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HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1

Yanan Lu, Dongni Xu, Jintao Peng, Zhaofan Luo, Chujie Chen, Yuqing Chen, Huimou Chen, Minghui Zheng, Peihong Yin, Zhi Wang
2019 EBioMedicine  
Mechanistically, we demonstrated that HNF1A regulates ABCB1 expression through binding to its specific promoter region and suppressing its transcription levels.  ...  Our study paved the road for finding novel treatment combinations using conventional cytotoxic agents with functional restoration of the HNF1A protein, individualized treatment through HNF1A staining and  ...  Hormone response of rodent phenyl- disruption of the transcription factor HNF1alpha.  ... 
doi:10.1016/j.ebiom.2019.05.013 pmid:31103629 pmcid:PMC6606897 fatcat:5fkd6j7p6nfapcbshs247t2umi

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactions in beta-cell function [article]

Taiyi Kuo, Wen Du, Yasutaka Miyachi, Prasanna K. Dadi, David A. Jacobson, Domenico Accili
2020 bioRxiv   pre-print
To model the functional significance we generated single and compound knockouts of FoxO1 and Hnf4a in beta-cells.  ...  Transcription factors Hnf4a (MODY1) and FoxO1 are respective examples of these two components, and are known to act through beta-cell-specific enhancers. However, their relationship is unclear.  ...  Introduction Genetic predisposition contributes to type 2 diabetes through changes in the expression and activity of transcription factors essential for β-cell function and insulin sensitivity (Ferrannini  ... 
doi:10.1101/2020.07.04.187864 fatcat:pbr36hnyufddffobnugoakp4ou

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes

Thomas Arbogast, Abdel-Mouttalib Ouagazzal, Claire Chevalier, Maksym Kopanitsa, Nurudeen Afinowi, Eugenia Migliavacca, Belinda S. Cowling, Marie-Christine Birling, Marie-France Champy, Alexandre Reymond, Yann Herault, Gregory S. Barsh
2016 PLoS Genetics  
Together, these data indicate that the dosage imbalance at the 16p11.2 locus perturbs the expression of modifiers outside the CNV that can modulate the penetrance, expressivity and direction of effects  ...  For the metabolism, the energy imbalance and adipocyte phenotypes were mirrored in the deletion and duplication carriers but opposite to the human phenotypes, the deletion mouse carriers were lean whereas  ...  Acknowledgments We are grateful to the animal caretakers and services of the PHENOMIN-ICS; to the members of the research group; to the IGBMC laboratory and to the partners of the GENCODYS and  ... 
doi:10.1371/journal.pgen.1005709 pmid:26872257 pmcid:PMC4752317 fatcat:gzhaopmdjjgilmwxyqt72qc5da

シンポジウム

Journal of the Japan Diabetes Society  
both insulin and glucagon secretion in pancreatic islets 山縣 和也 熊本大学大学院生命科学研究部病態生化学分野 Hepatocyte nuclear factor 1alpha (HNF1a) is a transcription factor, which is expressed in pancreatic beta-cells  ...  for the potential of this combination to make a difference within future treatment of obesity and metabolic diseases associated with obesity.  ... 
doi:10.11213/tonyobyo.64.s-56 fatcat:m5akr5mvz5bjvendp7rzouw5n4