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Nitrite and Nitrate: From Bench to Bedside
2012
Nitric oxide
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This special issue represents recent proceedings and developments in the fields of nitrite and nitrate chemistry, biology and therapeutics that were discussed at the biannual international meeting entitled "Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy Conference". This conference represents the fourth instillation of this meeting series that has served as a unique forum where investigators from diverse backgrounds have come together to better understand the chemical
doi:10.1016/j.niox.2012.04.165
pmid:22622235
pmcid:PMC4413921
fatcat:476ta564hfa4ndzvipty5yadyq
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... ology of nitrite and nitrate with an emphasis on therapeutic utility of nitrite and nitrate for various disease conditions.
Melatonin for Neonatal Encephalopathy: From Bench to Bedside
2021
International Journal of Molecular Sciences
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This review summarises the neuroprotective properties of melatonin, the key findings from the piglet and other animal studies to date, and the challenges we face to translate melatonin from bench to bedside ...
J. Mol. Sci. 2021, 22, 5481 11 of Pharmacokinetic Profile of Sigma-Aldrich Melatonin dissolved in ethanol (a) and Chiesi ethanol-free melatonin (b). ...
As we move towards translating melatonin from bench to bedside, several challenges remain in the drug development of suitable intravenous melatonin formulation prior to clinical trials. ...
doi:10.3390/ijms22115481
pmid:34067448
fatcat:ijqj75acd5em5kzehsfyjj42za
DNA nanostructures: A versatile lab-bench for interrogating biological reactions
2019
Computational and Structural Biotechnology Journal
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At its inception DNA nanotechnology was conceived as a tool for spatially arranging biological molecules in a programmable and deterministic way to improve their interrogation. To date, DNA nanotechnology has provided a versatile toolset of nanostructures and functional devices to augment traditional single molecule investigation approaches - including atomic force microscopy - by isolating, arranging and contextualising biological systems at the single molecule level. This review explores the
doi:10.1016/j.csbj.2019.06.013
pmid:31316727
pmcid:PMC6611922
fatcat:bv3novt2ojg27n2ex5fcfzxuby
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... tate-of-the-art of DNA-based nanoscale tools employed to enhance and tune the interrogation of biological reactions, the study of spatially distributed pathways, the visualisation of enzyme interactions, the application and detection of forces to biological systems, and biosensing platforms.
Keck Planet Finder: Zerodur optical bench mechanical design
2018
Ground-based and Airborne Instrumentation for Astronomy VII
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Springs are used to preload the optics and shims within pockets machined into the Zerodur bench. ...
Furthermore, Zerodur optics with integral mounts are used where possible, and are placed in contact with the bench through Zerodur shims. ...
The top and bottom slices become the spectrometer bench and a blank for another bench as a backup. ...
doi:10.1117/12.2313969
fatcat:ax6wz237vna5zjk3odyhajhanm
An N-band test bench for the METIS coronagraphic masks
2020
Ground-based and Airborne Instrumentation for Astronomy VIII
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This paper presents these requirements and describes the test bench design adopted. Then, based on preliminary results, we discuss the original solutions that permitted to reach our goals. ...
At Department of Astrophysics (CEA Saclay, France), responsible for the testing of the N-band AGPMs, a previously available test bench with a telescope simulator and cryogenic facility has been upgraded ...
To dim the air turbulence and improve stability of the point source, the whole bench is covered with a plastic sheet. Several distinct computers provide control command of the test bench. ...
doi:10.1117/12.2562261
fatcat:axcx2rvmpvgmph5crpd7gkur6e
Accentuated Eccentric Loading in the Bench Press: Considerations for Eccentric and Concentric Loading
2021
Sports
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Subjects completed bench press repetitions using concentric loads from 30% to 80% 1-RM in 10% increments in each experimental session. ...
This study examined the effects of accentuated eccentric loading (AEL) on bench press velocities across a spectrum of concentric and eccentric loads. ...
Subjects were required to have a minimum bench press relative strength ratio (1-RM divided by body mass) of 1.25 and had performed bench press consistently in training for the past year. ...
doi:10.3390/sports9050054
pmid:33925494
fatcat:s6gxkr6ednfanhgdr2rcvckt3m
Microbiota modification in hematology: still at the bench or ready for the bedside?
2019
Hematology ASH Education Program
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Growing evidence suggests that human microbiota likely influence diverse processes including hematopoiesis, chemotherapy metabolism, and efficacy, as well as overall survival in patients with hematologic malignancies and other cancers. Both host genetic susceptibility and host-microbiota interactions may impact cancer risk and response to treatment; however, microbiota have the potential to be uniquely modifiable and accessible targets for treatment. Here, we focus on strategies to modify
doi:10.1182/hematology.2019000365
pmid:31808861
pmcid:PMC6913456
fatcat:o3lu2c5f2bcezothd6zm32djeq
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... iota composition and function in patients with cancer. First, we evaluate the use of fecal microbiota transplant to restore microbial equilibrium following perturbation by antibiotics and chemotherapy, and as a treatment of complications of hematopoietic stem cell transplantation (HSCT), such as graft-versus-host disease and colonization with multidrug-resistant organisms. We then address the potential use of both probiotics and dietary prebiotic compounds in targeted modulation of the microbiota intended to improve outcomes in hematologic diseases. With each type of therapy, we highlight the role that abnormal, or dysbiotic, microbiota play in disease, treatment efficacy, and toxicity and evaluate their potential promise as emerging strategies for microbiota manipulation in patients with hematologic malignancies and in those undergoing HSCT.
The Gemini High-Resolution Optical SpecTrograph (GHOST) bench spectrograph optical design
2016
Ground-based and Airborne Instrumentation for Astronomy VI
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This paper outlines the optical design of the bench-mounted spectrograph and the predicted spectrograph resolution and efficiency for the spectrograph. ...
This paper focuses on the details of the optical design of the bench spectrograph from the exit of the micro lens slit unit to the detector. ...
The current design is the result of a trade study to produce a bench spectrograph design optimized to the capabilities and experience at HAA. ...
doi:10.1117/12.2234366
fatcat:fj7vf3d435ehjhkidrzjpnjifm
Bench stepping with incremental heights improves muscle volume, strength and functional performance in older women
2019
Experimental Gerontology
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Task-specific exercises such as bench stepping can improve functional ability and reduce falling incidents in older adults. ...
Training in the STEEP group consisted of 40 min of bench stepping exercise using modular height-adjustable stepping benches, performed 3 times per week for 12 weeks. ...
Bench stepping may simultaneously target strength and functional performance. ...
doi:10.1016/j.exger.2019.02.013
pmid:30797825
fatcat:he6xovoivzde3h4bmnhzkg5uam
Primary Double-Strike Therapy for Cancers to Overcome EGFR Kinase Inhibitor Resistance: Proposal from the Bench
2017
Journal of Thoracic Oncology
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J Thorac Oncol. Author manuscript; available in PMC 2017 February 27. ...
J Thorac Oncol. 2014; 9:554-558. [PubMed: 24736080]
39. Watanabe M, Kawaguchi T, Isa S, et al. ...
doi:10.1016/j.jtho.2016.09.003
pmid:27642065
pmcid:PMC5327855
fatcat:6i75ys3tb5cbjfimklq4xeztsa
Gene and cell therapy for cystic fibrosis: From bench to bedside
2011
Journal of Cystic Fibrosis
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Clinical trials in cystic fibrosis (CF) patients established proof-of-principle for transfer of the wild-type cystic fibrosis transmembrane conductance regulator (CFTR) gene to airway epithelial cells. However, the limited efficacy of gene transfer vectors as well as extra-and intracellular barriers have prevented the development of a gene therapy-based treatment for CF. Here, we review the use of new viral and nonviral gene therapy vectors, as well as human artificial chromosomes, to overcome
doi:10.1016/s1569-1993(11)60017-9
pmid:21658631
fatcat:o3aa25u7zncplj7pndznb2wyaq
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... arriers to successful CFTR expression. Pre-clinical studies will surely benefit from novel animal models, such as CF pigs and ferrets. Prenatal gene therapy is a potential alternative to gene transfer to fully developed lungs. However, unresolved issues, including the possibility of adverse effects on pre-and postnatal development, the risk of initiating oncogenic or degenerative processes and germ line transmission require further investigation. Finally, we discuss the therapeutic potential of stem cells for CF lung disease.
Extreme adaptive optics system optimization with the high order test bench
2006
Advances in Adaptive Optics II
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The high order test bench implements extreme adaptive optics on the MACAO test bench with realistic telescope conditions reproduced by star and turbulence generators. ...
We will describe the overall design of this test bench and will focus on the characterization of two essential sub-systems: the micro deformable mirror and the phase screens. ...
This rail will run down the edge of the HOT optical bench in the ESO specified position. ...
doi:10.1117/12.670183
fatcat:yt55edo7dzf7bmlson7l5fhrxq
High order test bench for extreme adaptive optics system optimization
2008
Adaptive Optics Systems
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The high order test bench (HOT) implements an XAO system under realistic telescope conditions reproduced by star and turbulence generators. ...
A first deformable mirror (60 bimorph elements) is used to correct the static aberrations of the bench and will work in a second phase of the project as woofer. ...
The HOT bench incorporates a turbulence generator with phase screens to simulate real seeing conditions for three cases: low reduced turbulence (0.5", 0.85" seeing) and full kolmogorov turbulence (0.65 ...
doi:10.1117/12.788710
fatcat:r24fw6bnp5dincuszy4cogplei
Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer
2004
Journal of Leukocyte Biology
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FROM BEDSIDE TO BENCH AND BACKѧ Immunotherapy using adoptive cell transfer is a promising approach that can result in the regression of bulky, invasive cancer in some patients. ...
doi:10.1189/jlb.0304120
pmid:15155774
pmcid:PMC1484508
fatcat:dwa6jubarjf77m72q5kii6hqhy
Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635
2000
Archives of General Psychiatry
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Pharmacological and postmortem investigations suggest that patients with major depressive disorder have alterations in function or density of brain serotonin 1A (5-HT 1A ) receptors. The aim of the present study was to use positron emission tomography with the selective 5-HT 1A receptor antagonist [ 11 C]WAY-100635 to measure 5-HT 1A receptor binding in depressed patients before and during treatment with selective serotonin reuptake inhibitors.
doi:10.1001/archpsyc.57.2.174
pmid:10665620
fatcat:43ulua6f6rhr7ncvkvy6yf4j5i
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