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Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging

Christine Bastin, Igor Yakushev, Mohamed Ali Bahri, Andreas Fellgiebel, Francis Eustache, Brigitte Landeau, Armin Scheurich, Dorothée Feyers, Fabienne Collette, Gael Chételat, Eric Salmon
2012 NeuroImage  
Lustig, Please find attached the revision of our manuscript entitled "Cognitive reserve impacts on interindividual variability in resting-state cerebral metabolism in normal aging" that we submit for publication  ...  There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning.  ...  Discussion This study examined whether cognitive reserve relates to resting-state cerebral metabolism in aging.  ... 
doi:10.1016/j.neuroimage.2012.06.074 pmid:22796505 fatcat:io7sewlxfjhqhigd2umiyr7bym

The influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging

Salmon Eric
2012 Frontiers in Human Neuroscience  
We further confirmed an increase in TNF-alpha in the plasma of FTLD patients by ELISA.  ...  Currently we are in the process of analyzing the immune phenotype of FTLD patients and comparing it to healthy controls.  ...  Background: There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning.  ... 
doi:10.3389/conf.fnhum.2012.210.00119 fatcat:sgpspqnjvzejvjmorfezcypevm

The influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging

Christine Bastin, Eric Salmon, Mohamed Ali Bahri, Brigitte Landau, Andreas Fellgiebel, Dorothée Feyers, Fabienne Collette, Gaël Chetelat, Igor Yakushev
2012 Alzheimer's & Dementia  
We further confirmed an increase in TNF-alpha in the plasma of FTLD patients by ELISA.  ...  Currently we are in the process of analyzing the immune phenotype of FTLD patients and comparing it to healthy controls.  ...  Background: There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning.  ... 
doi:10.1016/j.jalz.2012.05.193 fatcat:yjnnxqzzwncd3ob5dzwpct3g5u

Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders

Eider M. Arenaza-Urquijo, Brigitte Landeau, Renaud La Joie, Katell Mevel, Florence Mézenge, Audrey Perrotin, Béatrice Desgranges, David Bartrés-Faz, Francis Eustache, Gaël Chételat
2013 NeuroImage  
Thirtysix healthy elders were selected based on neuropsychological assessments and cerebral amyloid imaging, i.e. as presenting normal cognition and a negative florbetapir-PET scan.  ...  reserve in healthy elders.  ...  Studies investigating cerebral metabolism at rest showed a negative association between a proxy of reserve combining education and intelligence and metabolic activity in temporoparietal areas (Bastin  ... 
doi:10.1016/j.neuroimage.2013.06.053 pmid:23796547 fatcat:e2exts74jrchxjtyv64fqjeqzq

Is Verbal Episodic Memory in Elderly with Amyloid Deposits Preserved Through Altered Neuronal Function?

Rik Ossenkoppele, Cindee Madison, Hwamee Oh, Miranka Wirth, Bart N. M. van Berckel, William J. Jagust
2013 Cerebral Cortex  
A potential mechanism that enables intellectual preservation in cognitively normal elderly that harbor beta-amyloid (Aβ) pathology is heightened cerebral glucose metabolism.  ...  To investigate cross-sectional inter-relationships between Aβ, glucose metabolism, and cognition, 81 subjects (mean age: 75 ± 7 years) underwent [ 11 C] Pittsburgh Compound-B and [ 18 F]fluorodeoxyglucose  ...  Finally, the present study was not designed to assess the impact of cognitive reserve variables on preservation of cognitive function by means of increased metabolic function.  ... 
doi:10.1093/cercor/bht076 pmid:23537530 pmcid:PMC4089385 fatcat:47rypa3qovfnnadh57zwbhy6qi

Relationship between occupation attributes and brain metabolism in frontotemporal dementia

R. Nathan Spreng, Alexander Drzezga, Janine Diehl-Schmid, Alexander Kurz, Brian Levine, Robert Perneczky
2011 Neuropsychologia  
Occupation has been associated with cognitive reserve in healthy aging and Alzheimer's disease.  ...  We concluded that, consistent with the cognitive reserve hypothesis, lifelong occupation characteristics are related to focal cerebral metabolic deficits in bvFTD.  ...  The sponsors played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and the preparation, review, or approval of the manuscript.  ... 
doi:10.1016/j.neuropsychologia.2011.09.025 pmid:21958648 fatcat:j57hzw5uyjcfnoiz4p5kgsw3xe

Fact, Fiction, or Evolution: Mechanism Hypothesis of Alzheimer's Disease [chapter]

José V. Pardo
2019 Alzheimer's Dementia and Korsakoff's Disease - Linking Memory Pathology to the Autobiographical Self [Working Title]  
In normal aging and very mild AD, the cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) remained approximately constant, but the metabolism of glucose (CMRglu) declined markedly.  ...  These ideas and findings motivate aging and AD-research focus on the biochemistry and cell biology of cerebral metabolism.  ...  Data are integrated with advances in neuroimaging and brain metabolism as well as in preclinical models mostly focusing on the resting state. These results bear on the metabolism hypothesis of AD.  ... 
doi:10.5772/intechopen.83824 fatcat:j5yjihob4fgwdk4br3jx6m45rq

Association of individual resting state EEG alpha frequency and cerebral blood flow

Kay Jann, Thomas Koenig, Thomas Dierks, Chris Boesch, Andrea Federspiel
2010 NeuroImage  
Cognitive task performance differs considerably between individuals. Besides cognitive capacities, attention might be a source of such differences.  ...  Correlation of IAF with regional Cerebral Blood Flow (rCBF) in fifteen young healthy subjects revealed a network of brain areas that are associated with the modulation of attention and preparedness for  ...  Acknowledgments We would like to thank Mara Kottlow, Karin Zwygart and Verena Beutler for their assistance in data acquisition.  ... 
doi:10.1016/j.neuroimage.2010.02.024 pmid:20156573 fatcat:pi3eyd2jqvfyxokh27z4z3jzmu

Alterations in resting-state network dynamics along the Alzheimer's disease continuum: a combined MEG-PET/MR approach [article]

Delphine Puttaert, Nicolas Coquelet, Vincent Wens, Philippe Peigneux, Patrick Fery, Antonin Rovai, Nicola Trotta, Jean-Christophe Bier, Serge Goldman, Xavier De Tiege
2020 bioRxiv   pre-print
No significant difference was found in patients with SCD or aMCI. The time spent by participants in the activated posterior DMN state did not correlate significantly with cognitive scores.  ...  Human brain activity is intrinsically organized into resting-state networks (RSNs) that transiently activate or deactivate at the sub-second timescale.  ...  SCD is defined as a self-perceived decline in cognitive capacity despite normal performance at neuropsychological assessment and no significant impact on everyday activities 14 .  ... 
doi:10.1101/2020.05.18.101683 fatcat:5ns6ifchhvatpj6h6335hfgqse

Cerebral hemodynamics and the aging brain

Sushmita Purkayastha, Farzaneh A. Sorond
2014 International Journal of Clinical Neurosciences and Mental Health  
Recent studies have examined the impact of age on cerebral hemodynamics and brain structure and function.  ...  These studies have shown age related changes in resting cerebral blood flow, cerebral vasoreactivity, cerebral autoregulation, and neurovascular coupling.  ...  Therefore, the impact of advanced age (>75 years) on dCA is unknown.  ... 
doi:10.21035/ijcnmh.2014.1(suppl.1).s07 fatcat:674jcesnjbaqho2afr7ycirz6u

Perspectives for Multimodal Neurochemical and Imaging Biomarkers in Alzheimer's Disease

Stefan J. Teipel, Osama Sabri, Michel Grothe, Henryk Barthel, David Prvulovic, Katharina Buerger, Arun L.W. Bokde, Michael Ewers, Wolfgang Hoffmann, Harald Hampel, George Perry, Xiongwei Zhu (+3 others)
2012 Journal of Alzheimer's Disease  
We integrate biomarker findings into a comprehensive model of AD pathogenesis from healthy aging to cognitive decline, the resilience to cerebral amyloid load (RECAL) matrix. The RECAL framework S.J.  ...  Teipel et al. / Multimodal Biomarkers in AD integrates factors of risk and resilience to cerebral amyloid load for individual risk prediction.  ...  tensor estimation due to inter-scanner variability can be identified.  ... 
doi:10.3233/jad-2012-129030 pmid:22735677 fatcat:td3kcurc3rdt3gs7ioq5qx3rry

Why is delirium more frequent in the elderly?

Orso Bugiani
2021 Neurological Sciences  
An aging-related reduction in the brain's functional reserve may explain why delirium is more frequent in the elderly than in younger people insofar as the reserve becomes inadequate to cover the metabolic  ...  On the other hand, the developmental growth in functional reserve during childhood and adolescence makes the brain increasingly resistant to delirium, and residual reserve can allow the elderly to recover  ...  [54] found that rest-and task-activated structures were not functionally opposed in delirious subjects as they were in normal subjects and patients after recovery.  ... 
doi:10.1007/s10072-021-05339-3 pmid:34031797 pmcid:PMC8143064 fatcat:gum4o5aymnf3taljrmbix6go2e

Resting state cortical EEG rhythms in Alzheimer's disease [chapter]

Fabrizio Vecchio, Claudio Babiloni, Roberta Lizio, Fabrizio De Vico Fallani, Katarzyna Blinowska, Giulio Verrienti, Giovanni Frisoni, Paolo M. Rossini
2013 Supplements to Clinical Neurophysiology  
However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition.  ...  This review provides an overview of the studies on resting state eyes closed EEG rhythms recorded in amnesic mild cognitive impairment (MCI) and AD subjects.  ...  Resting state eyes closed cortical EEG rhythms along physiological aging and AD: classification of MCI and AD individuals based on EEG markers towards clinical applications In the previous section, the  ... 
doi:10.1016/b978-0-7020-5307-8.00015-6 pmid:24053043 fatcat:efdzlz2hkfb5dkelrj2ztqf7g4

Brain Ageing in the New Millennium

Julian N Trollor, Michael J Valenzuela
2001 Australian and New Zealand journal of psychiatry (Print)  
in the course of normal cellular metabolism.  ...  Deficits in relative cerebral metabolic rate of glucose utilization (rCMRgl) that are similar but less severe than those seen in AD have been observed in cognitively intact individuals from familial AD  ... 
doi:10.1046/j.1440-1614.2001.00969.x pmid:11990890 fatcat:ostl57km4rbhnlpc56vxtel3mi

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

Patrick J. Smith
2019 Brain Plasticity  
In addition, previous mechanistic assumptions linking lifestyle to neurocognition are discussed, with a focus on potential solutions to improve our understanding of individual neurocognitive differences  ...  exercise and dietary change, individually and together, improve neurocognitive performance among middle-aged and older adults.  ...  Resting-state multi-spectrum functional connectivity networks for identification of MCI patients. PLoS One. 2012;7(5):e37828. [447] Wee CY, Yap PT, Zhang D, et al.  ... 
doi:10.3233/bpl-190083 pmid:31970058 pmcid:PMC6971820 fatcat:7bmn3wrnmbe2nis7ynwove5cn4
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