300 Hits in 1.5 sec

Near-lossless Binarization of Word Embeddings [article]

Julien Tissier, Christophe Gravier, Amaury Habrard
2018 arXiv   pre-print
Pre-trained embeddings Our model produces binary vectors from several pre-trained embeddings: dict2vec (Tissier, Gravier, and Habrard 2017) which contains 2.3M words and has been trained on the full English  ... 
arXiv:1803.09065v3 fatcat:gne3z6wlufd6fcxv4jaqgos2qy

Antiphospholipid antibody syndrome with thrombotic splenic infarcts associated with acute cytomegalovirus infection

Christopher Denham, Ginger Tissier, Amit Golding
2019 Access Microbiology  
We describe a case of acute cytomegalovirus (CMV) infection complicated by acquired antiphospholipid antibodies and splenic thrombi. We discuss the associations between CMV infection and thrombosis risk and correlation with antiphospolipid antibodies. A previously healthy 32-year-old woman is hospitalized for acute abdominal pain and fever and found to have multiple splenic infarcts on an abdominal computed tomography (CT) scan. An infectious work-up is negative except for acute CMV, and a
more » ... coagulable work-up is only positive for antiphospholipid antibodies. The patient is discharged and placed on anti-coagulation therapy for 6 months. Co-incident thrombosis and antiphospholipid antibody syndrome can occur with acute viral infections, including CMV. We discuss the viral infection-associated increased risk of developing blood clots and antiphospholipid antibodies as being either correlative with or causative of viral-induced thrombosis.
doi:10.1099/acmi.0.000032 pmid:32974541 pmcid:PMC7481732 fatcat:ux6ehqluljdrfpd5uzdozs4yqi

Dict2vec : Learning Word Embeddings using Lexical Dictionaries

Julien Tissier, Christopher Gravier, Amaury Habrard
2017 Proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing  
Learning word embeddings on large unlabeled corpus has been shown to be successful in improving many natural language tasks. The most efficient and popular approaches learn or retrofit such representations using additional external data. Resulting embeddings are generally better than their corpus-only counterparts, although such resources cover a fraction of words in the vocabulary. In this paper, we propose a new approach, Dict2vec, based on one of the largest yet refined datasource for
more » ... ing words -natural language dictionaries. Dict2vec builds new word pairs from dictionary entries so that semantically-related words are moved closer, and negative sampling filters out pairs whose words are unrelated in dictionaries. We evaluate the word representation obtained using Dict2vec on eleven datasets for the word similarity task and on four datasets for a text classification task.
doi:10.18653/v1/d17-1024 dblp:conf/emnlp/TissierGH17 fatcat:stk4a2k4fjcmta4d3o2b4u46jm

Intensive care unit-acquired Stenotrophomonas maltophilia: incidence, risk factors, and outcome

Saad Nseir, Christophe Di Pompeo, Hélène Brisson, Florent Dewavrin, Stéphanie Tissier, Maimouna Diarra, Marie Boulo, Alain Durocher
2006 Critical Care  
The aim of this study was to determine incidence, risk factors, and impact on outcome of intensive care unit (ICU)-acquired Stenotrophomonas maltophilia. This prospective observational case-control study, which was a part of a cohort study, was conducted in a 30-bed ICU during a three year period. All immunocompetent patients hospitalised >48 hours were eligible. Patients with non-fermenting Gram-negative bacilli (NF-GNB) at ICU admission were excluded. Patients without ICU-acquired S.
more » ... ia who developed an ICU-acquired NF-GNB other than S. maltophilia were also excluded. Screening (tracheal aspirate and skin, anal, and nasal swabs) for NF-GNB was performed in all patients at ICU admission and weekly. Univariate and multivariate analyses were performed to determine risk factors for ICU-acquired S. maltophilia and for ICU mortality. Thirty-eight (2%) patients developed an S. maltophilia ICU-acquired colonisation and/or infection and were all successfully matched with 76 controls. Chronic obstructive pulmonary disease (COPD) and duration of antibiotic treatment (odds ratio [OR] [95% confidence interval (CI)] = 9.4 [3 to 29], p < 0.001, and 1.4 [1 to 2.3], p = 0.001, respectively) were independently associated with ICU-acquired S. maltophilia. Mortality rate (60% versus 40%, OR [95% CI] = 1.3 [1 to 1.7, p = 0.037]), duration of mechanical ventilation (23 +/- 16 versus 7 +/- 11 days, p < 0.001), and duration of ICU stay (29 +/- 21 versus 15 +/- 17 days, p < 0.001) were significantly higher in cases than in controls. In addition, ICU-acquired infection related to S. maltophilia was independently associated with ICU mortality (OR [95% CI] = 2.8 [1 to 7.7], p = 0.044). COPD and duration of antibiotic treatment are independent risk factors for ICU-acquired S. maltophilia. ICU-acquired S. maltophilia is associated with increased morbidity and mortality rates. ICU-acquired infection related to S. maltophilia is an independent risk factor for ICU mortality.
doi:10.1186/cc5063 pmid:17026755 pmcid:PMC1751051 fatcat:4ovum64kfvhglpihvlbfqujl6q

Captive-reared European hamsters follow an offensive strategy during risk-assessment

Mathilde L. Tissier, Christophe A. H. Bousquet, Julie Fleitz, Caroline Habold, Odile Petit, Yves Handrich, Jan M. Hemmi
2019 PLoS ONE  
We are also thankful to Christopher Turbill and Manfred Enstipp for their advice on this manuscript.  ...  Tissier ML, Bousquet CAH, Fleitz J, Chatelain N, Habold C, Handrich Y. An anti-predation device to facilitate and secure the crossing of small mammals in motorway wildlife underpasses.  ... 
doi:10.1371/journal.pone.0210158 pmid:30640936 pmcid:PMC6331116 fatcat:pwizx3nyi5fxlg3es5bxrzy67e

Distinct Albino3-dependent and -independent Pathways for Thylakoid Membrane Protein Insertion

Cheryl A. Woolhead, Simon J. Thompson, Misty Moore, Christophe Tissier, Alexandra Mant, Alison Rodger, Ralph Henry, Colin Robinson
2001 Journal of Biological Chemistry  
The homologous proteins Oxa1, YidC, and Alb3 mediate the insertion of membrane proteins in mitochondria, bacteria, and chloroplast thylakoids, respectively. Depletion of YidC in Escherichia coli affects the integration of every membrane protein studied, and Alb3 has been shown previously to be required for the insertion of a signal recognition particle (SRP)-dependent protein, Lhcb1, in thylakoids. In this study we have analyzed the "global" role of Alb3 in the insertion of thylakoid membrane
more » ... oteins. We show that insertion of two chlorophyll-binding proteins, Lhcb4.1 and Lhcb5, is almost totally blocked by preincubation of thylakoids with anti-Alb3 antibodies, indicating a requirement for Alb3 in the insertion pathway. Insertion of the related PsbS protein, on the other hand, is unaffected by Alb3 antibodies, and insertion of a group of SRP-independent, signal peptide-bearing proteins, PsbX, PsbW, and PsbY, is likewise completely unaffected. Proteinase K is furthermore able to completely degrade Alb3, but this treatment does not affect the insertion of these proteins. Among the thylakoid proteins studied here, Alb3 requirement correlates strictly with a requirement for stromal factors and nucleoside triphosphates. However, the majority of proteins tested do not require Alb3 or any other known form of translocation apparatus.
doi:10.1074/jbc.m106523200 pmid:11524428 fatcat:ojmmbui55zg6rntwhecaealkpa

Relationship between F-specific RNA phage genogroups, faecal pollution indicators and human adenoviruses in river water

Leslie Ogorzaly, Adeline Tissier, Isabelle Bertrand, Armand Maul, Christophe Gantzer
2009 Water Research  
C. Gantzer). A v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / w a t r e s 0043-1354/$ -see front matter ª w a t e r r e s e a r c h 4 3 ( 2 0 0 9 ) 1 2 5 7 -1 2 6 4
doi:10.1016/j.watres.2008.12.011 pmid:19121532 fatcat:54nsk4owxfdm5fiarj6baoeflu

Does the T1 subdivision correlate with the risk of recurrence of papillary thyroid cancer?

Nathalie Chereau, Christophe Trésallet, Severine Noullet, Gaelle Godiris-Petit, Frédérique Tissier, Laurence Leenhardt, Fabrice Menegaux
2016 Langenbeck's archives of surgery (Print)  
Based on the AJCC 7th TNM classification, T1 intraglandular tumours are subdivided into T1a (≤10 mm) and T1b (11-20 mm), but the differences in prognosis remain controversial. The present study aimed to determine the clinicopathological features and outcomes of T1a and T1b patients. Methods: A retrospective study of 2,518 T1 patients, including 1,840 T1a (73%) and 678 (27%) T1b patients who underwent surgery for PTC from 1978 to 2014, was conducted. In patients with a preoperative or operative
more » ... iagnosis of PTC, a total thyroidectomy (TT) with prophylactic (macroscopically N0) or therapeutic (evident N1) lymph node dissection (LND) was performed. Other patients had a TT or partial thyroidectomy without LND. The mean follow-up time was 8.9 ± 8.8 years (median, 6.5 years; range, 1-36.4 years). Results: A TT was performed in 2,273 patients (90%), including 1,184 (52%) with LND. Other patients (n=245) had a single lobectomy with isthmectomy. Multifocality, bilaterality, number of tumours, sum of the largest size of all foci, vascular invasion, and (in patients with LND) LN metastases were significantly more frequent in T1b than in T1a patients. Of the 1,184 patients with LND, 278 had LN metastases (N1, 23%), including 136/680 T1a (20%) and 142/504 (28%) T1b patients (p=0.002). These LN metastases were diagnosed after a prophylactic LND in 86/609 T1a (14%) and 93/440 T1b (21%) patients (p=0.001). Recurrences were more frequent in T1b (n=26, 3.8%) than in T1a patients (n=35, 1.9%, p=0.005). In the multivariate analysis, independent prognostic factors for recurrence in both groups were the number of tumours, the sum of the largest size of all foci and, in patients who had LND, LN metastases and extranodal extension. For N0-x patients, the recurrence rate was significantly higher in the T1b than in the T1a group (2.4% vs. 0.9%, respectively, p=0.005), although this rate was similar in N1 patients (16.2% for T1a and 9.2% for T1b patients, p=0.1). The 5-year disease-free survival rates for T1a and T1b patients were 98.3% and 96.6%, respectively (p=0.01). Conclusion: For PTC patients, T1b had poorer clinicopathological features and increased risk of recurrence than T1a.
doi:10.1007/s00423-016-1399-y pmid:26957089 fatcat:xujhb4jmzza2dnmr6lv6op347m

Novel approach reveals localisation and assembly pathway of the PsbS and PsbW proteins into the photosystem II dimer

Ellinor Thidholm, Viktoria Lindström, Christophe Tissier, Colin Robinson, Wolfgang P. Schröder, Christiane Funk
2002 FEBS Letters  
A blue-native gel electrophoresis system was combined with an in organello import assay to specifically analyse the location and assembly of two nuclear-encoded photosystem II (PSII) subunits. With this method we were able to show that initially the low molecular mass PsbW protein is not associated with the monomeric form of PSII. Instead a proportion of newly imported PsbW is directly assembled in dimeric PSII supercomplexes with very fast kinetics; its negatively charged Nterminal domain is
more » ... sential for this process. The chlorophyllbinding PsbS protein, which is involved in energy dissipation, is first detected in the monomeric PSII subcomplexes, and only at later time points in the dimeric form of PSII. It seems to be bound tighter to the PSII core complex than to light harvesting complex II. These data point to radically different assembly pathways for different PSII subunits. ß
doi:10.1016/s0014-5793(02)02314-1 pmid:11904154 fatcat:zr5jm5f4krdclbcbedgwogb6hq

Near-Lossless Binarization of Word Embeddings

Julien Tissier, Christophe Gravier, Amaury Habrard
Pre-trained embeddings Our autoencoder learns binary vectors from several pre-trained embeddings: dict2vec (Tissier, Gravier, and Habrard 2017) which contains 2.3M words and has been trained on the full  ... 
doi:10.1609/aaai.v33i01.33017104 fatcat:v5m3j6yg4bdxbadyj2o3yktyli

Partial Loss of Function of the GHRH Receptor Leads to Mild Growth Hormone Deficiency

Louise Cheryl Gregory, Kyriaki Sandy Alatzoglou, Mark James McCabe, Peter Christopher Hindmarsh, Jose William Saldanha, Nicola Romano, Paul Le Tissier, Mehul Tulsidas Dattani
2016 Journal of Clinical Endocrinology and Metabolism  
doi:10.1210/jc.2016-2254 pmid:27501283 fatcat:u46c33i3jrebrdjunbbio6ldqy

Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study

Clémence Marais, Caroline Claude, Nada Semaan, Ramy Charbel, Simon Barreault, Brendan Travert, Jean-Eudes Piloquet, Zoé Demailly, Luc Morin, Zied Merchaoui, Jean-Louis Teboul, Philippe Durand (+27 others)
2021 Annals of Intensive Care  
Background De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the
more » ... rence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit. Methods Retrospective analysis of the circulating myeloid cells phenotypes of adult COVID-19 critically ill patients. Phenotyping circulating immune cells was performed by flow cytometry daily for routine analysis and twice weekly for lymphocytes and monocytes subpopulations analysis, as well as monocyte human leukocyte antigen (mHLA)-DR expression. Results Out of the 29 critically ill adult patients with severe COVID-19 analyzed, 12 (41.4%) developed secondary infection and six patients died during their stay. Monocyte HLA-DR kinetics was significantly different between patients developing secondary infection and those without, respectively, at day 5–7 and 8–10 following admission. The monocytes myeloid-derived suppressor cells to total monocytes ratio was associated with 28- and 60-day mortality. Those myeloid characteristics suggest three phenotypes: hyperactivated monocyte/macrophage is significantly associated with mortality, whereas persistent immunodepression is associated with secondary infection occurrence compared to transient immunodepression. Conclusions Myeloid phenotypes of critically ill COVID-19 patients may be associated with development of secondary infection, 28- and 60-day mortality.
doi:10.1186/s13613-021-00896-4 fatcat:k2drljt5ovhpxllgnjxxmwo7w4

Post-operative neck ultrasound and risk stratification in differentiated thyroid cancer patients with initial lymph node involvement

Charlotte Lepoutre-Lussey, Dina Maddah, Jean-Louis Golmard, Gilles Russ, Frédérique Tissier, Christophe Trésallet, Fabrice Menegaux, André Aurengo, Laurence Leenhardt
2014 European Journal of Endocrinology  
ObjectiveCervical ultrasound (US) scan is a key tool for detecting metastatic lymph nodes (N1) in patients with papillary thyroid cancer (PTC). N1-PTC patients are stratified as intermediate-risk and high-risk (HR) patients, according to the American Thyroid Association (ATA) and European Thyroid Association (ETA) respectively. The aim of this study was to assess the value of post-operative cervical US (POCUS) in local persistent disease (PD) diagnosis and in the reassessment of risk
more » ... ion in N1-PTC patients.DesignRetrospective cohort study.MethodsBetween 1997 and 2010, 638 N1-PTC consecutive patients underwent a systematic POCUS. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of POCUS for the detection of PD were evaluated and a risk reassessment using cumulative incidence functions was carried out.ResultsAfter a median follow-up of 41.6 months, local recurrence occurred in 138 patients (21.6%), of which 121 were considered to have PD. Sensitivity, specificity, NPV, and PPV of POCUS for the detection of the 121 PD were 82.6, 87.4 95.6, and 60.6% respectively. Cumulative incidence of recurrence at 5 years was estimated at 26% in ETA HR patients, 17% in ATA intermediate-risk patients, and 35% in ATA HR patients respectively. This risk fell to 9, 8, and 11% in the above three groups when the POCUS result was normal and to <6% when it was combined with thyroglobulin results at ablation.ConclusionPOCUS is useful for detecting PD in N1-PTC patients and for stratifying individual recurrence risk. Its high NPV could allow clinicians to tailor follow-up recommendations to individual needs.
doi:10.1530/eje-13-0888 pmid:24659355 fatcat:bz7stkrzsfddjpgfrdwlhoa7ji

Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution

Geneviève Dom, Sandra Frank, Sebastien Floor, Pashalina Kehagias, Frederick Libert, Catherine Hoang, Guy Andry, Alex Spinette, Ligia Craciun, Nicolas de Saint Aubin, Christophe Tresallet, Frederique Tissier (+6 others)
2017 OncoTarget  
Non-autonomous thyroid nodules are common in the general population with a proportion found to be cancerous. A current challenge in the field is to be able to distinguish benign adenoma (FA) from preoperatively malignant thyroid follicular carcinoma (FTC), which are very similar both histologically and genetically. One controversial issue, which is currently not understood, is whether both tumor types represent different molecular entities or rather a biological continuum. To gain a better
more » ... ht into FA and FTC tumorigenesis, we defined their molecular profiles by mRNA and miRNA microarray. Expression data were analyzed, validated by qRT-PCR and compared with previously published data sets. The majority of deregulated mRNAs were common between FA and FTC and were downregulated, however FTC showed additional deregulated mRNA. Both types of tumors share deregulated pathways, molecular functions and biological processes. The additional deregulations in FTC include the lipid transport process that may be involved in tumor progression. The strongest candidate genes which may be able to discriminate follicular adenomas and carcinomas, CRABP1, FABP4 and HMGA2, were validated in independent samples by qRT-PCR and immunohistochemistry. However, they were not able to adequately classify FA or FTC, supporting the notion of continuous evolving tumors, whereby FA and FTC appear to show quantitative rather than qualitative changes. Conversely, miRNA expression profiles showed few dysregulations in FTC, and even fewer in FA, suggesting that miRNA play a minor, if any, role in tumor progression.
doi:10.18632/oncotarget.23130 pmid:29535811 pmcid:PMC5828225 fatcat:scwkbdxnxjf5vmqylbxlzguad4

Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice

Isabelle Sahut-Barnola, Cyrille de Joussineau, Pierre Val, Sarah Lambert-Langlais, Christelle Damon, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Geoffroy Marceau, Vincent Sapin, Frédérique Tissier, Bruno Ragazzon, Jérôme Bertherat (+4 others)
2010 PLoS Genetics  
Carney complex (CNC) is an inherited neoplasia syndrome with endocrine overactivity. Its most frequent endocrine manifestation is primary pigmented nodular adrenocortical disease (PPNAD), a bilateral adrenocortical hyperplasia causing pituitary-independent Cushing's syndrome. Inactivating mutations in PRKAR1A, a gene encoding the type 1 a-regulatory subunit (R1a) of the cAMP-dependent protein kinase (PKA) have been found in 80% of CNC patients with Cushing's syndrome. To demonstrate the
more » ... ion of R1a loss in the initiation and development of PPNAD, we generated mice lacking Prkar1a specifically in the adrenal cortex (AdKO). AdKO mice develop pituitary-independent Cushing's syndrome with increased PKA activity. This leads to autonomous steroidogenic genes expression and deregulated adreno-cortical cells differentiation, increased proliferation and resistance to apoptosis. Unexpectedly, R1a loss results in improper maintenance and centrifugal expansion of cortisol-producing fetal adrenocortical cells with concomitant regression of adult cortex. Our data provide the first in vivo evidence that loss of R1a is sufficient to induce autonomous adrenal hyper-activity and bilateral hyperplasia, both observed in human PPNAD. Furthermore, this model demonstrates that deregulated PKA activity favors the emergence of a new cell population potentially arising from the fetal adrenal, giving new insight into the mechanisms leading to PPNAD.
doi:10.1371/journal.pgen.1000980 pmid:20548949 pmcid:PMC2883593 fatcat:mta3ctqoafgyfb7m6grhizbgqu
« Previous Showing results 1 — 15 out of 300 results