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Apoplexy of Pituitary Macroadenoma after Combined Test of Anterior Pituitary Function

2000 Endocrine journal  
Pituitary apoplexy has been reported as a very rare complication of combined tests of anterior pituitary function and of TRH or gonadotropin-releasing hormone (GnRH) administration in pituitary tumor. A 34-year-old man with a GH-secreting pituitary macroadenoma and diabetes mellitus received an injection of 400 ,ug TRH, 100 ug GnRH, and 0.15 U/Kg regular insulin. Twenty minutes later, he complained of a severe headache and vomited. Visual acuity and visual field did not change and his headache
more » ... as persistent during the next 24 hours of conservative management. Magnetic resonance imaging (MRI) of the sella turcica done the day after the event showed definitive elevation of the optic chiasm and slight enlargement of tumor and focal areas of mixed high signal and low signal intensities in the macroadenoma on noncontrast Ti-weighted images. Headache subsided markedly within a day of octreotide therapy. Transsphenoidal removal of the pituitary tumor was performed 9 days after the hormone study. Ischemic necrosis and hemorrhage were confirmed in the acidophilic adenoma with positive immunostaining for GH. Postoperative course was uneventful and his serum insulin-like growth factor-1(IGF-1) level and blood glucose levels were normalized. Three months after the surgery the dynamic test was repeated without adverse effects. To our knowledge, this is a very rare case of apoplexy of GH-secreting pituitary adenoma after a combined stimulation test of anterior pituitary function.
doi:10.1507/endocrj.47.329 pmid:11036877 fatcat:ywdfx34l5vg3vnoclbfs2ihc34

Cervical Radiculopathy Focus on Characteristics and Differential Diagnosis

Kyung-Chung Kang, Hee Sung Lee, Jung-Hee Lee
2020 Asian Spine Journal  
Natural History Lee and Turner reported that the natural history of cervical radiculopathy was generally favorable and self-limited.  ... 
doi:10.31616/asj.2020.0647 pmid:33373515 pmcid:PMC7788378 fatcat:guf2rky2wvd5tpnz6s7mx35cve

In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains

Jun-Won Chung, Su Young Kim, Hee Jung Park, Chang Su Chung, Hee Woo Lee, Sun Mi Lee, Inki Kim, Jhang Ho Pak, Gin Hyug Lee, Jin-Yong Jeong
2017 Gut and Liver  
doi:10.5009/gnl16503 pmid:28750485 pmcid:PMC5593327 fatcat:dd7szunamnaqjeqjuaiqqsyoei

Radiation Safety in the Treatment of Patients with Thyroid Disease by131I

Sungmin Kang, Byung Il Kim, In-Ju Kim, Hee-Seung Bom, Ga Hee Lee, Jaetae Lee, Woong Youn Chung, Jae Hoon Chung
2012 Journal of Korean Thyroid Association  
doi:10.11106/jkta.2012.5.1.6 fatcat:zwpqjoicxvhrdmbaw6wbevi4za

Recent Developments in Heavy-Quarkonium Phenomenology [article]

Hee Sok Chung, Jungil Lee, Chaehyun Yu
2008 arXiv   pre-print
We review recent developments in heavy-quarkonium phenomenology within the nonrelativistic QCD factorization approach. Main issues we consider in this work include the polarization of prompt J/psi at the Fermilab Tevatron and the large relativistic and QCD corrections to double-charmonium production at the B factories. We also consider inclusive charm production in bottomonia decays.
arXiv:0809.0122v1 fatcat:hrtoyuidrfcuhd2aeocj4jzj54

Non - Hodgkin`s Lymphoma of the Thyroid and Adrenal Glands

Jae Hong Park, Je Jung Lee, Ik Joo Chung, Dong Jin Chung, Min Young Chung, Tai Hee Lee, Dae Ho Lee
2000 The Korean Journal of Internal Medicine  
We report a case of non-Hodgkin ' s l ymphoma(NHL) with sim ultaneous involvement of both thyroid and bilateral adrenal glands. Literature revie w on a computeriz ed search showed that this is an extremel y rare condition. The final diagnosis of diffuse large B cell l ymphoma was confirmed by biopsies of thyroid gland, enlarged cervical l ymph node and adrenal gland. The significant endocrine dysfunction of the thyroid, adrenal or other endocrine glands was absent in our case. The patient
more » ... ded dramaticall y to three cycles of chem otherapy with no complication or endocrine dysfunction and continues to be followed. Ke y W o rd s : Non-Hodgkin's l ymphoma: Thyroid gland; Adrenal glands Address reprint requests to :
doi:10.3904/kjim.2000.15.1.51 pmid:10714092 pmcid:PMC4531734 fatcat:psptn3kaw5ecfjbwaxo7fvhkai

Case ofMycobacterium MassilienseInfection Presenting as Recurrent Pneumonia in Sjogren's Syndrome

Ji Young Seo, Byung Hee Lee, Jang Won Lee, Myeong Hee Lee, Suk Gyeong O, Hyun Myung Cho, Chung Won Lee
2012 Korean Journal of Medicine  
Mycobacterium massiliense is an emerging pathogen that is increasingly reported as a causative agent occurring during medical procedures, at surgical sites, and intramuscularly [1] . Although previously classified as part of M. abscessus, M. massiliense has recently been identified as a new species of rapidly growing nontuberculous mycobacteria [1,3] via a comparative sequence analysis of rpoB and hsp65 [3, 5] . However, the clinical manifestations of M. massiliense have not been well
more » ... zed. We report here in a case of recurrent pneumonia for 3 years that improved with antibiotic treatment for M. massiliense in a 37-year-old woman with Sjogren's syndrome. The patient showed a substantial response to treatment with a combination of antimicrobial therapies comprising clarithromycin and amikacin without cefoxitin for 6 months. This is the first report of pulmonary infection of M. massiliense with Sjogren's syndrome in Korea. (Korean J Med 2012;83:243-248) 서 론 비결핵 항산균(nontuberculous mycobacteria, NTM)은 토양 과 물 등에 존재하고 있어 임상검체에서 분리되었을 때 대 부분 오염균이나 집락균으로 간주되었다[1,2]. 그러나 면역 기능 저하 환자뿐만 아니라 병원감염이나 면역기능이 정상인 사람에서도 감염을 유발할 수 있음이 알려져 NTM의 임상적 중요성에 대한 인식이 높아지면서 전 세계적으로 NTM의 분 리율 및 NTM에 의한 질환 발견이 점차 증가되고 있다[1,3]. M. massiliense는 치료 내성을 보이는 M. abscessus에서 처음 으로 구별되었고[4], 최근에 PCR 방법을 이용하여 신속 발육 항산균(rapid growing nontuberculous mycobacterium, RGM)으로 새롭게 분류된 균이다[3,5]. 종종 피부 감염을 비롯한 수술 창상 감염을 일으키는 것으로 보고되었으나[1,2,6] 아직 정
doi:10.3904/kjm.2012.83.2.243 fatcat:53zncey5xjfl5l66vmqjzfe32i

Seoul National University Bundang Hospital's Electronic System for Total Care

Sooyoung Yoo, Kee Hyuck Lee, Hak Jong Lee, Kyooseob Ha, Cheong Lim, Ho Jun Chin, Jonghoar Yun, Eun-Young Cho, Eunja Chung, Rong-Min Baek, Chin Youb Chung, Won Ryang Wee (+4 others)
2012 Healthcare Informatics Research  
Objectives: Seoul National University Bundang Hospital, which is the first Stage 7 hospital outside of North America, has adopted and utilized an innovative and emerging information technology system to improve the efficiency and quality of patient care. The objective of this paper is to briefly introduce the major components of the SNUBH information system and to describe our progress toward a next-generation hospital information system (HIS). Methods: SNUBH opened in 2003 as a fully digital
more » ... spital by successfully launching a new HIS named BESTCare, "Bundang hospital Electronic System for Total Care". Subsequently, the system has been continuously improved with new applications, including close-loop medication administration (CLMA), clinical data warehouse (CDW), health information exchange (HIE), and disaster recovery (DR), which have resulted in the achievement of Stage 7 status. Results: The BESTCare system is an integrated system for a university hospital setting. BESTCare is mainly composed of three application domains: the core applications, an information infrastructure, and channel domains. The most critical and unique applications of the system, such as the electronic medical record (EMR), computerized physician order entry (CPOE), clinical decision support system (CDSS), CLMA, CDW, HIE, and DR applications, are described in detail. Conclusions: Beyond our achievement of Stage 7 hospital status, we are currently developing a next-generation HIS with new goals of implementing infrastructure that is flexible and innovative, implementing a patient-centered system, and strengthening the IT capability to maximize the hospital value.
doi:10.4258/hir.2012.18.2.145 pmid:22844650 pmcid:PMC3402557 fatcat:6wvotzbq35cu7g5iccmropqati

Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells

Joung-Hee Kim, Eun-Yeong Kim, Kyu Jin Chung, Jung-Hee Lee, Hee-Jung Choi, Tae-Wook Chung, Keuk-Jun Kim
2021 Molecules  
Mealworm and mealworm oil (MWO) have been reported to affect antioxidant, anti-coagulation, anti-adipogenic and anti-inflammatory activities. However, the function of MWO in wound healing is still unclear. In this study, we found that MWO induced the migration of fibroblast cells and mRNA expressions of wound healing factors such as alpha-smooth muscle actin (α-SMA), collagen-1 (COL-1) and vascular endothelial growth factor (VEGF) in fibroblast cells. The tube formation and migration of
more » ... ial cells were promoted through the activation of VEGF/VEGF receptor-2 (VEGFR-2)-mediated downstream signals including AKT, extracellular signal-regulated kinase (ERK) and p38 by MWO-stimulated fibroblasts for angiogenesis. Moreover, we confirmed that MWO promoted skin wound repair by collagen synthesis, re-epithelialization and angiogenesis in an in vivo excisional wound model. These results demonstrate that MWO might have potential as a therapeutic agent for the treatment of skin wounds.
doi:10.3390/molecules26040779 pmid:33546205 fatcat:rvepopw7sjdl3ee6xwnxgo43gm

Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism

Hee Young Kim, Jigong Wang, Inhyung Lee, Hee Kee Kim, Kyungsoon Chung, Jin Mo Chung
2009 Pain  
Acupuncture to certain acupoints, such as BL40 (Wei-Chung) [39] , BL60 (K'un-Lun) [37] , GB30 (Huan-T'iao) and/or GB34 (Yang-Lin-Chuan) [36, 38] , GV2 (Yao-Shu) and GV6 (Chi-Chung) [8] , SI3 (Hou-Hsi  ... 
doi:10.1016/j.pain.2009.06.035 pmid:19646817 pmcid:PMC2762198 fatcat:dckzmxb3xrgv7ev4e65enkh3ne

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination

Moon Hee Lee, Sung Won Lee, Eun Joo Lee, Soo Joon Choi, Sung Soo Chung, Jae Il Lee, Joong Myung Cho, Jae Hong Seol, Sung Hee Baek, Keun Il Kim, Tomoki Chiba, Keiji Tanaka (+2 others)
2006 Nature Cell Biology  
The p53 tumour suppressor has a key role in the control of cell growth and differentiation, and in the maintenance of genome integrity 1,2 . p53 is kept labile under normal conditions, but in response to stresses, such as DNA damage, it accumulates in the nucleus for induction of cell-cycle arrest, DNA repair or apoptosis. Mdm2 is an ubiquitin ligase that promotes p53 ubiquitination and degradation 3-5 . Mdm2 is also selfubiquitinated and degraded. Here, we identified a novel cascade for the
more » ... rease in p53 level in response to DNA damage. A new SUMO-specific protease, SUSP4, removed SUMO-1 from Mdm2 and this desumoylation led to promotion of Mdm2 self-ubiquitination, resulting in p53 stabilization. Moreover, SUSP4 competed with p53 for binding to Mdm2, also resulting in p53 stabilization. Overexpression of SUSP4 inhibited cell growth, whereas knockdown of susp4 by RNA interference (RNAi) promoted of cell growth. UV damage induced SUSP4 expression, leading to an increase in p53 levels in parallel with a decrease in Mdm2 levels. These findings establish a new mechanism for the elevation of cellular p53 levels in response to UV damage.
doi:10.1038/ncb1512 pmid:17086174 fatcat:43ml6iyww5clphqz6ym23ldr3i

Pig-to-Nonhuman Primate (NHP) Naked Islet Xenotransplantation [chapter]

Jun-Seop Shin, Jong-Min Kim, Byoung-Hoon Min, Jung-Sik Kim, Il-Hee Yoon, Hyunwoo Chung, Won-Woo Lee, Hee Jung Kang, Chung-Gyu Park
2017 Xenotransplantation - New Insights  
Islet transplantation is an established therapy for selected type 1 diabetes (T1D) patients with severe hypoglycemic unawareness and glycemic liability despite of insulin treatment. However, the donor organ is limited. Porcine islets are the best alternative source to overcome this limitation, and pig-to-nonhuman primate (NHP) naked islet xenotransplantation studies are being performed worldwide. Several studies including our own have presented successful proof-of-concept results based on
more » ... suppression regimen including the anti-CD154 monoclonal antibody. Particularly, long-term control of diabetes by adult porcine islet transplantation has been demonstrated in five consecutive monkeys, and the longest survival was ~1000 days after transplantation. Currently, pig-to-NHP islet xenotransplantation based on clinically applicable immunosuppression regimen is being pursued. In this chapter, we will describe all the procedures of pigto-NHP naked islet xenotransplantation: (1) the porcine islet isolation from designated pathogen-free (DPF) miniature pigs, (2) diabetes induction in monkeys, (3) transplantation procedure via the portal vein, (4) immune monitoring comprising humoral and cellular immunity after porcine islet transplantation, and finally (5) liver biopsy and subsequent immunohistochemical procedure in detail.
doi:10.5772/intechopen.69001 fatcat:rovq7pzrrbbcrjaxbdf2xcnb5i

Ocular Sarcoidosis in a Korean Population

Sun Young Lee, Hee Gyung Lee, Dong Soon Kim, June-Gone Kim, Hyewon Chung, Young Hee Yoon
2009 Journal of Korean medical science  
The aim of current study was to evaluate the incidence and characteristics of ocular sarcoidosis in a Korean population. We conducted a retrospective study of 104 consecutive patients with biopsy-proven sarcoidosis seen at Asan Medical Center in Seoul, Korea, from 1993 to 2007. Medical records, photographs, and fluorescein angiograms were reviewed. Of 104 patients, 22 (21%) had intraocular involvement with female predominance (86%, M:F=3:19). Of the 39 eyes with ocular involvement, 16 (41%)
more » ... had isolated anterior uveitis, 12 (31%) eyes had intermediate uveitis, 6 eyes (15%) had panuveitis with retinal vasculitis, and 5 (13%) eyes had panuveitis with punched multifocal choroiditis. Mean duration of ophthalmologic follow-up was 62 months. All ocular inflammation was well managed with topical steroid and/or systemic steroid with relatively good final visual outcomes. Ocular complications such as cataract (12 eyes, 30%), glaucoma (6 eyes, 15%), vitreous opacity (1 eye, 3%), cystoid macular edema (3 eyes, 7%), neovascularization (2 eye, 5%), and epiretinal membrane (4 eye, 10%) were related to ocular sarcoidosis. In Korea, where sarcoidosis is very rare, our study indicates relatively low ocular and predominantly non posterior segment involvement with relatively good visual prognosis.
doi:10.3346/jkms.2009.24.3.413 pmid:19543502 pmcid:PMC2698185 fatcat:464fv5caebfuvajbsev36f6vhq

Functional state of knee arthritis patients and related factors

Jiyeon Lee, Jung-Hee Kim, EunJung Chung, Byoung-Hee Lee
2017 Journal of Physical Therapy Science  
[Purpose] The objective of this study is to provide a direction for efficient management of arthritis through the analysis of multiple factors related to the functional state of patients. [Subjects and Methods] The Visual Analog Scale, Knee Society Knee Score & Function Score, Hospital for Special Surgery, Short Form-36 Health Survey and Western Ontario McMaster Universities Osteoarthritis Index for a total of 135 patients with knee arthritis were determined with a survey. [Results] There is a
more » ... ignificant correlation between age, pain, Knee Society Knee Score, Hospital for Special Surgery, Knee Society Function Score, and Western Ontario McMaster Universities Osteoarthritis Index score. [Conclusion] It is necessary to improve the factors that affect knee function and quality of life, and a study on knee joint muscle strength is suggested as a follow-up study.
doi:10.1589/jpts.29.323 pmid:28265166 pmcid:PMC5332997 fatcat:3d3vs3ipnbcw3ag6kvd452fvjq

Comparison of Antioxidant Activities in Tomato Leaves and Stems

Kyung Jun Lee, Gi-An Lee, Jong-Ro Lee, Jong-Wook Chung, Yang-Hee Cho, Hee-Kyoung Kang, Kyung-Ho Ma
2016 Korean Journal of Plant Resources  
Materials and Methods Plant materials DPPH assay DPPH radical-scavenging activity was assessed using a previously published method with some modifications (Lee and Lee, 2004) .  ... 
doi:10.7732/kjpr.2016.29.6.642 fatcat:agftijfdk5g6lmvlkrq3puatbe
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