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Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
2010
Journal of Neuroscience
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This mechanism provides a testable hypothesis that is likely to accelerate the discovery and analysis of the biological circuitry for chemotaxis in C. elegans. ...
A dynamical systems analysis of 77 evolved networks revealed a novel neural mechanism for spatial orientation behavior. ...
Results
Klinotaxis from evolved neural networks To identify simple neural networks for klinotaxis in C. elegans, we generated a population of 100 different networks using a genetic algorithm. ...
doi:10.1523/jneurosci.2606-10.2010
pmid:20881110
pmcid:PMC3422662
fatcat:kfcptpneb5bhvmzcukjrwrei7a
Olfactory circuits and behaviors of nematodes
2016
Current Opinion in Neurobiology
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The free-living nematode Caenorhabditis elegans is a powerful model for parasitic nematodes: because sensory neuroanatomy is conserved across nematode species, an understanding of the microcircuits that ...
mediate olfaction in C. elegans may inform studies of olfaction in parasitic nematodes. ...
Functional organization of a neural network for aversive olfactory learning in
Caenorhabditis elegans. Neuron. 2010; 68:1173-1186. [PubMed: 21172617]
18. ...
doi:10.1016/j.conb.2016.09.002
pmid:27668755
pmcid:PMC5123917
fatcat:ccoodrqazzcklix5oinm4cvxau
Japanese studies on neural circuits and behavior of Caenorhabditis elegans
2013
Frontiers in Neural Circuits
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The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. ...
Here, we will review the recent studies on the neural circuits of C. elegans that have been conducted in Japan. ...
This work was supported by CREST-JST, Strategic Research Program for Brain Sciences, MEXT, and a Grant-in-Aid for Scientific Research on Innovative Area-Neural Diversity and Neocortical Organization from ...
doi:10.3389/fncir.2013.00187
pmid:24348340
pmcid:PMC3842693
fatcat:zr3uwfu3q5drhoakquaxjlvjjq
Behavioral plasticity, learning, and memory in C. elegans
2013
Current Opinion in Neurobiology
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Caenorhabditis elegans exhibits behavior plasticity that appears to correspond to non-associative and associative learning, and short-term and long-term memory. ...
Recent finding revealed that evolutionally conserved molecules such as insulin, monoamines, and neuropeptides are required for the plasticity. ...
We thank Yuki Tsukada and Shunji Nakano for materials for ...
doi:10.1016/j.conb.2012.09.005
pmid:23063296
fatcat:nxc2sih5ijboxigka3p45vk5si
The computational worm: spatial orientation and its neuronal basis in C. elegans
2011
Current Opinion in Neurobiology
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Recent work by the C. elegans research community has identified essential computational elements of the neural circuits underlying two orientation strategies that operate in five different sensory modalities ...
The nematode Caenorhabditis elegans orients to wide range of stimuli and has a numerically small and well-described nervous system making it advantageous for investigation the mechanisms of spatial orientation ...
Neuronal mechanisms of klinokinesis A candidate neural circuit for klinokinesis in gradients of tastants has been identified (Fig. 2C) . ...
doi:10.1016/j.conb.2011.06.009
pmid:21764577
pmcid:PMC3947813
fatcat:ml2jsczsc5calflyxnagyjt6kq
Searching for motifs in the behaviour of larvalDrosophila melanogasterandCaenorhabditis elegansreveals continuity between behavioural states
2015
Journal of the Royal Society Interface
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We present a novel method for the unsupervised discovery of behavioural motifs in larval Drosophila melanogaster and Caenorhabditis elegans. ...
Research Cite this article: Szigeti B, Deogade A, Webb B. 2015 Searching for motifs in the behaviour of larval Drosophila melanogaster and Caenorhabditis elegans reveals continuity between behavioural ...
Motifs for Caenorhabditis elegans ESA was developed with the analysis of larval Drosophila in mind, but can also be applied to C. elegans. The worm behavioural data were obtained from the CBD. ...
doi:10.1098/rsif.2015.0899
pmid:26609067
pmcid:PMC4707863
fatcat:4o57xwqplnhknfpivyishjowau
Deep phenotyping in C. elegans
[article]
2019
arXiv
pre-print
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For the living animal C. elegans, recent advances in genome-editing tools, microfluidic devices and phenotypic analyses allow for a deeper understanding of the genotype-to-phenotype pathway. ...
In this article, I reviewed the evolution of deep phenotyping study in cell development, neuron activity, and the behaviors of intact animals. ...
For instance, hierarchical clustering and Kmean clustering algorithms are used to extract the synaptic or behavioral features in order to identify mutants of C. elegans [5, [15] [16] [17] . ...
arXiv:1905.02335v1
fatcat:mzmfjpcsifa2bhb2izbqflwrge
Whole-animal modeling: piecing together nematode locomotion
2018
Current Opinion in Systems Biology
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With a reconstructed and extensively characterized neural circuit, Caenorhabditis elegans is a fascinating model system for the study of neural circuits and behavior. ...
dynamics, and structure-function relation in neural circuits. ...
The authors thank Thomas Ranner, Felix Salfelder, Gal Haspel, Ian Hope and Samuel Braunstein for useful discussions. ...
doi:10.1016/j.coisb.2018.12.002
fatcat:5dpbvnh3xffzdlxw6jrimdxuta
Circuit Motifs for Spatial Orientation Behaviors Identified by Neural Network Optimization
2007
Journal of Neurophysiology
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Circuit motifs for spatial orientation behaviors identified by neural network optimization. Spatial orientation behavior is universal among animals, but its neuronal basis is poorly understood. ...
The main objective of the present study was to identify candidate patterns of neuronal connectivity (motifs) for two widely recognized classes of spatial orientation behaviors: hill climbing, in which ...
The nematode Caenorhabditis elegans is an effective model system for studies of spatial orientation in two main respects. ...
doi:10.1152/jn.00074.2007
pmid:17522174
fatcat:u44gx23aw5fz7km4ttl7lhtx5i
Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans
2019
PLoS Genetics
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Here, we show that neuropeptides of the evolutionarily conserved MyoInhibitory Peptide (MIP)-family modify salt chemotaxis behavior in Caenorhabditis elegans according to previous experience. ...
MIP signaling, through activation of the G protein-coupled receptor SPRR-2, is required for short-term gustatory plasticity. ...
C. elegans strains used in this study. ...
doi:10.1371/journal.pgen.1007945
pmid:30779740
pmcid:PMC6380545
fatcat:jzm4m2jgxnc3bp6syhdc5sbgle
Hierarchical compression ofCaenorhabditis eleganslocomotion reveals phenotypic differences in the organization of behaviour
2016
Journal of the Royal Society Interface
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We find that the motifs identified by the compression algorithm are rare but relevant for comparisons between worms in different environments, suggesting that hierarchical compression can be a useful step ...
We apply a dictionary compression algorithm to behavioural sequences from the nematode worm Caenorhabditis elegans freely crawling on an agar plate both with and without food and during chemotaxis. ...
In C. elegans, we find that the dictionary sequences resulting from the compression algorithm represent rare but relevant behavioural motifs. ...
doi:10.1098/rsif.2016.0466
pmid:27581484
pmcid:PMC5014070
fatcat:o2c65zq4gng5xoafxoi5zxbuua
Beyond the connectome: A map of a brain architecture derived from whole-brain volumetric reconstructions
[article]
2020
bioRxiv
pre-print
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We find that the C. elegans connectome is not invariant, but that a precisely wired core circuit is embedded in a background of variable connectivity, and propose a corresponding reference connectome for ...
Animal nervous system organization is crucial for all body functions and its disruption can manifest in severe cognitive and behavioral impairment. ...
In particular, the feedforward motif, 148 previously identified in the C. elegans connectome, reappears in our map as the skeleton of the layered synaptic pathways 149 within each bundle (>80% of all C ...
doi:10.1101/2020.05.24.112870
fatcat:vjfqsr7svvcu3fo3mjbb5rda4m
Aversion and Attraction through Olfaction
2015
Current Biology
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For example, attractive odors of palatable food or a potential mate predict reward, while aversive odors of pathogen-laced food or a predator predict punishment. ...
Understanding the organization of neural circuitry that mediates odor aversion and attraction will provide key insights into how the brain functions. ...
Acknowledgments We thank Zecai Liang, David Strochlic and Erika Williams for comments on the manuscript, and an NIH grant (RO1DC013289 to SDL) for support. ...
doi:10.1016/j.cub.2014.11.044
pmid:25649823
pmcid:PMC4317791
fatcat:fppp67il5rfn5ek4praeztstpy
The C. elegans Glutamate Receptor Subunit NMR-1 Is Required for Slow NMDA-Activated Currents that Regulate Reversal Frequency during Locomotion
2001
Neuron
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In particular, one used genetic and electrophysiological methods to role for NMDA receptors in the retina depends on its demonstrate that NMR-1, a Caenorhabditis elegans slow rate of desensitization. ...
We also show that a slowly distinguishing features, participates in neural circuits desensitizing variant of a non-NMDA receptor can resthroughout the central nervous system. ...
Introduction approach to investigate how NMDA receptors contribute to synaptic function in Caenorhabditis elegans. ...
doi:10.1016/s0896-6273(01)00394-4
pmid:11545720
fatcat:xrdg45gybrflphy67wya3jeiyi
Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion
2015
PLoS Computational Biology
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A quantitative understanding of the nature of behavioural variation will inform research on the function and evolution of neural circuits. Syntax in C. elegans Locomotion PLOS Computational Biology | ...
Here we introduce a discrete representation of behaviour in the nematode C. elegans. ...
Acknowledgments We thank Mario de Bono and Kate Weber for providing us with the wild isolates used in this study and Alexander Gottschalk for providing ZX46 worms.
Author Contributions ...
doi:10.1371/journal.pcbi.1004322
pmid:26295152
pmcid:PMC4546679
fatcat:efxpvhn3ungjrf2pdugewicldy
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