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Additive Runge–Kutta schemes for convection–diffusion–reaction equations

Christopher A. Kennedy, Mark H. Carpenter
2003 Applied Numerical Mathematics  
Characteristics and coefficients of _he scheme , =- c -1 2'tx ' _l(t) (C -1 -H 2) yl(t)-H - Y2( ) Y2(t) ----Yl(t) --Y2(_) --y2(t), (Go) where 0 < t < 1 and whose exact solution is yl(t) = yg(t), y2(t  ...  ., z[N]) ' Det[I - _=12v (z[_]A[_]) -H _=IN (z[_]e @ B[_]T) ] Det [I --_=IN (z[']A['])] where AM = "ij_["],b["] = bi['] method is considered using ]_(2 '[1] ' 2 [2] ' 18) , 16) = oi aij + oj aji --b i  ... 
doi:10.1016/s0168-9274(02)00138-1 fatcat:5dq62x55qre2xe2sag5qxs2fde

Endoscopic endonasal transsphenoidal surgery for growth hormone–secreting pituitary adenomas

Christoph P. Hofstetter, Raaid H. Mannaa, Lynn Mubita, Vijay K. Anand, John W. Kennedy, Amir R. Dehdashti, Theodore H. Schwartz
2010 Neurosurgical Focus  
Kennedy is a principal investigator for Lilly and Novo Nordisk Diabetes Clinical Trials.  ... 
doi:10.3171/2010.7.focus10173 pmid:20887131 fatcat:o4zyi5wmzjabtbu2jrxqidhgeq

Review of the First Year of an Overseas Military Gambling Treatment Program

Carrie H. Kennedy, Jeffrey H. Cook, Daniel R. Poole, Christopher L. Brunson, David E. Jones
2005 Military medicine  
This study provides descriptive information and preliminary first-year outcome data on the only overseas military gambling treatment option currently available. Implemented in January 2003 within the Substance Abuse Rehabilitation Program, U.S. Naval Hospital, Okinawa, Japan, gambling treatment was developed as a specific track within the overall substance abuse program. The present study explores the various considerations and requirements for setting up such a program, as well as a
more » ... of individuals seeking gambling treatment and preliminary outcome data. Participants consisted of all gambling referrals (N ϭ 35, 26 males; mean age, 33.2 years; SD ϭ 8.93) obtained over the first year that gambling services were offered. A significant degree of depression, suicidality, and substance abuse problems were observed in the sample. Results revealed that the gambling program was easily implemented within an established substance abuse program. The program was effective in preventing suicides in both military members and eligible beneficiaries and was effective in facilitating the retention of military members with gambling problems.
doi:10.7205/milmed.170.8.683 pmid:16173209 fatcat:n3yetf64fnf6vjdiw3tsgnh234

Induction of genomic instability in normal human bronchial epithelial cells by 238Pu α-particles

Christopher H. Kennedy, Charles E. Mitchel, Noelle H. Fukushima, Robin E. Neft, John F. Lechner
1996 Carcinogenesis  
After drying the gel was exposed to X-ray film at -72°C for 24-72 h.  ...  (4) reported RRs for lung cancer at 100 working level months (WLM, 1 WLM = 3.5 X lO" 3 J-h/m 3 or 2.7 mGy) as ranging from 1.2 to 6.1 (4) .  ... 
doi:10.1093/carcin/17.8.1671 pmid:8761424 fatcat:fytmxiqovraa3elwcd3pytwq4i

Low-storage, explicit Runge–Kutta schemes for the compressible Navier–Stokes equations

Christopher A. Kennedy, Mark H. Carpenter, R.Michael Lewis
2000 Applied Numerical Mathematics  
KENNEDY , MARK H. CARPENTERy , AND R. MICHAEL LEWISz Abstract.  ...  Kennedy Sandia National Laboratories, Livermore, California Mark H. Carpenter NASA Langley Research Center, Hampton, Virginia R.  ... 
doi:10.1016/s0168-9274(99)00141-5 fatcat:sooqbxnvxfhyxou7wp3r7bqltu

Exploratory Disposal and Reuse Feasibility Analysis of Winter Maintenance Wash Water

Heather L. Ullinger, Marla J. Kennedy, William H. Schneider, Christopher M. Miller, Zhi Zhou
2016 PLoS ONE  
Additional treatment in the form of dilution occurs at Location H.  ...  If this were to change, the projected reuse limits for Location S would be based on the same standards as Location H.  ... 
doi:10.1371/journal.pone.0149500 pmid:26908148 pmcid:PMC4764334 fatcat:xng7qzetfffu5iscveojj4w4b4

Development of a model for the representation of nanotechnology-specific terminology

LeeAnn O Bailey, Christopher H Kennedy, Martin J Fritts, Francis W Hartel
2006 AMIA Annual Symposium Proceedings  
Nanotechnology is an important, rapidly-evolving, multidisciplinary field. The tremendous growth in this area necessitates the establishment of a common, open-source terminology to support the diverse biomedical applications of nanotechnology. Currently, the consensus process to define and categorize conceptual entities pertaining to nanotechnology is in a rudimentary stage. We have constructed a nanotechnology-specific conceptual hierarchy that can be utilized by end users to retrieve
more » ... controlled terminology regarding emerging nanotechnology and corresponding clinical applications.
pmid:17238469 pmcid:PMC1839578 fatcat:2rrsmsmdz5eaxk5hvkp4f26nsi

In Brief: Mayfield et al. Classification: Carpal Dislocations and Progressive Perilunar Instability

Stephen A. Kennedy, Christopher H. Allan
2012 Clinical Orthopaedics and Related Research  
doi:10.1007/s11999-012-2275-x pmid:22322787 pmcid:PMC3293970 fatcat:aemtedgr3vf7fceyqufwg2v2tu

Genetics of P-element transposition into Drosophila melanogaster centric heterochromatin

Alexander Y Konev, Christopher M Yan, David Acevedo, Cameron Kennedy, Elaina Ward, Arlene Lim, Sanjay Tickoo, Gary H Karpen
2003 Genetics  
H. Cuaycong, S. C. Elgin and L. L. Wallrath, tion starting sites affect insert distributions.  ...  Kennedy, V. M. Velasco, T. L. McGrath, J. Weko et al., 2001 Identification of chromosome inheritance cific cytogenetic regions. These P insertions can also be modifiers in Drosophila melanogaster.  ... 
pmid:14704184 pmcid:PMC1462875 fatcat:l75civcfv5cdhi65c36uqp4pzu

Evaluation of Management Alternatives for Truck Wash Water Generated During Winter Maintenance Activities

Christopher M. Miller, William H. Schneider, Marla J. Kennedy
2014 Public Works Management & Policy  
As part of routine winter maintenance activities, salt trucks are washed frequently at the Ohio Department of Transportation's (ODOT) 88 county and 136 outpost garages during the winter months. In locations where sanitary sewer is available, truck wash water is treated with an oil/water separator and discharged directly to the sanitary sewer system. However, at facilities that do not have access to sanitary sewer, truck wash water must be collected and managed, often at a significant cost. The
more » ... urrent ODOT policy for truck wash water management, tying these facilities into the sanitary sewer system, has a high capital cost, and is not always possible. The purpose of this research was to identify alternative strategies for managing wash water generated during routine washing of salt trucks at ODOT maintenance facilities lacking access to sanitary sewer, assess their costs, and compare the cost of alternative management strategies with the cost of tying into the sanitary sewer system. Six viable wash water management strategies were identified and the annualized costs of each option were calculated for individual maintenance facilities. The cost analysis indicated that site specific conditions, including the volume of wash water generated, the distance to the potential disposal locations, and the capital cost of tying into the sanitary sewer, directly impact the cost effectiveness of alternative management strategies. Under the conditions of the cost analysis, pursuing off-site disposal, rather than tying into the sanitary sewer, could yield an annual cost savings of approximately $1.1 million across ODOT's 12 county and 66 outpost garages lacking access to sanitary sewer. The analysis iv also showed that, for a typical county garage with 12 trucks and 30 winter events, when the capital cost of tying into the sanitary sewer is greater than $300,000, four of the five management alternatives identified are more cost effective than tying into the sanitary sewer.
doi:10.1177/1087724x14522601 fatcat:cwguntkvr5dulebodynmbznaby

Breast cancer risk and drinking water contaminated by wastewater: a case control study

Julia Green Brody, Ann Aschengrau, Wendy McKelvey, Christopher H Swartz, Theresa Kennedy, Ruthann A Rudel
2006 Environmental Health  
Drinking water contaminated by wastewater is a potential source of exposure to mammary carcinogens and endocrine disrupting compounds from commercial products and excreted natural and pharmaceutical hormones. These contaminants are hypothesized to increase breast cancer risk. Cape Cod, Massachusetts, has a history of wastewater contamination in many, but not all, of its public water supplies; and the region has a history of higher breast cancer incidence that is unexplained by the population's
more » ... ge, in-migration, mammography use, or established breast cancer risk factors. We conducted a case-control study to investigate whether exposure to drinking water contaminated by wastewater increases the risk of breast cancer. Methods: Participants were 824 Cape Cod women diagnosed with breast cancer in 1988-1995 and 745 controls who lived in homes served by public drinking water supplies and never lived in a home served by a Cape Cod private well. We assessed each woman's exposure yearly since 1972 at each of her Cape Cod addresses, using nitrate nitrogen (nitrate-N) levels measured in public wells and pumping volumes for the wells. Nitrate-N is an established wastewater indicator in the region. As an alternative drinking water quality indicator, we calculated the fraction of recharge zones in residential, commercial, and pesticide land use areas. Results: After controlling for established breast cancer risk factors, mammography, and length of residence on Cape Cod, results showed no consistent association between breast cancer and average annual nitrate-N (OR = 1.8; 95% CI 0.6 -5.0 for ≥ 1.2 vs. < .3 mg/L), the sum of annual nitrate-N concentrations (OR = 0.9; 95% CI 0.6 -1.5 for ≥ 10 vs. 1 to < 10 mg/L), or the number of years exposed to nitrate-N over 1 mg/L (OR = 0.9; 95% CI 0.5 -1.5 for ≥ 8 vs. 0 years). Variation in exposure levels was limited, with 99% of women receiving some of their water from supplies with nitrate-N levels in excess of background. The total fraction of residential, commercial, and pesticide use land in recharge zones of public supply wells was associated with a small statistically unstable higher breast cancer incidence (OR = 1.4; 95% CI 0.8-2.4 for highest compared with lowest land use), but risk did not increase for increasing land use fractions. Conclusion: Results did not provide evidence of an association between breast cancer and drinking water contaminated by wastewater. The computer mapping methods used in this study to link routine measurements required by the Safe Drinking Water Act with interview data can enhance individual-level epidemiologic studies of multiple health outcomes, including diseases with substantial latency.
doi:10.1186/1476-069x-5-28 pmid:17026759 pmcid:PMC1622744 fatcat:3qyr4snaenatxhblvj5ut7mypm

Self-Assessment of Acute Mountain Sickness in Adolescents: A Pilot Study☆

Christopher H.E. Imray, Caroline H. Kennedy, Kyle Pattinson, Stephen Brearey, Alex Wright
2004 Wilderness & environmental medicine (Print)  
Objective.-To perform a pilot study exploring the prevalence of acute mountain sickness (AMS) in adolescents on ascent to altitude and evaluating whether this age group is capable of self-assessment of AMS using the Lake Louise scoring system. Methods.-Twelve teenagers aged 15 to 18 years old (5 girls) traveled for 21 days between 2400 and 5500 m. Each member of the expedition completed a Lake Louise self-assessment questionnaire on a daily basis. Group leaders (nonmedical) were informed about
more » ... ny subject with a score of 3 or more. Appropriate treatments were then initiated. Detailed analysis of data was undertaken on return to the UK. Results.-There was 100% completion of 252 questionnaires. Eleven of the 12 subjects (91.7%) had symptom scores greater than or equal to 3, consistent with a diagnosis of AMS, on at least one day (range, 0-8). Symptoms of AMS were more common in the female group members (P ϭ .041). Conclusions.-AMS seems to be a common problem among adolescents. There are increasing numbers of adolescents traveling to high altitudes, and there seems to be a lack of information about the prevalence of AMS in this age group. Motivated adolescents seemed capable of self-monitoring for AMS using the Lake Louise questionnaire. Combined with an appropriate ascent profile and support, we feel this approach may contribute to safety in the mountains and merits further study.
doi:10.1580/1080-6032(2004)15[202:soamsi];2 pmid:15473461 fatcat:7gjw7v2rjjfglg5dmwphi7re44

Overexpression ofhMTH1mRNA: a molecular marker of oxidative stress in lung cancer cells

Christopher H Kennedy, Rafael Cueto, Steven A Belinsky, John F Lechner, William A Pryor
1998 FEBS Letters  
Probe labeling and hybridization were as described except that a second wash was performed at 65³C for 1 h.  ...  The blots were pre-hybridized in a constant temperature shaking water bath at 65³C for 4 h in 100 ml of 250 mM sodium phosphate bu¡er (pH 7.2) containing 7% (w/v) sodium dodecyl sulfate (SDS).  ... 
doi:10.1016/s0014-5793(98)00505-5 pmid:9657375 fatcat:to5fmv5f4ng4temj7cvyas27b4

Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins

Skyler L. Jackman, Christopher H. Chen, Selmaan N. Chettih, Shay Q. Neufeld, Iain R. Drew, Chimuanya K. Agba, Isabella Flaquer, Alexis N. Stefano, Thomas J. Kennedy, Justine E. Belinsky, Keiramarie Roberston, Celia C. Beron (+3 others)
2018 Cell Reports  
(H) Comparison of expression following implantation of fibers coated with silk/AAV or AAV alone.  ... 
doi:10.1016/j.celrep.2018.02.081 pmid:29562189 pmcid:PMC5894120 fatcat:kblrrrjverbd7dxklfsrpcc6tm

Combustion Products of 1,3-Butadiene Are Cytotoxic and Genotoxic to Human Bronchial Epithelial Cells

W. James Catallo, Christopher H. Kennedy, William Henk, Steven A. Barker, Stephen C. Grace, Arthur Penn
2001 Environmental Health Perspectives  
The steady-state levels of •H adducts also shown result from POBN chemical reactions in situ.  ...  We detected PAHs with higher molecular mass, ranging as high as 1,000 amu (not shown), with compounds in the range 228-366 amu well represented (Figure 2 ; M+H •+ masses > 500 not shown) and in large  ... 
doi:10.2307/3455000 fatcat:gxo6n4eymjeljiyezhocwaqggu
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