Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions
If microscopic reversibility is obeyed, then the number of forward and backward transitions per unit time for each individual reaction step will, on average, be identical and, consequently, the gating ...
No significant differences were observed between the forward and backward analysis of the two-dimensional dwell-time distributions, suggesting time reversibility. ...
Owen McManus for providing some of the data that were analyzed for this study, and Dr. W. Ferguson for carrying out some of the preliminary analysis. This work was supported in part by grants to K. ...