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Deregulation of the cell cycle machinery by Epstein–Barr virus nuclear antigen 3C

Pankaj Kumar, Masanao Murakami, Rajeev Kaul, Abhik Saha, Qiliang Cai, Erle S Robertson
2009 Future Virology  
Epstein-Barr nuclear antigen (EBNA)3C is one of the latent proteins shown to be essential for transformation of primary human B lymphocytes in vitro.  ...  Keywords cell cycle n Epstein-Barr nuclear antigen 3C n Epstein-Barr virus n latency n transcriptional regulator n viral transformation Review For reprint orders, please contact: reprints@futuremedicine.com  ...  EBER: Epstein-Barr virus-encoded small nonpolyadenylated RNA; EBNA: Epstein-Barr nuclear antigen; LMP: Latent membrane protein; TR: Terminal repeat.  ... 
doi:10.2217/17460794.4.1.79 pmid:25635182 pmcid:PMC4307939 fatcat:va2oftw555cdpdmamci6hywa2m

Epstein–Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis

Ahmed El-Sharkawy, Lobna Al Zaidan, Ahmed Malki
2018 Frontiers in Oncology  
The Epstein-Barr virus (EBV) is the first herpesvirus identified to be associated with human cancers known to infect the majority of the world population.  ...  It also aims to provide a quick look on the six members of the EBV nuclear antigens and their roles in dysregulating apoptosis.  ...  Analysis of cells infected with EBNA-3 KO or estrogen-inducible EBNA-3 proteins conditional viruses showed that EBNA-3A and -3C cooperate to downregulatethrough epigenetic silencing-the tumor suppressors  ... 
doi:10.3389/fonc.2018.00265 pmid:30116721 pmcid:PMC6082928 fatcat:tzf53htoxjcmbb4weakpghyrqm

Comparison of TGF-β, IL-10 levels and LMP-1 in gastric and oropharyngeal carcinoma associated with EBV infection

Anna Dworzanska, Malgorzata Strycharz-Dudziak, Ewa Kliszczewska, Bartlomiej Drop, Malgorzata Polz-Dacewicz
2019 Current Issues in Pharmacy and Medical Sciences  
(EBVCA), Epstein-Barr virus nuclear antigen (EBNA) and early antigen (EA) frequency in the serum of patients with GC and OPC.  ...  Further studies are required to clarify the role of Epstein-Barr virus in cancer development.  ...  Epstein-Barr nuclear protein 1 (EBNA-1) is present in all latency types, and also EBNA is the only type of protein produced during activation into the lytic cycle.  ... 
doi:10.2478/cipms-2019-0040 fatcat:sut5wmjkjvbnpewawwtz6a6t7e

Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival

U. Zimber-Strobl, B. Kempkes, G. Marschall, R. Zeidler, C. Van Kooten, J. Banchereau, G. W. Bornkamm, W. Hammerschmidt
1996 EMBO Journal  
., Marchini,A. and Kieff,E. (1991) The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J. Virol., 65, 6826-6837.  ...  ., Robertson,E. and Kieff,E. (1993) Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B- lymphocyte growth transformation. J. Virol., 67, 2014-2025.  ... 
doi:10.1002/j.1460-2075.1996.tb01098.x fatcat:i2x4djpasjaxvk5ptydazq2wwq

Epstein-barr virus immortalization and latency

David T Rowe
1999 Frontiers in Bioscience  
Epstein-Barr virus infects human B lymphocytes. The interaction between the virus and these cells has been the subject of investigation for over three decades.  ...  Recent in vitro and in vivo studies, reviewed here, are revealing the mechanisms by which EBV induces and controls proliferation through the expression of six viral nuclear proteins and two plasma membrane  ...  Kieff: The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol 65(12, Dec):6826-6837 (1991) 125. Mannick, J., X. Tung, A.  ... 
doi:10.2741/a433 fatcat:m2szpnkq2jhlrm3rkn3gdmqsxa

Epstein-barr virus immortalization and latency

David, T. Rowe
1999 Frontiers in Bioscience  
Epstein-Barr virus infects human B lymphocytes. The interaction between the virus and these cells has been the subject of investigation for over three decades.  ...  Recent in vitro and in vivo studies, reviewed here, are revealing the mechanisms by which EBV induces and controls proliferation through the expression of six viral nuclear proteins and two plasma membrane  ...  Kieff: The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol 65(12, Dec):6826-6837 (1991) 125. Mannick, J., X. Tung, A.  ... 
doi:10.2741/rowe pmid:10077545 fatcat:i3j6jwwa7jff3mpnzbjoswaaca

The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73

J B Mannick, X Tong, A Hemnes, E Kieff
1995 Journal of Virology  
Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation.  ...  The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) plays a critical role in EBV-induced transformation (4, 9).  ...  We thank Mary Anne Stevenson and Stuart Calderwood for helpful advice and for the rabbit polyclonal antiserum directed against hsp72 and hsc73.  ... 
doi:10.1128/jvi.69.12.8169-8172.1995 fatcat:2bl6fvkuozdu3o2rlg5umdnu5q

The role of the Epstein-barr virus in human disease

LS Young
2002 Frontiers in Bioscience  
Jiang WQ, L Szekely, V Wendel-Hansen, N Ringertz, G Klein & A Rosen: Co-localization of the retinoblastoma protein and the Epstein-Barr virus-encoded nuclear antigen EBNA-5.  ...  Robertson ES: The Epstein-Barr virus EBNA3 protein family as regulators of transcription. Epstein-Barr Virus Report 4, 143-150 (1997) 55.  ... 
doi:10.2741/a792 fatcat:pyt2qsxxv5hw5p3idxnxfwsgga

Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology

David López-Valencia, Ángela Medina-Ortega, Diego Fernando Hoyos-Samboní, Jhan Sebastián Saavedra-Torres, Carolina Salguero
2019 Revista de la Facultad de Medicina  
Epstein-Barr virus is an infectious agent used to immortalize and induce polyclonal activation of B cells.  ...  between Epstein-Barr virus and multiple sclerosis.  ...  Acknowledgements None stated by the authors.  ... 
doi:10.15446/revfacmed.v67n3.70149 fatcat:c5n36bel6bgjnjr3z75r65soxi

Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein

S D Abbot, M Rowe, K Cadwallader, A Ricksten, J Gordon, F Wang, L Rymo, A B Rickinson
1990 Journal of Virology  
In contrast, the cells infected with the P3HR1 Epstein-Barr virus strain, a deletion mutant that cannot encode Epstein-Barr nuclear antigen 2 (EBNA2) or a full-length EBNA-LP, expressed EBNAs1, 3a, 3b,  ...  is also involved in activating the expression of a second virus-encoded effector protein, LMP.  ...  In contrast, the cells infected with the P3HR1 Epstein-Barr virus strain, a deletion mutant that cannot encode Epstein-Barr nuclear antigen 2 (EBNA2) or a full-length EBNA-LP, expressed EBNAsl, 3a, 3b,  ... 
pmid:2157875 pmcid:PMC249370 fatcat:z72vjbd5nbgznnp6uzpduom6xu

Molecular mimicry, genetic homology, and gene sharing proteomic "molecular fingerprints" using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease

David H. Dreyfus, Antonella Farina, Giuseppina Alessandra Farina
2018 Immunologic research  
expressed primarily during the viral lytic replication cycle, and EBNA-1 (Epstein-Barr Virus Nuclear Antigen) expressed during the viral latency cycle respectively were characterized using a laser-printed  ...  EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies.  ...  Conventional serologic testing for EBV is available using specific immunoglobulin G (IgG) binding to viral proteins such as EBNA-1 (Epstein-Barr Virus Nuclear Antigen-1), VCA (Viral Capsid Antigen), and  ... 
doi:10.1007/s12026-018-9045-0 pmid:30552620 fatcat:o5nlxtyn2ra4tcycuesjjhgjuu

The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73

J B Mannick, X Tong, A Hemnes, E Kieff
1995 Journal of Virology  
Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation.  ...  We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed  ...  We thank Mary Anne Stevenson and Stuart Calderwood for helpful advice and for the rabbit polyclonal antiserum directed against hsp72 and hsc73.  ... 
pmid:7494344 pmcid:PMC189776 fatcat:x24pwnkomrheba2j7u5tfo5gtm

Epstein-Barr Virus – pathogenesis, latency and cancers

Ewa Kliszczewska, Adrian Jarzyński, Anastazja Boguszewska, Justyna Pasternak, Małgorzata Polz-Dacewicz
2017 Journal of Pre-Clinical and Clinical Research  
The Epstein-Barr virus (EBV) was discovered in 1964 by Michael Anthony Epstein and Yvonne Barr, who discovered a herpesvirus-like infectious agent in a biopsy specimen from a patient with Burkitt's lymphoma  ...  This virus belongs to the Herpesviridae family (subfamily Gammaherpesvirinae, genus Lymphocryptovirus). EBV is a ubiquitous herpesvirus that is causally associated with various malignant tumours.  ...  The Epstein-Barr virus belongs to the Herpesviridae family (subfamily Gammaherpesvirinae, genus Lymphocryptovirus).  ... 
doi:10.26444/jpccr/81214 fatcat:v6nioxxzwzhjxfqre6oyqnioxu

The Link Of Epstein Barr Virus Infection And Rheumatoid Arthritis Immunopathogenesis

Huriatul Masdar
2017 Jurnal Ilmu Kedokteran  
The cause of Rheumatoid Arthritis (RA) remains unknown. Environmental factors as well as genetic factors have beenlinked to pathogenesis of RA, in particular Epstein Barr Virus (EBV) infection.  ...  several EBV proteins detected in RA patient sera, the molecular mimicryof EBV proteins with RA susceptible alleles, cross reactive of several antibodies against EBV with proteins in RAsynovium, the higher  ...  Arthritis Res Ther, 2005. membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen.  ... 
doi:10.26891/jik.v4i2.2010.79-88 fatcat:ttektepprbe55lswkvnx4ilcza

Epstein Barr Virus Associated Lymphomas and Epithelia Cancers in Humans

Richmond Ayee, Maame Ekua Ofori, Edward Wright, Osbourne Quaye
2020 Journal of Cancer  
Epstein Barr virus (EBV) is a cosmopolitan oncogenic virus, infecting about 90% of the world's population and it is associated to tumors originating from both epithelia and hematopoietic cells.  ...  (EBNAs), three latent membrane proteins (LMP), and untranslated RNA called EBV encoded RNA (EBER), shown to efficiently transform B cells into lymphoblastic cells.  ...  EBNA-3 family of nuclear proteins consist of three large nuclear phosphoproteins, EBNA-3A, -3B, and -3C [44] .  ... 
doi:10.7150/jca.37282 pmid:32194785 pmcid:PMC7052849 fatcat:qdbnp3iawffafnfoy5staot6w4
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