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Classification of the dermal-epidermal junction using in-vivo confocal microscopy

J. Robic, B. Perret, A. Nkengne, M. Couprie, H. Talbot
2017 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)  
We improve the restitution of the epidermal and dermal labels while reducing the thickness of the uncertainty area in a coherent biological way from 16.9 µm (ground-truth) to 10.3 µm.  ...  Reflectance confocal microscopy (RCM) is a powerful tool to visualize the skin layers at cellular resolution. The dermalepidermal junction (DEJ) is a thin complex 3D structure.  ...  In this paper, we provide a method to automatically segment the dermo-epidermal junction in 3 classes : epidermis (ED), uncertain area (U), and dermis (D) using in vivo reflectance confocal microscopy  ... 
doi:10.1109/isbi.2017.7950513 dblp:conf/isbi/RobicPNCT17 fatcat:f7zo64t74fbqbnznjukpev2qvi

Reflectance confocal microscopy characteristics for melanocytic nevi

Yan Jing, Chang-Bing Shen, Ke Xue, Cheng-Xu Li, Xue Shen, Zi-Yi Wang, Feng Xu, Ru-Song Meng, Jian-Bin Yu, Yong Cui
2019 Chinese Medical Journal  
It will probably further increase in vivo diagnostic acumen and provide new insights into the in vivo dynamics of melanocytic neoplasms.  ...  Reflectance confocal microscopy analysis had revealed ringed or meshwork structures in majority of junctional nevi.  ...  Conflicts of interest None.  ... 
doi:10.1097/cm9.0000000000000440 pmid:31567389 pmcid:PMC6831067 fatcat:w3bzmjqlbbcyfevjd5qi3c7j44

Confocal Microscopy in Diagnosis and Management of Melasma: Review of Literature

Dimitris Sgouros Giovanni Pellacani
2015 Journal of Pigmentary Disorders  
Reflectance Confocal Microscopy (RCM) is a novel, non-invasive technique that offers an in vivo analysis of the skin layers at a cellular level resolution.  ...  of brighter cellular structures at the level of the dermo-epidermal junction.  ...  RCM findings were in accordance with previous studies, confirming the usefulness of in vivo confocal analysis in the evaluation of melasma treatment [26] (Figures 1 and 2 ).  ... 
doi:10.4172/2376-0427.1000s1005 fatcat:xijbsgelfffrldobdywtmw7c3q

A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum

Caterina Longo, Guido Gambara, Virginia Espina, Alessandra Luchini, Barney Bishop, Alexis S. Patanarut, Emanuel F. Petricoin III, Francesca Beretti, Barbara Ferrari, Enrico Garaci, Anto De Pol, Giovanni Pellacani (+1 others)
2010 Experimental Dermatology  
Biomarker levels were correlated with confocal microscopy, thereby representing a combination of new technologies for in vivo histologic documentation.  ...  Conclusions-Our study links serum proteome analysis with confocal microscopic clinical in vivo histologic classification of melanomas. Bak has not been previously measured in serum.  ...  Acknowledgments This work was partly supported by the Italian Istituto Superiore di Sanità, Rome, Italy in the framework of the Italy/ USA cooperation agreement between the U.S.  ... 
doi:10.1111/j.1600-0625.2010.01187.x pmid:21158936 pmcid:PMC3777620 fatcat:pxceygzdyzbq5i24qyq6x2v43e

In vivoreflectance-mode confocal microscopy assessments: impact of overweight on human skin microcirculation and histomorphology

Ahmet A. Altintas, Matthias C. Aust, Robert Krämer, Peter M. Vogt, Mehmet A. Altintas
2016 Journal of Biomedical Optics  
Reflectance-mode confocal microscopy (RCM) enables in vivo assessment of the human skin.  ...  evaluated using RCM: dermal blood cell flow (DBCF), density of dermal capillaries (DDC), epidermal thickness (ET), and epidermal cell size (ECS).  ...  Fig. 4 4 Fig. 4 Illustrated is the ET measured in vivo using confocal microscopy as the distance between skin surface and the apical plane of the dermal papillae.  ... 
doi:10.1117/1.jbo.21.3.036009 pmid:27020601 fatcat:lkezsrp4hvca3g4ks6wzyujcqe

Automated Segmentation of Skin Strata in Reflectance Confocal Microscopy Depth Stacks

Samuel C. Hames, Marco Ardigò, H. Peter Soyer, Andrew P. Bradley, Tarl W. Prow, Konradin Metze
2016 PLoS ONE  
Reflectance confocal microscopy (RCM) is a powerful tool for in-vivo examination of a variety of skin diseases.  ...  The mean absolute error in determining the interface depth for each of the stratum corneum/viable epidermis, viable epidermis/dermal-epidermal junction and dermal-epidermal junction/papillary dermis interfaces  ...  Introduction Reflectance confocal microscopy (RCM) is capable of imaging human skin in-vivo at high resolution, with available machines capable of lateral resolutions of 0.5-1 μ m [1] .  ... 
doi:10.1371/journal.pone.0153208 pmid:27088865 pmcid:PMC4835045 fatcat:yq6sdfl2ave7phy7tbjbh3skpi

Automated segmentation of skin strata in reflectance confocal microscopy depth stacks [article]

Samuel Hames, Marco Ardigò, H. Peter Soyer, Andrew P. Bradley, Tarl W. Prow
2015 bioRxiv   pre-print
Reflectance confocal microscopy (RCM) is a powerful tool for in-vivo examination of a variety of skin diseases.  ...  The mean absolute error in determining the interface depth for each of the stratum corneum/viable epidermis, viable epidermis/dermal-epidermal junction and dermal-epidermal junction/papillary dermis interfaces  ...  Introduction Reflectance confocal microscopy (RCM) is capable of imaging human skin in-vivo at high resolution, with available machines capable of lateral resolutions of 0.5-1 μ m [1] .  ... 
doi:10.1101/022137 fatcat:uq6ivoiofzbvtn4tfkf6jgfiiu

Histometric data obtained by in vivo confocal laser scanning microscopy in patients with systemic sclerosis

Kirsten Sauermann, Thilo Gambichler, Sören Jaspers, Michael Radenhausen, Solveig Rapp, Susanne Reich, Peter Altmeyer, Sven Clemann, Stefan Teichmann, Joachim Ennen, Klaus Hoffmann
2002 BMC Dermatology  
To investigate the skin of patients with systemic sclerosis using confocal laser scanning microscopy in vivo and to develop histometric parameters to describe characteristic cutaneous changes of systemic  ...  All subjects were investigated using confocal laser scanning microscopy in vivo.  ...  In vivo confocal laser scanning microscopy (CLSM) A commercially available CLSM (Vivascope 1000; Lucid Inc, Henrietta, NY; [http://www.lucid-tech.com] was used for in vivo confocal laser scanning microscopy  ... 
doi:10.1186/1471-5945-2-8 pmid:12162791 pmcid:PMC122067 fatcat:osy6cxhmnzer7fgfovrkee5diy

Reflectance confocal microscopy features of BRAF V600E mutated thin melanomas detected by immunohistochemistry

Ana Claudia Urvanegia, Juliana Casagrande Tavoloni Braga, Danielle Shitara, Jose Humberto Fregnani, Jose Ivanildo Neves, Clovis Antonio Pinto, Ashfaq A. Marghoob, Joao Pedreira Duprat, Gisele Gargantini Rezze, Nikolas K. Haass
2017 PLoS ONE  
BRAF positive melanomas were related to younger age (p = 0.035), invasive melanomas (p = 0.03) and to the presence of hiporreflective cells (p = 0.02), epidermal nests (p = 0.02), dermal-epidermal junction  ...  We analyzed BRAF V600E mutated melanomas to explore the Reflectance confocal microscopy (RCM) utility as a screening aid in the evaluation of the most appropriate patients for genetic testing.  ...  Reflectance confocal microscopy and immunohistochemistry of BRAF V600E in thin melanomas One of the novel findings of our study was that not only the presence of dermal-epidermal nest but also the presence  ... 
doi:10.1371/journal.pone.0179745 pmid:28662062 pmcid:PMC5491027 fatcat:ztkvcxdo6ncuplgwqydp52y4wu

In Vivo Microscopic Features of Nodular Melanomas

Sonia Segura, Giovanni Pellacani, Susana Puig, Caterina Longo, Sara Bassoli, Pascale Guitera, Josep Palou, Scott Menzies, Stefania Seidenari, Josep Malvehy
2008 Archives of Dermatology  
Objective: To characterize nodular melanoma (NM) using dermoscopy, in vivo reflectance-mode confocal microscopy, and histopathologic analysis.  ...  Design: Consecutive pure NMs and superficial spreading melanomas (SSMs) with nodular or blue areas were studied using dermoscopy and confocal microscopy, and a correlation with histopathologic findings  ...  The nonvisibility of dermal papillae resulted at confocal microscopy in the sudden transition between epidermal layers and dermal structures, corresponding at histologic analysis with a thin flattened  ... 
doi:10.1001/archderm.144.10.1311 pmid:18936395 fatcat:dqswtgarpranzjwy77syi3yrxu

Abstracts from the 2016 Joint Meeting of the International Confocal Group (ICG), the International Dermoscopy Society (IDS), and the International Society for Digital Imaging of the Skin (ISDIS)

2016 Dermatology Practical & Conceptual  
Acquired confocal images clearly visualized characteristic cellular features of human skin down to the dermal-epidermal junction, including cell nuclei in spinous layer and dermal papilla.  ...  We present preliminary results of imaging human skin in vivo with slit-SECM.  ...  Acquired confocal images clearly visualized characteristic cellular features of human skin down to the dermal-epidermal junction, including cell nuclei in spinous layer and dermal papilla.  ... 
doi:10.5826/dpc.0602a11 fatcat:3kt5cdcquvhj3awhnh7rutowp4

Artificial Intelligence-Based Approaches to Reflectance Confocal Microscopy Image Analysis in Dermatology

Ana Maria Malciu, Mihai Lupu, Vlad Mihai Voiculescu
2022 Journal of Clinical Medicine  
However, the current visual method for identifying the dermal-epidermal junction (DEJ) in RCM images is subjective, and there is a lot of variation.  ...  Given that in vivo RCM is becoming more widely used in dermatology, numerous deep learning technologies have been developed in recent years to provide a more objective approach to RCM image analysis.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm11020429 pmid:35054123 pmcid:PMC8780225 fatcat:uh735ndpdbanleivh72t35srfq

Handheld In Vivo Reflectance Confocal Microscopy for the Diagnosis of Eyelid Margin and Conjunctival Tumors

Elisa Cinotti, Aurélie Singer, Bruno Labeille, Damien Grivet, Pietro Rubegni, Catherine Douchet, Frédéric Cambazard, Gilles Thuret, Philippe Gain, Jean Luc Perrot
2017 JAMA ophthalmology  
OBJECTIVE To assess the diagnostic accuracy of handheld in vivo reflectance confocal microscopy (IVCM) for the diagnosis of eyelid margin and conjunctival tumors.  ...  Analysis of all neoformations (155 excised and 140 in follow-up) confirmed these differences in the diagnostic accuracy of the clinical examination and IVCM.  ...  In vivo reflectance confocal microscopy diagnosis was in agreement with the histopathologic examination in all 7 cases of MM, showing sensitivity of 100% for MM, but it misdiagnosed MM in 2 dermal nevi  ... 
doi:10.1001/jamaophthalmol.2017.2019 pmid:28654937 pmcid:PMC5710297 fatcat:ii6u5vok5zhaxgfiai73t7dfdi

Automating reflectance confocal microscopy image analysis for dermatological research: a review

Imane Lboukili, Georgios Stamatas, Xavier Descombes
2022 Journal of Biomedical Optics  
Algorithms for image classification to epidermal layers, delineation of the dermal-epidermal junction, classification of skin lesions, and demarcation of individual cells within an image, all important  ...  Reflectance confocal microscopy (RCM) is a noninvasive, in vivo technology that offers near histopathological resolution at the cellular level.  ...  RCM, reflectance confocal microscopy; DEJ, dermal-epidermal junction.  ... 
doi:10.1117/1.jbo.27.7.070902 pmid:35879817 pmcid:PMC9309100 fatcat:llvma322vjfxpkoutu6tzboyly

Reflectance-mode confocal microscopy of pigmented skin lesions–improvement in melanoma diagnostic specificity

Giovanni Pellacani, Anna Maria Cesinaro, Stefania Seidenari
2005 Journal of American Academy of Dermatology  
In vivo confocal microscopy enables skin visualization with a quasihistopathologic resolution.  ...  In multivariate analysis, the presence of nonedged dermal papillae, atypical cells, and isolated nucleated cells within dermal papilla, pagetoid cells, widespread pagetoid infiltration, and cerebriform  ...  II Frequency of in vivo reflectance-mode confocal laser microscopy features and odds ratio values observed at basal layers and dermoepidermal junction in benign and malignant melanocytic lesions MM (37  ... 
doi:10.1016/j.jaad.2005.08.022 pmid:16310058 fatcat:uvsaulrhk5hhfbdma543hp57l4
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