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Collaborative intra-tumor heterogeneity detection
2019
Bioinformatics
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Besides that, the majority of the existing datasets consist of bulk sequencing data of single tumor sample of an individual. ...
, a phenomenon known as intra-tumor heterogeneity (ITH). ...
Conclusions We presented Hintra as a new method for collaborative ITH detection. ...
doi:10.1093/bioinformatics/btz355
pmid:31510674
pmcid:PMC6612880
fatcat:kgivksnfwna5tmtnznjncr3unq
Glioblastoma Multiforme: A Look Inside Its Heterogeneous Nature
2014
Cancers
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There are two types of heterogeneity: inter-tumor and intra-tumor heterogeneity. ...
While inter-tumor heterogeneity has been studied widely, intra-tumor heterogeneity has been neglected even though numerous studies support this aspect of tumor pathobiology. ...
Models for the origin of intra-tumor heterogeneity. ...
doi:10.3390/cancers6010226
pmid:24473088
pmcid:PMC3980595
fatcat:vn4s5dxuinesdjhjpt434cxm4u
Intra-tumor heterogeneity in head and neck cancer and its clinical implications
2016
World Journal of Otorhinolaryngology-Head and Neck Surgery
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The presence of heritable differences among cancer cells within a tumor, called intra-tumor genetic heterogeneity, has long been suspected of playing a role in poor responses to therapy. ...
After a brief review of this background, we describe the development of a measure of intra-tumor genetic heterogeneity, based on whole-exome sequencing of individual tumor samples, that could be applied ...
Sequencing methods and intra-tumor heterogeneity The most direct way to examine intra-tumor genetic heterogeneity is to compare DNA sequences among regions of a tumor. ...
doi:10.1016/j.wjorl.2016.05.007
pmid:28642939
pmcid:PMC5477669
fatcat:i6oupafrurgvthmwbt72lw37z4
Quantitative Characterization of CD8+ T Cell Clustering and Spatial Heterogeneity in Solid Tumors
2019
Frontiers in Oncology
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The results indicate a higher intra-tumoral heterogeneity compared with the heterogeneity across patients. ...
The intra- and inter-tumoral spatial heterogeneities are potentially key to the understanding of the dose-response relationships, but they also bring challenges to properly parameterizing and validating ...
We also detected cell aggregates using cluster analysis, and used the calculated shape descriptors for each cluster to capture the intra-tumoral heterogeneity. ...
doi:10.3389/fonc.2018.00649
pmid:30666298
pmcid:PMC6330341
fatcat:2xfaumohhnfvxnbqxonchtfd44
The Promise and Challenges of Personalized Medicine in Hematologic Malignancies
2015
Journal of Hematology & Thrombosis
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Personalized medicine in oncology seeks to individualize cancer care and treatment decisions based upon features unique to each patient and each patient's tumor. ...
The concept of personalized medicine hopes to not only enhance the patient quality of life and survival but also to lower overall healthcare costs through early-detection, prevention, accurate risk assessments ...
The fundamental basis that underlies intra tumor heterogeneity is the molecular variability of the tissue microenvironment and neoplastic cells within a single tumor, in particular with epigenetic heterogeneity ...
doi:10.13188/2380-6842.1000007
fatcat:6alp55o6encq5amp55z2ie7ogi
Tumor Quantification in Clinical Positron Emission Tomography
2013
Theranostics
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Positron emission tomography (PET) is used extensively in clinical oncology for tumor detection, staging and therapy response assessment. ...
We describe current efforts to improve the accuracy of tumor uptake measurements, characterize overall metabolic tumor burden and heterogeneity of tumor uptake, and account for the effects of image noise ...
Intra-tumoral heterogeneity can be caused by cell proliferation, blood flow, hypoxia and necrosis. 73 Quantification of intra-tumoral heterogeneity is useful in monitoring and predicting response to ...
doi:10.7150/thno.5629
pmid:24312151
pmcid:PMC3840412
fatcat:pyvibhbszfcbxj72wqjfwglyya
Circulating Tumor Cells as a Tool to Untangle the Breast Cancer Heterogeneity Issue
2021
Biomedicines
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In this review, we report the latest findings in the field of CTCs for intra-tumoral heterogeneity unmasking in BC, supporting the need to deepen their analysis to investigate their role in metastatic ...
Breast cancer (BC) is a disease characterized by high degrees of heterogeneity at morphologic, genomic, and genetic levels, even within the same tumor mass or among patients. ...
Contextually, in addition to the differences occurring among different patients (intertumor heterogeneity), high levels of diversity have been described even within each individual tumor (intra-tumor heterogeneity ...
doi:10.3390/biomedicines9091242
pmid:34572427
fatcat:kbs6m5szkvg4tf25fpmjsmif4u
Concepts of Precision Medicine in Breast Cancer
2018
Oncology & Hematology Review (US)
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How can precision medicine address the challenge of intra-tumor heterogeneity resulting from clonal evolution of the disease? ...
Advances in genetic sequencing analysis are helping to illuminate the prevalence of intra-tumor heterogeneity, which allows us to answer compelling high priority clinical questions. ...
doi:10.17925/ohr.2018.14.1.16
fatcat:ecnjdeni35ewpmoaz2bx6p4evy
Personalized Medicine for Gliomas
2015
Surgical neurology international
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In glioblastoma multiforme (GBM), the most common adult brain tumor, this inter-tumoral heterogeneity is further complicated by intra-tumoral heterogeneity within the tumor. ...
Our ability to molecularly characterize tumor cells has increased dramatically and shown that there are significant differences between samples from patients with the same tumor type. ...
For instance, till date, no mouse model demonstrates the significant intra-tumoral heterogeneity seen in human GBM. ...
doi:10.4103/2152-7806.151351
pmid:25722938
pmcid:PMC4338492
fatcat:ra3wykdepnecjielkk3b5yyxiy
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis
1996
Genes & Development
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The MMTVD/myc transgenic mice spontaneously develop oligoclonal CD4+CD8 + T-ceU tumors. We used provirus insertional mutagenesis in these mice to identify putative collaborators of c-myc. ...
These results suggest that Notchl can be a frequent collaborator of c-myc for oncogenesis. ...
We thank Yves Paquette for providing transgenic mice for assessment of tumor latencies. We thank Benoit Laganihre and Ginette Mass6 for their excellent technical assistance. ...
doi:10.1101/gad.10.15.1930
pmid:8756350
fatcat:attpgdz3mze6bkpb3ynpaus7gm
The Role of Genomic Profiling in Advanced Breast Cancer: The Two Faces of Janus
2016
Translational Oncogenomics
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Next, is the puzzle on spatial and temporal tumoral heterogeneity, which remains to be solved by ultra-deep sequencing and optimizing liquid biopsy techniques. ...
heterogeneity SUPPLEMENT: status of cancer Dna sequencing in the clinic CITATIoN: ...
within the same tumor called "intra-tumor heterogeneity". 20 The term "spatial intra-tumor heterogeneity" refers to the occurrence of genetic aberrations at different geographic locations within the ...
doi:10.4137/tog.s39410
pmid:27547031
pmcid:PMC4986714
fatcat:qibdbdfagjhkjkzf2q36y6w23m
Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions
2018
Journal of Thoracic Oncology
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Methods-We performed RNA sequencing to analyze inter-tumor heterogeneity in thirty specimens (primary tumors, intra-thoracic, and extra-thoracic metastatic lesions) obtained from five treatment-naïve lung ...
Introduction-Data regarding the pre-treatment inter-tumor heterogeneity of potential biomarkers in advanced-stage lung cancers is limited. ...
regions in clinically resectable non-small cell lung cancers (NSCLCs; intra-tumor heterogeneity) 7 , or between multiple intrathoracic lesions obtained from operable NSCLCs 5 . ...
doi:10.1016/j.jtho.2018.05.039
pmid:29933065
pmcid:PMC6153034
fatcat:earb6iw66rejfkmxsb2rjoyrga
T cell receptor β-chain repertoire analysis of tumor infiltrating lymphocytes in pancreatic cancer
2018
Cancer Science
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This study aimed to test the relationship between the TCR β repertoire of the tumor and peripheral blood, and also to investigate the intra-tumor spatial heterogeneity of the TCR β repertoire in pancreatic ...
Whereas, intra-tumoral TCR β repertoires were spatially homogeneous between different regions of a single tumor tissue. ...
The heterogeneity is probably driven by intra-tumoral competition and selection by the host's immune response to tumor therapeutics. 17, 18 It is necessary to assess the clonal composition of TIL across ...
doi:10.1111/cas.13877
pmid:30426614
pmcid:PMC6317932
fatcat:z3tewhsdazbc7fhpbexldqye5e
Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer
2018
Journal of Translational Medicine
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In this study, we addressed the question whether intra-tumoral heterogeneity can be reliably detected in tissue-micro-arrays in breast cancer by comparing expression levels of conventional predictive/prognostic ...
Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. ...
Results
Intra-tumoral heterogeneity Expression levels of all markers were compared between tissue cores of central and peripheral tumor parts to assess intra-tumoral heterogeneity. ...
doi:10.1186/s12967-018-1495-6
pmid:29739401
pmcid:PMC5941467
fatcat:hfogamxu5jhfdgbif3xrloplti
Avoiding Pitfalls in the Statistical Analysis of Heterogeneous Tumors
2009
Biomedical Informatics Insights
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Differences between cells within individual tumors (intratumor heterogeneity) and between tumors of different patients (intertumor heterogeneity) may mean that a small sample is not representative of the ...
tumor as a whole, particularly for solid tumors which are the focus of this paper. ...
However, intra-tumor heterogeneity will not be detected once the data for many cells or many regions within each tumor are combined to characterize each patient's tumor. ...
doi:10.4137/bii.s2222
fatcat:43viqnreojaubbd26i3ssqjgay
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