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Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
2016
BMC Bioinformatics
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To demonstrate the utility of the clusters, phage libraries were constructed for three of the representative scaffolds and panned against interleukin-23. ...
Only 20 peptide scaffolds accounted for most of the natural DRP structural diversity, providing suitable starting points for seeding phage display experiments. ...
Acknowledgements The authors wish to acknowledge Ben Webb for assistance with MODELLER and Praveen Madala for thoughtful discussions. ...
doi:10.1186/s12859-016-1350-9
pmid:27881076
pmcid:PMC5120537
fatcat:jloxdqcsgfdzdgdmer7x2opnq4
Protein-Catalyzed Capture Agents
2019
Chemical Reviews
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The development of epitope-targeted PCCs was motivated by the desire to fully generalize pioneering work from the Sharpless and Finn groups in which in situ click screens were used to develop potent, divalent ...
We provide a historical context for PCCs and place them within the broader scope of biological and synthetic aptamers. ...
phage display technologies. 135 Unlike later PCC macrocycles, this anchor was cyclized by a disulfide bridge between two cysteine residues. ...
doi:10.1021/acs.chemrev.8b00660
pmid:30838853
pmcid:PMC6731165
fatcat:c7pnvrw4arbo3gfn2ihumz7fvi
TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches
2020
Molecules
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employed by pharmaceutical companies and academic researchers for the development of pharmacologically active drugs. ...
Furthermore, this article provides an overview of the computational methods that can benefit a broad audience in this field and help with the development of novel drugs for TLR-related disorders. ...
through phage display. ...
doi:10.3390/molecules25030627
pmid:32023919
pmcid:PMC7037830
fatcat:faw3prwk5fb27gbjdxyw4isdbm
Computer applications for prediction of protein–protein interactions and rational drug design
2009
Advances and Applications in Bioinformatics and Chemistry
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for computational proteomics. ...
In recent years, protein-protein interactions are becoming the object of increasing attention in many different fields, such as structural biology, molecular biology, systems biology, and drug discovery ...
Discovery of PPi agonists/antagonists: experimental approaches Phage-display selection of peptides Phage display has been used to probe hot-spots as well as to identify novel peptide agonist/antagonists ...
doi:10.2147/aabc.s6272
fatcat:ib3ynmetnvg5jhywiqbzw27thi
Computer applications for prediction of protein-protein interactions and rational drug design
2009
Advances and Applications in Bioinformatics and Chemistry
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for computational proteomics. ...
In recent years, protein-protein interactions are becoming the object of increasing attention in many different fields, such as structural biology, molecular biology, systems biology, and drug discovery ...
Discovery of PPi agonists/antagonists: experimental approaches Phage-display selection of peptides Phage display has been used to probe hot-spots as well as to identify novel peptide agonist/antagonists ...
pmid:21918619
pmcid:PMC3169948
fatcat:54u2fw4ma5csdcqftwypntgage
IBC's 22nd Annual Antibody Engineering and 9th Annual Antibody Therapeutics International Conferences and the 2011 Annual Meeting of The Antibody Society, December 5–8, 2011, San Diego, CA
2012
mAbs
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of subtiligase by a combination of phage and yeast display. ...
The resulting antigens may be used for antibody generation by hybridoma technology or for screening of phage display libraries. ...
10G11) were used for the construction of several DVD-Ig molecules, by swapping the orientation of IL-1α and IL-1β-specific VH/VL domains, and using different linker lengths. 11 The selected isotype ...
doi:10.4161/mabs.4.2.19495
pmid:22453091
pmcid:PMC3361653
fatcat:gntlkfumg5c7tg4bi4gyc4vwty
Antibody Engineering and Therapeutics
2014
mAbs
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Eleven unpublished, high-resolution x-ray Fab crystal structures (provided by investigators at Janssen R&D, LLC and The Scripps Research Institute) from diverse species and covering a wide range of antigen-binding ...
The workshop aimed to address this question by presenting and discussing the results of the second 3D Antibody Modeling Assessment (AMA-II). ...
Osbourn (MedImmune) discussed the discovery of adalimumab (Humira®) using the phage display system at Cambridge Antibody Technology in the 1990s. ...
doi:10.4161/mabs.28421
pmid:24589717
pmcid:PMC4011904
fatcat:ga63frfoina7jh2ekkzoo4xunm
PDZ Domains as Drug Targets
2019
Advanced Therapeutics
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An overview of potential new therapeutic interventions in PDZ-mediated protein networks is also provided. ...
In this review, the authors describe structural and genetic aspects of PDZ-containing proteins and discuss the current status of the development of small-molecule and peptide modulators of PDZ domains. ...
[226] Phage display has also been used to identify peptide-based inhibitors for Dvl. ...
doi:10.1002/adtp.201800143
pmid:32313833
pmcid:PMC7161847
fatcat:o42un72gkzgffleesyh2cljmni
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
2020
Advanced Drug Delivery Reviews
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Acknowledgements A.V. and S.S. contributed equally to this work. A.V. acknowledges the support of the NSF through a graduate research fellowship.
References [1] ...
In contrast to other salt-leached silk scaffolds, the swelling behaviors of these scaffolds as measured by Discovery V20 stereomicroscope were low, and the mechanical properties were suitable for soft ...
While this hydrogel was primarily engineered J o u r n a l P r e -p r o o f for tissue engineering applications, it provides an example of how peptides can be appended to the RLP sequence for other biomedical ...
doi:10.1016/j.addr.2020.08.008
pmid:32871201
pmcid:PMC7456198
fatcat:g2saqupm6fcalne6rbj4glzrm4
The 28th Annual Symposium of The Protein Society: Program & Abstracts
2014
Protein Science
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An advantage of cell surface display over other systems such as phage display is the possibility to use flow-cytometric cell sorting. ...
These disulfide-bonded Lsm clusters are readily disengaged by a reducing step. ...
designed, synthetized, purified and characterized by our team 1 . ...
doi:10.1002/pro.2504
pmid:25043257
pmcid:PMC4116645
fatcat:yjhug3aif5futn3icovvrkgebm
Abstracts of the 29th Annual Symposium of The Protein Society
2015
Protein Science
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Nonetheless, our approach clearly demonstrates the ability of biological systems to produce advanced, functional nanomaterials, and provides a template for engineering biological systems to high-value ...
Here, we engineer a yeast strain for the production of medium chain fatty acids by screening different thioesterases. ...
This mechanism also leads, for example, to the spread of antibiotic resistance genes and virulence factors among bacterial species. ...
doi:10.1002/pro.2823
pmid:26452528
pmcid:PMC4632850
fatcat:ejmksoqj3zbsrkabl4jyp7emgi
Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017
2017
Protein Science
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Grouping by Topics Pages ...
In the present study, we aimed to improve the ExM method for imaging of proteins in human clinical tissue samples, for diagnostic pathology and research. ...
ExPath enables morphological and protein imaging and analysis of tissue microarrays, by providing $70nm resolution imaging of proteins in any type of human tissues, using optical microscopes (currently ...
doi:10.1002/pro.3349
pmid:29280217
fatcat:jrxtwzblare37gxsvc5szbwuhu
Peptide Vaccines for Cancer
[chapter]
2011
Encyclopedia of Cancer
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The affinity selection of peptides and antibodies for diagnostic and therapeutic purposes are today the most widely used and commercially most successful applications of phage display libraries. ...
Phage display technology offers a potential tool for developing anticancer agents for both therapeutic and diagnostic applications. ...
According to the result of the phase III trials, Sipuleucel-T administration was well tolerated and provided a modest but real survival advantage to patients, as the overall survival was extended by 4.1 ...
doi:10.1007/978-3-642-16483-5_4441
fatcat:g5gzz7mzanbb7el5lc6adyh5fy
Plasminogen-Activating System
[chapter]
2011
Encyclopedia of Cancer
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The affinity selection of peptides and antibodies for diagnostic and therapeutic purposes are today the most widely used and commercially most successful applications of phage display libraries. ...
Phage display technology offers a potential tool for developing anticancer agents for both therapeutic and diagnostic applications. ...
According to the result of the phase III trials, Sipuleucel-T administration was well tolerated and provided a modest but real survival advantage to patients, as the overall survival was extended by 4.1 ...
doi:10.1007/978-3-642-16483-5_4605
fatcat:keaft6ozlbclvnkyzcgrvcvud4
Particle-induced Cancer
[chapter]
2011
Encyclopedia of Cancer
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The affinity selection of peptides and antibodies for diagnostic and therapeutic purposes are today the most widely used and commercially most successful applications of phage display libraries. ...
Phage display technology offers a potential tool for developing anticancer agents for both therapeutic and diagnostic applications. ...
According to the result of the phase III trials, Sipuleucel-T administration was well tolerated and provided a modest but real survival advantage to patients, as the overall survival was extended by 4.1 ...
doi:10.1007/978-3-642-16483-5_4396
fatcat:guepwtopobdgbiqi23os5zaely
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