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Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia

Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing, Zhongcong Xie
2018 PLoS ONE  
Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)induced neuroinflammation and sickness behavior in mice. Dexmedetomidine diminished LPS-induced neuroinflammation in the mouse brain and modulated the cytokine-associated changes in sickness behavior. mood, motivation, and behavior. Dex
more » ... ay be a beneficial part of a pharmacological strategy to decrease infection-induced neuroinflammation and sickness behaviors.
doi:10.1371/journal.pone.0191070 pmid:29351316 pmcid:PMC5774758 fatcat:xnsddmooobbjborse5uqaufpzm

Distributed Bundle Adjustment [article]

Karthikeyan Natesan Ramamurthy, Chung-Ching Lin, Aleksandr Aravkin, Sharath Pankanti, Raphael Viguier
2017 arXiv   pre-print
Most methods for Bundle Adjustment (BA) in computer vision are either centralized or operate incrementally. This leads to poor scaling and affects the quality of solution as the number of images grows in large scale structure from motion (SfM). Furthermore, they cannot be used in scenarios where image acquisition and processing must be distributed. We address this problem with a new distributed BA algorithm. Our distributed formulation uses alternating direction method of multipliers (ADMM),
more » ... , since each processor sees only a small portion of the data, we show that robust formulations improve performance. We analyze convergence of the proposed algorithm, and illustrate numerical performance, accuracy of the parameter estimates, and scalability of the distributed implementation in the context of synthetic 3D datasets with known camera position and orientation ground truth. The results are comparable to an alternate state-of-the-art centralized bundle adjustment algorithm on synthetic and real 3D reconstruction problems. The runtime of our implementation scales linearly with the number of observed points.
arXiv:1708.07954v1 fatcat:zx3tuqjw2bh5pjoevake27w5jy

Evaluation of a Streptococcal Pharyngitis Score in Southern Taiwan

Ching-Tang Shih, Ching-Chiang Lin, Chung-Ching Lu
2012 Pediatrics and Neonatology  
In this study, we already used stricter inclusion criteria compared with the McIsaac 9 and the Lin 14 studies. We included children who complained of sore throat and fever (body temperature >38 C).  ...  disease prevalence is a higher predominance of viral illness in children presenting with upper respiratory infections. 13, 14 However, it is puzzling that studies conducted in Taipei, Northern Taiwan by Lin  ... 
doi:10.1016/j.pedneo.2011.11.010 pmid:22348495 fatcat:lsjo3idtijddnhlyh2j3fbo4lu

Association of the Risk of Primary Sjögren's Syndrome With Fibrocystic Breast Disease: A Nationwide, Population-Based Study

Hsin-Hua Chen, Hsin-Hua Chen, Hsin-Hua Chen, Hsin-Hua Chen, Hsin-Hua Chen, Hsian-Min Chen, Hsian-Min Chen, Hsian-Min Chen, Hsian-Min Chen, Ching-Heng Lin, Ching-Heng Lin, Ching-Heng Lin (+13 others)
2021 Frontiers in Medicine  
Objective: Primary Sjögren's syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored.Methods: We used the 2003–2013 data retrieved from Taiwan's National Health Insurance Research Database (NHIRD) to conduct the present population-based study. We identified newly diagnosed pSS female patients during the 2001–2013 period, as well as age-matched (1:20) and
more » ... ropensity-score-matched (1:2) non-SS individuals (as controls). We explored the associations between pSS and a history of mastitis and fibrocystic breast disease by determining adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using a conditional logistical regression analysis after controlling for potential confounders.Results: We identified 9,665 patients with pSS and 193,300 age-matched non-SS controls, as well as 9,155 SS cases and 18,310 propensity-score-matched non-SS controls. We found that fibrocystic breast disease (aOR, 1.75; 95% CI, 1.63–1.88) were independently associated with incident SS, whereas mastitis and childbirth-associated breast infections were not associated with incident SS. We also found positive associations between SS and previously reported SS-associated diseases, including cardiovascular diseases, thyroid diseases, pancreatitis, bronchiectasis, infectious diseases, osteoporosis, and ankylosing spondylitis. In the propensity-score-matched populations, the associations between pSS and fibrocystic breast disease (aOR, 1.74; 95% CI, 1.58–1.91) remained consistent.Conclusion: The present population-based study revealed a previously unexplored association between pSS and history of fibrocystic breast disease, and the finding highlights the need to survey pSS in patients with mammary-gland-inflammation-associated diseases.
doi:10.3389/fmed.2021.704593 doaj:90d17407b1284515a8bc90549bf0864a fatcat:fmin6ezwjfdjjdrz3psb56hfem

Brain and Behavior Plasticity: From Fundamental Science to Health Outcomes

Keh-chung Lin, Steven L. Wolf, Chetwyn Chan, Ching-yi Wu, Ching-Po Lin
2015 Neural Plasticity  
doi:10.1155/2015/985790 pmid:26421194 pmcid:PMC4569784 fatcat:k6zsk4ljqfedpjah46l5uoriw4

Nanolithography made from water-based spin-coatable LSMO resist

Chih-Min Chuang, Ming-Chung Wu, Yu-Ching Huang, Kuo-Chung Cheng, Ching-Fu Lin, Yang-Fang Chen, Wei-Fang Su
2006 Nanotechnology  
The authors also thank C H Kuan, C W Chen, H L Chen, Mr M Y Tu, Mr Y Y Lin, Mr K T Huang and Mr W H Gan of National Taiwan University for helpful discussions.  ... 
doi:10.1088/0957-4484/17/17/019 fatcat:n7arvwv5vbecth5sldwo23hmpm

Bladder Pain Syndrome/Interstitial Cystitis Is Associated with Hyperthyroidism

Shiu-Dong Chung, Shih-Ping Liu, Ching-Chun Lin, Hsien-Chang Li, Herng-Ching Lin, Praveen Thumbikat
2013 PLoS ONE  
Although the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC) is still unclear, a common theme with BPS/IC patients is comorbid disorders which are related to the autonomic nervous system that connects the nervous system to end-organs. Nevertheless, no study to date has reported the association between hyperthyroidism and BPS/IC. In this study, we examined the association of IC/BPS with having previously been diagnosed with hyperthyroidism in Taiwan. Design: Data in this study
more » ... re retrieved from the Longitudinal Health Insurance Database. Our study consisted of 736 female cases with BPS/IC and 2208 randomly selected female controls. We performed a conditional logistic regression to calculate the odds ratio (OR) for having previously been diagnosed with hyperthyroidism between cases and controls. Results: Of the 2944 sampled subjects, there was a significant difference in the prevalence of prior hyperthyroidism between cases and controls (3.3% vs. 1.5%, p,0.001). The conditional logistic regression analysis revealed that compared to controls, the OR for prior hyperthyroidism among cases was 2.16 (95% confidence interval (CI): 1.27,3.66). Furthermore, the OR for prior hyperthyroidism among cases was 2.01 (95% CI: 1.15,3.53) compared to controls after adjusting for diabetes, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Conclusions: Our study results indicated an association between hyperthyroidism and BPS/IC. We suggest that clinicians treating female subjects with hyperthyroidism be alert to urinary complaints in this population.
doi:10.1371/journal.pone.0072284 pmid:23991081 pmcid:PMC3749104 fatcat:lku5eaj5hbgr5iy3ymknhokx5q

MMP-13 is involved in oral cancer cell metastasis

Shun-Hong Huang, Ching-Hsuan Law, Ping-Hsueh Kuo, Ren-Yu Hu, Ching-Chieh Yang, Ting-Wen Chung, Ji-Min Li, Li-Hsun Lin, Yi-Chung Liu, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei (+9 others)
2016 OncoTarget  
The oral cancer cell line OC3-I5 with a highly invasive ability was selected and derived from an established OSCC line OC3. In this study, we demonstrated that matrix metalloproteinases protein MMP-13 was up-regulated in OC3-I5 than in OC3 cells. We also observed that expression of epithelial-mesenchymal transition (EMT) markers including Twist, p-Src, Snail1, SIP1, JAM-A, and vinculin were increased in OC3-I5 compared to OC3 cells, whereas E-cadherin expression was decreased in the OC3-I5
more » ... . Using siMMP-13 knockdown techniques, we showed that siMMP-13 not only reduced the invasion and migration, but also the adhesion abilities of oral cancer cells. In support of the role of MMP-13 in metastasis, we used MMP-13 expressing plasmid-transfected 293T cells to enhance MMP-13 expression in the OC3 cells, transplanting the MMP-13 over expressing OC3 cells into nude mice led to enhanced lung metastasis. In summary, our findings show that MMP-13 promotes invasion and metastasis in oral cancer cells, suggesting altered expression of MMP-13 may be utilized to impede the process of metastasis.
doi:10.18632/oncotarget.7942 pmid:26958809 pmcid:PMC4941377 fatcat:e4rrhyjvfjfqdm4qoqndhfrl5i

Four New Briarane Diterpenoids from Taiwanese Gorgonian Junceella fragilis

Chia-Ching Liaw, Yu-Chi Lin, Yun-Sheng Lin, Chung-Hsiung Chen, Tsong-Long Hwang, Ya-Ching Shen
2013 Marine Drugs  
Four new 8-hydroxybriarane diterpenoids, frajunolides P-S (1-4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis,
more » ... ding 1D-and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).
doi:10.3390/md11062042 pmid:23752357 pmcid:PMC3721220 fatcat:jht2wtvlezbu7cmk6rdxx3nyjm

Anesthetic Propofol Causes Glycogen Synthase Kinase-3β-regulated Lysosomal/Mitochondrial Apoptosis in Macrophages

Chung-Hsi Hsing, Yu-Hong Chen, Chia-Ling Chen, Wei-Ching Huang, Ming-Chung Lin, Po-Chun Tseng, Chi-Yun Wang, Cheng-Chieh Tsai, Pui-Ching Choi, Chiou-Feng Lin
2012 Anesthesiology  
Phagocytic Analysis Staphylococcus aureus was obtained from Ching-Fen Shen, M.D., Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan and fixed with 1% formaldehyde  ... 
doi:10.1097/aln.0b013e31824af68a pmid:22334036 fatcat:bjckieejwfdnpbuctnnyab4ltu

Combined Hemorrhagic Shock and Unilateral Common Carotid Occlusion Induces Neurological Injury in Adult Male Rats

Chung-Ching Chio, Chien-Chin Hsu, Yu-Feng Tian, Chung-Han Wang, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin
2017 International Journal of Medical Sciences  
The distortion of infarct volume caused by brain edema was also corrected according to the report of Lin et al. [26] .  ... 
doi:10.7150/ijms.21022 pmid:29200946 pmcid:PMC5707749 fatcat:engwrqp5ivdhvmkb5rtj23mgcq

A case–control study on the association between bladder cancer and prior bladder calculus

Shiu-Dong Chung, Ming-Chieh Tsai, Ching-Chun Lin, Herng-Ching Lin
2013 BMC Cancer  
Bladder calculus is associated with chronic irritation and inflammation. As there is substantial documentation that inflammation can play a direct role in carcinogenesis, to date the relationship between stone formation and bladder cancer (BC) remains unclear. This study aimed to examine the association between BC and prior bladder calculus using a population-based dataset. Methods: This case-control study included 2,086 cases who had received their first-time diagnosis of BC between 2001 and
more » ... 09 and 10,430 randomly selected controls without BC. Conditional logistic regressions were employed to explore the association between BC and having been previously diagnosed with bladder calculus. Results: Of the sampled subjects, bladder calculus was found in 71 (3.4%) cases and 105 (1.1%) controls. Conditional logistic regression analysis revealed that the odds ratio (OR) of having been diagnosed with bladder calculus before the index date for cases was 3.42 (95% CI = 2.48-4.72) when compared with controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, and renal disease, tobacco use disorder, obesity, alcohol abuse, and schistosomiasis, bladder outlet obstruction, and urinary tract infection. We further analyzed according to sex and found that among males, the OR of having been previously diagnosed with bladder calculus for cases was 3.45 (95% CI = 2.39-4.99) that of controls. Among females, the OR was 3.05 (95% CI = 1.53-6.08) that of controls. Conclusions: These results add to the evidence surrounding the conflicting reports regarding the association between BC and prior bladder calculus and highlight a potential target population for bladder cancer screening.
doi:10.1186/1471-2407-13-117 pmid:23497224 pmcid:PMC3602047 fatcat:a4pqxq2jnvay5mrwmu6u2io7wq

Risk Factor Analysis of Early-Onset Cataracts in Taiwan

Lung-Hui Tsai, Ching-Chung Chen, Chien-Ju Lin, Sheng-Pei Lin, Ching-Ying Cheng, Hsi-Pao Hsieh
2022 Journal of Clinical Medicine  
Approval was obtained from the Institutional Review Board of the Chung Shan Medical University Hospital (Taichung, Taiwan) (Approval number: CS18131).  ...  Materials and Methods A cross-sectional study was conducted from 11 November 2019 to 30 March 2020 in the Department of Ophthalmology, Cheng Ching Hospital, Taichung.  ...  Institutional Review Board Statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Chung Shan Medical University Hospital (  ... 
doi:10.3390/jcm11092374 pmid:35566498 pmcid:PMC9101402 fatcat:2kkd7wchnrge5nrvytp2wkp4pq

Evaluation of chloroplast DNA markers for distinguishing Phalaenopsis species

Jhong-Yi Lin, Bo-Yen Lin, Ching-Dong Chang, Sin-Chung Liao, Yu-Chang Liu, Wen-Luan Wu, Ching-Chun Chang
2015 Scientia Horticulturae  
Comparative analysis of chloroplast DNA (cpDNA) between two endemic moth orchids in Taiwan, Phalaenopsis aphrodite subsp. formosana and P. equestris, previously revealed many evolutionary hotspots. In this study, we explored 27 pre-screened cpDNA regions to evaluate molecular markers for distinguishing Phalaenopsis species. Fifteen cpDNA markers were highly variable among moth orchids, with polymorphic information contents ≥8.0. The rps16-trnQ marker showed the best discrimatory power which 15
more » ... ndemic moth orchids could be successfully separated into 13 groups. From the sequences of the seven selected cpDNA regions, the rps16-trnQ intergenic spacer was the best DNA barcode which 19 endemic moth orchids could be completely distinguished. The petN-psbM intergenic spacer could be better used as a DNA barcode to differentiate P. aphrodite subsp. formosana and P. amabilis. Additionally, the inheritance mode of cpDNA in moth orchids was maternally predominated. Phylogenetic analysis revealed non-monophyletic relationships below the Phalaenopsis genus level. In summary, we have revealed a set of cpDNA markers that could be used for identification and phylogenetic study of Phalaenopsis orchids.
doi:10.1016/j.scienta.2015.06.019 fatcat:lux5nvefnvedlnrnmd2mb7h2ui

Overexpression of Transcobalamin 1 is an Independent Negative Prognosticator in Rectal Cancers Receiving Concurrent Chemoradiotherapy

Yi-Ying Lee, Yu-Ching Wei, Yu-Feng Tian, Ding-Ping Sun, Ming-Jen Sheu, Ching-Chieh Yang, Li-Ching Lin, Chen-Yi Lin, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Pei-Ling Hsieh (+1 others)
2017 Journal of Cancer  
Objective: Neoadjuvant concurrent chemoradiotherapy (CCRT) is an increasingly common therapeutic strategy for locally advanced rectal cancer, but stratification of risk and final outcomes remain a major challenge. Transcobalamin 1 (TCN1), a vitamin B12 (cobalamin)-binding protein, regulates cobalamin homeostasis. High expression of TCN1 have been reported in neoplasms such as breast cancer and hepatocellular carcinoma. However, little is known about the relevance of TCN1 to rectal cancer
more » ... ng CCRT. This study examined the predictive and prognostic impact of TCN1 expression in patients with rectal cancer following neoadjuvant CCRT. Methods: Through data mining from a published transcriptome of rectal cancers (GSE35452), we identified upregulation of TCN1 gene as the most significantly predicted poor response to CCRT among ion transport-related genes (GO:0006811). We evaluated TCN1 immunohistochemistry and performed an H-score analysis on endoscopic biopsy specimens from 172 rectal cancer patients receiving neoadjuvant CCRT followed by curative surgery. Expression levels of TCN1 were further correlated with clinicopathologic features, therapeutic response, tumor regression grade (TRG) and survivals including metastasis-free survival (MeFS), disease-specific survival (DSS) and recurrent-free survival (LRFS). Results: TCN1 overexpression was significantly related to advanced post-treatment tumor (T3, T4; p<0.001) and nodal status (N1, N2; p<0.001), vascular invasion (p=0.003) and inferior tumor regression grade (p < 0.001). In survival analyses, TCN1 overexpression was significantly associated with shorter DSS (p<0.0001), MeFS (p=0.0002) and LRFS (p=0.0001). Furthermore, it remained an independent prognosticator of worse DSS (p=0.002, hazard ratio=3.344), MeFS (p=0.021, hazard ratio=3.015) and LRFS (p=0.037, hazard ratio=3.037) in the multivariate comparison. Conclusion: Overexpression of TCN1 is associated with poor therapeutic response and adverse outcomes in rectal cancer patients receiving CCRT, justifying the potential prognostic value of TCN1 in rectal cancer receiving CCRT.
doi:10.7150/jca.18274 pmid:28638446 pmcid:PMC5479237 fatcat:sexfsxyo6zd7pcglukyqikp47e
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