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Acknowledgements We want to thankfully acknowledge the Michaela Kaiser, Claudia Kocksch and Felix Hoerner for their excellent technical support during preparation and execution of experiments. ... Age-dependent changes in VBM The grey matter changes detected by VBM follow a pattern previously described (Bilbao, Falfan-Melgoza et al. 2018) , with age-related volume increasing in the cerebellum and ... possible by extending VBM to animal studies, leading to a better understanding of pathologyrelated changes in brain structure (Seminowicz, Laferriere et al. 2009 , Biedermann, Fuss et al. 2012 , Bilbao, Falfan-Melgoza ...doi:10.1101/559765 fatcat:bsjzcafhijgxtiprrwabxfszse
Acknowledgements We want to thank Michaela Kaiser, Claudia Kocksch and Felix Hoerner for their excellent technical support during preparation and execution of experiments. ...doi:10.1038/s41598-021-83491-8 pmid:33608622 pmcid:PMC7895945 fatcat:hefoxfpzzncuxmvnr6dosl3tdy
Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating early effects of a cafeteria-diet on gray and white brain matter volume by means of voxel-based morphometry (VBM) and region-of-interest (ROI) analysis.doi:10.1007/s11682-016-9638-y pmid:27734300 pmcid:PMC5653704 fatcat:w7hiroddmzbqhm3kguw3red5nq
more »... alf of the mice performed voluntary wheel running to study if regular physical exercise prevents unfavorable effects of a cafeteria-diet. In addition, histological analyses for myelination and neurogenesis were performed. As expected, wheel running resulted in a significant increase of gray matter volume in the CA1-3 areas, the dentate gyrus and stratum granulosum of the hippocampus in the VBM analysis, while a positive effect of the cafeteria-diet was shown for the whole hippocampal CA1-3 area only in the ROI analysis, indicating a regional volume effect. It was earlier found that hippocampal neurogenesis may be related to volume increases after exercise. Interestingly, while running resulted in a significant increase in neurogenesis assessed by doublecortin (DCX)-labeling, this was not true for cafeteria diet. This indicates different underlying mechanisms for gray matter increase. Moreover, animals receiving cafeteria diet only showed mild deficits in long-term memory assessed by the puzzle-box paradigm, while executive functioning and short term memory were not affected. Our data therefore highlight that high caloric diet impacts on the brain and behavior. Physical exercise seems not to interact with these mechanisms.
AbstractTask-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows comparison with invasive or terminal procedures. To date, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. We introduce StandardRat, a consensus rat functional MRI acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisitiondoi:10.1101/2022.04.27.489658 fatcat:j6hewy7verdn7m324v5s5ekuom
more »... d processing parameters, we initially aggregated 65 functional imaging datasets acquired in rats from 46 centers. We developed a reproducible pipeline for the analysis of rat data acquired with diverse protocols and determined experimental and processing parameters associated with a more robust functional connectivity detection. We show that the standardized protocol enhances biologically plausible functional connectivity patterns, relative to pre-existing acquisitions. The protocol and processing pipeline described here are openly shared with the neuroimaging community to promote interoperability and cooperation towards tackling the most important challenges in neuroscience.
We thank Felix Hörner, Katja Lankisch and Claudia Falfan-Melgoza for their excellent technical assistance. ...doi:10.1038/tp.2016.233 pmid:27922640 pmcid:PMC5315561 fatcat:lv7f66nwwfhndeb7oj32cg6dfu
Acknowledgment We thank Felix Ho¨rner and Claudia Falfan-Melgoza for their excellent technical assistance. ...doi:10.1177/0271678x15606455 pmid:26661158 pmcid:PMC4794094 fatcat:xytsrqlgazelvmhn6j2phnzucm
Acknowledgements The authors thank Felix Hörner, Helene Schamber, and Claudia Falfan-Melgoza for their superb technical assistance. ...doi:10.1038/s41398-019-0506-6 pmid:31253763 pmcid:PMC6599014 fatcat:yqb7drsonbeu5aae62wzeipgdy
ACKNOWLEDGEMENTS The authors thank Felix Hörner and Claudia Falfan-Melgoza for their excellent technical assistance. ...doi:10.1038/npp.2013.290 pmid:24136293 pmcid:PMC3924524 fatcat:fw54rjwkrfhjzblgvetfjp2j5i
We thank Claudia Falfan-Melgoza and Felix Hörner for their excellent technical assistance with MRI acquisitions. We thank Dr. Hamid Noori for expert feedbacks. ...doi:10.1038/s41598-020-76182-3 pmid:33168866 fatcat:fchq34ay7ve3lla7tirxyukv5a
Jonathan Reinwald, Claudia Falfan-Melgoza, and Dr. ...doi:10.11588/heidok.00027272 fatcat:lhdk4we4afhg3hydaapbvr7b6y