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Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions

Eric M. Reiman, Kewei Chen, Richard J. Caselli, Gene E. Alexander, Daniel Bandy, Jennifer L. Adamson, Wendy Lee, Ashley Cannon, Elizabeth A. Stephan, Dietrich A. Stephan, Andreas Papassotiropoulos
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
Cholesterol-related genetic risk scores were associated with hypometabolism in AD-affected brain regions, even when controlling for the effects of APOE ε4 gene dose.  ...  aggregate cholesterol-related genetic score (CREGS) to characterize a person's risk.  ...  ACKNOWLEDGMENTS This study was presented in July 2006 at the 10 th International Conference on Alzheimer's Disease and Related Disorders, Madrid.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2007.12.066">doi:10.1016/j.neuroimage.2007.12.066</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18280754">pmid:18280754</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2441925/">pmcid:PMC2441925</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/odwj5jtkxvhhffjv3wtzemkala">fatcat:odwj5jtkxvhhffjv3wtzemkala</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191126221657/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2441925&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/44/76/44766e878f0e09809b07e86cb74ba2314212109e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2007.12.066"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441925" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

From The Cover: Correlations between apolipoprotein E 4 gene dose and brain-imaging measurements of regional hypometabolism

E. M. Reiman, K. Chen, G. E. Alexander, R. J. Caselli, D. Bandy, D. Osborne, A. M. Saunders, J. Hardy
<span title="2005-06-02">2005</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
with lower CMRgl in the brain regions preferentially affected by AD.  ...  level, we now find that 4 gene dose is correlated with lower CMRgl in each of these brain regions.  ...  This study was supported by the National Institute of Mental Health (R01 MH57899), the National Institute on Aging (P30 AG19610), the Arizona Alzheimer's Research Center, and the Banner Health and Mayo  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.0500579102">doi:10.1073/pnas.0500579102</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15932949">pmid:15932949</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1149416/">pmcid:PMC1149416</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uh7tl5qaz5hy5nbsk4jqczfjlq">fatcat:uh7tl5qaz5hy5nbsk4jqczfjlq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729100558/http://www.pnas.org/content/pnas/102/23/8299.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9a/73/9a73bd2315ea423d4646bf68aafa1f613e0d5ef8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.0500579102"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149416" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions

C. M. Burns, K. Chen, A. W. Kaszniak, W. Lee, G. E. Alexander, D. Bandy, A. S. Fleisher, R. J. Caselli, E. M. Reiman
<span title="2013-03-27">2013</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dogs2nidlzdtxigbzvv6d2bbc4" style="color: black;">Neurology</a> </i> &nbsp;
Objective: To investigate whether higher fasting serum glucose levels in cognitively normal, nondiabetic adults were associated with lower regional cerebral metabolic rate for glucose (rCMRgl) in brain  ...  Results: As predicted, higher fasting serum glucose levels were significantly correlated with lower rCMRgl and were confined to the vicinity of brain regions preferentially affected by AD.  ...  Accepted in final form January 15, 2013.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0b013e31828f17de">doi:10.1212/wnl.0b013e31828f17de</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23535495">pmid:23535495</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3662330/">pmcid:PMC3662330</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/enlmgrrcvrhkfgocbei53ccq44">fatcat:enlmgrrcvrhkfgocbei53ccq44</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191202040819/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3662330&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0f/38/0f389431c8ae32697163abe9dc5933109b47969a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0b013e31828f17de"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662330" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

Lisa Mosconi, Alberto Pupi, Mony J. De Leon
<span title="2008-12-08">2008</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hs2remnzfbfmnf33cof2z4ajhi" style="color: black;">Annals of the New York Academy of Sciences</a> </i> &nbsp;
mitochondrial enzymes and in glucose metabolism in AD brain tissue.  ...  CMRglc reductions were observed on FDG-PET before the onset of disease in several groups of at-risk individuals, including patients with mild cognitive impairment (MCI), often a prodrome to AD; presymptomatic  ...  Rachel Mistur for her assistance in the preparation of the manuscript. This study was supported by NIH-NIA AG13616, AG12101, AG08051, AG022374, and the Alzheimer's Association.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1196/annals.1427.007">doi:10.1196/annals.1427.007</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19076441">pmid:19076441</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2661241/">pmcid:PMC2661241</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ayz6z5d34vh3ppigvcdtb2cpd4">fatcat:ayz6z5d34vh3ppigvcdtb2cpd4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200427231634/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2661241&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b1/1a/b11ac45c868e89bc3857f6080bbfe3bcccb18804.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1196/annals.1427.007"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661241" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders

Julia Gamache, Young Yun, Ornit Chiba-Falek
<span title="2020-08-01">2020</span> <i title="The Company of Biologists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s6p4bs5qazhcbhqumqmuipbqh4" style="color: black;">Disease Models &amp; Mechanisms</a> </i> &nbsp;
to identify major mechanistic themes underlying the exacerbation of LOAD-associated neurodegeneration and pathology in the female brain.  ...  In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained.  ...  Funding This work was funded in part by the National Institutes of Health/National Institute on Aging [R01-AG057522-01 and R01-AG040370-01A1 to O.C-F.].  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/dmm.045211">doi:10.1242/dmm.045211</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32859588">pmid:32859588</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hcb4webicrhkbaymfqdq5ms4ce">fatcat:hcb4webicrhkbaymfqdq5ms4ce</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200909104237/https://dmm.biologists.org/content/dmm/13/8/dmm045211.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ce/9b/ce9ba37a43aec3a8b57d552923de3f7aaa89b3ef.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1242/dmm.045211"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Longitudinal Effects of Metabolic Syndrome on Alzheimer and Vascular Related Brain Pathology

Feng Lin, Raymond Y. Lo, Daniel Cole, Simon Ducharme, Ding-Geng Chen, Mark Mapstone, Anton Porsteinsson
<span title="2014-06-28">2014</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fi5stx63jzhtzlhhd7wfw55sha" style="color: black;">Dementia and Geriatric Cognitive Disorders Extra</a> </i> &nbsp;
Confirmatory factor analysis was employed to determine a MetS latent composite score using baseline data of vascular risk factors.  ...  We examined the changes of two Alzheimer's disease (AD) biomarkers, namely [ 18 F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) regions of interest and medial temporal lobe volume over 5  ...  ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the Alzheimer's Association, Alzheimer's Drug  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000363285">doi:10.1159/000363285</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25337075">pmid:25337075</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4187257/">pmcid:PMC4187257</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zoauo52itvcspjhsrmgfjuy74q">fatcat:zoauo52itvcspjhsrmgfjuy74q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719073431/https://www.karger.com/Article/Pdf/363285" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/60/a0/60a06422f1c2b17dd53446a771e50737868b4d1e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000363285"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187257" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism

L. Mosconi, M. Brys, R. Switalski, R. Mistur, L. Glodzik, E. Pirraglia, W. Tsui, S. De Santi, M. J. de Leon
<span title="2007-11-14">2007</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects.  ...  This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.  ...  Institutes of Health/National Center for Research Resources Grant M01-RR0096; and by the Alzheimer's Association.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.0705036104">doi:10.1073/pnas.0705036104</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18003925">pmid:18003925</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2141909/">pmcid:PMC2141909</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3okxritud5fctfkplxzeoypqxe">fatcat:3okxritud5fctfkplxzeoypqxe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180726194920/http://www.pnas.org/content/pnas/104/48/19067.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/22/04/220419ca63b04e138102b6948ae25b2fa7ee9fcf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.0705036104"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141909" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Henrietta M. Nielsen, Kewei Chen, Wendy Lee, Yinghua Chen, Robert J. Bauer, Eric Reiman, Richard Caselli, Guojun Bu
<span title="2017-01-30">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mvbrssyf7fcebaalpjhndnvzqa" style="color: black;">Alzheimer&#39;s Research &amp; Therapy</a> </i> &nbsp;
Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer's disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently  ...  Whether low plasma apoE levels are associated with structural and functional brain measurements and cognitive performance remains to be investigated.  ...  Acknowledgements The authors wish to thank Dr Eduardo Martinez-Morillo at the Hospital Universitario Central de Asturias in Spain for critical input on the massspectrometric analysis of apoE isoforms in  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13195-016-0231-9">doi:10.1186/s13195-016-0231-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28137305">pmid:28137305</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5282900/">pmcid:PMC5282900</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/po2fxl53wvhgvhyxbwtftjdxke">fatcat:po2fxl53wvhgvhyxbwtftjdxke</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171008112846/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/06f/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvczEzMTk1LTAxNi0wMjMxLTkucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7d/fe/7dfeb9df8da340e99255b6412b805c1650e35d73.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13195-016-0231-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282900" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Page 1570 of Psychological Abstracts Vol. 83, Issue 4 [page]

<span title="">1996</span> <i title="American Psychological Association"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_psychological-abstracts" style="color: black;">Psychological Abstracts </a> </i> &nbsp;
(U Washington Medical Ctr, Div of Medical Genetics, Dept of Medicine, Seattle) Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer’s disease: A case-control  ...  These impairments are similar to those seen in patients with right hemisphere brain lesions or Parkinson’s dis- ease.  ... 
<span class="external-identifiers"> </span>
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An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer's Disease

Chantal Vidal, Li Zhang
<span title="2021-03-04">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3iichab3fbz7jq46o55l6trkq" style="color: black;">Cells</a> </i> &nbsp;
Several alterations have been implicated in driving this disease, including blood–brain barrier dysfunction, hypoxia, mitochondrial dysfunction, oxidative stress, glucose hypometabolism, and altered heme  ...  This review will discuss the most common neurological and molecular alterations associated with AD and point out the critical role heme plays in the development of this disease.  ...  Genetic Risk Factors Family history has shown to increase a person's chance of developing AD. There are various genetic risk factors associated with the development of AD.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells10030546">doi:10.3390/cells10030546</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33806317">pmid:33806317</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7998384/">pmcid:PMC7998384</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sxb2223axbehvdvsa7eqghz3lq">fatcat:sxb2223axbehvdvsa7eqghz3lq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429111609/https://res.mdpi.com/d_attachment/cells/cells-10-00546/article_deploy/cells-10-00546-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4f/8a/4f8a5bbd910c8187e46da6045682d197499db9a8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells10030546"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998384" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Alzheimer Disease as a Vascular Disorder: Nosological Evidence

J.C. de la Torre
<span title="2002-04-01">2002</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nt32gxt4mzgqjgkz2v37fxi6oe" style="color: black;">Stroke</a> </i> &nbsp;
of regional cerebral hypoperfusion with the use of neuroimaging techniques to preclinically identify AD candidates; (5) presence of regional brain microvascular abnormalities before cognitive and neurodegenerative  ...  According to elementary statistics, the probability or chance that all these findings are due to an indirect pathological effect or to coincidental circumstances related to the disease process of AD seems  ...  Acknowledgment This research was supported by an investigator-initiated research grant from the Alzheimer's Association.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/01.str.0000014421.15948.67">doi:10.1161/01.str.0000014421.15948.67</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11935076">pmid:11935076</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gsptsxtfcndsfdvgwau2cmpvia">fatcat:gsptsxtfcndsfdvgwau2cmpvia</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719083856/http://stroke.ahajournals.org/content/strokeaha/33/4/1152.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/68/78/687815568411ad9cf54e29f7f05ba21328f6de5e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/01.str.0000014421.15948.67"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers

G. Chételat, M. Fouquet
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d6is4ru4endw3ankuxyxhrxam4" style="color: black;">Revue neurologique (Paris)</a> </i> &nbsp;
The E4 allele of the apolipoprotein E (APOE4) is the major known genetic risk factor for AD, with a dramatic increase in the risk of developing AD as the number of APOE4 alleles increases from 0 to 2.  ...  As for FDG-PET metabolism, the few studies show decreased metabolism, again especially in AD-sensitive regions such as posterior associative parietal areas, with a dose-dependent effect (i.e. worsening  ...  For example, Bookheimer et al., (2000) reported an increase in both the magnitude and the extent of brain activation during memory-activation tasks in regions affected by Alzheimer's disease, including  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neurol.2013.07.025">doi:10.1016/j.neurol.2013.07.025</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24016463">pmid:24016463</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lv2yfqk6dzhbxmnvm64rz5udau">fatcat:lv2yfqk6dzhbxmnvm64rz5udau</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171203000141/http://www.hal.inserm.fr/inserm-00909398/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ad/b7/adb702af5c94c03d73a2ba63d105f4b159f11ba7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neurol.2013.07.025"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery

Lisa Mosconi, Valentina Berti, Crystal Guyara-Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S. Osorio, Christopher Connaughty, Alberto Pupi, Shankar Vallabhajosula, Richard S. Isaacson, Mony J. de Leon, Russell H. Swerdlow (+2 others)
<span title="2017-10-10">2017</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined.  ...  Biomarkers correlated with immediate and delayed memory scores (Pearson's 0.26 r 0.32, p 0.05).  ...  Present findings were independent of APOE genotype, a well-known genetic risk factor for late-onset AD [49] which associates with increased risk of AD in women more than in men [1, 50] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0185926">doi:10.1371/journal.pone.0185926</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29016679">pmid:29016679</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5634623/">pmcid:PMC5634623</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qvuadnmfyfdgnakyuuxv54nbhi">fatcat:qvuadnmfyfdgnakyuuxv54nbhi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722062218/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0185926&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/af/71/af7157a961edd38f22976e2d21a46498d66679de.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0185926"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634623" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages

Bryan J. Neth, Suzanne Craft
<span title="2017-10-31">2017</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xyafp6gbr5et3ghi4kqddnyolm" style="color: black;">Frontiers in Aging Neuroscience</a> </i> &nbsp;
Furthermore, various genetic studies including genome-wide association studies (GWAS) have identified several genes involved with lipid and cholesterol metabolism as increasing risk for AD.  ...  in cholesterol and beta-amyloid peptide (Aβ) homeostasis (Genin et al., 2011; Karch et al., 2012; Alzheimer's Association, 2015) .  ...  The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2017.00345">doi:10.3389/fnagi.2017.00345</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29163128">pmid:29163128</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5671587/">pmcid:PMC5671587</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/72p5bu2jmfdzjgzxthydny4fpq">fatcat:72p5bu2jmfdzjgzxthydny4fpq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228145839/http://pdfs.semanticscholar.org/a4d8/fd93b78690f16519a2393619d8fd4e87cb75.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a4/d8/a4d8fd93b78690f16519a2393619d8fd4e87cb75.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnagi.2017.00345"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671587" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Dissection of prodromal Alzheimer rsquo s disease

Ying Han
<span title="">2018</span> <i title="Frontiers in Bioscience"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mfwufqll45bepinkdxuteuecia" style="color: black;">Frontiers in Bioscience</a> </i> &nbsp;
The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive  ...  To identify individuals with high risk of conversion to AD and apply the research concept of prodromal AD into clinical practice, the utility of various biomarkers for distinguishing prodromal AD is evaluated  ...  Additionally, hypometabolism in posterior cingulate, combined with Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) Total Mod and Mini-Mental State Exam (MMSE) scores could improve the progressive  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/4643">doi:10.2741/4643</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28930599">pmid:28930599</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5yzeruxgl5evpi2buq4qxmezru">fatcat:5yzeruxgl5evpi2buq4qxmezru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190303192826/http://pdfs.semanticscholar.org/ba97/e49258bb56064f56adf396684da57844511f.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ba/97/ba97e49258bb56064f56adf396684da57844511f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2741/4643"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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