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MicroRNAs in acute kidney injury

Pei-Chun Fan, Chia-Chun Chen, Yung-Chang Chen, Yu-Sun Chang, Pao-Hsien Chu
2016 Human Genomics  
Acute kidney injury (AKI) is an important clinical issue that is associated with significant morbidity and mortality. Despite research advances over the past decades, the complex pathophysiology of AKI is not fully understood. The regulatory mechanisms underlying post-AKI repair and fibrosis have not been clarified either. Furthermore, there is no definitively effective treatment for AKI. MicroRNAs (miRNAs) are endogenous single-stranded noncoding RNAs of 19~23 nucleotides that have been shown
more » ... o be crucial to the post-transcriptional regulation of various cellular biological functions, including proliferation, differentiation, metabolism, and apoptosis. In addition to being fundamental to normal development and physiology, miRNAs also play important roles in various human diseases. In AKI, some miRNAs appear to act pathogenically by promoting inflammation, apoptosis, and fibrosis, while others may act protectively by exerting anti-inflammatory, anti-apoptotic, anti-fibrotic, and pro-angiogenic effects. Thus, miRNAs have not only emerged as novel biomarkers for AKI; they also hold promise to be potential therapeutic targets.
doi:10.1186/s40246-016-0085-z pmid:27608623 pmcid:PMC5016954 fatcat:s4uux224fnfepefq27jbcsm4im

Distributed Layer-Partitioned Training for Privacy-Preserved Deep Learning [article]

Chun-Hsien Yu, Chun-Nan Chou, Emily Chang
2019 arXiv   pre-print
Deep Learning techniques have achieved remarkable results in many domains. Often, training deep learning models requires large datasets, which may require sensitive information to be uploaded to the cloud to accelerate training. To adequately protect sensitive information, we propose distributed layer-partitioned training with step-wise activation functions for privacy-preserving deep learning. Experimental results attest our method to be simple and effective.
arXiv:1904.06049v1 fatcat:ria6usa5incybfymz72hvtxgoi

Supplementary document for Electro-tunable achromatic polarization rotator - 5033345.pdf

Tsung-Hsien Lin, Duan-Yi Guo, Li-Min Chang, Chun-Wei Chen, Cheng-Chang Li, Hung-Chang Jau, Chun Wang, Wen-Sung Kuo
2021 figshare.com  
Supplementary Information
doi:10.6084/m9.figshare.13653263.v1 fatcat:mwkjyhizkfhb5mi5qwjrijgfgu

Supplementary document for Electro-tunable achromatic polarization rotator - 5033345.pdf

Tsung-Hsien Lin, Duan-Yi Guo, Li-Min Chang, Chun-Wei Chen, Cheng-Chang Li, Hung-Chang Jau, Chun Wang, Wen-Sung Kuo
2021 figshare.com  
Supplementary Information
doi:10.6084/m9.figshare.13653263.v2 fatcat:fzycybdhgnbx3cs4gtpmqdashm

Smart Window with Active-Passive Hybrid Control

Heng-Yi Tseng, Li-Min Chang, Kuan-Wu Lin, Cheng-Chang Li, Wan-Hsuan Lin, Chun-Ta Wang, Chien-Wen Lin, Shih-Hsien Liu, Tsung-Hsien Lin
2020 Materials  
The photochromic dichroic dye causes a change in transmittance from high to low upon exposure to sunlight. When the light source is removed, the smart window returns from colored to colorless.  ...  Response Time Form Transparent to Scattering Form Scattering to Transparent Before Color Change (ms) 292 16.8 After Color Change (ms) 277.2 23.6  ...  Irradiation by UV light changed the sample from colorless to deep purple.  ... 
doi:10.3390/ma13184137 pmid:32957577 pmcid:PMC7560287 fatcat:5tu7amz3ebd5bblngjj6rsf6eq

Rhabdomyosarcoma of the adult nasopharynx: a case report

Bo-Jiun Chang, Chen-Hsiang Liao, Hsi-Chang Chang, Suat-Yee Lee, Hsin-Lin Chen, Shih-Tsung Chang, Yueh-Chun Lee, Ying-Hsiang Chou, Hsien-Chun Tseng
2021 Therapeutic Radiology and Oncology  
Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes  ... 
doi:10.21037/tro-20-52 fatcat:f6xthbbkzrh25hd2fgaupmo5yy

A 5-bit X-band GaN HEMT-Based Phase Shifter

Hsien-Chin Chiu, Chun-Ming Chen, Li-Chun Chang, Hsuan-Ling Kao
2021 Electronics  
The phase does not change when the transistor is turned on (V G = 0 V).  ...  B and X change signs when switching from a high-pass to a low-pass. For a matched lossless, B and X can be determined to be: X = tan ∆φ 4 , B = sin ∆φ 2 .  ... 
doi:10.3390/electronics10060658 fatcat:iquudp2dcrbz3ixrazf2khuk5e

Fast Template Matching by Subsampled Circulant Matrix [article]

Sung-Hsien Hsieh and Chun-Shien Lu and and Soo-Chang Pei
2015 arXiv   pre-print
Template matching is widely used for many applications in image and signal processing and usually is time-critical. Traditional methods usually focus on how to reduce the search locations by coarse-to-fine strategy or full search combined with pruning strategy. However, the computation cost of those methods is easily dominated by the size of signal N instead of that of template K. This paper proposes a probabilistic and fast matching scheme, which computation costs requires O(N) additions and
more » ... K \log K) multiplications, based on cross-correlation. The nuclear idea is to first downsample signal, which size becomes O(K), and then subsequent operations only involves downsampled signals. The probability of successful match depends on cross-correlation between signal and the template. We show the sufficient condition for successful match and prove that the probability is high for binary signals with K^2/log K >= O(N). The experiments shows this proposed scheme is fast and efficient and supports the theoretical results.
arXiv:1509.04863v1 fatcat:mx6u2dinufattjxp4uawxqkj64

Quantification of contractile mechanics in the rat heart from ventricular pressure alone

Chih-Hsien Wang, Ru-Wen Chang, Chun-Yi Chang, Ming-Shiou Wu, Hsien-Li Kao, Liang-Chuan Lai, Tai-Horng Young, Hsi-Yu Yu, Yih-Sharng Chen, Kuo-Chu Chang
2017 OncoTarget  
to changes in preload, afterload, and heart rate (HR) in a specific constant contractile status of the heart [4] [5] [6] .  ...  This condition might have induced changes in the LV pressure pulse and introduced reflex effects not found under ordinary conditions.  ... 
doi:10.18632/oncotarget.21815 pmid:29221195 pmcid:PMC5707089 fatcat:f7mbu63dt5ay5mdsmgnuridmaa

Defects in Vascular Mechanics Due to Aging in Rats: Studies on Arterial Wave Properties from a Single Aortic Pressure Pulse

Chun-Yi Chang, Ru-Wen Chang, Shu-Hsien Hsu, Ming-Shiou Wu, Ya-Jung Cheng, Hsien-Li Kao, Liang-Chuan Lai, Chih-Hsien Wang, Kuo-Chu Chang
2017 Frontiers in Physiology  
Changes in vascular mechanics due to aging include elevated vascular impedance, diminished aorta distensibility, and an accelerated return of pulse wave reflection, which may increase the systolic workload  ...  ., 2006; Chang et al., 2017) .  ...  DISCUSSION Earlier studies on the age-related changes of arterial mechanical properties in different species have shown that considerable changes occur in response to age.  ... 
doi:10.3389/fphys.2017.00503 pmid:28751867 pmcid:PMC5508003 fatcat:4aa2tojodbhvvpuca54epaqphi

Acute kidney injury in patients with pulmonary embolism

Chih-Hsiang Chang, Chung-Ming Fu, Pei-Chun Fan, Shao-Wei Chen, Su-Wei Chang, Chun-Tai Mao, Ya-Chung Tian, Yung-Chang Chen, Pao-Hsien Chu, Tien-Hsing Chen
2017 Medicine  
This result implies that intensive treatment and renal replacement therapy are warranted to protect the vital organs and might markedly change the outcomes.  ...  [9] This study was conducted on the basis of the Declaration of Helsinki and was approved by the ethics committee of the Institutional Review Board of Chang Gung Memorial Hospital.  ... 
doi:10.1097/md.0000000000005822 pmid:28248851 pmcid:PMC5340424 fatcat:xnohn5jgunbfxo7v3dklanrslq

Brain Stimulation in Alzheimer's Disease

Chun-Hung Chang, Hsien-Yuan Lane, Chieh-Hsin Lin
2018 Frontiers in Psychiatry  
TMS delivers a rapidly changing current through a coiled wire encased in plastic above the scalp.  ...  Clinical Global Impression of Change (CGIC) scores also improved by 1.0 and 1.6 points, respectively.  ...  Copyright © 2018 Chang, Lane and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fpsyt.2018.00201 pmid:29910746 pmcid:PMC5992378 fatcat:7hzxzqqkfbgdpoz4nd5lvj32oa

KG-GAN: Knowledge-Guided Generative Adversarial Networks [article]

Che-Han Chang, Chun-Hsien Yu, Szu-Ying Chen, Edward Y. Chang
2019 arXiv   pre-print
Can generative adversarial networks (GANs) generate roses of various colors given only roses of red petals as input? The answer is negative, since GANs' discriminator would reject all roses of unseen petal colors. In this study, we propose knowledge-guided GAN (KG-GAN) to fuse domain knowledge with the GAN framework. KG-GAN trains two generators; one learns from data whereas the other learns from knowledge with a constraint function. Experimental results demonstrate the effectiveness of KG-GAN
more » ... n generating unseen flower categories from seen categories given textual descriptions of the unseen ones.
arXiv:1905.12261v2 fatcat:y5ihdmnqmbfnff22d5xzpj6dyy

The Prognostic Values of Leukocyte Rho Kinase Activity in Acute Ischemic Stroke

Cheng-I. Cheng, Yu-Chun Lin, Tzu-Hsien Tsai, Hung-Sheng Lin, Chia-Wei Liou, Wen-Neng Chang, Cheng-Hsien Lu, Chun-Man Yuen, Hon-Kan Yip
2014 BioMed Research International  
Neither amlodipine nor pioglitazone can change in vitro ROCK activity in leukocytes.  ...  These results suggest that some commonly used cardiovascular medications may potentially change leukocyte activity.  ... 
doi:10.1155/2014/214587 pmid:24716192 pmcid:PMC3955656 fatcat:lxed2vi4fvembmjyga3uv46bai

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

Mei-Huey Lin, Kung-Yu Liang, Chang-Hsien Tsai, Yu-Chun Chen, Hung-Chang Hsiao, Yi-Syuan Li, Chung-Hao Chen, Hau-Chun Wu
2016 Molecules  
We thank the assistance from Jui-Hsien Huang's group for the X-ray structure determination.  ... 
doi:10.3390/molecules21020238 pmid:26907234 fatcat:y74veunsuzdqboj3w35bkxy5ze
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