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Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease

Yi Li, Juha O. Rinne, Lisa Mosconi, Elizabeth Pirraglia, Henry Rusinek, Susan DeSanti, Nina Kemppainen, Kjell Någren, Byeong-Chae Kim, Wai Tsui, Mony J. de Leon
2008 European Journal of Nuclear Medicine and Molecular Imaging  
emission tomography (PET) and amyloid-beta pathology using Pittsburgh Compound-B ([11C]PIB)-PET in the evaluation of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) compared  ...  Parametric images of PIB uptake and MRglc were sampled using automated regions-of-interest (ROI).  ...  Conclusions We demonstrate an automated technique that enables one to regionally sample individual brain PET scans with high anatomical precision without requiring an MRI scan for reference or spatial  ... 
doi:10.1007/s00259-008-0833-y pmid:18566819 pmcid:PMC2693402 fatcat:agdrqtqqwbfthhf2qhic2oprte

Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approaches

Ann D. Cohen, Wenzhu Mowrey, Lisa A. Weissfeld, Howard J. Aizenstein, Eric McDade, James M. Mountz, Robert D. Nebes, Judith A. Saxton, Beth Snitz, Steven DeKosky, Jeff Williamson, Oscar L. Lopez (+3 others)
2013 NeuroImage  
We previously reported the iterative outlier approach (IO) for the analysis of Pittsburgh Compound-B (PiB) PET data.  ...  IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects  ...  Acknowledgments Supported by: The National Institutes of Health grants: K01 AG037562, R01 AG033042, P50 AG005133, R37 AG025516, P01 AG025204.  ... 
doi:10.1016/j.neuroimage.2013.01.015 pmid:23353602 pmcid:PMC3605888 fatcat:d5pnduryyzfyjmt2sxoqskdtvm

Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET

Bedda L. Rosario, Lisa A. Weissfeld, Charles M. Laymon, Chester A. Mathis, William E. Klunk, Michael D. Berginc, Jeffrey A. James, Jessica A. Hoge, Julie C. Price
2011 NeuroImage  
Manual region-of-interest (ROI) delineation on structural magnetic resonance (MR) images is generally the reference standard for the extraction of count-rate data from PET images, as compared to automated  ...  The goal of this work was to assess the inter-rater reliability of manual ROI delineation for PiB PET amyloid retention measures and the impact of CSF dilution correction (CSF) on this reliability for  ...  Acknowledgments We thank our University of Pittsburgh colleagues at the Alzheimer Disease Research Center and the PET facility for their efforts in conducting and analyzing these studies.  ... 
doi:10.1016/j.neuroimage.2010.12.070 pmid:21195782 pmcid:PMC3057323 fatcat:stnsbpf7yrg25gacn55eggmihy

Quantitative analysis of regional distribution of tau pathology with 11C-PBB3-PET in a clinical setting

Elham Yousefzadeh-Nowshahr, Gordon Winter, Peter Bohn, Katharina Kneer, Christine A. F. von Arnim, Markus Otto, Christoph Solbach, Sarah Anderl-Straub, Dörte Polivka, Patrick Fissler, Joachim Strobel, Peter Kletting (+7 others)
2022 PLoS ONE  
Pittsburg compound B (11C-PIB) PET was available for 17, 18F-flurodeoxyglucose (18F-FDG) PET for 16, and cerebrospinal fluid (CSF) protein levels for 11 patients.  ...  The atlas-based analysis supported the outcome of the voxel-wise quantification analysis.  ...  Acknowledgments A part of data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI  ... 
doi:10.1371/journal.pone.0266906 pmid:35404966 pmcid:PMC9045369 fatcat:xm7dnc3cdbbbpawvmpujkb3toq

Amyloid- Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods

S. M. Landau, C. Breault, A. D. Joshi, M. Pontecorvo, C. A. Mathis, W. J. Jagust, M. A. Mintun
2012 Journal of Nuclear Medicine  
Here, we evaluated PiB and florbetapir in a retrospective convenience sample of cognitively normal older controls, patients with mild cognitive impairment, and patients with Alzheimer disease from the  ...  (11)C-Pittsburgh compound B ((11)C-PiB) and (18)F-florbetapir amyloid-β (Aβ) PET radioligands have had a substantial impact on Alzheimer disease research.  ...  Data Analysis PiB and florbetapir image data were analyzed using 2 processing streams. The PET-template analysis method was described in a separate study (10) .  ... 
doi:10.2967/jnumed.112.109009 pmid:23166389 pmcid:PMC3747730 fatcat:vic6p3ecsnaq7mzifw6dbvfmx4

Relationships between biomarkers in aging and dementia

W. J. Jagust, S. M. Landau, L. M. Shaw, J. Q. Trojanowski, R. A. Koeppe, E. M. Reiman, N. L. Foster, R. C. Petersen, M. W. Weiner, J. C. Price, C. A. Mathis
2009 Neurology  
Data were analyzed using continuous regression and dichotomous outcomes with subjects classified as "positive" or "negative" for AD based on cutoffs established in patients with AD and controls from other  ...  PET imaging using [(18)F]fluorodeoxyglucose (FDG) and [(11)C]Pittsburgh compound B (PIB) have been proposed as biomarkers of Alzheimer disease (AD), as have CSF measures of the 42 amino acid beta-amyloid  ...  The PIB-PET data were resliced to the dimensions of the MCI template, and normalized counts were extracted from each ROI.  ... 
doi:10.1212/wnl.0b013e3181bc010c pmid:19822868 pmcid:PMC2764726 fatcat:ephdww7jqnavhfsxarx6w43wfm

A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients

Claes N. Ladefoged, Ian Law, Udunna Anazodo, Keith St. Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M. Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes (+16 others)
2017 NeuroImage  
These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based.  ...  Using a unified quantitative evaluation with identical metrics, subject cohort, and common CT-based reference, the aims of this study were to evaluate a selection of novel methods proposed in the literature  ...  the mean Rel % for each region in the template.  ... 
doi:10.1016/j.neuroimage.2016.12.010 pmid:27988322 pmcid:PMC6818242 fatcat:b4ish35snjgijcprv4zf6ectfm

Implementation and Validation of an Adaptive Template Registration Method for 18F-Flutemetamol Imaging Data

R. Lundqvist, J. Lilja, B. A. Thomas, J. Lotjonen, V. L. Villemagne, C. C. Rowe, L. Thurfjell
2013 Journal of Nuclear Medicine  
relation for the AIBL 11 C-PIB data (Pearson r 5 0.94).  ...  Conclusion: The derived adaptive template registration method allows for robust, accurate, and fully automated quantification of uptake for 18 Fflutemetamol and 11 C-PIB scans without the use of MR imaging  ...  It may be possible that the quality of the registration of 11 C-PIB data can be further improved if a 11 C-PIB-specific adaptive template is built, but this has to be further evaluated.  ... 
doi:10.2967/jnumed.112.115006 pmid:23740104 fatcat:nvbbw7qu3bbrtlvwklydme6b6y

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015

William J. Jagust, Susan M. Landau, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Julie C. Price, Norman L. Foster, Angela Y. Wang
2015 Alzheimer's & Dementia  
Four different laboratories are involved in data analysis, and have examined factors such as longitudinal florbetapir analysis, use of [ 18 F]fluorodeoxyglucose (FDG)-PET in clinical trials, and relationships  ...  Conclusion: The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting.  ...  Using baseline and 24-month follow-up florbetapir PET images from ADNI, we compared the power of template-based cerebellar, pontine, and a cerebral white matter reference regions to track SUVR increases  ... 
doi:10.1016/j.jalz.2015.05.001 pmid:26194311 pmcid:PMC4510459 fatcat:76u74vuo5rdgjkmwnmusug2e64

Comparison of 18F-FDG and PiB PET in Cognitive Impairment

V. J. Lowe, B. J. Kemp, C. R. Jack, M. Senjem, S. Weigand, M. Shiung, G. Smith, D. Knopman, B. Boeve, B. Mullan, R. C. Petersen
2009 Journal of Nuclear Medicine  
Global measures for PiB and 18 F-FDG PET uptake, normalized to cerebellum for PiB and pons for 18 F-FDG, were compared.  ...  Partial-volume correction, standardized uptake value (SUV), and cortical ratio methods of image analysis were also evaluated in an attempt to optimize the analysis for each test.  ...  Image Analysis Methods We evaluated various methods of analysis of PiB and 18 F-FDG PET data in this project to assess and optimize the performance of each test.  ... 
doi:10.2967/jnumed.108.058529 pmid:19443597 pmcid:PMC2886669 fatcat:tp6ivdelv5actpxl3dbw5wzerq

Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer's Disease in AIBL Data: Group and Individual Analyses

Vahab Youssofzadeh, Bernadette McGuinness, Liam P. Maguire, KongFatt Wong-Lin
2017 Frontiers in Human Neuroscience  
In this work, we apply a multi-modal imaging machine-learning framework to enhance AD classification and prediction of diagnosis of subject-matched gray matter MRI and Pittsburgh compound B (PiB)-PET data  ...  Magnetic resonance imaging (MRI) and positron emission tomography (PET) are neuroimaging modalities typically used for evaluating brain changes in Alzheimer's disease (AD).  ...  Nevertheless, for a better evaluation, future work should compare the performance of two SVC and MKL methods under two region-based and whole-brain strategies, using a similar dataset e.g., ADNI or AIBL  ... 
doi:10.3389/fnhum.2017.00380 pmid:28790908 pmcid:PMC5524673 fatcat:ftsrnn4kjfdvdp2ifueuhd436a

Amyloid pathway-based candidate gene analysis of [11C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort

Shanker Swaminathan, Li Shen, Shannon L. Risacher, Karmen K. Yoder, John D. West, Sungeun Kim, Kwangsik Nho, Tatiana Foroud, Mark Inlow, Steven G. Potkin, Matthew J. Huentelman, David W. Craig (+6 others)
2011 Brain Imaging and Behavior  
Further investigation at whole-brain voxel-wise level indicated that non-carriers of the minor allele had higher PiB uptake in frontal regions compared to carriers.  ...  Amyloid imaging with [ 11 C]Pittsburgh Compound-B (PiB) provides in vivo data on plaque deposition in those with, or at risk for, Alzheimer's disease (AD).  ...  Additional support for data analysis was provided by NIA R01 AG19771 and P30 AG10133.  ... 
doi:10.1007/s11682-011-9136-1 pmid:21901424 pmcid:PMC3256261 fatcat:a6iisstnffe2pdkjvs3bp3qdta

An MRI-Based Atlas for Correlation of Imaging and Pathologic Findings in Alzheimer's Disease

Mekala R. Raman, Christopher G. Schwarz, Melissa E. Murray, Val J. Lowe, Dennis W. Dickson, Clifford R. Jack, Kejal Kantarci
2016 Journal of Neuroimaging  
Our objective was to develop a brain MRI atlas representing the cortical regions that are routinely sampled at autopsy for the diagnosis of Alzheimer's disease (AD).  ...  These ROIs were then registered to a common template and combined to form one ROI representing the volume of tissue that was sampled by the pathologists.  ...  Robert Reid for his assistance with creating Figure 2 .  ... 
doi:10.1111/jon.12341 pmid:27017996 pmcid:PMC4848115 fatcat:o6bizdhwjrfprmzkrzhsl3inba

Detection of Alzheimer's Disease Using Multitracer Positron Emission Tomography Imaging

H. Dehghan
2013 International Journal of Engineering  
The subject's brain image was automatically parcellated into 48 pre-defined regions of interest. Then, 96 features were extracted for each subject.  ...  The principal features weere extracted using principal component analysis, then they were combined based on intersection strategy.  ...  Preliminary experimental results of individual modality as shown in proposed method for combination of FDG-PET and PIB-PET achieved higher accuracies compared to the approach reported in [18] (see Table  ... 
doi:10.5829/idosi.ije.2014.27.01a.07 fatcat:crkjpd3aj5doxh36u6ljfbwpjq

The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly

Miranka Wirth, Hwamee Oh, Elizabeth C. Mormino, Candace Markley, Susan M. Landau, William J. Jagust
2013 Alzheimer's & Dementia  
Within each ROI, metabolism was quantified with [ 18 F] fluorodeoxyglucose (FDG) PET, and the gray matter structure was evaluated using volume (hippocampus) or thickness (cortical regions).  ...  PiB retention interacted predominantly with the cortical neurodegenerative composite for nonmemory change.  ...  Data analysis The statistical analysis procedure was based on multiple regression models.  ... 
doi:10.1016/j.jalz.2012.10.012 pmid:23474040 pmcid:PMC3823816 fatcat:tlnr7es3zjcx5nw6pgentmu7gm
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