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Chiroptical Properties and Conformation of Four Lasiocepsin-Related Antimicrobial Peptides: Structural Role of Disulfide Bridges

Markéta Pazderková, Václav Profant, Petr Maloň, Rina K. Dukor, Václav Čeřovský, Vladimír Baumruk, Lucie Bednárová
2020 Symmetry  
We report an investigation of the role of disulfide bridges in the 27-residue antimicrobial peptide lasiocepsin (I) containing two disulfide groups (Cys8–Cys25, Cys17–Cys27) and three its analogs lacking  ...  Selective alternate incorporation of one or both disulfide bridges influences symmetry, conformation and biological properties of these peptides as demonstrated in their chiroptical (particularly Raman  ...  Acknowledgments: We thank Zuzana Flegelová (Spyder s.r.o.) for the custom peptide synthesis. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/sym12050812 fatcat:jcrk56m4a5gizb5ybipr4whxpu