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Numerical Simulations of Vaccination and Wolbachia on Dengue Transmission Dynamics in the Nonlinear Model

Prem Junsawang, Samina Zuhra, Zulqurnain Sabir, Muhammad Asif Zahoor Raja, Muhammad Shoaib, Thongchai Botmart, Wajaree Weera
2022 IEEE Access  
Exploring the prospect of fixing linear/nonlinear systems using the high predictive capabilities of feedforward artificial neural networks (ANNs) optimized with the combined capabilities of local/global  ...  Artificial neural networks are used in conjunction with the features of the Genetic algorithm's global and Active-set algorithm as local search methodologies.  ...  His research interests include mathematical modeling, unsupervised/supervised neural networks, artificial intelligence, mathematical modeling, and implementation of computational-based traditional as well  ... 
doi:10.1109/access.2022.3159813 fatcat:upqozurbozhy7mc34srs6yj4x4

Gene prediction in metagenomic fragments: A large scale machine learning approach

Katharina J Hoff, Maike Tech, Thomas Lingner, Rolf Daniel, Burkhard Morgenstern, Peter Meinicke
2008 BMC Bioinformatics  
In the second stage, an artificial neural network combines these features with open reading frame length and fragment GC-content to compute the probability that this open reading frame encodes a protein  ...  In particular, the combination of linear discriminants and neural networks is promising and should be considered for integration into metagenomic analysis pipelines.  ...  Subsequently, we will depict the neural network architecture and the methods we used for large scale training and validation from labeled ORFs in artificial fragments.  ... 
doi:10.1186/1471-2105-9-217 pmid:18442389 pmcid:PMC2409338 fatcat:f63d4jpihndutayeoqpyui5o6e

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

Jeffrey A. Rosenfeld, Darryl Reeves, Mercer R. Brugler, Apurva Narechania, Sabrina Simon, Russell Durrett, Jonathan Foox, Kevin Shianna, Michael C. Schatz, Jorge Gandara, Ebrahim Afshinnekoo, Ernest T. Lam (+15 others)
2016 Nature Communications  
The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host  ...  A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models.  ...  Acknowledgements This study was supported by the Tri-Institutional Training Program in Computational Biology and Medicine (via NIH training grant 1T32GM083937) and the American Museum of Natural History  ... 
doi:10.1038/ncomms10164 pmid:26836631 pmcid:PMC4740774 fatcat:i5lwbo6esbaudmp7rqw4265uxq

Plant Virus–Insect Vector Interactions: Current and Potential Future Research Directions

Ralf Dietzgen, Krin Mann, Karyn Johnson
2016 Viruses  
High-resolution microscopy showed that CaMV P2 bound to aphid stylets and appeared to localize at the very tip of the stylet; this stylet region was proposed as a potential common foothold for non-circulative  ...  Plant viruses can interact with their insect host in a variety of ways including both non-persistent and circulative transmission; in some cases, the latter involves virus replication in cells of the insect  ...  The dramatic antiviral effect of Wolbachia in artificially infected mosquitoes, together with the reproductive genetic drive are being harnessed in field trials using Wolbachia-infected Aedes aegypti mosquitoes  ... 
doi:10.3390/v8110303 pmid:27834855 pmcid:PMC5127017 fatcat:wgp2nuzh4rainfhxojyqdixdce

New Madrid in motion

Martitia P. Tuttle
2005 Nature  
Thus, any distributed visual coding scheme would predict substantial overlap in the neural groups representing Aniston and Roberts; cells responding to one and not the other would be rare.  ...  movements than the 1-inch-diameter steel rods used in the previous network 5 .  ... 
doi:10.1038/4351037a pmid:15973390 fatcat:v7ky56nexjhi3a5cx7bmh5ou2e

Abstracts from the 41st Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry

2020 Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)  
Our results suggested that the actual connectome data is useful in creating neural network models for the motion detection.  ...  of spiking in neurons are important as"neural codes"to generate information to drive animal behavior.  ... 
doi:10.3330/hikakuseiriseika.37.3 fatcat:a4qyhbqggzhprncb7wg3hoi3we

Comparative genomics of first available bovine Anaplasma phagocytophilum genome obtained with targeted sequence capture

Thibaud Dugat, Valentin Loux, Sylvain Marthey, Marco Moroldo, Anne-Claire Lagrée, Henri-Jean Boulouis, Nadia Haddad, Renaud Maillard
2014 BMC Genomics  
SignalP incorporates cleavage site prediction and signal peptide/non-signal peptide prediction, based on a combination of several artificial neural networks and hidden Markov models.  ...  In BOV-10_179, we detected 261 CDS (26.1% of the total predicted CDS) which coded for small peptides.  ... 
doi:10.1186/1471-2164-15-973 pmid:25400116 pmcid:PMC4239370 fatcat:pqdhp4jzfraynfcm6g4sckccjm

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Robert Adamu Shey, Stephen Mbigha Ghogomu, Kevin Kum Esoh, Neba Derrick Nebangwa, Cabirou Mounchili Shintouo, Nkemngo Francis Nongley, Bertha Fru Asa, Ferdinand Njume Ngale, Luc Vanhamme, Jacob Souopgui
2019 Scientific Reports  
The 3D structure was predicted, refined, and validated using bioinformatics tools. Protein-protein docking of the chimeric vaccine peptide with the TLR4 protein predicted efficient binding.  ...  Conservation of the selected proteins and predicted epitopes in other parasitic nematode species suggests that the generated chimera could be helpful for cross-protection.  ...  MHC class I binding and proteasomal cleavage are performed using artificial neural networks. TAP transport efficiency is predicted using a weight matrix 95 .  ... 
doi:10.1038/s41598-019-40833-x pmid:30867498 pmcid:PMC6416346 fatcat:s5l7pirjizgg7obooq3t4bquyy

Digital, three-dimensional average shaped atlas of the heliothis virescens brain with integrated gustatory and olfactory neurons

Pål Kvello
2009 Frontiers in Systems Neuroscience  
We use the moth Heliothis virescens as model organism for studying the neural network involved in chemosensory coding and learning.  ...  Here we report on a laboratory study, in which we artificially selected upwards and downwards on sperm length in S. stercoraria.  ...  The overriding conclusion is that, as for neuroscience in general, molecular neuroscience has to take into account potential sex influences that might modify signalling pathways.  ... 
doi:10.3389/neuro.06.014.2009 pmid:19949481 pmcid:PMC2784302 fatcat:3ol42nrslzeoloymlb43crqyyu

Near-Infrared Spectroscopy as a Potential COVID-19 Early Detection Method: A Review and Future Perspective

Muna E. Raypah, Asma Nadia Faris, Mawaddah Mohd Azlan, Nik Yusnoraini Yusof, Fariza Hanim Suhailin, Rafidah Hanim Shueb, Irneza Ismail, Fatin Hamimi Mustafa
2022 Sensors  
In recent years, a significant advancement in instrumentation and spectral analysis methods has resulted in a remarkable impact on the NIRS applications, especially in the medical discipline.  ...  The rapid dispersion of the infection globally results in unparalleled economic, social, and health impacts.  ...  Up to now, other calibration models that comprise an artificial neural network (ANN), a wavelet neural network (WNN), and a support vector machine (SVM) are utilized for regression and prediction functions  ... 
doi:10.3390/s22124391 pmid:35746172 pmcid:PMC9229781 fatcat:hrhfsnyjz5ckjcdqqbj4oblvwm

Genome-wide association study of sleep in Drosophila melanogaster

Susan T Harbison, Lenovia J McCoy, Trudy FC Mackay
2013 BMC Genomics  
Many of these loci are known to interact physically and/or genetically, enabling us to place them in candidate genetic networks.  ...  sex-biased effects, and were generally located in non-coding regions.  ...  is in LD with other potential candidate genes ( Table 2) .  ... 
doi:10.1186/1471-2164-14-281 pmid:23617951 pmcid:PMC3644253 fatcat:gonny3fknvcv7bxh7a4n5voxwq


2022 2022 International Conference on Decision Aid Sciences and Applications (DASA)  
The proposed method can further be used to detect other neurological disorders.  ...  Only Hjorth parameters (activity, mobility, complexity) are selected using the Kruskal-Wallis test.  ...  to predict potential network operating limit overloads.  ... 
doi:10.1109/dasa54658.2022.9765271 fatcat:ttqppf4j3navnaxe653mrzmezi

Fruit Flies in Biomedical Research

M. F. Wangler, S. Yamamoto, H. J. Bellen
2015 Genetics  
Indeed, there has been an overall decline in support in funding for research from the National Institutes of Health and the National Science Foundation.  ...  Within the Drosophila field, some of us question how long this funding crunch will last as it demotivates principal investigators and perhaps more importantly affects the longterm career choice of many  ...  It was even expanded in the past 10 years by selecting Drosophila as a model organism to unravel neural networks at the recently developed Janelia Research Campus.  ... 
doi:10.1534/genetics.114.171785 pmid:25624315 pmcid:PMC4349060 fatcat:vmpaaa4rtfcbdhuh2a5jsghth4

Fuzzy Genome Sequence Assembly for Single and Environmental Genomes [chapter]

Sara Nasser, Adrienne Breland, Frederick C. Harris, Monica Nicolescu, Gregory L. Vert
2009 Studies in Fuzziness and Soft Computing  
We propose a sequence assembly solution based on fuzzy logic, which allows for tolerance of inexactness or errors in fragment matching and that can be used for improved assembly.  ...  We evaluate our method on artificially created environmental genomes to test various combinations of organisms and on an environmental genome.  ...  Clustering or classification can be achieved by several techniques such as K-means and artificial neural networks.  ... 
doi:10.1007/978-3-540-89968-6_2 fatcat:dhn5s7xzsnc6datdonyzb6wazy

Computational Design and Preliminary Serological Analysis of a Novel Multi-Epitope Vaccine Candidate against Onchocerciasis and Related Filarial Diseases

Robert Adamu Shey, Stephen Mbigha Ghogomu, Cabirou Mounchili Shintouo, Francis Nongley Nkemngo, Derrick Neba Nebangwa, Kevin Esoh, Ntang Emmaculate Yaah, Muyanui Manka'aFri, Joel Ebai Nguve, Roland Akwelle Ngwese, Ferdinand Ngale Njume, Fru Asa Bertha (+4 others)
2021 Pathogens  
Several observations in both humans and animals have provided evidence for the development of both natural and artificial acquired immunity.  ...  The high-percentage conservation of the selected proteins and epitopes predicted in related nematode parasitic species hints that the generated chimera may be instrumental for cross-protection.  ...  The server uses artificial neural networks to predict MHC class I binding and proteasomal cleavage while TAP transport efficiency is predicted using a weight matrix.  ... 
doi:10.3390/pathogens10020099 pmid:33494344 pmcid:PMC7912539 fatcat:b7eydhaf6jeudajulkceqr6may
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