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Grey matter volume changes and corresponding cellular metrics identified in a longitudinal in vivo imaging approach [article]

Livia Asan, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Carlo Beretta, Thomas Kuner, Johannes Knabbe
2019 bioRxiv   pre-print
Acknowledgements We want to thankfully acknowledge the Michaela Kaiser, Claudia Kocksch and Felix Hoerner for their excellent technical support during preparation and execution of experiments.  ...  Age-dependent changes in VBM The grey matter changes detected by VBM follow a pattern previously described (Bilbao, Falfan-Melgoza et al. 2018) , with age-related volume increasing in the cerebellum and  ...  possible by extending VBM to animal studies, leading to a better understanding of pathologyrelated changes in brain structure (Seminowicz, Laferriere et al. 2009 , Biedermann, Fuss et al. 2012 , Bilbao, Falfan-Melgoza  ... 
doi:10.1101/559765 fatcat:bsjzcafhijgxtiprrwabxfszse

Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy

Livia Asan, Claudia Falfán-Melgoza, Carlo A Beretta, Markus Sack, Lei Zheng, Wolfgang Weber-Fahr, Thomas Kuner, Johannes Knabbe
2021 Scientific Reports  
Acknowledgements We want to thank Michaela Kaiser, Claudia Kocksch and Felix Hoerner for their excellent technical support during preparation and execution of experiments.  ... 
doi:10.1038/s41598-021-83491-8 pmid:33608622 pmcid:PMC7895945 fatcat:hefoxfpzzncuxmvnr6dosl3tdy

Early effects of a high-caloric diet and physical exercise on brain volumetry and behavior: a combined MRI and histology study in mice

Markus Sack, Jenny N. Lenz, Mira Jakovcevski, Sarah V. Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K. Stalla, Alexander Sartorius, Peter Gass (+3 others)
2016 Brain Imaging and Behavior  
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis.
more » ... alf of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet. In addition, histological analyses for myelination and neurogenesis were performed. As expected, wheel running resulted in a significant increase of gray matter volume in the CA1-3 areas, the dentate gyrus and stratum granulosum of the hippocampus in the VBM analysis, while a positive effect of the cafeteria-diet was shown for the whole hippocampal CA1-3 area only in the ROI analysis, indicating a regional volume effect. It was earlier found that hippocampal neurogenesis may be related to volume increases after exercise. Interestingly, while running resulted in a significant increase in neurogenesis assessed by doublecortin (DCX)-labeling, this was not true for cafeteria diet. This indicates different underlying mechanisms for gray matter increase. Moreover, animals receiving cafeteria diet only showed mild deficits in long-term memory assessed by the puzzle-box paradigm, while executive functioning and short term memory were not affected. Our data therefore highlight that high caloric diet impacts on the brain and behavior. Physical exercise seems not to interact with these mechanisms.
doi:10.1007/s11682-016-9638-y pmid:27734300 pmcid:PMC5653704 fatcat:w7hiroddmzbqhm3kguw3red5nq

StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain [article]

Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A Barrière, Ines Blockx, Aleksandra B Bortel, Margaret Broadwater, Beatriz M Cardoso, Marina Célestine, Jorge E Chavez-Negrete (+197 others)
2022 bioRxiv   pre-print
AbstractTask-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. We introduce StandardRat, a consensus rat functional MRI acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition
more » ... d processing parameters, we initially aggregated 65 functional imaging datasets acquired in rats from 46 centers. We developed a reproducible pipeline for the analysis of rat data acquired with diverse protocols and determined experimental and processing parameters associated with a more robust functional connectivity detection. We show that the standardized protocol enhances biologically plausible functional connectivity patterns, relative to pre-existing acquisitions. The protocol and processing pipeline described here are openly shared with the neuroimaging community to promote interoperability and cooperation towards tackling the most important challenges in neuroscience.
doi:10.1101/2022.04.27.489658 fatcat:j6hewy7verdn7m324v5s5ekuom

Brain network reorganization differs in response to stress in rats genetically predisposed to depression and stress-resilient rats

N Gass, R Becker, A J Schwarz, W Weber-Fahr, C Clemm von Hohenberg, B Vollmayr, A Sartorius
2016 Translational Psychiatry  
We thank Felix Hörner, Katja Lankisch and Claudia Falfan-Melgoza for their excellent technical assistance.  ... 
doi:10.1038/tp.2016.233 pmid:27922640 pmcid:PMC5315561 fatcat:lv7f66nwwfhndeb7oj32cg6dfu

Optogenetic fMRI in the mouse hippocampus: Hemodynamic response to brief glutamatergic stimuli

Philipp Lebhardt, Christian Clemm von Hohenberg, Wolfgang Weber-Fahr, Wolfgang Kelsch, Alexander Sartorius
2015 Journal of Cerebral Blood Flow and Metabolism  
Acknowledgment We thank Felix Ho¨rner and Claudia Falfan-Melgoza for their excellent technical assistance.  ... 
doi:10.1177/0271678x15606455 pmid:26661158 pmcid:PMC4794094 fatcat:xytsrqlgazelvmhn6j2phnzucm

Differences between ketamine's short-term and long-term effects on brain circuitry in depression

Natalia Gass, Robert Becker, Jonathan Reinwald, Alejandro Cosa-Linan, Markus Sack, Wolfgang Weber-Fahr, Barbara Vollmayr, Alexander Sartorius
2019 Translational Psychiatry  
Acknowledgements The authors thank Felix Hörner, Helene Schamber, and Claudia Falfan-Melgoza for their superb technical assistance.  ... 
doi:10.1038/s41398-019-0506-6 pmid:31253763 pmcid:PMC6599014 fatcat:yqb7drsonbeu5aae62wzeipgdy

Sub-Anesthetic Ketamine Modulates Intrinsic BOLD Connectivity Within the Hippocampal-Prefrontal Circuit in the Rat

Natalia Gass, Adam James Schwarz, Alexander Sartorius, Esther Schenker, Celine Risterucci, Michael Spedding, Lei Zheng, Andreas Meyer-Lindenberg, Wolfgang Weber-Fahr
2013 Neuropsychopharmacology  
ACKNOWLEDGEMENTS The authors thank Felix Hörner and Claudia Falfan-Melgoza for their excellent technical assistance.  ... 
doi:10.1038/npp.2013.290 pmid:24136293 pmcid:PMC3924524 fatcat:fw54rjwkrfhjzblgvetfjp2j5i

Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI

Nazzareno Cannella, Alejandro Cosa-Linan, Tatiane Takahashi, Wolfgang Weber-Fahr, Rainer Spanagel
2020 Scientific Reports  
We thank Claudia Falfan-Melgoza and Felix Hörner for their excellent technical assistance with MRI acquisitions. We thank Dr. Hamid Noori for expert feedbacks.  ... 
doi:10.1038/s41598-020-76182-3 pmid:33168866 fatcat:fchq34ay7ve3lla7tirxyukv5a

Brain networks in pharmacological fMRI of NMDA antagonists

Robert Becker
Jonathan Reinwald, Claudia Falfan-Melgoza, and Dr.  ... 
doi:10.11588/heidok.00027272 fatcat:lhdk4we4afhg3hydaapbvr7b6y

Combining Optogenetics and fMRI to Study Cerebral Networks in Animal Models

Philipp Lebhardt
Acknowledgments We thank Felix Hörner and Claudia Falfan-Melgoza for their excellent technical assistance.  ... 
doi:10.11588/heidok.00023376 fatcat:ivm2ppbsxzhv7f4hrf3cujit5y