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Cyclic gas injection has been proven to be an effective enhanced oil recovery (EOR) technique for tight oil reservoirs. During such processes, we expect recovery mechanisms such as oil swelling, oil viscosity reduction, vaporization, and pressure support, which highly relies on the successful conformance control of the injected gas. In this work, we present the numerical simulation study of using foam for improving the conformance control of cyclic gas injection in tight oil reservoir. We focusdoi:10.1155/2022/6571525 fatcat:3pja36cws5fixa3ct3gryonh5y
more »... on improving two categories of conformance control problems using foam, making the injection profile for single well more evenly distributed and mitigating the gas breakthrough to adjacent wells through the connected hydraulic fractures in a multiwell setting. The simulation results show that foam has shown major impact in improving the gas conformance control in both cases. Typical recovery factor improvements are estimated to be up to 1% for lean gas injection in this tight oil reservoir. In conclusion, we have demonstrated the great potential of using foam to improve the conformance in tight oil cyclic gas injection process.
Chuanzhen Yushun Renjing ... Zang received the Ph.D. degree in Control Theory and Engineering from the Department of Automation, Tsinghua University. ...doi:10.1007/s10796-008-9109-0 fatcat:p7mj37hob5hzhdyjztdxshvpse
A competent DNA damage response (DDR) helps prevent cancer, but once cancer has arisen, DDR can blunt the efficacy of chemotherapy and radiotherapy that cause lethal DNA breakage in cancer cells. Thus, blocking DDR may improve the efficacy of these modalities. Here, we report a new DDR mechanism that interfaces with inflammatory signaling and might be blocked to improve anticancer outcomes. Specifically, we report that the ubiquitin-editing enzyme A20/TNFAIP3 binds and inhibits the E3 ubiquitindoi:10.1158/0008-5472.can-17-2143 pmid:29233925 fatcat:wp5newjunffwdoubeudlw3plqa
more »... ligase RNF168, which is responsible for regulating histone H2A turnover critical for proper DNA repair. A20 induced after DNA damage disrupted RNF168-H2A interaction in a manner independent of its enzymatic activity. Furthermore, it inhibited accumulation of RNF168 and downstream repair protein 53BP1 during DNA repair. A20 was also required for disassembly of RNF168 and 53BP1 from damage sites after repair. Conversely, A20 deletion increased the efficiency of error-prone nonhomologous DNA end-joining and decreased errorfree DNA homologous recombination, destablizing the genome and increasing sensitivity to DNA damage. In clinical specimens of invasive breast carcinoma, A20 was widely overexpressed, consistent with its candidacy as a therapeutic target. Taken together, our findings suggest that A20 is critical for proper functioning of the DDR in cancer cells and it establishes a new link between this NFkBregulated ubiquitin-editing enzyme and the DDR pathway. Significance: This study identifies the ubiquitin-editing enzyme A20 as a key factor in mediating cancer cell resistance to DNAdamaging therapy, with implications for blocking its function to leverage the efficacy of chemotherapy and radiotherapy. Cancer Res; 78(4); 1069-82. Ó2017 AACR.
| www.pnas.org/cgi/doi/10.1073/pnas.1910250116 Zang et al. | www.pnas.org/cgi/doi/10.1073/pnas.1910250116 Zang et al. | www.pnas.org/cgi/doi/10.1073/pnas.1910250116 Zang et al. ... | www.pnas.org/cgi/doi/10.1073/pnas.1910250116 Zang et al. ...doi:10.1073/pnas.1910250116 pmid:31796584 pmcid:PMC6926050 fatcat:aosmgkew75hcxm4d47aousjm54
Ribosomal proteins are the building blocks of ribosome biogenesis. Beyond their known participation in ribosome assembly, the ribosome-independent functions of ribosomal proteins are largely unknown. Here, using immunoprecipitation, subcellular fractionation, His-ubiquitin pulldown, and immunofluorescence microscopy assays, along with siRNA-based knockdown approaches, we demonstrate that ribosomal protein L6 (RPL6) directly interacts with histone H2A and is involved in the DNA damage responsedoi:10.1074/jbc.ra118.007009 pmid:30598506 pmcid:PMC6393625 fatcat:arg4xwf23vcopf6jrllw4xu36q
more »... DR). We found that in response to DNA damage, RPL6 is recruited to DNA damage sites in a poly(ADP-ribose) polymerase (PARP)-dependent manner, promoting its interaction with H2A. We also observed that RPL6 depletion attenuates the interaction between mediator of DNA damage checkpoint 1 (MDC1) and H2A histone family member X, phosphorylated (γH2AX), impairs the accumulation of MDC1 at DNA damage sites, and reduces both the recruitment of ring finger protein 168 (RNF168) and H2A Lys-15 ubiquitination (H2AK15ub). These RPL6 depletion-induced events subsequently inhibited the recruitment of the following downstream repair proteins: tumor protein P53-binding protein 1 (TP53BP1) and BRCA1, DNA repair-associated (BRCA1). Moreover, the RPL6 knockdown resulted in defects in the DNA damage-induced G2-M checkpoint, DNA damage repair, and cell survival. In conclusion, our study identifies RPL6 as a critical regulatory factor involved in the DDR. These findings expand our knowledge of the extraribosomal functions of ribosomal proteins in cell physiology and deepen our understanding of the molecular mechanisms underlying DDR regulation.
ACKNOWLEDGMENT Yimin Shen would like to thank Sen Zeng, Wei Tan, John He, Jian Zhou, Suiping Jiang, Xiaoyan Bin, and Chuanzhen Zang for their comments which led to improvements of this paper. ...doi:10.1109/icsmc.2007.4413993 dblp:conf/smc/ShenF07 fatcat:ntlzfqovofe7lhz6z5y6ckha2q
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chéngjì 城市 chéngshì 橙色 chéngsè 橙汁 chéngzhī 吃 chī 吃饭 chīfàn 迟到 chídào 出 chū 出发 chūfā 出国 chūguó 出口 chūkǒu 出来 chūlái 出去 chūqù 出生 chūshēng 出租(汽)车 chūzū (qì)chē 初中 chūzhōng 除了 chúle 厨房 chúfáng 穿 chuān 传真 chuánzhēn ... ) hēi (sè) 红(色) hóng (sè) 蓝(色) lán (sè) 绿(色) lǜ (sè) 橙色 chéngsè 粉红色 fěnhóngsè 灰色 huīsè 紫色 zǐsè 棕色 zōngsè 5.2.6 Material / Material 木头 mùtou 石头 shítou 丝/丝绸 sī/sīchóu 5.2.7 Others / Andere 干净 gānjìng 脏 zàng ...doi:10.17169/refubium-19534 fatcat:yibb2hsbxnf35dgeyriul2zelu