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Enhancing the LOCKSS Digital Preservation Technology
2015
D-Lib Magazine
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Lipkis and Claire T. Griffin
LOCKSS Program, Stanford University Libraries
Point of Contact: David S. H. ...
Claire Griffin is a Senior Software Engineer of the LOCKSS program at the Stanford University Libraries responsible for design and implementation of extensions to the LOCKSS platform. ...
doi:10.1045/september2015-rosenthal
fatcat:af3zldlwcbh2pe3fuw6wcff47i
Expanding the Repertoire of Amyloid Polymorphs by Co-polymerization of Related Protein Precursors
2013
Journal of Biological Chemistry
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 2 -microglobulin; ANS, 8-anilino naphthalene sulfonate; HFIP, hexafluoroisopropanol; RFDR, radio frequency-driven recoupling; ZF TEDOR, Z-filtered transferred-echo double resonance; ThT, thioflavin T; ...
A final concentration of 10 M thioflavin T (ThT) was added where appropriate. Fibrils were left to assemble for ϳ5 days before analysis. ...
B, shown is fibril formation of 0.5 mg/ml ⌬N6 (black lines) and h 2 m (gray lines, no growth) at pH 6.2 measured using thioflavin T fluorescence (relative fluorescence units (rfu)). ...
doi:10.1074/jbc.m112.447524
pmid:23329840
pmcid:PMC3591641
fatcat:hh3vqgl3vrbyvoz6dmtjng6sya
Fate of Aneurysmal Common Iliac Artery Landing Zones Used for Endovascular Aneurysm Repair
2015
Journal of Endovascular Therapy
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Purpose: To determine outcomes of aneurysmal common iliac arteries (aCIA) used for landing zones (LZs) during endovascular aneurysm repair (EVAR). Methods: This single-center study retrospectively compared 57 EVAR patients (mean age 72±8 years; 56 men) with 70 aCIAs (diameter ≥20 mm) to 25 control EVAR subjects (mean age 73±7 years; 20 men) with 50 normal (≤15-mm) CIA LZs treated consecutively during the same time interval. The CIA LZ measurements were analyzed using random effects linear mixed
doi:10.1177/1526602815602121
pmid:26290584
pmcid:PMC5624232
fatcat:s6prdk3yhnfphns5rvvhn4rm5i
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... models to determine diameter change over time. Life tables were used to estimate freedom from endoleak, reintervention, and all-cause mortality. Results: The mean maximum preoperative CIA diameter in the aCIA LZ group was 24.8±4.5 mm (range 20.0-47.3, median 23.9) vs 13.6±1.5 mm (range 9.2-15.0, median 13.9; p<0.001) in the controls. Nineteen aCIA LZs were treated outside the instructions for use of the device. Median follow-up in the aCIAs LZ cohort was 39.2 months [interquartile range (IQR) 15, 61] vs 49.3 months (IQR 36, 61) in the controls (p=0.06). The rate of aCIA LZ change (0.09 mm/mo, 95% CI 0.07 to 0.1) was significantly greater than controls (0.03 mm/mo, 95% CI -0.009 to 0.07; p<0.0001). No type Ib endoleaks developed in either group; however, aCIA LZ patients had 6 (11%) iliac limb-related reinterventions. There were significantly more endograft-related reinterventions in the aCIA LZ patients (n=10, 14%) compared with controls (n=2, 4%; p=0.06). There was no difference in mortality or freedom from any post-hospital discharge endoleak. Conclusion: Aneurysmal CIA LZs used during EVAR experience greater dilatation compared with normal LZs, but no significant difference in outcome was noted in midterm follow-up. However, an increased incidence of graft limb complications or endograft-related reintervention may be encountered. Use of aCIA LZs appears to be safe; however, greater patient numbers and longer follow-up are needed to understand the clinical implications of morphologic changes in these vessels when used during EVAR.
A Revised Protocol for Culture of Airway Epithelial Cells as a Diagnostic Tool for Primary Ciliary Dyskinesia
2020
Journal of Clinical Medicine
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Matched samples were analysed using the parametric paired student's t test or non-parametric Wilcoxon test. ...
Two sample comparisons were undertaken using the student t-test when normality test passed or Mann-Whitney test when normality tests failed. ...
doi:10.3390/jcm9113753
pmid:33233428
fatcat:fufag42a7nb4nagavix2g3y6ja
Megafire affects stream sediment flux and dissolved organic matter reactivity, but land use dominates nutrient dynamics in semiarid watersheds
2021
PLoS ONE
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To test for differences in BDOC and PDOC (i.e. for the presence of photopriming), we used paired T-tests. ...
Clair SB, O'Connor R, Gill R, McMillan B. Biotic resistance and disturbance: rodent consumers regulate post-fire plant invasions and increase plant community diversity. ...
doi:10.1371/journal.pone.0257733
pmid:34555099
pmcid:PMC8460006
fatcat:jqsnxlv4xnczjmskifn66mi5pu
Secondary Structure in the Core of Amyloid Fibrils Formed from Human β2m and its Truncated Variant ΔN6
2014
Journal of the American Chemical Society
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Peak identification and assignment were performed with Sparky (T. D. Goddard and D. G. Kneller, SPARKY 3, University of California, San Francisco). ...
The efficiency of magnetization transfer in dipolar-based CP experiments largely depends on the rigidity of the sites, while DP spectra sample regions which exhibit short 13 C T 1 's. ...
doi:10.1021/ja4126092
pmid:24679070
pmcid:PMC4017606
fatcat:6eosgm67x5cjvacdred3mn4ggu
Pericyte insulin receptors modulate retinal vascular remodeling and endothelial angiopoietin signaling
2021
Endocrinology
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Where appropriate, an unpaired or paired t-test has been performed; when distributions were heterogeneous in variability, a Welch-t-test was performed instead. ...
Washes in 0.02% TBS-T were performed before incubation with a secondary antibody against mouse (30), or rabbit (31), diluted in blocking buffer or 0.02% TBS-T for 2 hours at room temperature. ...
doi:10.1210/endocr/bqab182
pmid:34460911
pmcid:PMC8462386
fatcat:k4ka6coltfdofnd5a6hk4o5dj4
Zika viral dynamics and shedding in rhesus and cynomolgus macaques
2016
Nature Medicine
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Most major lymphocyte subsets (B, T and natural killer (NK) cells) exhibited declines during this period (naive and central memory CD4 + T cells, all CD8 + T cell subsets, naive B cells and all NK cell ...
All six monkeys developed weak anamnestic CD4 + T cell responses and similarly weak CD8 + T cell recall responses after re-challenge (Fig. 5g) . ...
doi:10.1038/nm.4206
pmid:27694931
pmcid:PMC5293594
fatcat:lazbid6mo5hqtoelhpbcfcmofq
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions
2013
MedChemComm
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OCH 3 , t-Bu (4o and 4p). ...
Thus, potency was conferred by chloroor bromo-substituents (4c, 4m, and 4n) or electron-withdrawing groups e.g. nitro or cyano (4q-t). ...
doi:10.1039/c3md00161j
pmid:24078862
pmcid:PMC3777193
fatcat:yg43jtpwp5hgtmb4guay4iij2u
Simian Immunodeficiency Virus-Infected Memory CD4+ T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS
2020
mBio
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Of these cells, both brain macrophages and brain memory CD4+ T cells harbor replication-competent SIV DNA; however, only brain CD4+ T cells harbored SIV DNA in animals without SIVE. ...
Immunohistochemistry of brain sections demonstrated infiltration of CD4+ T cells (CD4) and macrophages (MΦs) to the site of MNGCs. ...
though there were CD4 T cells infiltrating the brain. ...
doi:10.1128/mbio.00602-20
fatcat:bps63ia6xnag5jdkcrqymjlhr4
Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series
2022
Pharmaceutics
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Predicting Preclinical Outcomes: An In Vitro-In Silico Approach to Guide Oral Formulation Design (Brendan Griffin) With estimates of >75% of new drugs emerging from drug discovery programmes displaying ...
doi:10.3390/pharmaceutics14051010
pmid:35631595
fatcat:dtbvuxdlzrgvpglyy3cyz54dt4
Piperaquine Monotherapy of Drug-SusceptiblePlasmodium falciparumInfection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia
2016
Journal of Infectious Diseases
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T. W. designed and executed the qRT-PCR assays. C. J. P. designed and executed flow cytometry. L. M. and P. O. R. performed statistical analysis. J. M. C., C. J. P., P. O. R., and L. ...
The CYP2D6 loss-of-function polymorphisms panel included CYP2D6*4 (c.353-1 G > A) rs3892097, CYP2D6*41 (c.832 + 39 G > A) rs28371725, CYP2D6*3 (c755delA) rs35742686, CYP2D6*10 (*4) (c.100C > T) rs1065852 ...
Table 2 . 2 Cohort-Specific Parasite Reduction Ratios (PRRs) and Parasite Clearance Half-lives (t 1/2 ) With Corresponding 95% Confidence Intervals (CIs) Cohort Parasite Clearance, (Piperaquine Dose) No ...
doi:10.1093/infdis/jiw128
pmid:27056954
pmcid:PMC4907420
fatcat:oqt4nzrtezg7hdslginolian64
North American deer mice are susceptible to SARS-CoV-2
[article]
2020
bioRxiv
pre-print
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D A K Q E E D Y Q L L S Y N Q E N K D 73.7% (14/19) 73.7% (14/19) Fruit bat L T K T E E D Y Q L L T Y D E E K K G E I K T K E D H Q L L N Y N E N N K G 63.2% (12/19) Masked Palm Civet L T T Y E Q E Y Q ...
V L T Y D Q E N K G S. ...
doi:10.1101/2020.07.25.221291
fatcat:pkdqokwj7rc7jaozozdgyixvdm
Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
2005
Bioorganic & Medicinal Chemistry Letters
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The substituents chosen were: Ar = phenyl, 4-(2-trimethylsilylethoxy)methoxyphenyl, and 4-chlorophenyl; R 1 = n-propyl, benzyl, and 2acetamidoethyl; R 2 = 4-t-butylbenzyloxy, 3,5-dimethoxy-4-hydroxybenzyloxy ...
g), none of the newly synthesised compounds displayed improved potency, with only the syringic alcohol derivative 2k and the 2-(2-pyridyl)ethoxy derivative 2m showing inhibition comparable with the 4-t-butylbenzyloxy ...
doi:10.1016/j.bmcl.2004.12.061
pmid:15713419
fatcat:b4jlgechd5hsvgzuc52h2eyzze
SARS-CoV-2 infection and transmission in the North American deer mouse
2021
Nature Communications
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K T E E D Y Q L L T Y D E E K K G 68.4% (13/19) 68.4% (13/19)
Chinese rufous horseshoe bat E I K T K E D H Q L L N Y N E N N K G 63.2% (12/19) Masked Palm Civet L T T Y E Q E Y Q V L T Y D Q E N K G ...
57.9% (11/19) 68.4% (13/19) Ferret L T K Y E E E Y Q L H T Y D E Q N K R 52.6% (10/19) 57.9% (11/19) Mouse N T N Q E E D Y Q L T S F T Q A N H G and IL-6 mRNA expression was elevated in all infected mice ...
doi:10.1038/s41467-021-23848-9
pmid:34127676
fatcat:vlgazvi6nbflxk6xor34hgeukm
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