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Force-vs-distance (f-d) curves were acquired at rates of translation in the z direction in the range 2-5 μm s −1 to minimize drag, with each curve consisting of 600 data points. ...doi:10.1093/infdis/jit309 pmid:23847056 fatcat:ayiestafafdt7eqz3lr4g6ki7a
National Security The national security community has not traditionally viewed infectious diseases as part of their mission WATSON ET AL Volume 17, Number 5, 2019 space, and therefore they have not adequately ... the House of Representatives Julie Gerberding, MD, MPH Former Director of the US Centers for Disease Control and Prevention (CDC) Director of the Centers for Disease Control and Prevention WATSON ...doi:10.1089/hs.2019.0097 pmid:31593508 fatcat:wswt3xyvfze7vlb5jmbsu7x2ty
Biographical notes: Gregory S. ... Christopher L. Brown is currently a Senior Lecturer in Chemistry within the ... Jolanta Watson was partially funded by the Griffith University Postdoctoral Research Fellowship Scheme. ...doi:10.1504/ijnm.2010.029929 fatcat:abx3hkgqjjc3jhcaerbeevvnmq
Module 14's GO terms were clustered into 4 annotation clusters: 1) sterol metabolic process GO categories; 2) fatty acid metabolism related GOs; 3) membrane biological component and 4) nucleotide related ...doi:10.1186/1471-2164-14-13 pmid:23324119 pmcid:PMC3575264 fatcat:ng4nzy55pfhirl6dqaz5vd7j3e
Within analyses of Global Positioning System (GPS) observations, unmodelled sub-daily signals are known to propagate into long-period signals via a number of different mechanisms. In this paper, we investigate the effects of time-variable satellite geometry and the propagation of an unmodelled multipath signal that is analogous to a change in the elevation dependant phase centre of the receiving antenna. Multipath reflectors at H=0.1 m, 0.2 m and 1.5 m below the antenna are modeled and theirdoi:10.1029/2009jb006543 fatcat:cwnd5r36crgk5jvejzajczhw4i
more »... ects on GPS coordinate time series are examined. Simulated time series at 20 global IGS sites for 2000-2008 were derived using the satellite geometry as defined by daily broadcast orbits, in addition to that defined using a perfectly repeating synthetic orbit. For the simulations generated using the broadcast orbits with a perfectly clear horizon, we observe the introduction of a time variable bias in the time series of up to several centimeters. Considerable site to site variability of the frequency and magnitude of the signal is observed, in addition to variation as a function of multipath source. When adopting realistic GPS observation geometries obtained from real data (e.g., those that include the effects of tracking outages, local obstructions, etc.), we observe concerning levels of temporal coordinate variation in the presence of the multipath signals. In these cases, we observe spurious signals across the frequency domain, in addition to what appears as offsets and secular trends. Velocity biases of more than 1mm/yr are evident at some few sites. The propagated signal in the vertical component is consistent with a noise model with a spectral index marginally above flicker noise (mean index -1.4), with some sites exhibiting power law magnitudes at comparable levels to actual height time series generated in GIPSY. The propagated signal also shows clear spectral peaks across all coordinate components at harmonics of the draconitic year for a GPS satellite (351.4 days). When a perfectly repeating synthetic GPS constellation is used, the simulations show near-negligible power law variability highlighting that subtle variations in the GPS constellation can propagate multipath signals differently over time, producing significant temporal variations in time series. We conclude that the time variable nature of GPS observation geometry and satellite orbits combined with a multipath signal that is manifested as an elevation dependant bias can introduce a spurious signal that is a potential significant contributor to flicker noise present in GPS time series. Further, the spurious signal also makes a potential significant contribution to the energy present at frequencies related to the draconitic year and harmonic thereof observed in GPS analyses.
Device and Process Technologies for Microelectronics, MEMS, and Photonics IV
The surface structure and chemistry of polymers affect their functionality for a great range of applications in areas as diverse as biosensors, corrosion protection, semiconductor processing, biofouling, tissue engineering and biomaterials technology. Some of those applications require purposeful tailoring of laterally differentiated regions (e.g., array structures for multi-channel/multi-analyte biosensors and patterning for promotion of selective adhesion of cells/proteins). While suchdoi:10.1117/12.638345 fatcat:pdrq55zrirbbjor357fbvzbfp4
more »... ng is currently taking place on the μm-scale, it is likely in the future to progress into the nm-regime. Attachment of biological moieties at surfaces and interfaces has been shown to be highly dependant on local chemistry at the intended site of attachment. Additionally, the local molecular-scale geometry may promote or hinder attachment events, as in the case of biofilms. To date, however, the effect of frictional properties of surfaces for chemical and biomolecular attachment is a much less understood phenomenon. In this study we show controlled patterning of a polymer surface (polydimethylsiloxane (PDMS)) arising from manipulation by Atomic Force Microscopy (AFM). PDMS is a bio-active/selective polymer having a broad range of applications, such as biomedical devices, molecular stamps, hydraulic fluid devices and in soft lithography. The polymer surface has been selectively altered by high speed scanning in order to generate regions on the surface that exhibit differentiated frictional properties. By altering the loading force, scan width, and area of the AFM probe-to-polymer contact it is possible to produce a variety of detailed and complex patterns with frictional contrast, including anisotropic frictional gradients on the polymer surface. The controlled manipulation of the polymer surface can be carried out on the micro-, meso-and nano-scale.
Global mean sea level (GMSL) has been rising at a faster rate during the satellite altimetry period (1993-2014) than previous decades, and is expected to accelerate further over the coming century 1 . However, the accelerations observed over century and longer periods 2 have not been clearly detected in altimeter data spanning the past two decades 3-5 . Here we show that the rise, from the sum of all observed contributions to GMSL, increases from 2.2 ± 0.3 mm yr −1 in 1993 to 3.3 ± 0.3 mm yr −1doi:10.1038/nclimate3325 fatcat:vfstgbnvd5favcrdjegc5r5ety
more »... in 2014. This is in approximate agreement with observed increase in GMSL rise, 2.4 ± 0.2 mm yr −1 (1993) to 2.9 ± 0.3 mm yr −1 (2014), from satellite observations that have been adjusted for small systematic drift, particularly a ecting the first decade of satellite observations 6 . The mass contributions to GMSL increase from about 50% in 1993 to 70% in 2014 with the largest, and statistically significant, increase coming from the contribution from the Greenland ice sheet, which is less than 5% of the GMSL rate during 1993 but more than 25% during 2014. The suggested acceleration and improved closure of the sea-level budget highlights the importance and urgency of mitigating climate change and formulating coastal adaption plans to mitigate the impacts of ongoing sea-level rise. Projections of future sea levels must be based on a sound understanding of historical changes in GMSL and its underlying processes, as well as recent changes in the rate of rise 1 . In a previous study, the apparent decrease in the rate of GMSL rise from 3.2 mm yr −1 in the first decade of satellite altimetry to 2.8 mm yr −1 in the second was suggested to be primarily a result of natural interannual variability, related to water exchange between ocean and land during El Niño/Southern Oscillation (ENSO) cycles 3 . After removing this variability, the underlying rate of GMSL rise was 3.3 ± 0.4 mm yr −1 for both decades, with neither deceleration nor acceleration of GMSL inferred over 1993 to 2014. This lack of observed acceleration of GMSL contrasts with a simultaneously increased contribution from the Greenland ice sheet (GIS) and a less certain increase from the Antarctica ice sheet (AIS) overall 7 , and is inconsistent with the positive acceleration presented in century-long tide gauge data 8 and global mean sea-level reconstructions 2 . By comparing tide gauge and satellite altimeter sea-level observations, a recent study 6 identified a possible systematic drift within the altimeter record, particularly affecting the first six years (1993)(1994)(1995)(1996)(1997)(1998)(1999). This systematic error erroneously elevates the GMSL trend during 1993-1998 by between 0.9 ± 0.5 and 1.5 ± 0.5 mm yr −1 , depending on whether a glacial isostatic
Of these, Genomic signatures of mitonuclear coevolution across populations of Tigriopus californicus Felipe S. Barreto 1,2 *, Eric T. Watson 3 , Thiago G. Lima 2,4 , Christopher S. ... p s = 0.0032, ω s = 3.66 0.00175 28S ribosomal protein S35 mrps35 0.106 9.892 p s = 0.0163, ω s = 3.02 0.00711 39S ribosomal protein L46 mrpl46 0.272 9.828 p s = 0.0129, ω s = 4.58 0.00734 ... Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) ...doi:10.1038/s41559-018-0588-1 pmid:29988158 fatcat:attb6fwecrbotenlmzzifftfku
The liver was from a 71-year-old brainstem dead donor (DBD), who died following an intracranial haemorrhage. Macroscopically, the donor liver was moderately steatotic with a yellowish appearance ( Figure 1 ) and a decision was made to test viability using the Liver Assist device. Viability was determined using parameters we have previously published. 1 Perfusion criteria were favourable, and the liver was transplanted into a 69-year-old female with alcoholic liver disease. Initial graftdoi:10.1097/tp.0000000000003462 fatcat:wvnjjbrhi5gbdaimrr25vxekou
more »... was satisfactory (Supplementary Table 1 ). Time 0 biopsy of the implant demonstrated mild to moderate macrosteatosis with a moderate degree of reperfusion injury. A transient rise in liver biochemistry at day 17 posttransplantation prompted ultrasound imaging and, due to suboptimal views, a computed tomography (CT) scan was performed. This identified multiple linear low attenuation areas within an otherwise normal liver and patent vasculature. The low attenuation areas correspond to the cradle lattice of the Liver Assist, clearly seen on volume-rendered 3D and axial CT images (Figure 1) . Currently, graft function remains good over 2 years after transplantation.
The Newcastle records also have problems with subsidence (Watson, 2011). ... The Burnie gauge serves as one of few international in situ validation sites for the Jason-class altimeter missions (Watson et al. 2011). ... This depression of sea level is about 0.2 mm yr -1 for the majority of the east Australian coast and over 0.25 mm yr -1 from 28°S to 36°S. ...doi:10.1016/j.earscirev.2014.05.011 fatcat:or5oxw6pafegjmdmc2y5k6s6cq
S U M M A R Y Secular motion of Earth's rotation pole results in large-scale secular deformation of Earth. ... D I S C U S S I O N The importance of this effect falls into two end-member scenarios. ... C O N C L U S I O N S Rapid polar motion observed since around 2005 has resulted in large-scale elastic radial deformation of Earth that reached ±0.38 mm yr −1 around 2009. ...doi:10.1093/gji/ggu325 fatcat:k5erbz7c4zht7jffyoic75ym5i
., , 2011 Watson et al., 2008 Watson et al., , 2009 Chabot and Watson, 2010; Watson and Chabot, 2010) . ... Moreover, when they are subsequently exposed to DD, they also tend to switch to a tidal pattern of activity (Chabot et al., 2004 Watson et al., 2008; reviewed in Chabot and Watson, 2010) . ...doi:10.1086/bblv225n1p42 pmid:24088795 fatcat:bn5esuirmjghfjpbbo3o3xoypq
Assuming that the average initial area of the layer per nanopillar is S i ¼ d 2 , the areas S A and S B are given by the following expressions: S A ¼ 2pR 2 ð1 À cos qÞ S B ¼ d 2 À pR 2 sin 2 q case I S ... F ¼ εn 0 S A 1 þ a A þ k 2 a 2 A S A 1 þ a A þ a 2 B S B 1 þ a B þ lk S A 1 þ a A þ S B 1 þ a B À S i 1 þ a i : (5) Here we consider that the unperturbed membrane is stretched up to the initial stretching ...doi:10.1016/j.bpj.2012.12.046 pmid:23442962 pmcid:PMC3576530 fatcat:vn33ec6cfncs5bvstqqkb7jyli
followed by 0.9 mA/2 s shock). ... Fear conditioning consisted of 10 trials of 30 s/75 dB white noise followed by a 2 s/0.9 mA footshock. Trials were presented at a fixed interval with 120 s ITIs. ...doi:10.3389/fneur.2020.553190 pmid:33324313 pmcid:PMC7724082 fatcat:35ktfbrfsnfppp76m5joaqzxoy
As shown in Figure 3A , phosphorylation of Syk Y525/6, SLP-76 Y145, LAT Y200, Btk Y223 and Y551, and PLCγ2 Y1217 was blocked by 70 nM ibrutinib with IC 50 s similar to those for aggregation (Table 1 ... Flow adhesion studies DiOC6 labelled whole blood was flowed at 125 s-1 across podoplanin-Fc (100 μg/ml) coated micro-capillaries within Cellix Vena8 Fluoro+ Biochips (Cellix Limited, Dublin) as previously ...doi:10.3324/haematol.2019.218545 pmid:31949019 pmcid:PMC7776357 fatcat:6dm35gqntvgufcoouubm5xfibq
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