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Hsien-Li Kao, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan Predictors for Successful CAO Recanalization S E P T E M B E R 1 2 , 2 0 1 6 : 1 8 2 5 -3 2 CONCLUSIONS ...doi:10.1016/j.jcin.2016.06.015 pmid:27609258 fatcat:lexjsycq75ffzbzxr3kttpkd4q
In order to facilitate public health response and to achieve early control of infectious disease epidemics, an adjustable epidemiologic information system (AEIS) was established in the Taiwan public health network in February 2006. Methodology/Principal Findings: The performance of AEIS for the period 2006 through 2008 was evaluated based on a number of response times (RT) and the public health impact. After implementation of the system, the apparent overall shortened RT was mainly due to thedoi:10.1371/journal.pone.0014596 pmid:21298043 pmcid:PMC3029279 fatcat:skzddzn2afcszj23fe7sew6yva
more »... ortening of personnel response time (PRT) and the time needed to draft a new questionnaire that incurred as personnel-system interface (PSI); PRT dropped from a fluctuating range of 9.8 ,28.8 days in the first four months to ,10 days in the following months and remained low till 2008 (0.8861.52 days). The PSIs for newly emerged infectious diseases were 2.6 and 3.4 person-hours for H5N1 in 2007 and chikungunya in 2008, respectively, a much improvement from 1142.5 person-hours for SARS in 2003. The duration of each rubella epidemic cluster was evaluated as public health impact and showed a shortening trend (p = 0.019) that concurred with the shortening of PRT from 64.8647.3 to 25.2638.2 hours per cluster (p,0.0001). Conclusions/Significance: The first evaluation of the novel instrument AEIS that had been used to assist Taiwan's multilevel government for infectious diseases control demonstrated that it was well integrated into the existing public health infrastructure. It provided flexible tools and computer algorithms with friendly interface for timely data collection, integration, and analysis; as a result, it shortened RTs, filled in gaps of personnel lacking sufficient experiences, created a more efficient flow of response, and identified asymptomatic/mild cases early to minimize further spreading. With further development, AEIS is anticipated to be useful in the application of other acute public health events needing immediate orchestrated data collection and public health actions.
Conventional mesa isolation process in AlGaAs/In-GaAs heterostructure FETs results in the gate contacting the exposed highly doped region at the mesa sidewalls, forming a parasitic gate leakage path. In this letter, we suppress the gate leakage from the mesa-sidewall and enhance microwave power performance by performing additional second mesa etching. The device gate leakage characteristics under high-input power swing are particularly investigated to reveal the improvement of device linearity,doi:10.1109/55.974793 fatcat:5yttatid2re2lb3njdksip3foi
more »... which is sensitive to the sidewall gate leakage. This modified device (M-HFETs) provides not only a higher linear rf output power but also a lower IM3 product than those characteristics in conventional HFETs. Index Terms-Air-bridge gate, DCFET, leakage, power performance.
High-power and high-efficiency GaAs heterostructure field-effect transistors (FETs) are attracting tremendous attention in RF power amplifier applications. However, thermal effects can be an important issue in RF power devices, owing to the huge amount of heat generated during their operation. In this paper, the temperature-dependent characteristics of Al 0 3 Ga 0 7 As/In 0 15 Ga 0 85 As doped-channel FETs (DCFETs) are investigated and compared with conventional pseudomorphic-HEMTs (pHEMTs)doi:10.1109/16.954456 fatcat:7ie557biwrgjtm6jznm3azuoyy
more »... ces, in terms of their dc, microwave and RF power performance at temperatures ranging from room temperature to 150 C. Due to conducting carriers being less influenced by temperature and the better Schottky diode characteristics that can be obtained in DCFETs, the intrinsic device parameters and output performance remain almost constant at high temperatures, which also results in better device reliability. The performance variation of DCFETs associated with temperatures from 25 C to 150 C all fall within a single digit, i.e., output power ( out , 16.2 dBm versus 15.8 dBm), power gain ( , 16.6 dB versus 15.1 dB), power added efficiency (PAE, 34.2% versus 31.3%), which is not the case for conventional pHEMTs. Therefore, DC devices are very promising for microwave power device applications operating at high temperature.
Chiu, D.D.-S. Jiang); National Taiwan University College of Medicine, Taipei (C.-C. Hung); Department of Health, Taipei (C.-S. Lai); Gifu University Graduate School of Medicine, Gifu, Japan (Z. ...doi:10.3201/eid1512.090619 pmid:19961701 pmcid:PMC3044530 fatcat:cgppnl4kfvajngztfjcigotpp4
et al. 25 Muscle fatigue task Muscular endurance was measured by the muscle fatigue task as previously described by Chiu et al. 25 Briefly, the mice were accommodated to training prior to the fatigue ... Valley, PA, USA) into monolateral soleus muscles under inhalational anaesthesia with a mixture gas of isoflurane (3%) (Baxter Healthcare of Puerto Rico, Guayama, PR, USA) and oxygen (97%) as described by Chiu ... Conflict of interest Hsien-Chun Chiu, Chen-Yuan Chiu, Rong-Sen Yang, Ding-Cheng Chan, Shing-Hwa Liu, and Chih-Kang Chiang stated that they have no conflict of interest. ...doi:10.1002/jcsm.12289 pmid:29512306 pmcid:PMC5989760 fatcat:t23xof5oxvfmrh4ifuckxslpti
It has been shown that imprecise cleavage of a primary or precursor RNA by Drosha or Dicer, respectively, may yield a group of microRNA (miRNA) variants designated as "isomiR". Variations in the relative abundance of isoforms for a given miRNA among different species and different cell types beg the question whether these isomiRs might regulate target genes differentially. We compared the capacity of three miR-31 isoforms (miR-31-H, miR-31-P, and miR-31-M), which differ only slightly in theirdoi:10.1371/journal.pone.0058169 pmid:23472152 pmcid:PMC3589381 fatcat:6jngxmq2izdslg2wehbpborlty
more »... -and/or 39-end sequences, to regulate several known targets and a predicted target, Dicer. Notably, we found isomiR-31s displayed concordant and discordant regulation of 6 known target genes. Furthermore, we validated a predicted target gene, Dicer, to be a novel target of miR-31 but only miR-31-P could directly repress Dicer expression in both MCF-7 breast cancer cells and A549 lung cancer cells, resulting in their enhanced sensitivity to cisplatin, a known attribute of Dicer knockdown. This was further supported by reporter assay using full length 39-untranslated region (UTR) of Dicer. Our findings not only revealed Dicer to be a direct target of miR-31, but also demonstrated that isomiRs displayed similar and disparate regulation of target genes in cell-based systems. Coupled with the variations in the distribution of isomiRs among different cells or conditions, our findings support the possibility of fine-tuning gene expression by miRNAs.
Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, especially when subclinical cases are more likely to be present in the early stages. Little is known of the infection and transmissibility of the 2009 H1N1 pandemic influenza (pH1N1) virus outside of Mexico prior to clinical cases being reported, and of the knowledge pertaining to immunity and incidence of infection during April-June, which is essential for understanding thedoi:10.1371/journal.pone.0014555 pmid:21267441 pmcid:PMC3022590 fatcat:qaw4nzrru5bmzj4w6dw32mbtve
more »... ture of viral transmissibility as well as for planning surveillance and intervention of future pandemics. Methodology/Principal Findings: Starting in the fall of 2008, 306 persons from households with schoolchildren in central Taiwan were followed sequentially and serum samples were taken in three sampling periods for haemagglutination inhibition (HI) assay. Age-specific incidence rates were calculated based on seroconversion of antibodies to the pH1N1 virus with an HI titre of 1:40 or more during two periods: April-June and September-October in 2009. The earliest time period with HI titer greater than 40, as well as a four-fold increase of the neutralization titer, was during April 26-May 3. The incidence rates during the pre-epidemic phase (April-June) and the first wave (July-October) of the pandemic were 14.1% and 29.7%, respectively. The transmissibility of the pH1N1 virus during the early phase of the epidemic, as measured by the effective reproductive number R 0 , was 1.16 (95% confidence interval (CI): 0.98-1.34). Conclusions: Approximately one in every ten persons was infected with the 2009 pH1N1 virus during the pre-epidemic phase in April-June. The lack of age-pattern in seropositivity is unexpected, perhaps highlighting the importance of children as asymptomatic transmitters of influenza in households. Although without virological confirmation, our data raise the question of whether there was substantial pH1N1 transmission in Taiwan before June, when clinical cases were first detected by the surveillance network.
Acute mountain sickness (AMS) is commonly found among people traveling above 2500 m. We investigated whether the occurrence of AMS is related to differences in individual physical fitness and BMI in subjects 11-13 years of age. Methods: This study was conducted at Xue Mountain, Taiwan (elevation of 3886 m) between June 13, 2011 and June 17, 2011. Subjects were asked to ascend from Taipei City (25 m) to the summit (3886 m) over 3 days and 2 nights. Gender, age, weight, height, and fitness indexdoi:10.1186/s12887-015-0373-0 pmid:25947200 pmcid:PMC4493965 fatcat:uz7nma537rglncf66vkkv74lfm
more »... determined using a 3-minute step test) were recorded at sea level before ascent. The Lake Louise AMS score was used to record symptoms and diagnose AMS. Results: A total of 179 subjects (mean age: 11.8 years; 102 males, 77 females) were included in the analysis. A total of 44.7% of subjects were diagnosed with AMS. Male gender (p = 0.004) and elevated body mass index (BMI) (p < 0.001) were each associated with the development of AMS. However the physical fitness index was comparable in subjects with and without AMS (67.8 ± 10.1 vs. 68.0 ± 9.3, p = 0.9). Conclusions: This study shows that both BMI and male gender were associated with the development of AMS in 11-13 year old children. Physical fitness was not associated with the occurrence of AMS.
The repeated administration of methamphetamine (MA) to animals in a single-day 'binge' dosing regimen produces damage to dopamine and serotonin terminals and psychosis-like behaviours similar to those observed in MA abusers. The present study aimed to examine the effects of MA binge exposure on 5-HT 2A receptors, the subtype of serotonin receptors putatively involved in psychosis. ICR male mice were treated with MA (4 × 5 mg/kg) or saline at 2 h intervals. Recognition memory and socialdoi:10.1017/s1461145714000455 pmid:24763081 fatcat:oaqrtozgxbgqrhc2qnk4rrj7qm
more »... s were sequentially evaluated by a novel location recognition test, a novel object recognition test, a social interaction and a nest-building test to confirm the persistent cognitive and behavioural impairments after this dosing regimen. Subsequently, a hallucinogenic 5-HT 2A/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI)-induced head-twitch, molecular and electrophysiological responses were monitored. Finally, the levels of 5-HT 2C , 5-HT 1A , 5-HT 2A and mGlu2 receptors in the medial prefrontal cortex were determined. MA binge exposure produced recognition memory impairment, reduced social behaviours, and increased DOI-induced head-twitch response, c-Fos and Egr-2 expression and field potentials in the medial prefrontal cortex. Furthermore, MA binge exposure increased 5-HT 2A and decreased mGlu2 receptor expression in the medial frontal cortex, whereas 5-HT 2C and 5-HT 1A receptors were unaffected. These data reveal that the increased behavioural, molecular and electrophysiological responses to DOI might be associated with an up-regulation of 5-HT 2A receptors in the medial prefrontal cortex after MA binge exposure. Identifying the biochemical alterations that parallel the behavioural changes in a mouse model of MA binge exposure may facilitate targeting therapies for treatment of MA-related psychiatric disorders.
REPORT Evolution of Human Herpesvirus Type 8-associated Gastric Kaposi's Sarcoma Following Corticosteroid Treatment for Asthma Cheng-Chuan Su,* Jang-Jih Lu, 1 Cherng-Lih Perng, 1 Fu-Tien Yu, 2 Chan-Hsien ... Chiu 3 ©2006 Elsevier & Formosan Medical Association only within the vascular spaces but also within the clefts between the spindle cells. ...doi:10.1016/s0929-6646(09)60337-5 pmid:16477336 fatcat:5xyv5gabyvcsjdi3kbam2queqq
doi:10.1016/j.ijid.2011.05.012 pmid:21767970 fatcat:3snjtjwtnfcxbbjvvt6es4dipq
Ya-Ting Chang, Chi-Ren Huang, and Cheng-Hsien Lu contributed equally to this work. ...doi:10.1155/2014/902492 pmid:24822219 pmcid:PMC4005097 fatcat:m7hojs2mxvbypofocprltq27l4
Heavy metals, the common pollutants emitted from industrial activities, are believed to cause harmful effects, partially through the mechanism of elevated oxidative stress, and antioxidant intake has been hypothesized to provide a potential protective effect against oxidative stress. This study aims to investigate the heavy metal exposure and the associated oxidative damage of young children living near a petrochemical complex and to assess the protective effect of antioxidant intake. Theredoi:10.3390/ijerph17113920 pmid:32492875 pmcid:PMC7312654 fatcat:7bsmcsdqbnhapi27kkj3i7qlbi
more »... 168 children recruited from the kindergartens near a huge petrochemical complex, with 87 as the high exposure group and 81 as the low exposure group. Urinary concentrations of eleven metals were detected by inductively coupled plasma mass spectrometry, and four biomarkers of oxidative stress were measured in urine by liquid chromatography-tandem mass spectrometry. The food frequency questionnaire was collected to assess participants' intake of antioxidants. Multiple linear regression was performed to determine the predictors of metals for oxidative stress and to measure the beneficial effect of antioxidants. Weighted quantile sum regression was performed to determine the contributors among metals to the oxidative stress. Results showed that high exposure group had significantly higher concentrations of chromium, manganese, nickel, arsenic, strontium, cadmium, and lead when compared to those in low exposure group. There was no obviously difference on the total antioxidant intake and dietary profile between two groups. The elevated levels of two oxidative stress markers were significantly associated with most of the urinary metal concentrations in all study subjects after adjusting confounders, while no significant association was found between oxidative stress and antioxidant intake. Among the metals, mercury and strontium showed the dominated contributions for elevated levels of oxidative stress. It concluded that higher metal exposure was associated with elevated oxidative stress but with no protective effect by antioxidant intake among the young children residents near a petrochemical industry.
Palmyra palm syrup, produced from Borassus flabellifer flowers' sap, is rich in nutrients and minerals and has unique flavors. This study evaluated the in vitro antioxidant activity, physicochemical characteristics, and Maillard reaction products of palmyra palm syrup prepared by thermal and ultrafiltration processes. Palmyra palm syrup prepared by a thermal process had smaller L*, b* values, and larger a* values than that prepared by an ultrafiltration process. Palmyra palm syrup contained 10doi:10.3390/biology10101028 pmid:34681127 fatcat:r7b4wgzbwveelib34on47tzyiu
more »... itamins, the most abundant being vitamin E. Overall, 38 volatile compounds were found and classified into six groups in the order of alcohols > acids > ketones > sulfurs > pyrazines > phenols and aldehyde. Volatile compounds depended on concentration, temperature, and ultrafiltration process. Protein content decreased because of participation in the Maillard reaction and increased 5-hydroxymethylfurfural (HMF) and total phenolic content. The HMF content was very low (0.02–14.95 mg/100 g). The radical scavenging activity of 2,2-diphenyl-1-1 picrylhydrazyl and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) in palmyra palm syrup with thermal process was higher than with ultrafiltration. This study established that ultrafiltration pretreatment of palmyra palm syrup generated a good appearance and reduced the HMF content, however, it negatively affected the volatile compounds and physicochemical characteristics.
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