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Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD

Katherine Reiter, Kathryn I. Alpert, Derin J. Cobia, Mary J. Kwasny, John C. Morris, John C. Csernansky, Lei Wang
2012 NeuroImage  
Children of Alzheimer's Disease (AD) patients are at heightened risk of developing AD due to genetic influences, including the apolipoprotein E4 (ApoE4) allele.  ...  In this study, we assessed the earliest cortical changes associated with AD in 71 cognitively healthy, adult children of AD patients (AD offspring) as compared with 69 with no family history of AD (non-AD  ...  The principal investigator (JGC) takes responsibility for the integrity of the data and the accuracy of the data analysis.  ... 
doi:10.1016/j.neuroimage.2012.03.083 pmid:22503937 pmcid:PMC3358455 fatcat:jexhqxqu5nau5f7uwojz2mxmna

Effects of Hypoperfusion in Alzheimer's Disease

Benjamin P. Austin, Veena A. Nair, Timothy B. Meier, Guofan Xu, Howard A. Rowley, Cynthia M. Carlsson, Sterling C. Johnson, Vivek Prabhakaran, J. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley (+4 others)
2011 Journal of Alzheimer's Disease  
persons at high-risk for developing AD due to family history or genetic factors.  ...  state and be used to explore treatments to prevent, or at least slow, the progression of the disease.  ...  Arterial Spin Labeling Numerous studies have used ASL perfusion MRI to investigate CBF in AD, MCI, and in individuals at high-risk for developing AD, i.e., those with a parental history of AD or with at  ... 
doi:10.3233/jad-2011-0010 pmid:21971457 pmcid:PMC3303148 fatcat:x7vwrfqbebadbezmuasio55zwq

Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes

Elijah Mak, Silvy Gabel, Habib Mirette, Li Su, Guy B Williams, Adam Waldman, Katie Wells, Karen Ritchie, Craig Ritchie, John O'Brien
2017 Ageing Research Reviews  
Structural neuroimaging modalities have been used to identify brain changes related to risk factors for AD, such as familial genetic mutations, risk genes (for example apolipoprotein epsilon-4 allele),  ...  preclinical and sporadic AD.  The imaging literature in relation to AD risk factors was highly discrepant.  More research and validation studies of structural imaging techniques are needed.  ...  Characteristic AD patterns of cortical thinning in temporal regions have been reported in cognitively normal AB+ individuals (Dickerson et al., 2009) .  ... 
doi:10.1016/j.arr.2016.10.001 pmid:27777039 fatcat:am6tolnzsfagdf5y4ofkb4ai3q

APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease

Ivar Reinvang, Thomas Espeseth, Lars Tjelta Westlye
2013 Neuroscience and Biobehavioral Reviews  
Individuals carrying the *E4 allele of the apolipoprotein E gene (APOE) are at increased risk of developing Alzheimer's disease (AD).  ...  Furthermore, the effect of APOE genotype on development, maintenance and aging of the normal brain is poorly understood because of the strong bias toward studying disease associations.  ...  Upon comparison of the *E4specific age-related thinning with previously published patterns of thinning in normal aging and AD, they concluded that *E4 may function to accelerate thinning in areas found  ... 
doi:10.1016/j.neubiorev.2013.05.006 pmid:23701948 fatcat:js4cp5zvjrfpnf7elnq6g3jcky

Correlations between amyloid and metabolic pet imaging in cognitively normal adults with a family history of late-onset Alzheimer's disease

Megan Cummings, Juha Rinne, Lisa Mosconi, Wai Tsui, John Murray, Yi Li, Lidia Glodzik, Pauline McHugh, Schantel Williams, Stanley Goldsmith, Shankar Vallabhajosula, Noora Scheinin (+3 others)
2011 Alzheimer's & Dementia  
using this marker would be at elevated risk for cognitive decline consistent with symptoms of early AD.  ...  We hypothesized that Preclinical AD individuals would be at elevated risk of Cognitive Decline.  ... 
doi:10.1016/j.jalz.2011.05.589 fatcat:cjwkt4ka6bdn5cccliz234bbni

Decreased White Matter Integrity in Neuropsychologically Defined Mild Cognitive Impairment Is Independent of Cortical Thinning

Nikki H. Stricker, David H. Salat, Jessica M. Foley, Tyler A. Zink, Ida L. Kellison, Craig P. McFarland, Laura J. Grande, Regina E. McGlinchey, William P. Milberg, Elizabeth C. Leritz
2013 Journal of the International Neuropsychological Society  
These results provide further support for the potential role of white matter integrity as an early biomarker for individuals at risk for AD and highlight that changes in white matter may be independent  ...  Improved understanding of the pattern of white matter changes in early and prodromal Alzheimer's disease (AD) states such as mild cognitive impairment (MCI) is necessary to support earlier preclinical  ...  The current sample, while at risk for AD, may reflect a variety of etiologies for MCI.  ... 
doi:10.1017/s1355617713000660 pmid:23809097 pmcid:PMC4356249 fatcat:2w4bz5npyfdbdhg3xcvm5twbja

Cortical thinning and flattening in schizophrenia and their unaffected parents

Jing Yan, Yue Cui, Qianqian Li, Lin Tian, Bing Liu, Tianzi Jiang, Dai Zhang, Hao Yan
2019 Neuropsychiatric Disease and Treatment  
of the patients, as well as 30 young controls for patients and 28 elderly controls for parents with age, sex and education level being well-matched.  ...  Conclusion: The results suggest that cortical morphology may be susceptible to a genetic risk of schizophrenia and could underlie the cognitive dysfunction in patients and their unaffected relatives.  ...  Author contributions All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the  ... 
doi:10.2147/ndt.s195134 pmid:31114205 pmcid:PMC6489638 fatcat:y2hjbbsqifff5jyzkh2edf3dzm

Prosocial behavior relates to the rate and timing of cortical thinning from adolescence to young adulthood

Lia Ferschmann, Nandita Vijayakumar, Håkon Grydeland, Knut Overbye, Donatas Sederevicius, Paulina Due-Tønnessen, Anders M. Fjell, Kristine B. Walhovd, Jennifer H. Pfeifer, Christian K. Tamnes
2019 Developmental Cognitive Neuroscience  
Mapping the biological foundations of prosociality may thus aid our understanding of both normal and abnormal development, yet how prosociality relates to cortical development is largely unknown.  ...  The sample consisted of 169 healthy individuals (92 females) aged 12-26 with repeated MRI from up to 3 time points, at approximately 3-year intervals (301 scans).  ...  For the most part, more adaptive psychological and behavioral patterns were associated with greater cortical thinning.  ... 
doi:10.1016/j.dcn.2019.100734 pmid:31739096 pmcid:PMC6974908 fatcat:a7gfrf5da5g3jctdy7l6h7qcmy

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Susan Bookheimer, Alison Burggren
2009 Annual Review of Clinical Psychology  
This review examines the most recent data on brain changes in genetic risk for AD and discusses the benefits and potential risks of detecting individuals at risk.  ...  Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological  ...  These age-related brain changes cannot be understated: Even in patients who never develop dementia or significant cognitive decline, there is a characteristic brain deterioration in normal aging that includes  ... 
doi:10.1146/annurev.clinpsy.032408.153625 pmid:19327032 pmcid:PMC3118550 fatcat:y6rar2w4cne45pzhnndx3nl2dy

Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease

Meredith N. Braskie, Andrea D. Klunder, Kiralee M. Hayashi, Hillary Protas, Vladimir Kepe, Karen J. Miller, S.-C. Huang, Jorge R. Barrio, Linda M. Ercoli, Prabha Siddarth, Nagichettiar Satyamurthy, Jie Liu (+4 others)
2010 Neurobiology of Aging  
We examined this relationship at each cortical surface point in 23 older adults (10 cognitively intact, 6 with amnestic mild cognitive impairment, 7 with AD). [(18)F]FDDNP-PET signal was highly correlated  ...  Regions in which cognitive performance was significantly correlated with [(18)F]FDDNP signal include those that deteriorate earliest in AD, suggesting the potential utility of [(18)F]FDDNP for early diagnosis  ...  cog- 380 nitive aging that is considered age-normal actually may 381 reflect pathological brain changes, particularly in subjects 382 at risk for AD.  ... 
doi:10.1016/j.neurobiolaging.2008.09.012 pmid:19004525 pmcid:PMC2891885 fatcat:4gcuv4p765amtmrc2czj43t4am

Cellular correlates of cortical thinning throughout the lifespan

Didac Vidal-Pineiro, the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen (+3 others)
2020 Scientific Reports  
We found that inter-regional profiles of cortical thinning related to expression profiles for marker genes of CA1 pyramidal cells, astrocytes and, microglia during development and in aging.  ...  During the two stages of life, the relationships went in opposite directions: greater gene expression related to less thinning in development and vice versa in aging.  ...  Data used in the preparation of this article were partially obtained from the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL) funded by the Commonwealth Scientific and Industrial  ... 
doi:10.1038/s41598-020-78471-3 pmid:33311571 fatcat:l4rfkxt4uvcqffgjabszcly56i

Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease

Stella M. Sánchez, Carolina Abulafia, Barbara Duarte-Abritta, M. Soledad Ladrón de Guevara, Mariana N. Castro, Lucas Drucaroff, Gustavo Sevlever, Charles B. Nemeroff, Daniel E. Vigo, David A. Loewenstein, Mirta F. Villarreal, Salvador M. Guinjoan (+1 others)
2017 Journal of Alzheimer's Disease  
aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls.  ...  limbic dysfunction in persons at risk for 519 LOAD.  ... 
doi:10.3233/jad-170491 pmid:28984601 fatcat:ajc6oyizr5dotnyuseyeefjy3u

Evaluating Cerebral Perfusion in Alzheimer Patients and First-Degree Relatives: Lessons from Artemisa Province, Cuba

2021 MEDICC Review  
Alzheimer disease is related to several risk factors including aging, family history, high blood pressure and diabetes.  ...  This study involved 128 persons (87 clinically diagnosed with Alzheimer disease and 41 of their first-degree relatives with normal cognition), all from Artemisa Province, Cuba.  ...  We divided participants into two groups: AD patients (87 with a clinical diagnosis of AD) and their fi rst-degree relatives with normal cognition (41 parents, children or siblings).  ... 
doi:10.37757/mr2021.v23.n1.11 pmid:33780424 fatcat:zff5erfrtrc2bfgxlh5ye7lusq

Biomarkers Predicting Alzheimer's Disease in Cognitively Normal Aging

Yong S. Shim, John C. Morris
2011 Journal of Clinical Neurology  
This concept of preclinical AD has arisen from the observation of AD pathologic findings such as senile plaques and neurofibrillary tangles in the brains of people who at the time of death had normal cognitive  ...  Functional and structural brain alterations that begin with amyloid-β accumulation already show the patterns of abnormality seen in individuals with dementia due to AD.  ...  Since potential intervention with diseasemodifying therapies may provide the greatest chance of preserving normal cognition, it will be critical to identify individuals with preclinical AD before the development  ... 
doi:10.3988/jcn.2011.7.2.60 pmid:21779293 pmcid:PMC3131540 fatcat:mmmvdkedbfgs7bz45bj4bgkm64

White matter integrity and vulnerability to Alzheimer's disease: Preliminary findings and future directions

Brian T. Gold, Nathan F. Johnson, David K. Powell, Charles D. Smith
2012 Biochimica et Biophysica Acta - Molecular Basis of Disease  
The present review summarizes recent evidence suggesting that WM integrity declines are present in individuals at high AD-risk, prior to cognitive decline.  ...  Preliminary evidence suggests that some AD-risk declines are characterized by increases of radial diffusivity, raising the possibility that a myelin-related pathology may contribute to AD onset.  ...  Acknowledgments We gratefully acknowledge our collaborators at the Alzheimer's Disease Research Center, and Magnetic Resonance Imaging and Spectroscopy Center at the University of Kentucky.  ... 
doi:10.1016/j.bbadis.2011.07.009 pmid:21803153 pmcid:PMC3213315 fatcat:f5a67z5smncrveicqhm4tf2afi
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