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Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
2014
NeuroImage
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The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic ...
We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. ...
The BrainSCALE study (PI HH and DB) was supported by grants from the Dutch Organization for Scientific Research (NWO) to HEH (051.02.061) and HEH, DIB and RSK (051.02.060). ...
doi:10.1016/j.neuroimage.2014.03.033
pmid:24657781
pmcid:PMC4043878
fatcat:mxe7lkp2hfdyrdmcgzzhdbh3zm
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group
2013
NeuroImage
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As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data ...
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic ...
This work from the ENIGMA-DTI working group lays the foundation to select phenotypes for large future multi-site joint-analytic genetic association studies with DTI data. ...
doi:10.1016/j.neuroimage.2013.04.061
pmid:23629049
pmcid:PMC3729717
fatcat:j4q3mc76wzbazexgmsz7xybx3a
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
2015
NeuroImage
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FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis ...
We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, ...
The ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) consortium was organized to facilitate this by bringing together genetic imaging researchers and developing methods for multi-site data ...
doi:10.1016/j.neuroimage.2015.02.050
pmid:25747917
pmcid:PMC4387079
fatcat:s4lpvm3wozd27fdqjc36aewfoe
Do Candidate Genes Affect the Brain's White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans
[article]
2017
bioRxiv
pre-print
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(WM) microstructure in the healthy human brain, as assessed through diffusion tensor imaging (DTI). ...
Additive association tests were conducted for each SNP. We used several meta-analytic and mega-analytic designs, and we evaluated regions of interest at multiple granularity levels. ...
(MR/K026992/1), for which funding from the BBSRC and MRC is gratefully acknowledged. ...
doi:10.1101/107987
fatcat:wynoj6llkfazren7x5rxgpxy5i
ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease Across More Than 40 Countries
2020
Biological Psychiatry
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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying ...
Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide ...
and Behavior Working Group (R01 MH117601; to N.J. and L.S.), the ENIGMA Epilepsy Working Group (R01 NS107739; to C.R.M.), a genotyping grant from the Australian NHMRC (APP1103623 and APP1158127; to SEM ...
doi:10.1016/j.biopsych.2020.02.167
fatcat:rcamgpjlcvfgzikfleqbunef3u
An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration
2020
Human Brain Mapping
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International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting ...
In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents ...
imaging data and genetics, van den Heuvel and Stein proposed adding an ENIGMA-OCD working group to the ENIGMA consortium in 2013. ...
doi:10.1002/hbm.24972
pmid:32154629
pmcid:PMC8675414
fatcat:utcosnl3xvb3tdwww54wm7ogiq
ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
2020
Translational Psychiatry
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In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. ...
The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. ...
Acknowledgements ENIGMA MDD work is supported by NIH grants U54 EB020403 (Thompson), R01 MH116147 (Thompson), and R01 MH117601 (Jahanshad & Schmaal) ...
doi:10.1038/s41398-020-0842-6
pmid:32472038
pmcid:PMC7260219
fatcat:vayt4cozyzg6tkd7nm2fqeys6u
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
2020
Translational Psychiatry
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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying ...
Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide ...
and Behavior Working Group (R01 MH117601; to N.J. and L.S.), the ENIGMA Epilepsy Working Group (R01 NS107739; to C.R.M.), a genotyping grant from the Australian NHMRC (APP1103623 and APP1158127; to SEM ...
doi:10.1038/s41398-020-0705-1
pmid:32198361
pmcid:PMC7083923
fatcat:b4oftx6e3rg7vhwcuhnjcab7pa
In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis via the ENIGMA Consortium
[article]
2022
medRxiv
pre-print
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Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls (CTR) using diffusion tensor imaging (DTI). ...
All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ...
ACKNOWLEDGMENTS ENIGMA Core: U.S. National Institutes of Health grants, R01 EB015611, U54 EB020403, ...
doi:10.1101/2022.02.11.22270818
fatcat:2fvxa4sskrgslgc7n6wiuw5tse
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
2019
Neuropsychopharmacology
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Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous ...
This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. ...
Thus, we analyzed DTI data from the ENIGMA-BD working group with the objectives of (i) identifying reliable generalizable WM abnormalities in BD using mega-and meta-analytics; (ii) testing if clinical ...
doi:10.1038/s41386-019-0485-6
pmid:31434102
pmcid:PMC6898371
fatcat:5nd5pmmdp5hsbheatqou6mz54i
Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data
2019
Frontiers in Neuroinformatics
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We performed this evaluation in a simulated twin-sibling pedigree and phenotypes and in diffusion tensor imaging (DTI) data from three twin-sibling cohorts, the human connectome project (HCP), netherlands ...
The heritability estimates from the two MLE approaches provided excellent agreement in both simulated and imaging data. ...
SOLAR-Eclipse is frequently used in imaging genetic studies especially in the multi-site analyses that aggregate measurements across multiple datasets using meta and mega-analyses (Jahanshad et al., 2013 ...
doi:10.3389/fninf.2019.00016
pmid:30914942
pmcid:PMC6422938
fatcat:zo5ci45nwra7jcwcvthim5xury
ENIGMA-Sleep: Challenges, opportunities, and the road map
2021
Journal of Sleep Research
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Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding ...
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. ...
neuroimaging and genetics data that are pooled across centres via meta-and mega-analytical approaches (Figure 2). ...
doi:10.1111/jsr.13347
pmid:33913199
pmcid:PMC8803276
fatcat:zt3a456gozehznnydp5jf3yuiu
Genetic imaging consortium for addiction medicine
[chapter]
2016
Progress in Brain Research
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The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. ...
Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. ...
The Addiction working group will adopt the meta-analytic methods used successfully by the ENIGMA project. ...
doi:10.1016/bs.pbr.2015.07.026
pmid:26822360
pmcid:PMC4820288
fatcat:4k6tgnb4qja7fecgipftwwfu44
Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: a worldwide ENIGMA-Epilepsy study
2021
NeuroImage: Clinical
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") and without ("non-lesional") radiographic features suggestive of underlying hippocampal sclerosis from the multinational (multi-center) ENIGMA-Epilepsy consortium. ...
We used support vector machine (SV) and deep learning (DL) models based on region of interest (ROI-based) structural (n = 336) and diffusion (n = 863) brain MRI data from patients with TLE with ("lesional ...
Next, diffusion-tensor imaging (DTI) images were processed using the ENIGMA-DTI protocols. ...
doi:10.1016/j.nicl.2021.102765
pmid:34339947
pmcid:PMC8346685
fatcat:lvkohmlatrhi5ajslnk65qqysq
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs
2021
Human Brain Mapping
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The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement ...
In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. ...
In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. ...
doi:10.1002/hbm.25354
pmid:33615640
pmcid:PMC8675420
fatcat:xqlzybzqr5ft3pi4wbqoej3inq
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