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Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension

Dorothee Saur, Björn Schelter, Susanne Schnell, David Kratochvil, Hanna Küpper, Philipp Kellmeyer, Dorothee Kümmerer, Stefan Klöppel, Volkmar Glauche, Rüdiger Lange, Wolfgang Mader, David Feess (+2 others)
2010 NeuroImage  
Here, we introduce a novel combination of functional and anatomical connectivity to study the network topology subserving a cognitive function of interest.  ...  This combined approach is applied to the language domain to investigate the network topology of two levels of auditory comprehension: lower-level speech perception (i.e., phonological processing) and higher-level  ...  Acknowledgments The work was supported by the Federal Ministry of Education and Research (BMBF-research collaborations "Mechanisms of brain reorganization in the language network" [01GW0661] and "Neuroimaging  ... 
doi:10.1016/j.neuroimage.2009.11.009 pmid:19913624 fatcat:nkruiiltjnftvcfivk7lzpboki

Ventral and dorsal pathways for language

D. Saur, B. W. Kreher, S. Schnell, D. Kummerer, P. Kellmeyer, M.-S. Vry, R. Umarova, M. Musso, V. Glauche, S. Abel, W. Huber, M. Rijntjes (+2 others)
2008 Proceedings of the National Academy of Sciences of the United States of America  
Combining functional magnetic resonance imaging (fMRI) with a novel diffusion tensor imaging (DTI)based tractography method we were able to identify the most probable anatomical pathways connecting brain  ...  Built on an analogy between the visual and auditory systems, the following dual stream model for language processing was suggested recently: a dorsal stream is involved in mapping sound to articulation  ...  This research was funded by the Bundesministerium fü r Bildung und Forschung (Research Collaborations Grant 01GW0661 for ''Mechanisms of Brain Reorganisation in the Language Network'') and the Deutsche  ... 
doi:10.1073/pnas.0805234105 pmid:19004769 pmcid:PMC2584675 fatcat:dzyt4stccjdodjohohw4fedhai

White matter architecture of the language network

Vanja Kljajevic
2014 Translational Neuroscience  
AbstractThe relevance of anatomical connectivity for understanding of the neural basis of language was recognized in the 19th century, and yet this topic has only recently become the subject of wider research  ...  as their functional interpretation.  ...  Red U-shaped tracts connect the superior and middle frontal gyri and the inferior and middle frontal gyri.  ... 
doi:10.2478/s13380-014-0232-8 fatcat:xplbezc6rvhwhlevkxdp32ywrq

Cross-language differences in the brain network subserving intelligible speech

Jianqiao Ge, Gang Peng, Bingjiang Lyu, Yi Wang, Yan Zhuo, Zhendong Niu, Li Hai Tan, Alexander P. Leff, Jia-Hong Gao
2015 Proceedings of the National Academy of Sciences of the United States of America  
We used functional MRI and dynamic causal modeling (DCM) analysis to compute and compare brain network models exhaustively with all possible connections among nodes of interested language regions in temporal  ...  It is a hot debate between one brain for all languages and different brains for different languages that emphasize commonality or specificity respectively.  ...  As it ha s been revealed that anatomical connection exists between each pair of the three brain regions (7, 18) , it is assumed that reciprocal fixed connectio n between each pair of the brain regions  ... 
doi:10.1073/pnas.1416000112 pmid:25713366 pmcid:PMC4364212 fatcat:sndxyyot3bfwjfpimobzvunoeq

The Neural Architecture of the Language Comprehension Network: Converging Evidence from Lesion and Connectivity Analyses

And U. Turken, Nina F. Dronkers
2011 Frontiers in Systems Neuroscience  
Functional neuroimaging investigations have also highlighted distributed activation patterns in the healthy brain during the performance of tasks that involve language comprehension and the processing  ...  By combining the information from these two connectivity analyses, we sought to determine the relationships among the brain regions identified as being important for auditory sentence comprehension in  ...  We applied the second method to identify brain areas that were functionally connected with each of the regions critical for auditory sentence comprehension.  ... 
doi:10.3389/fnsys.2011.00001 pmid:21347218 pmcid:PMC3039157 fatcat:x76t23wicrgnzjtmrxrjolaqpm

Attention shifts the language network reflecting paradigm presentation

Kathrin Kollndorfer, Julia Furtner, Jacqueline Krajnik, Daniela Prayer, Veronika Schöpf
2013 Frontiers in Human Neuroscience  
Results: GLM analysis revealed modality-specific brain activation for both language paradigms for the contrast visual > auditory in the area of the intraparietal sulcus and the hippocampus, two areas related  ...  In both experiments, two language paradigms (one for language comprehension and one for language production) used in clinical practice were investigated.  ...  ACKNOWLEDGMENTS The authors thank the subjects for their participation and Thomas Schlegl for his support in analyzing eye-tracking data.  ... 
doi:10.3389/fnhum.2013.00809 pmid:24324429 pmcid:PMC3838991 fatcat:elsntd3cs5gnzf2wczhdaj5n7i

Resting functional connectivity of language networks: characterization and reproducibility

D Tomasi, N D Volkow
2012 Molecular Psychiatry  
However, recent resting-state functional connectivity (RSFC) and lesion studies have implicated a more extended network in language processing.  ...  The language network also exhibited anti-correlated activity with auditory (only for Wernicke's area) and visual cortices that suggests integrated sequential activity with regions involved with listening  ...  Acknowledgments We are very grateful to Olaf Sporns for assistance during computation of the modularity of the language network with the Brain Connectivity Toolbox.  ... 
doi:10.1038/mp.2011.177 pmid:22212597 pmcid:PMC3323720 fatcat:fjygfharcjg2rjfxu64ojcgbsa

Neuroanatomical Prerequisites for Language Functions in the Maturing Brain

Jens Brauer, Alfred Anwander, Angela D. Friederici
2010 Cerebral Cortex  
Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.  ...  The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF).  ...  The authors thank Marc Tittgemeyer for helpful comments on study design and Yves von Cramon, Roberto Cozatl, and Karsten Mu¨ller for helpful comments on a previous version of the manuscript.  ... 
doi:10.1093/cercor/bhq108 pmid:20566580 fatcat:q3zelmi6h5hubmgvmzxzfhwyku

Imaging of Cortical and White Matter Language Processing

Andrew P. Klein, David S. Sabsevitz, John L. Ulmer, Leighton P. Mark
2015 Seminars in ultrasound, CT, and MRI  
Although investigations into the functional and anatomical organization of language within the human brain began centuries ago, it is recent advanced imaging techniques including functional magnetic resonance  ...  An understanding of functional and dysfunctional language anatomy is critical for practicing radiologists.  ...  Introduction T he functional and anatomical relationships for language in the human brain have been widely studied using anatomical dissections, lesion localization studies, intraoperative stimulations  ... 
doi:10.1053/j.sult.2015.05.011 pmid:26233859 fatcat:spo5ox56szfdxnnujnnwdl66py

The Neural Correlates of Spoken Sentence Comprehension in the Chinese Language: An fMRI Study

Hengshuang Liu, SH Annabel Chen
2020 Psychology Research and Behavior Management  
The current Chinese network seems to largely resemble the auditory semantic network for alphabetic languages but with features specific to Chinese.  ...  Thus, the current study attempted to investigate the neural network of speech comprehension specifically for the Chinese language.  ...  Based on the auditory semantic network for alphabetic languages and past studies of Chinese neuro-networks, whole-brain activations were hypothesized to be observed in the bilateral posterior superior  ... 
doi:10.2147/prbm.s251935 pmid:32982499 pmcid:PMC7500081 fatcat:wwsoscfrxrde5jdxxlrquex4me

The neurobiology of language: Relevance to linguistics

E. Susan Duncan, Sarah Tune, Steven L. Small
2016 Yearbook of the Poznan Linguistic Meeting  
Decades of electrophysiological and anatomical studies of the macaque monkey support the existence of dual streams for the processing of auditory information.  ...  The development of high resolution brain imaging methods and brain stimulation has advanced our ability to study, in vivo, the structures and processes underlying the language network.  ...  Secondly, in a network analysis comparing models of effective connectivity, children demonstrate weaker functional connections from IFGop to SMG, regions associated with the dorsal auditory stream.  ... 
doi:10.1515/yplm-2016-0003 fatcat:s4dw6rp6b5fvhew44fatloaxdq

Temporal lobe networks supporting the comprehension of spoken words

Leonardo Bonilha, Argye E Hillis, Gregory Hickok, Dirk B den Ouden, Chris Rorden, Julius Fridriksson
2017 Brain  
We observed that damage to the inferior temporal gyrus, to the fusiform gyrus and to a white matter network including the left posterior temporal region and its connections to the middle temporal gyrus  ...  These results suggest that the posterior lateral and inferior temporal regions are crucial for word comprehension, serving as a hub to integrate auditory and conceptual processing.  ...  (PI: Fridriksson), DC014664 (PI: Fridriksson); DC05375 (PI: Hillis), and from the American Heart Association: SFDRN26030003 (PI: Bonilha)  ... 
doi:10.1093/brain/awx169 pmid:29050387 fatcat:6wyozkpuzbe7ja4cv34yqk4bwe

Exploring the functional connectivity characteristics of brain networks in post-stroke patients with global aphasia: a healthy control based resting-state fMRI study

Xinlei Xu, Caili Ren, Hui Fang, Zhaohui Li, Ping Chen, Jian Yang, Tong Wang
2021 Annals of Palliative Medicine  
basis for the accurate selection of therapeutic targets in the future to promote better recovery of language function.  ...  PGA patients showed decreased inter-hemispheric connectivity of homologs within the sensorimotor network (SMN), salience network, and language network.  ...  Exploring the functional connectivity of brain networks in global aphasia is critical for further understanding the abnormal language performance and revealing its injury and recover mechanisms.  ... 
doi:10.21037/apm-21-2750 pmid:35016467 fatcat:ecxaukoo6nhepmvwt5uh36p5gu

Simulated attack reveals how lesions affect network properties in post-stroke aphasia [article]

John D. Medaglia, Brian A. Erickson, Dorian Pustina, Apoorva S. Kelkar, Andrew T. DeMarco, J. Vivian Dickens, Peter E. Turkeltaub
2021 bioRxiv   pre-print
We focused on measures of global network organization thought to support overall brain function and resilience in the whole brain and within the left hemisphere.  ...  Overall, global measures of network topology in the whole brain and left hemisphere accounted for 10% variance or more of the WAB-AQ and the lexical factor score beyond lesion volume and null permutations  ...  The network measures and behavior residualized for lesion volume revealed that additional variance was accounted for by anatomical network topology.  ... 
doi:10.1101/2021.11.01.466833 fatcat:kpum2mrmmzg5peag4op42hdusa

Damage to ventral and dorsal language pathways in acute aphasia

Dorothee Kümmerer, Gesa Hartwigsen, Philipp Kellmeyer, Volkmar Glauche, Irina Mader, Stefan Klöppel, Julia Suchan, Hans-Otto Karnath, Cornelius Weiller, Dorothee Saur
2013 Brain  
Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal-ventral brain network: a dorsal stream connects temporoparietal with frontal  ...  A ventral stream connects temporal and prefrontal regions via the extreme capsule and mediates meaning, e.g. in auditory comprehension.  ...  Brain lesions were simulated by reducing both function and connectivity of the network components (layers).  ... 
doi:10.1093/brain/aws354 pmid:23378217 pmcid:PMC3572927 fatcat:nyly5wyjqzgmlnl3eyt5oxvae4
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