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Acute kidney injury (AKI) is an important clinical issue that is associated with significant morbidity and mortality. Despite research advances over the past decades, the complex pathophysiology of AKI is not fully understood. The regulatory mechanisms underlying post-AKI repair and fibrosis have not been clarified either. Furthermore, there is no definitively effective treatment for AKI. MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs of 19~23 nucleotides that have been showndoi:10.1186/s40246-016-0085-z pmid:27608623 pmcid:PMC5016954 fatcat:s4uux224fnfepefq27jbcsm4im
more »... o be crucial to the post-transcriptional regulation of various cellular biological functions, including proliferation, differentiation, metabolism, and apoptosis. In addition to being fundamental to normal development and physiology, miRNAs also play important roles in various human diseases. In AKI, some miRNAs appear to act pathogenically by promoting inflammation, apoptosis, and fibrosis, while others may act protectively by exerting anti-inflammatory, anti-apoptotic, anti-fibrotic, and pro-angiogenic effects. Thus, miRNAs have not only emerged as novel biomarkers for AKI; they also hold promise to be potential therapeutic targets.
Deep Learning techniques have achieved remarkable results in many domains. Often, training deep learning models requires large datasets, which may require sensitive information to be uploaded to the cloud to accelerate training. To adequately protect sensitive information, we propose distributed layer-partitioned training with step-wise activation functions for privacy-preserving deep learning. Experimental results attest our method to be simple and effective.arXiv:1904.06049v1 fatcat:ria6usa5incybfymz72hvtxgoi
Supplementary Informationdoi:10.6084/m9.figshare.13653263.v1 fatcat:mwkjyhizkfhb5mi5qwjrijgfgu
Supplementary Informationdoi:10.6084/m9.figshare.13653263.v2 fatcat:fzycybdhgnbx3cs4gtpmqdashm
The photochromic dichroic dye causes a change in transmittance from high to low upon exposure to sunlight. When the light source is removed, the smart window returns from colored to colorless. ... Response Time Form Transparent to Scattering Form Scattering to Transparent Before Color Change (ms) 292 16.8 After Color Change (ms) 277.2 23.6 ... Irradiation by UV light changed the sample from colorless to deep purple. ...doi:10.3390/ma13184137 pmid:32957577 pmcid:PMC7560287 fatcat:5tu7amz3ebd5bblngjj6rsf6eq
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes ...doi:10.21037/tro-20-52 fatcat:f6xthbbkzrh25hd2fgaupmo5yy
The phase does not change when the transistor is turned on (V G = 0 V). ... B and X change signs when switching from a high-pass to a low-pass. For a matched lossless, B and X can be determined to be: X = tan ∆φ 4 , B = sin ∆φ 2 . ...doi:10.3390/electronics10060658 fatcat:iquudp2dcrbz3ixrazf2khuk5e
Template matching is widely used for many applications in image and signal processing and usually is time-critical. Traditional methods usually focus on how to reduce the search locations by coarse-to-fine strategy or full search combined with pruning strategy. However, the computation cost of those methods is easily dominated by the size of signal N instead of that of template K. This paper proposes a probabilistic and fast matching scheme, which computation costs requires O(N) additions andarXiv:1509.04863v1 fatcat:mx6u2dinufattjxp4uawxqkj64
more »... K \log K) multiplications, based on cross-correlation. The nuclear idea is to first downsample signal, which size becomes O(K), and then subsequent operations only involves downsampled signals. The probability of successful match depends on cross-correlation between signal and the template. We show the sufficient condition for successful match and prove that the probability is high for binary signals with K^2/log K >= O(N). The experiments shows this proposed scheme is fast and efficient and supports the theoretical results.
to changes in preload, afterload, and heart rate (HR) in a specific constant contractile status of the heart    . ... This condition might have induced changes in the LV pressure pulse and introduced reflex effects not found under ordinary conditions. ...doi:10.18632/oncotarget.21815 pmid:29221195 pmcid:PMC5707089 fatcat:f7mbu63dt5ay5mdsmgnuridmaa
Changes in vascular mechanics due to aging include elevated vascular impedance, diminished aorta distensibility, and an accelerated return of pulse wave reflection, which may increase the systolic workload ... ., 2006; Chang et al., 2017) . ... DISCUSSION Earlier studies on the age-related changes of arterial mechanical properties in different species have shown that considerable changes occur in response to age. ...doi:10.3389/fphys.2017.00503 pmid:28751867 pmcid:PMC5508003 fatcat:4aa2tojodbhvvpuca54epaqphi
This result implies that intensive treatment and renal replacement therapy are warranted to protect the vital organs and might markedly change the outcomes. ...  This study was conducted on the basis of the Declaration of Helsinki and was approved by the ethics committee of the Institutional Review Board of Chang Gung Memorial Hospital. ...doi:10.1097/md.0000000000005822 pmid:28248851 pmcid:PMC5340424 fatcat:xnohn5jgunbfxo7v3dklanrslq
TMS delivers a rapidly changing current through a coiled wire encased in plastic above the scalp. ... Clinical Global Impression of Change (CGIC) scores also improved by 1.0 and 1.6 points, respectively. ... Copyright © 2018 Chang, Lane and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fpsyt.2018.00201 pmid:29910746 pmcid:PMC5992378 fatcat:7hzxzqqkfbgdpoz4nd5lvj32oa
Can generative adversarial networks (GANs) generate roses of various colors given only roses of red petals as input? The answer is negative, since GANs' discriminator would reject all roses of unseen petal colors. In this study, we propose knowledge-guided GAN (KG-GAN) to fuse domain knowledge with the GAN framework. KG-GAN trains two generators; one learns from data whereas the other learns from knowledge with a constraint function. Experimental results demonstrate the effectiveness of KG-GANarXiv:1905.12261v2 fatcat:y5ihdmnqmbfnff22d5xzpj6dyy
more »... n generating unseen flower categories from seen categories given textual descriptions of the unseen ones.
Neither amlodipine nor pioglitazone can change in vitro ROCK activity in leukocytes. ... These results suggest that some commonly used cardiovascular medications may potentially change leukocyte activity. ...doi:10.1155/2014/214587 pmid:24716192 pmcid:PMC3955656 fatcat:lxed2vi4fvembmjyga3uv46bai
We thank the assistance from Jui-Hsien Huang's group for the X-ray structure determination. ...doi:10.3390/molecules21020238 pmid:26907234 fatcat:y74veunsuzdqboj3w35bkxy5ze
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