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Oxygen isotopes (δ 18 O) trace photochemical hydrocarbon oxidation at the sea surface

Collin P. Ward, Charles M. Sharpless, David L. Valentine, Christoph Aeppli, Kevin M. Sutherland, Scott D. Wankel, Christopher M. Reddy
2019 Geophysical Research Letters  
By accounting for different oxygen sources (H 2 O or O 2 ) and kinetic isotopic fractionation of photochemically incorporated O 2 , which was −9‰ for a wide range of OC sources, a mass balance was established  ...  In less than one-week, δ 18 O Oil increased from −0.6 to 7.2‰, a shift representing~25% of the δ 18 O OC dynamic range observed in nature.  ...  ., 2009; Latch & McNeill, 2006; Miller & Zepp, 1995; Ward, Sharpless, et al., 2018) .  ... 
doi:10.1029/2019gl082867 fatcat:36opnjcfwnfktfcjcw7c4t3ncm

Optimizing Abdominal MR Imaging: Approaches to Common Problems

Roberta K. Yang, Christopher G. Roth, Robert J. Ward, Joseph O. deJesus, Donald G. Mitchell
2010 Radiographics  
This can be of phases represented along the phase-encoding axis is limited to 360 o . Any phase above or below this range is incorrectly assigned to within the 360° range.  ... 
doi:10.1148/rg.301095076 pmid:20083593 fatcat:jkwxou735bdsvftdesl3mzco24


Abhishek Mukherji, Xika Lin, Christopher R. Botaish, Jason Whitehouse, Elke A. Rundensteiner, Matthew O. Ward, Carolina Ruiz
2013 Proceedings of the 2013 international conference on Management of data - SIGMOD '13  
a O(N 2 ) time offline redundancy abstraction step [7] .  ...  The RM query takes O(N) time for N rules valid for input (minsupp, minconf ).  ... 
doi:10.1145/2463676.2465245 dblp:conf/sigmod/MukherjiLBWRWR13 fatcat:rmqgsrrm5fhw5ny4vlexxhyzha


Abhishek Mukherji, Jason Whitehouse, Christopher R. Botaish, Elke A. Rundensteiner, Matthew O. Ward
2013 Proceedings of the 22nd ACM international conference on Conference on information & knowledge management - CIKM '13  
We demonstrate our SPHINX system that not only derives but also visualizes evidence-hypotheses relationships on a parameter space of belief and plausibility. SPHINX facilitates the analyst to interactively explore the contribution of different pieces of evidence towards the hypotheses. The key technical contributions of SPHINX include both computational and visual dimensions. The computational contributions cover (a.) flexible computational model selection; and (b.) real-time incremental
more » ... h computations. The visual contributions include (a.) sense-making over parameter space; (b.) filtering and abstraction options; (c.) novel visual displays such as evidence glyph and skyline views. Using two real datasets, we will demonstrate that the SPHINX system provides the analysts with rich insights into evidence-hypothesis relationships facilitating the discovery and decision making process.
doi:10.1145/2505515.2508202 dblp:conf/cikm/MukherjiWBRW13 fatcat:vj52xgmgy5cb7dx6mmlnyaqfzm

Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards

Matthew M. Churpek, Trevor C. Yuen, Christopher Winslow, David O. Meltzer, Michael W. Kattan, Dana P. Edelson
2016 Critical Care Medicine  
We compared the accuracy of different techniques for detecting clinical deterioration on the wards in a large, multicenter database. DESIGN-Observational cohort study.  ...  Outcomes The primary outcome of the study was the composite of ward cardiac arrest, ward to ICU transfer, or death on the wards without attempted resuscitation.  ...  ICU transfers were determined using location-stamped vital signs, and death on the wards was confirmed using administrative databases.  ... 
doi:10.1097/ccm.0000000000001571 pmid:26771782 pmcid:PMC4736499 fatcat:kcpkap2lq5bfnp2yb3keudz3nu

Adverse effects of wood smoke PM2.5exposure on macrophage functions

Christopher T. Migliaccio, Emily Kobos, Quinton O. King, Virginia Porter, Forrest Jessop, Tony Ward
2013 Inhalation Toxicology  
Ward, personal communication, 2010) .  ...  Multiple types of PAHs and dioxin-like compounds have been described in WS (Ward et al., 2005; Ward & Lincoln 2006) .  ... 
doi:10.3109/08958378.2012.756086 pmid:23363038 pmcid:PMC4757468 fatcat:fcho7hpbtfb5xjyrdmoc2x4tji


Abhishek Mukherji, Xika Lin, Jason Whitehouse, Christopher R. Botaish, Elke A. Rundensteiner, Matthew O. Ward
2013 Proceedings of the 22nd ACM international conference on Conference on information & knowledge management - CIKM '13  
While significant strides have been made on efficient association rule mining, the usability of mining systems woefully lags behind. In particular, the usability of rule mining systems is limited by the lack of support for interactive exploration of the relationships among rule results produced with various parameter settings. Based on a novel parameter space-driven approach, our proposed Framework for Interactive Rule Exploration (FIRE) addresses the usability shortcoming. FIRE features
more » ... ive visual displays and effective interactions that enable analysts to conduct rule exploration at the speed of thought. Particularly, the parameter space view (PSpace) displays the distribution of rules produced for diverse parameter settings. This not only facilitates user parameter selection but also empowers analyst's to understand rule relationships in the parameter space context. Our user study with 22 subjects establishes the usability and effectiveness of the proposed features and interactions of FIRE using benchmark datasets. Overall, this research encompasses significant contributions at the intersection of data mining, knowledge management and visual analytics.
doi:10.1145/2505515.2505631 dblp:conf/cikm/MukherjiLWBRW13 fatcat:aooygivggre2hij5auyjll6wdm

Multicenter Development and Validation of a Risk Stratification Tool for Ward Patients

Matthew M. Churpek, Trevor C. Yuen, Christopher Winslow, Ari A. Robicsek, David O. Meltzer, Robert D. Gibbons, Dana P. Edelson
2014 American Journal of Respiratory and Critical Care Medicine  
Rationale: Most ward risk scores were created using subjective opinion in individual hospitals and only use vital signs.  ...  Methods: All patients hospitalized on the wards in five hospitals were included in this observational cohort study.  ...  These patients were censored at the time of their last ward vital sign before the procedure and then reentered the study after returning to the ward from the ICU.  ... 
doi:10.1164/rccm.201406-1022oc pmid:25089847 pmcid:PMC4214112 fatcat:h3lymlupb5c2fgjjpsa7ofcfhu

Mice Null for Calsequestrin 1 Exhibit Deficits in Functional Performance and Sarcoplasmic Reticulum Calcium Handling

Rotimi O. Olojo, Andrew P. Ziman, Erick O. Hernández-Ochoa, Paul D. Allen, Martin F. Schneider, Christopher W. Ward, Wei-Chun Chin
2011 PLoS ONE  
The cross-sectional area for each muscle was determined by dividing the mass of the muscle (g) by the product of its length (L o , mm) and the density of muscle (1.06 g/cm 3 ; [36] ).  ...  physiological saline solution (PSS; pH 7.6) containing (in mM) 119 NaCl, 5 KCl, 1 MgSO 4 , 5 NaHCO 3 , 1.25 CaCl 2 , 1 KH 2 PO 4 , 10, HEPES, 10 glucose, and maintained at 30uC under aeration with 95 O  ... 
doi:10.1371/journal.pone.0027036 pmid:22164205 pmcid:PMC3229475 fatcat:7a7ztnx3lnattl5s77eawuf62a

Modeling and sensitivity analysis of fire emissions in southern Africa during SAFARI 2000

Stefania Korontzi, David P. Roy, Christopher O. Justice, Darold E. Ward
2004 Remote Sensing of Environment  
A fuel carbon content of 50% is assumed in all emission factors calculations (Ward et al., 1996) .  ...  Sensitivity of regional fire emissions to MODIS, GBA-2000, and GLOBSCAR complete combustion and release more CO (Ward et al., 1996) .  ... 
doi:10.1016/j.rse.2004.06.010 fatcat:msuntdcmwje7jnwkzmkd2pk52y

Modeling and sensitivity analysis of fire emissions in southern Africa during SAFARI 2000

Stefania Korontzi, David P. Roy, Christopher O. Justice, Darold E. Ward
2004 Remote Sensing of Environment  
., 2003; Ward et al., 1996; Yokelson et al., 2003) .  ...  The model's predictions, regardless of the burned area product, are consistent with published field studies of emission patterns from woodland and grassland fires (Hoffa et al., 1999; Ward et al., 1996  ... 
doi:10.1016/j.rse.2004.06.023 fatcat:nrgordug2vevxdej2w6uqcmqty

Global research alliance N 2 O chamber methodology guidelines: Summary of modelling approaches

Donna Giltrap, Jagadeesh Yeluripati, Pete Smith, Nuala Fitton, Ward Smith, Brian Grant, Christopher D Dorich, Jia Deng, Cairistiona FE Topp, Mohamed Abdalla, Lìyǐn L. Liáng, Val Snow
2020 Journal of Environmental Quality  
Therefore, N2 O models have an important role to play.  ...  We also review examples of N2 O modeling for different purposes and describe three commonly used process-based N2 O models (APSIM, DayCent, and DNDC).  ...  Giltrap Ward Smith Christopher D.  ... 
doi:10.1002/jeq2.20119 pmid:33016456 fatcat:z4xyjr4tjjgh3kjp7p3voncwsm

ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth

Elizabeth L. Tudor, Michael S. Perkinton, Anja Schmidt, Steven Ackerley, Janet Brownlees, Nicholas J. O. Jacobsen, Helen L. Byers, Malcolm Ward, Alan Hall, P. Nigel Leigh, Christopher E. Shaw, Declan M. McLoughlin (+1 others)
2005 Journal of Biological Chemistry  
Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine nucleotide exchange factors (GEFs) that promote GDP release and GTP binding. ALS2/Alsin is a recently described GEF that contains a central domain that is predicted to regulate the activities of Rac and/or Rho and Cdc42 activities. Mutations in ALS2 cause some recessive familial forms
more » ... f amyotrophic lateral sclerosis (ALS) but the function of ALS2 is poorly understood. Here we demonstrate that ALS2 is present within growth cones of neurons, in which it co-localizes with Rac. Furthermore, ALS2 stimulates Rac but not Rho or Cdc42 activities, and this induces a corresponding increase in PAK1 activity. Finally, we demonstrate that ALS2 promotes neurite outgrowth. Defects in these functions may therefore contribute to motor neuron demise in ALS.
doi:10.1074/jbc.m506216200 pmid:16049005 fatcat:xh2ifutufbf7fg2qrpmdb7gy2q

Exploring large scale time-series data using nested timelines

Zaixian Xie, Matthew O. Ward, Elke A. Rundensteiner, Pak Chung Wong, David L. Kao, Ming C. Hao, Chaomei Chen, Christopher G. Healey
2013 Visualization and Data Analysis 2013  
Ward and Guo employed N-gram approach to map temporal data to multiple glyphs, and then utilize the PCA algorithm to position these glyphs.  ... 
doi:10.1117/12.2003897 dblp:conf/vda/XieWR13 fatcat:2yexarlvtndctouloeb7iwrlkq

Lung function measures following simulated wildland firefighter exposures

Matthew D. Ferguson, Erin O. Semmens, Emily Weiler, Joe Domitrovich, Mary French, Christopher Migliaccio, Charles Palmer, Charles Dumke, Tony Ward
2017 Journal of Occupational and Environmental Hygiene  
Across the world, biomass smoke is a major source of air pollution and is linked with a variety of adverse health effects. This is particularly true in the western US where wood smoke from wildland forest fires are a significant source of PM 2.5 . Wildland firefighters are impacted as they experience elevated PM 2.5 concentrations over extended periods of time, often occurring during physical exertion. Various epidemiological studies have investigated wood smoke impacts on human health,
more » ... g occupational field exposures experienced by wildland firefighters. As there are numerous challenges in carrying out these field studies, having the ability to research the potential health impacts to this occupational cohort in a controlled setting would provide important information that could be translated to the field setting. To this end, we have carried out a simulated wildland firefighter exposure study in a wood smoke inhalation facility. Utilizing a randomized crossover trial design, we exposed 10 participants once to clean filtered-air, 250 μg/m 3 , and 500 μg/m 3 wood stove-generated wood smoke PM 2.5 . Participants exercised on a treadmill at an absolute intensity designed to simulate wildland firefighting for 1.5 hours. In addition to measured PM 2.5 smoke concentrations, mean levels of CO 2 , CO, and % relative humidity were continuously monitored and recorded and were representative of occupational 'real-world' exposures. Pulmonary function was measured at three time points: before, immediately after, and 1-hour post-exposure. Although there were some reductions in FVC, FEV 1 , and FVC:FEV 1 measures, results of the spirometry testing did not show significant changes in lung function. The development of this wood smoke inhalational facility provides a platform to further address unique research questions related to wood smoke exposures and associated adverse health effects.
doi:10.1080/15459624.2017.1326700 pmid:28609218 pmcid:PMC6101969 fatcat:754dhmvqf5b63dqfkimxwiz3di
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