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This special issue represents recent proceedings and developments in the fields of nitrite and nitrate chemistry, biology and therapeutics that were discussed at the biannual international meeting entitled "Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy Conference". This conference represents the fourth instillation of this meeting series that has served as a unique forum where investigators from diverse backgrounds have come together to better understand the chemicaldoi:10.1016/j.niox.2012.04.165 pmid:22622235 pmcid:PMC4413921 fatcat:476ta564hfa4ndzvipty5yadyq
more »... ology of nitrite and nitrate with an emphasis on therapeutic utility of nitrite and nitrate for various disease conditions.
This review summarises the neuroprotective properties of melatonin, the key findings from the piglet and other animal studies to date, and the challenges we face to translate melatonin from bench to bedside ... J. Mol. Sci. 2021, 22, 5481 11 of Pharmacokinetic Profile of Sigma-Aldrich Melatonin dissolved in ethanol (a) and Chiesi ethanol-free melatonin (b). ... As we move towards translating melatonin from bench to bedside, several challenges remain in the drug development of suitable intravenous melatonin formulation prior to clinical trials. ...doi:10.3390/ijms22115481 pmid:34067448 fatcat:ijqj75acd5em5kzehsfyjj42za
At its inception DNA nanotechnology was conceived as a tool for spatially arranging biological molecules in a programmable and deterministic way to improve their interrogation. To date, DNA nanotechnology has provided a versatile toolset of nanostructures and functional devices to augment traditional single molecule investigation approaches - including atomic force microscopy - by isolating, arranging and contextualising biological systems at the single molecule level. This review explores thedoi:10.1016/j.csbj.2019.06.013 pmid:31316727 pmcid:PMC6611922 fatcat:bv3novt2ojg27n2ex5fcfzxuby
more »... tate-of-the-art of DNA-based nanoscale tools employed to enhance and tune the interrogation of biological reactions, the study of spatially distributed pathways, the visualisation of enzyme interactions, the application and detection of forces to biological systems, and biosensing platforms.
Ground-based and Airborne Instrumentation for Astronomy VII
Springs are used to preload the optics and shims within pockets machined into the Zerodur bench. ... Furthermore, Zerodur optics with integral mounts are used where possible, and are placed in contact with the bench through Zerodur shims. ... The top and bottom slices become the spectrometer bench and a blank for another bench as a backup. ...doi:10.1117/12.2313969 fatcat:ax6wz237vna5zjk3odyhajhanm
Ground-based and Airborne Instrumentation for Astronomy VIII
This paper presents these requirements and describes the test bench design adopted. Then, based on preliminary results, we discuss the original solutions that permitted to reach our goals. ... At Department of Astrophysics (CEA Saclay, France), responsible for the testing of the N-band AGPMs, a previously available test bench with a telescope simulator and cryogenic facility has been upgraded ... To dim the air turbulence and improve stability of the point source, the whole bench is covered with a plastic sheet. Several distinct computers provide control command of the test bench. ...doi:10.1117/12.2562261 fatcat:axcx2rvmpvgmph5crpd7gkur6e
Subjects completed bench press repetitions using concentric loads from 30% to 80% 1-RM in 10% increments in each experimental session. ... This study examined the effects of accentuated eccentric loading (AEL) on bench press velocities across a spectrum of concentric and eccentric loads. ... Subjects were required to have a minimum bench press relative strength ratio (1-RM divided by body mass) of 1.25 and had performed bench press consistently in training for the past year. ...doi:10.3390/sports9050054 pmid:33925494 fatcat:s6gxkr6ednfanhgdr2rcvckt3m
Growing evidence suggests that human microbiota likely influence diverse processes including hematopoiesis, chemotherapy metabolism, and efficacy, as well as overall survival in patients with hematologic malignancies and other cancers. Both host genetic susceptibility and host-microbiota interactions may impact cancer risk and response to treatment; however, microbiota have the potential to be uniquely modifiable and accessible targets for treatment. Here, we focus on strategies to modifydoi:10.1182/hematology.2019000365 pmid:31808861 pmcid:PMC6913456 fatcat:o3lu2c5f2bcezothd6zm32djeq
more »... iota composition and function in patients with cancer. First, we evaluate the use of fecal microbiota transplant to restore microbial equilibrium following perturbation by antibiotics and chemotherapy, and as a treatment of complications of hematopoietic stem cell transplantation (HSCT), such as graft-versus-host disease and colonization with multidrug-resistant organisms. We then address the potential use of both probiotics and dietary prebiotic compounds in targeted modulation of the microbiota intended to improve outcomes in hematologic diseases. With each type of therapy, we highlight the role that abnormal, or dysbiotic, microbiota play in disease, treatment efficacy, and toxicity and evaluate their potential promise as emerging strategies for microbiota manipulation in patients with hematologic malignancies and in those undergoing HSCT.
Ground-based and Airborne Instrumentation for Astronomy VI
This paper outlines the optical design of the bench-mounted spectrograph and the predicted spectrograph resolution and efficiency for the spectrograph. ... This paper focuses on the details of the optical design of the bench spectrograph from the exit of the micro lens slit unit to the detector. ... The current design is the result of a trade study to produce a bench spectrograph design optimized to the capabilities and experience at HAA. ...doi:10.1117/12.2234366 fatcat:fj7vf3d435ehjhkidrzjpnjifm
Task-specific exercises such as bench stepping can improve functional ability and reduce falling incidents in older adults. ... Training in the STEEP group consisted of 40 min of bench stepping exercise using modular height-adjustable stepping benches, performed 3 times per week for 12 weeks. ... Bench stepping may simultaneously target strength and functional performance. ...doi:10.1016/j.exger.2019.02.013 pmid:30797825 fatcat:he6xovoivzde3h4bmnhzkg5uam
J Thorac Oncol. Author manuscript; available in PMC 2017 February 27. ... J Thorac Oncol. 2014; 9:554-558. [PubMed: 24736080] 39. Watanabe M, Kawaguchi T, Isa S, et al. ...doi:10.1016/j.jtho.2016.09.003 pmid:27642065 pmcid:PMC5327855 fatcat:6i75ys3tb5cbjfimklq4xeztsa
Clinical trials in cystic fibrosis (CF) patients established proof-of-principle for transfer of the wild-type cystic fibrosis transmembrane conductance regulator (CFTR) gene to airway epithelial cells. However, the limited efficacy of gene transfer vectors as well as extra-and intracellular barriers have prevented the development of a gene therapy-based treatment for CF. Here, we review the use of new viral and nonviral gene therapy vectors, as well as human artificial chromosomes, to overcomedoi:10.1016/s1569-1993(11)60017-9 pmid:21658631 fatcat:o3aa25u7zncplj7pndznb2wyaq
more »... arriers to successful CFTR expression. Pre-clinical studies will surely benefit from novel animal models, such as CF pigs and ferrets. Prenatal gene therapy is a potential alternative to gene transfer to fully developed lungs. However, unresolved issues, including the possibility of adverse effects on pre-and postnatal development, the risk of initiating oncogenic or degenerative processes and germ line transmission require further investigation. Finally, we discuss the therapeutic potential of stem cells for CF lung disease.
Advances in Adaptive Optics II
The high order test bench implements extreme adaptive optics on the MACAO test bench with realistic telescope conditions reproduced by star and turbulence generators. ... We will describe the overall design of this test bench and will focus on the characterization of two essential sub-systems: the micro deformable mirror and the phase screens. ... This rail will run down the edge of the HOT optical bench in the ESO specified position. ...doi:10.1117/12.670183 fatcat:yt55edo7dzf7bmlson7l5fhrxq
Adaptive Optics Systems
The high order test bench (HOT) implements an XAO system under realistic telescope conditions reproduced by star and turbulence generators. ... A first deformable mirror (60 bimorph elements) is used to correct the static aberrations of the bench and will work in a second phase of the project as woofer. ... The HOT bench incorporates a turbulence generator with phase screens to simulate real seeing conditions for three cases: low reduced turbulence (0.5", 0.85" seeing) and full kolmogorov turbulence (0.65 ...doi:10.1117/12.788710 fatcat:r24fw6bnp5dincuszy4cogplei
FROM BEDSIDE TO BENCH AND BACKѧ Immunotherapy using adoptive cell transfer is a promising approach that can result in the regression of bulky, invasive cancer in some patients. ...doi:10.1189/jlb.0304120 pmid:15155774 pmcid:PMC1484508 fatcat:dwa6jubarjf77m72q5kii6hqhy
Pharmacological and postmortem investigations suggest that patients with major depressive disorder have alterations in function or density of brain serotonin 1A (5-HT 1A ) receptors. The aim of the present study was to use positron emission tomography with the selective 5-HT 1A receptor antagonist [ 11 C]WAY-100635 to measure 5-HT 1A receptor binding in depressed patients before and during treatment with selective serotonin reuptake inhibitors.doi:10.1001/archpsyc.57.2.174 pmid:10665620 fatcat:43ulua6f6rhr7ncvkvy6yf4j5i
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