Filters








33 Hits in 8.3 sec

Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling

Peter Kochunov, Neda Jahanshad, Emma Sprooten, Thomas E. Nichols, René C. Mandl, Laura Almasy, Tom Booth, Rachel M. Brouwer, Joanne E. Curran, Greig I. de Zubicaray, Rali Dimitrova, Ravi Duggirala (+29 others)
2014 NeuroImage  
The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic  ...  We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites.  ...  The BrainSCALE study (PI HH and DB) was supported by grants from the Dutch Organization for Scientific Research (NWO) to HEH (051.02.061) and HEH, DIB and RSK (051.02.060).  ... 
doi:10.1016/j.neuroimage.2014.03.033 pmid:24657781 pmcid:PMC4043878 fatcat:mxe7lkp2hfdyrdmcgzzhdbh3zm

Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group

Neda Jahanshad, Peter V. Kochunov, Emma Sprooten, René C. Mandl, Thomas E. Nichols, Laura Almasy, John Blangero, Rachel M. Brouwer, Joanne E. Curran, Greig I. de Zubicaray, Ravi Duggirala, Peter T. Fox (+19 others)
2013 NeuroImage  
As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data  ...  The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic  ...  This work from the ENIGMA-DTI working group lays the foundation to select phenotypes for large future multi-site joint-analytic genetic association studies with DTI data.  ... 
doi:10.1016/j.neuroimage.2013.04.061 pmid:23629049 pmcid:PMC3729717 fatcat:j4q3mc76wzbazexgmsz7xybx3a

Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data

Peter Kochunov, Neda Jahanshad, Daniel Marcus, Anderson Winkler, Emma Sprooten, Thomas E. Nichols, Susan N. Wright, L. Elliot Hong, Binish Patel, Timothy Behrens, Saad Jbabdi, Jesper Andersson (+41 others)
2015 NeuroImage  
FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis  ...  We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe,  ...  The ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) consortium was organized to facilitate this by bringing together genetic imaging researchers and developing methods for multi-site data  ... 
doi:10.1016/j.neuroimage.2015.02.050 pmid:25747917 pmcid:PMC4387079 fatcat:s4lpvm3wozd27fdqjc36aewfoe

Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans [article]

Neda Jahanshad, Habib Ganjgahi, Janita Bralten, Anouk den Braber, Joshua Faskowitz, Annchen Knodt, Herve Lemaitre, Talia Nir, Binish Patel, Stuart Richie, Emma Sprooten, Kimm van Hulzen (+47 others)
2017 bioRxiv   pre-print
(WM) microstructure in the healthy human brain, as assessed through diffusion tensor imaging (DTI).  ...  Additive association tests were conducted for each SNP. We used several meta-analytic and mega-analytic designs, and we evaluated regions of interest at multiple granularity levels.  ...  (MR/K026992/1), for which funding from the BBSRC and MRC is gratefully acknowledged.  ... 
doi:10.1101/107987 fatcat:wynoj6llkfazren7x5rxgpxy5i

ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries

Paul Thompson
2020 Biological Psychiatry  
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying  ...  Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide  ...  and Behavior Working Group (R01 MH117601; to N.J. and L.S.), the ENIGMA Epilepsy Working Group (R01 NS107739; to C.R.M.), a genotyping grant from the Australian NHMRC (APP1103623 and APP1158127; to SEM  ... 
doi:10.1016/j.biopsych.2020.02.167 fatcat:rcamgpjlcvfgzikfleqbunef3u

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

Odile A. Heuvel, Premika S.W. Boedhoe, Sara Bertolin, Willem B. Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang‐Zhen Kong, Jun S. Kwon, Joseph O'Neill, Tomas Paus, Yash Patel (+51 others)
2020 Human Brain Mapping  
International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting  ...  In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents  ...  imaging data and genetics, van den Heuvel and Stein proposed adding an ENIGMA-OCD working group to the ENIGMA consortium in 2013.  ... 
doi:10.1002/hbm.24972 pmid:32154629 pmcid:PMC8675414 fatcat:utcosnl3xvb3tdwww54wm7ogiq

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal, Elena Pozzi, Tiffany C. Ho, Laura S. van Velzen, Ilya M. Veer, Nils Opel, Eus J. W. Van Someren, Laura K. M. Han, Lybomir Aftanas, André Aleman, Bernhard T. Baune, Klaus Berger (+66 others)
2020 Translational Psychiatry  
In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions.  ...  The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents.  ...  Acknowledgements ENIGMA MDD work is supported by NIH grants U54 EB020403 (Thompson), R01 MH116147 (Thompson), and R01 MH117601 (Jahanshad & Schmaal)  ... 
doi:10.1038/s41398-020-0842-6 pmid:32472038 pmcid:PMC7260219 fatcat:vayt4cozyzg6tkd7nm2fqeys6u

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson, for the ENIGMA Consortium, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow (+159 others)
2020 Translational Psychiatry  
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying  ...  Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide  ...  and Behavior Working Group (R01 MH117601; to N.J. and L.S.), the ENIGMA Epilepsy Working Group (R01 NS107739; to C.R.M.), a genotyping grant from the Australian NHMRC (APP1103623 and APP1158127; to SEM  ... 
doi:10.1038/s41398-020-0705-1 pmid:32198361 pmcid:PMC7083923 fatcat:b4oftx6e3rg7vhwcuhnjcab7pa

In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis via the ENIGMA Consortium [article]

Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E Bearden (+32 others)
2022 medRxiv   pre-print
Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls (CTR) using diffusion tensor imaging (DTI).  ...  All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant.  ...  ACKNOWLEDGMENTS ENIGMA Core: U.S. National Institutes of Health grants, R01 EB015611, U54 EB020403,  ... 
doi:10.1101/2022.02.11.22270818 fatcat:2fvxa4sskrgslgc7n6wiuw5tse

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Pauline Favre, for the ENIGMA Bipolar Disorder Working Group, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abé, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A. Andreassen, Bernhard T. Baune (+48 others)
2019 Neuropsychopharmacology  
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous  ...  This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network.  ...  Thus, we analyzed DTI data from the ENIGMA-BD working group with the objectives of (i) identifying reliable generalizable WM abnormalities in BD using mega-and meta-analytics; (ii) testing if clinical  ... 
doi:10.1038/s41386-019-0485-6 pmid:31434102 pmcid:PMC6898371 fatcat:5nd5pmmdp5hsbheatqou6mz54i

Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data

Peter Kochunov, Binish Patel, Habib Ganjgahi, Brian Donohue, Meghann Ryan, Elliot L. Hong, Xu Chen, Bhim Adhikari, Neda Jahanshad, Paul M. Thompson, Dennis Van't Ent, Anouk den Braber (+9 others)
2019 Frontiers in Neuroinformatics  
We performed this evaluation in a simulated twin-sibling pedigree and phenotypes and in diffusion tensor imaging (DTI) data from three twin-sibling cohorts, the human connectome project (HCP), netherlands  ...  The heritability estimates from the two MLE approaches provided excellent agreement in both simulated and imaging data.  ...  SOLAR-Eclipse is frequently used in imaging genetic studies especially in the multi-site analyses that aggregate measurements across multiple datasets using meta and mega-analyses (Jahanshad et al., 2013  ... 
doi:10.3389/fninf.2019.00016 pmid:30914942 pmcid:PMC6422938 fatcat:zo5ci45nwra7jcwcvthim5xury

ENIGMA-Sleep: Challenges, opportunities, and the road map

Masoud Tahmasian, André Aleman, Ole A Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna Bright, Michael W L Chee, Daphne Chylinski, Wei Cheng, Michele Deantoni (+65 others)
2021 Journal of Sleep Research  
Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding  ...  The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites.  ...  neuroimaging and genetics data that are pooled across centres via meta-and mega-analytical approaches (Figure 2).  ... 
doi:10.1111/jsr.13347 pmid:33913199 pmcid:PMC8803276 fatcat:zt3a456gozehznnydp5jf3yuiu

Genetic imaging consortium for addiction medicine [chapter]

Scott Mackey, Kees-Jan Kan, Bader Chaarani, Nelly Alia-Klein, Albert Batalla, Samantha Brooks, Janna Cousijn, Alain Dagher, Michiel de Ruiter, Sylvane Desrivieres, Sarah W. Feldstein Ewing, Rita Z. Goldstein (+35 others)
2016 Progress in Brain Research  
The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data.  ...  Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects.  ...  The Addiction working group will adopt the meta-analytic methods used successfully by the ENIGMA project.  ... 
doi:10.1016/bs.pbr.2015.07.026 pmid:26822360 pmcid:PMC4820288 fatcat:4k6tgnb4qja7fecgipftwwfu44

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: a worldwide ENIGMA-Epilepsy study

Ezequiel Gleichgerrcht, Brent C. Munsell, Saud Alhusaini, Marina K.M. Alvim, Núria Bargalló, Benjamin Bender, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Karen Blackmon, Maria Eugenia Caligiuri, Fernando Cendes (+54 others)
2021 NeuroImage: Clinical  
") and without ("non-lesional") radiographic features suggestive of underlying hippocampal sclerosis from the multinational (multi-center) ENIGMA-Epilepsy consortium.  ...  We used support vector machine (SV) and deep learning (DL) models based on region of interest (ROI-based) structural (n = 336) and diffusion (n = 863) brain MRI data from patients with TLE with ("lesional  ...  Next, diffusion-tensor imaging (DTI) images were processed using the ENIGMA-DTI protocols.  ... 
doi:10.1016/j.nicl.2021.102765 pmid:34339947 pmcid:PMC8346685 fatcat:lvkohmlatrhi5ajslnk65qqysq

Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

Ida E Sønderby, Christopher R K Ching, Sophia I Thomopoulos, Dennis van der Meer, Daqiang Sun, Julio E Villalon-Reina, Ingrid Agartz, Katrin Amunts, Celso Arango, Nicola J Armstrong, Rosa Ayesa-Arriola, Geor Bakker (+93 others)
2021 Human Brain Mapping  
The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement  ...  In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data.  ...  In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data.  ... 
doi:10.1002/hbm.25354 pmid:33615640 pmcid:PMC8675420 fatcat:xqlzybzqr5ft3pi4wbqoej3inq
« Previous Showing results 1 — 15 out of 33 results