individual participant data prospective meta-analysis comparing regular clinical trial data collection to the semi-automated one.  ...  Study design The main idea of this evaluation is to take advantage of real ongoing clinical trials (support CT), by performing a semi-automatic data collection in addition, and independently, to the usual  ... 
doi:10.3233/shti200184 pmid:32570408 fatcat:pe6mozqlorfxnfk3rixgvqgmea

Improving the pre-screening of eligible patients in order to increase enrollment in cancer clinical trials

Boris Campillo-Gimenez, Camille Buscail, Oussama Zekri, Brigitte Laguerre, Elisabeth Le Prisé, Renaud De Crevoisier, Marc Cuggia
2015 Trials  
This study aims to explore the pre-screening phase of four prostate cancer RCTs to identify the impact of a systematic pre-selection of eligible patients for RCT recruitment.  ...  Thus, our study confirms the potential gain in using semi-automated pre-selection of MDC reports, in order to avoid missing out on patients eligible for RCTs.  ...  The authors would like to especially thank Delphine Rosille, Sahar Bayat, Marc Carpentier, and Regis Duvauferrier for their valuable comments.  ... 
doi:10.1186/s13063-014-0535-7 pmid:25592642 pmcid:PMC4301877 fatcat:rlu7bikipzeq3asgo7nhwikzcu

Adipose Tissue Stem Cells for Therapy: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application

Dinh-Toi Chu, Thuy Nguyen Thi Phuong, Nguyen Le Bao Tien, Dang Khoa Tran, Le Bui Minh, Vo Van Thanh, Pham Gia Anh, Van Huy Pham, Vu Thi Nga
2019 Journal of Clinical Medicine  
In fact, the number of clinical trials on ASCs is going to increase by years; however, most trials are in phase I and II, and lack phase III and IV.  ...  Adipose tissues (AT) have the advantage in the harvesting, isolation, and expansion of ASCs, especially an abundant amount of stem cells compared to bone marrow.  ...  Acknowledgments: We would like to thank Phuong Linh Nguyen (an English editor) and Tran Uyen Ngoc (Nong Lam University, Ho Chi Minh, Vietnam) for critical reading and checking to improve the manuscript  ... 
doi:10.3390/jcm8070917 pmid:31247996 pmcid:PMC6678927 fatcat:uzgmt5oqczdb7j5c74et6ycl5a

Using OncoDoc as a computer-based eligibility screening system to improve accrual onto breast cancer clinical trials

Brigitte Séroussi, Jacques Bouaud
2003 Artificial Intelligence in Medicine  
However, the analysis of the reasons for non-accrual of potentially eligible patients showed that physicians' psychological reluctance to refer patients to clinical trials, measured during the experiment  ...  OncoDoc is a decision support system designed to provide best therapeutic recommendations for breast cancer patients.  ...  For any new patient entered into the system, trials that the new patient is not eligible for are ruled out and relevant clinical trials are displayed in order of likelyhood of match.  ... 
doi:10.1016/s0933-3657(03)00040-x pmid:12957785 fatcat:4an27qrajzdzldenlnrf4sh4dm

Using ONCODOC as a Computer-Based Eligibility Screening System to Improve Accrual onto Breast Cancer Clinical Trials [chapter]

Brigitte Séroussi, Jacques Bouaud, Eric-Charles Antoine, Laurent Zelek, Marc Spielmann
2001 Lecture Notes in Computer Science  
However, the analysis of the reasons for non-accrual of potentially eligible patients showed that physicians' psychological reluctance to refer patients to clinical trials, measured during the experiment  ...  OncoDoc is a decision support system designed to provide best therapeutic recommendations for breast cancer patients.  ...  For any new patient entered into the system, trials that the new patient is not eligible for are ruled out and relevant clinical trials are displayed in order of likelyhood of match.  ... 
doi:10.1007/3-540-48229-6_58 fatcat:mlpwvpfjizgldbzj6dbugiljxu

Formalization of clinical trial eligibility criteria: Evaluation of a pattern-based approach

K. Milian, A. Bucur, Annette Ten Teije
2012 2012 IEEE International Conference on Bioinformatics and Biomedicine  
The semi-automatic evaluation of eligibility criteria can facilitate the recruitment for clinical trials, timely completion of studies and generation of clinical evidence about new approaches to treatment  ...  and can support patient recruitment.  ...  CONCLUSION In this paper we presented the evaluation of our approach to the formalization of eligibility criteria which aims to support semi-automatic verification of patient eligibility for clinical trials  ... 
doi:10.1109/bibm.2012.6392733 dblp:conf/bibm/MiliariBT12 fatcat:7fuzygbaebexhdr65ofqxgnole

Developing stepped care treatment for depression (STEPS): study protocol for a pilot randomised controlled trial

Jacqueline J Hill, Willem Kuyken, David A Richards
2014 Trials  
Compared with alternative systems, it is assumed to achieve equivalent clinical effects and greater efficiency. However, no trials have examined these assumptions.  ...  Quantitative trial data on recruitment, retention and the pathway of patients through treatment will be used to assess feasibility.  ...  The trial randomisation database was designed and hosted by the Peninsula Clinical Trials Unit.  ... 
doi:10.1186/1745-6215-15-452 pmid:25409886 pmcid:PMC4247766 fatcat:h2irr6vhwbfftgbh2s7tjro3zy

Challenges to and Facilitators of Recruitment to an Alzheimer's Disease Clinical Trial: A Qualitative Interview Study

Clare Clement, Lucy E. Selman, Patrick G. Kehoe, Beth Howden, J. Athene Lane, Jeremy Horwood
2019 Journal of Alzheimer's Disease  
Low participation in clinical trials is a major challenge to advancing clinical Alzheimer's disease (AD) research and care. Factors influencing recruitment to AD trials are not fully understood.  ...  This study was designed and delivered in collaboration with the Bristol Randomised Trials Collaboration (BRTC), a UKCRC registered clinical trials unit which, as part of the Bristol Trials Centre, is in  ...  receipt of National Institute for Health Research CTU support funding.  ... 
doi:10.3233/jad-190146 pmid:31156168 pmcid:PMC6598018 fatcat:7fjbep567vbjvnxlavtgzh3cqy

Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies

Anca Bucur, Jasper van Leeuwen, David Perez-Rey, Raul Alonso Calvo, Brecht Claerhout, Kristof de Schepper
2012 2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)  
of the eligibility of patients for available trials.  ...  An important objective of the INTEGRATE project 1 is to build tools that support the efficient execution of post-genomic multi-centric clinical trials in breast cancer, which includes the automatic assessment  ...  (semi)-automatic trial matching.  ... 
doi:10.1109/bibe.2012.6399762 dblp:conf/bibe/BucurLPACS12 fatcat:iuyya3xp5zbc3axrx36vrfnvhe

A Medical Informatics Perspective on Decision Support Systems

P. Ruch
2012 IMIA Yearbook of Medical Informatics  
Decision Support Systems for Computerized Provider Order Entry, both for physicians and pharmacists, as well as more specific developments such as instruments to improve processing of data related to Clinical  ...  This selected set of scientific investigations clearly question the way decision support systems are deployed in clinical environments as these systems seem to have little impact on patient safety and  ...  Acknowledgement I greatly acknowledge the support of Martina Hutter and of the reviewers in the selection process of the IMIA Yearbook.  ... 
doi:10.1055/s-0038-1639440 fatcat:zmtqgksg7fhdbiwyfiprg7jppm

Promoting adherence to treatment for latent TB infection through mobile phone text messaging: study protocol for a pilot randomized controlled trial

Eyal Oren, Melanie L. Bell, Francisco Garcia, Carlos Perez-Velez, Lynn B. Gerald
2017 Pilot and Feasibility Studies  
Trial registration: NCT02690818 (Clinical Trials.gov)  ...  Methods/design: We aim to determine the feasibility and acceptability of text reminders for improving adherence in latent TB patients using a randomized controlled single-blinded trial, measuring adherence  ...  Acknowledgements The authors would like to acknowledge the study and clinic staffs who are contributing to or are involved in this project.  ... 
doi:10.1186/s40814-017-0128-9 pmid:28293431 pmcid:PMC5346839 fatcat:5yiknbwx6zamfp6yw7psak3zba

Measurement of Alveolar Recruitment at the Bedside: The Beginning of a New Era in Respiratory Monitoring?

J.-J. Rouby, C. Arbelot, H. Brisson, Q. Lu, B. Bouhemad
2013 Respiratory care  
before being recommended for clinical use.  ...  different PEEP levels. 5 Use of PV curves for measuring recruitment in patients with ARDS relies on a strong rationale.  ... 
doi:10.4187/respcare.02363 pmid:23443286 fatcat:7qmgxhyuhfbj7dq27jc4ejcigy

Feasibility and acceptability of TRANSFoRm to improve clinical trial recruitment in primary care

Nikolaos Mastellos, Grzegorz Bliźniuk, Dorota Czopnik, Mark McGilchrist, Andrzej Misiaszek, Piotr Bródka, Vasa Curcin, Josip Car, Brendan C Delaney, Anna Andreasson
2015 Family Practice  
In another study, the use of clinical trial alerts for the identification of patients whose EHR data met specific eligibility criteria resulted in increased physician participation, recruitment efficacy  ...  Methods Study aim and objectives This study examines physician and patient acceptability of TRANSFoRm with the aim to confirm its feasibility to perform clinical trial recruitment and follow-up in primary  ... 
doi:10.1093/fampra/cmv102 pmid:26711958 fatcat:qug7y4lutzesvj6japrslj3dxe
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