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Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice
2022
Journal of Diabetes Research
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Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function still needs further study. Gut microbiota disorder is one of the important factors that cause diabetes. To explore the effect of SL decoction on intestinal microbiota, gut microbiota of mice was analyzed by sequencing the gut bacterial 16S rRNA
doi:10.1155/2022/7802107
pmid:35187178
pmcid:PMC8855168
fatcat:6y6hnmx44bbetdwiomevc7mmuu
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... V4 region and metagenomics. In this study, results demonstrated that SL decoction had a better hypoglycemic effect and β cell protection effect than either ginseng or Coptis chinensis. Alpha diversity analysis showed that all interventions with ginseng, Coptis, and SL decoction could reverse the increased diversity and richness of gut microbiota in db/db mice. PCoA analysis showed oral SL decoction significantly alters gut microbiota composition in db/db mice. 395 OTUs showed significant differences after SL treatment, of which 37 OTUs enriched by SL decoction showed a significant negative correlation with FBG, and 204 OTUs decreased by SL decoction showed a significant positive correlation with FBG. Results of KEGG analysis and metagenomic sequencing showed that SL decoction could reduce the Prevotellaceae, Rikenellaceae, and Helicobacteraceae, which were related to lipopolysaccharide biosynthesis, riboflavin metabolism, and peroxisome, respectively. It could also upregulate the abundance of Bacteroidaceae, which contributed to the metabolism of starch and sucrose as well as pentose-glucuronate interconversions. In the species level, SL decoction significantly upregulates the relative abundance of Bacteroides_acidifaciens which showed a significant negative correlation with FBG and was reported to be a potential agent for modulating metabolic disorders such as diabetes and obesity. In conclusion, SL decoction was effective in hypoglycemia and its mechanism may be related to regulating gut microbiota via upregulating Bacteroides_acidifaciens.
Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs
[article]
2021
bioRxiv
pre-print
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N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, play important roles in tuning the chromatin state and transcription. Among diverse RNA-chromatin interacting modes, the nuclear RNA scaffold is considered important for trans-interactions but has not yet been connected with m6A yet. Here, we found that Ythdc1 played indispensable roles in the embryonic stem cell (ESC) self-renewal and differentiation potency, and these roles highly depended on
doi:10.1101/2021.01.10.426065
fatcat:kcgpcezb75gtvmkd5vdnliioce
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... s m6A-binding ability. Ythdc1 deficiency in ESCs resulted in decreased rRNA synthesis and the activation of 2-cell (2C) embryo-specific transcriptional program, and these observations recapitulated the transcriptome defects induced by dysfunction of the long interspersed nuclear element-1 (LINE1)-scaffold, which were unrelated to the direct targeting of Ythdc1. A detailed analysis revealed that Ythdc1 recognized m6A on LINE1 and was physically involved in the formation of the LINE1- Nucleolin partnership and the chromatin recruitment of Kap1. In summary, our study reveals a new link between m6A and the RNA scaffold and thus provides a new regulatory model for the crosstalk between RNA and the chromatin epigenome.
Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
2019
Journal of Experimental & Clinical Cancer Research
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Xiao-Yong H, Jia-Bin C, Jia-Cheng L, Chao G, Hai-Xiang S, Qiang G, Dou-Sheng B analyzed the data. Jia F, Guo-Ming S, Ai-Wu K designed the research. ...
Rui P, Peng-Fei Z, Xuan Y, Chuan-Yuan W prepared and revised the manuscript and other files. All authors read and approved the final manuscript. ...
doi:10.1186/s13046-019-1113-3
fatcat:jyq4keln5nhgfjf3fjtahridby
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
2021
Protein & Cell
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RESEARCH ARTICLE Chuan Chen et al.
Embryoid body differentiation ESCs were trypsinized and resuspended at 50,000 cells/mL in LIFfree ESC medium. ...
Here we also noticed that compared to the global loss of KAP1 binding in the genome resulted from Kap1 KD, the
RESEARCH ARTICLE Chuan Chen et al. ...
doi:10.1007/s13238-021-00837-8
pmid:33886094
fatcat:v5kypdveyjcwfbglox2xx7asz4
circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma
2021
Journal of Experimental & Clinical Cancer Research
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Background Accumulating evidence indicates that circRNAs may serve as essential regulators in the progression of several human cancers, but the function and mechanism of circRNAs in intrahepatic cholangiocarcinoma (ICC) are largely unknown. Methods RNA-seq was used to assess differentially expressed circRNAs between 4 ICC and peritumor tissues. Quantitative RT-PCR and in situ hybridization were used to determine the circHMGCS1–016 expression in ICC tissues. The function and mechanism of
doi:10.1186/s13046-021-02095-2
pmid:34526098
fatcat:j6qjjaxd3faijoqvd2gmaxvxgq
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... S1–016 were further identified via in vivo experiments. The clinical characteristics and prognostic significance of circHMGCS1–016 were analyzed by a retrospective study. The functions of circHMGCS1–016 were assessed via modifying circRNA expression in ICC cells. Moreover, the molecular mechanisms of circHMGCS1–016 in ICC cells were explored by circRNA precipitation, miRNA immunoprecipitation, SILAC and luciferase reporter assays. Results We identified that compared with peritumor tissues, ICC tissues expressed hsa_circ_0008621 (circHMGCS1–016) high by RNA-seq, which was further identified by qRT-PCR and in situ hybridization. Moreover, the expression of circHMGCS1–016 was revealed to be associated with survival and recurrence of ICC patients. By regulating circHMGCS1–016 expression, we found that elevated circHMGCS1–016 promoted ICC development both in vitro and in vivo. By SILAC and circRNA-pull down, we demonstrated that circHMGCS1–016 induced ICC cell invasion and reshaped the tumor immune microenvironment via the miR-1236-3p/CD73 and GAL-8 axis. In ICC tissues, we uncovered that a high level of circHMGCS1–016 was positively associated with CD73 and GAL-8 expression and negatively related to the CD8+ T cells infiltration, which was further validated by establishing a humanized mouse tumor model. Importantly, we displayed that ICC patients with high levels of circHMGCS1–016 in tumor tissues benefited less from anti-PD1 treatment compared to those with low levels of circHMGCS1–016. Conclusions CircHMGCS1–016 is a forceful contributor in ICC development and immune tolerance via miR-1236-3p/CD73 and GAL-8 axis. CircHMGCS1–016 can be explored as a new potential biomarker and therapeutic target for PD1-resistant ICC.
A Preliminary Investigation of the Adversity Reading in Archaic WEI Passives
2012
Journal of Social Sciences (New York, N.Y.)
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kang Zhou-chao feng tongxing WEI hou, Zuo-chuan shuo yu guo shi ji xia ben ji di er jiao, hua, huo, yang, han, WEI zhe-xie guojia dou shi ji xing 。 ...
Source shi ji wai qi shi jia di shi jiu Archaic Chinese dou huang hou xiong dou zhang jun, di yue dou guang guo, zi shao jun 。 ...
doi:10.3844/jssp.2012.435.446
fatcat:eywgqlvw5fa6zap6qufidy6vza
Volume 5 Isolated Compounds (T-Z) References TCM Plants and Congeners
[chapter]
2010
Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications
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Source: CHUAN DANG SHEN Codonopsis tangshen. C 34 H 46 O 17 (726.74). Source: CHUAN DANG SHEN Codonopsis tangshen. C 46 H 64 O 26 (1033.01). Source: CHUAN DANG SHEN Codonopsis tangshen. ...
Source: JIANG GUO ZI SHAN Taxus baccata, HONG
DOU SHAN Taxus chinensis. Ref: 662. ...
doi:10.1007/978-3-642-16741-6_1
fatcat:dla6vtdu7ngxhawb443r5wtrb4
The Great Gatsby: A Contrastive Study of Its Two Chinese Versions
2009
Asian Social Science
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Wu 1 : ta zhe hui de chuan dai hai suan ti mian le, yun dong shan tang zhe ling kou, zu ta lu you xie, chuan yi tiao yan se mo hu de fan bu ku. ...
(P66) Wu 1 : zhen shi hua ji tou le , wo jing liang ren zhu bu xiao, ta de hua ju ju dou shi na me fa wei, yi zhi yu chu le ke yi xiang xiang yi ge dai tou jing de "gaui ren"zai bu long gong yuan zhui ...
doi:10.5539/ass.v4n8p32
fatcat:nuli27hmonbwnjgtcdtns5jncq
The Conceptual Metaphor of Governance in The Governance of China
2021
OALib
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DOI: 10.4236/oalib.1108147 4 Open Access Library Journal velopments in neuroscience
6) wǒ shuō guò, hù lián wǎng shì dāng qián xuān chuán sī xiǎng gōng zuò de zhǔ zhèn dì. ) huí gù dǎng de fèn dòu lì ...
bú néng wàng jì zǒu guò de lù; zǒu dé zài yuǎn, z ǒu dào zài huī huáng de wèi lái, yě bú néng wàng jì zǒu guò de guò qù, bú néng wàng jì wéi shí me chū fā. miàn xiàng wèi lái, miàn duì tiāo zhàn, quán ...
doi:10.4236/oalib.1108147
fatcat:65lsr75icrglxjayu27y7icnxu
An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids
2015
Scientific Reports
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Garden
hai nan xian guo dou ling
Thottea hainanensis
5
YC0677MT01-05
KM092242-45
KM213896-900
Hainan
bei xi xin
xixin
Asarum heterotropoides
var. mandshuricum #
6
YC0365MT01-06 KM092198 ...
dian xi xin
Asarum delavayi
0
FJ428626 a
chuan bei xi xin
Asarum chinense
0
FJ428623 a
nan chuan xi xin
Asarum nanchuanense
0
FJ428618 a
yun nan xi xin
Asarum yunnanense
0
FJ428656 a ...
doi:10.1038/srep11318
pmid:26270958
pmcid:PMC4535178
fatcat:qkffbwr6x5bk5mclzy5f6cb224
Volume 2 Isolated Compounds (D-G)
[chapter]
2010
Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications
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Source: ZA JIAO JIE ZHI HONG DOU SHAN Taxus x media. Ref: 662. Source: JIANG GUO ZI SHAN Taxus baccata. Ref: 662. Source: JIANG GUO ZI SHAN Taxus baccata. ED 50 = 0.53g/kg). ...
Source: HONG DOU SHAN Taxus chinensis, SU MEN DA LA HONG DOU SHAN Taxus sumatrana (twig and leaf) [4800] . Source: JIANG GUO ZI SHAN Taxus baccata, HONG DOU SHAN Taxus chinensis. Ref: 662. ...
doi:10.1007/978-3-642-16738-6_1
fatcat:qkn5dtffdndfxedmnllspm6uaq
COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese–Western Medicine for the Management of 2019 Novel Coronavirus Disease
2020
THE American journal of Chinese medicine
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6 g, bin-lang 10 g, cang-zhu 10 g Hua-shi 20 g, huang-qin 10 g, yin-chen 10 g, huo-xiang 6 g, lian-qiao 10 g, shi-chang-pu 6 g, bai-dou-kou 6 g, bao-he 6 g, tong-cao 6 g, she-gan 10 g, chuan-bei-mu 10 ...
, chan-tui, jiang-huang, da-huang Huo-pu-xia-ling decoction Huo-xiang, hou-pu, ban-xia, chi-fu-ling, xing-ren, yi-yi-ren, bai-dou-kou, zhu-ling, dan-dou-chi, ze-xie Huo-xiang-zheng-qi powder Huo-xiang, ...
doi:10.1142/s0192415x20500378
pmid:32164424
fatcat:jjql6f6mkfcc5e6aujnc3xmjju
Table of content
2020
2020 2nd International Conference on Industrial Artificial Intelligence (IAI)
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IAI20-0029 Operation Performance Assessment and Non-optimal Reasons Traceability for IAI20-0043 Fault Detection for Wind Turbines via Long Short-term Memory NetworkXiaoxuan Dou, WenTan, Sixuan Chen, Mengjie ...
Helicopter Suspension
Zhifu Tang, Dongli Yuan,Junfei Zhang
IAI20-0067 Attitude Control for Rocket Main-stage-booster Recovery with Parafoil Using Sliding Mode Control
Fenghao LI, Xiaojun Xing, Yiming Guo ...
doi:10.1109/iai50351.2020.9262180
fatcat:7jqkonrv7nef3d2hlstqiu2l6i
Acknowledgement to Reviewers of Polymers in 2018
2019
Polymers
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, Zhanhu
Guo, Qiuquan
Guo, Zhanyong
Guo, Zhao-Xia
Guo, Hui
Gupta, Anju
Gupta, Prachi
Gupta, Mohit
Gupta, Kajal
Gupta, Sanju
Gurikov, Pavel
Gutekunst, Will R. ...
Piotr
Dodiuk, Hanna
Döhler, Diana
Dolez, Patricia
Domb, Avi
Domenici, Valentina
Dominguez, Cesar
Dong, Wei
Dong, Chensong
Dong, Yingchao
Dorado, Christina
Dorfman, Kevin
Doroudiani, Saeed
Dou ...
doi:10.3390/polym11010150
fatcat:5ptfdnrsljgxtbqtlkwlogolgm
Page 1813 of Mathematical Reviews Vol. , Issue 94c
[page]
1994
Mathematical Reviews
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Chen, Guan Rong 93050-9305i Chen, Guo Liang ... See Chen, Guo Liang! Chen, Guo Liang! ...
Chazelle, Bernard oD A nee 17018,58229 IE We bcdscccccacasacccunzede 76039 Chen, Bang-Yen sua Sones Chen, Bo Shan Chen, Bor Sen Chen, Cao Yu Chen, Chuan Dan 8 | ee See Chen, Gen Shun Chen, Gen Shun Chen ...
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