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Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks

Stefano Luccioli, Eshel Ben-Jacob, Ari Barzilai, Paolo Bonifazi, Alessandro Torcini, Olaf Sporns
2014 PLoS Computational Biology  
The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation  ...  Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture.  ...  The coherent activity of the network can be even arrested by removing or stimulating any of these neurons, which are functional hubs arranged in a clique regulating the neuronal bursting.  ... 
doi:10.1371/journal.pcbi.1003823 pmid:25255443 pmcid:PMC4177675 fatcat:o4e5vpxk7bhvdartwz7sbectea

Modeling driver cells in developing neuronal networks [article]

Stefano Luccioli, David Angulo-Garcia, Rosa Cossart, Arnaud Malvache, Laura Modol, Vitor Hugo Sousa, Paolo Bonifazi, Alessandro Torcini
2018 biorxiv/medrxiv   pre-print
The functional hubs arranged in a clique orchestrated the synchronization build-up, while the LC drivers were lately or not at all recruited in the synchronization process.  ...  We have developed a spiking network model capable to reproduce the experimental results, thus identifying two classes of driver cells: functional hubs and low functionally connected (LC) neurons.  ...  A population burst is identified whenever the spike count involves more than 25% of the neural population.  ... 
doi:10.1101/260422 fatcat:sj2nfgbbw5eynefsokkb5cpbay

Modeling driver cells in developing neuronal networks

Stefano Luccioli, David Angulo-Garcia, Rosa Cossart, Arnaud Malvache, Laura Módol, Vitor Hugo Sousa, Paolo Bonifazi, Alessandro Torcini, Michele Giugliano
2018 PLoS Computational Biology  
The functional hubs arranged in a clique orchestrated the synchronization build-up, while the LC drivers were lately or not at all recruited in the synchronization process.  ...  We explain the role of hub neurons, arranged in a clique, for the orchestration of the PLOS Computational Biology | https://doi.bursting activity in control conditions.  ...  A population burst is identified whenever the spike count involves more than 25% of the neural population.  ... 
doi:10.1371/journal.pcbi.1006551 fatcat:nlms2zbta5bepftoojv4rv27uu

Emergence of a Small-World Functional Network in Cultured Neurons

Julia H. Downes, Mark W. Hammond, Dimitris Xydas, Matthew C. Spencer, Victor M. Becerra, Kevin Warwick, Ben J. Whalley, Slawomir J. Nasuto, Olaf Sporns
2012 PLoS Computational Biology  
The functional networks of cultured neurons exhibit complex network properties similar to those found in vivo.  ...  In the present study, evolution of functional connectivity was estimated from correlations of spontaneous activity.  ...  Interestingly, structural and functional hubs have recently been identified in the developing hippocampus where GABAergic interneuron hubs were found to orchestrate network synchrony [52] , firing immediately  ... 
doi:10.1371/journal.pcbi.1002522 pmid:22615555 pmcid:PMC3355061 fatcat:3tibwcr3ibfyjkj777ldyr35ou

29th Annual Computational Neuroscience Meeting: CNS*2020

2020 BMC Neuroscience  
Investigations of this question have, to date, focused largely on deep neural networks trained using supervised learning, in tasks such as image classification.  ...  by visual experience, and (iii) how patterns of neural activity in the zebrafish brain develop to facilitate precisely targeted hunting behaviour.  ...  Acknowledgments: The research reported here was supported, in part, by NSF grant #1544383 and in part by AFOSR grant #FA9550-16-1-0410.  ... 
doi:10.1186/s12868-020-00593-1 pmid:33342424 fatcat:edosycf35zfifm552a2aogis7a

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
Currently, most functional models of neural activity are based on firing rates, while the most relevant signals for inter-neuron communication are spikes.  ...  within the constraints of biological networks.  ...  O14 On the role of arkypallidal and prototypical neurons for neural synchronization in the basal ganglia Acknowledgements This work was supported by NIH-NIBIB (R01-EB027584).  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu

Systems biology analysis of gene expression in cardiopoiesis

Tomasz Leja, Michael Schneider, Mauricio Barahona, British Heart Foundation
2020
Sox17 was shown to be essential in regulating Mesp1 induction, and a Sox17-Hhex-Cer1 circuit was further identified in mediating cardiac mesoderm specification.  ...  Here, a quantitative systems approach is utilised to unravel the intricate network of genetic cues involved in cardiopoiesis, both from embryonic and adult stem cells.  ...  Therefore, the analysis of closely connected hubs in the RMST co-expression network provides an opportunity to identify Sox17-dependent genes with shared regulatory function.  ... 
doi:10.25560/81505 fatcat:7pomnxdtk5f67o4xxeu24zvqr4

Heterogeneity and Context-Specificity in Biological Systems

Oren Litvin
2017
features explain, predict or exert influence on the phenotype in only a subset of cases.  ...  In my studies of both yeast and cancer, I found vast heterogeneity between individuals that hampers the prediction power of many statistical models.  ...  It constructs protein-protein interaction networks from genes within recurrently aberrant regions and defines drivers as hubs in these networks.  ... 
doi:10.7916/d84t6ghb fatcat:e7vjbx4yzrh3pbalk7szwne2ma

On becoming and being a musician: A mixed methods study of musicianship in children and adults

Dawn Rose
2016
and subcortical sensory-motor neural networks.  ...  The second study is a qualitative grounded theory investigation of a range of 28 adult musicians reflecting contemporary working musicians in the U.K.  ...  in structural and functional neural networks and ultimately in behaviours.  ... 
doi:10.25602/gold.00019105 fatcat:24fp6aqnxvecxewbdo56wt26eu