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Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics

Ju-Chuan Hu, Chia-Yen Lin, Shian-Shiang Wang, Kun-Yuan Chiu, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Cheng-Kuang Yang, Yen-Chuan Ou, Chen-Li Cheng, Shun-Fa Yang
2020 Diagnostics  
Active surveillance is the preferred strategy for very low risk, low risk, and some favorable intermediate risk of prostate cancer. However, the current risk stratifications with initial prostate-specific antigen (iPSA) levels and Gleason scores at biopsy can underestimate the true oncologic threat. More precise predictors are required to avoid the overtreatment of prostate cancer. H19 single-nucleotide polymorphisms (SNPs) have been found to play crucial roles in numerous malignancies, but not
more » ... yet in prostate cancer. This study assessed the clinicopathologic effects of H19 SNPs on prostate cancer to identify potential active surveillance candidates. A total of 579 patients with prostate cancer who underwent robot-assisted radical prostatectomy between 2012 and 2017 were recruited. The patients were grouped by iPSA levels, and five H19 SNPs were evaluated. Our results show that patients with an iPSA level of ≤7 ng/mL had increased an likelihood of having Gleason score and group grade upgrades after radical prostatectomy compared with patients with an iPSA level of >7 ng/mL. Moreover, patients with loci polymorphisms in either rs3024270 or rs3741219 had a significantly higher risk of perineural invasion (rs3024270: Odds ratio (OR) 2.76, 95% confidence interval (CI) 1.30–5.87, p = 0.01; rs3741219: OR 2.30, 95% CI 1.17–4.54, p = 0.018). In conclusion, our results suggested that H19 SNPs play a role in the perineural invasion of prostate cancer.
doi:10.3390/diagnostics10090656 pmid:32878251 fatcat:urkpqtmuz5hfpk64dlnqdy7p6e

Zigbee Wireless Sensor Nodes With Hybrid Energy Storage System Based On Li-Ion Battery And Solar Energy Supply

Chia-Chi Chang, Chuan-Bi Lin, Chia-Min Chan
2014 Zenodo  
The storage unit consists of a rechargeable 1200 mAh Li-ion battery and a battery charger using a constant-current/constant-voltage algorithm. Our solution to extend node lifetime is implemented.  ...  Battery and SolarEnergy Supply Chia-Chi Chang, Chuan-Bi Lin, Chia-Min Chan W World Academy of Science, Engineering and Technology International Journal of Industrial and Manufacturing Engineering  ...  Chia-Chi Chang and Chuan-Bi Lin are with the Department of Information and Communication Engineering, Chaoyang University of Technology, Taichung, Taiwan (e-mail:,  ... 
doi:10.5281/zenodo.1092586 fatcat:cqzqr6xsdrh6dhasyzocndq42u

Associations between LncRNA MALAT1 Polymorphisms and Lymph Node Metastasis in Prostate Cancer

Ju-Chuan Hu, Shian-Shiang Wang, Ying-Erh Chou, Kun-Yuan Chiu, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Cheng-Kuang Yang, Yen-Chuan Ou, Chen-Li Cheng, Chia-Yen Lin, Shun-Fa Yang
2021 Diagnostics  
Current evidence elucidates that long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) could regulate genetic expression and play a crucial role in both the diagnosis and prognosis of prostate cancer. Single-nucleotide polymorphisms (SNPs) of MALAT1 could alter the oncogenesis in various cancers. However, the associations between MALAT1 SNPs and prostate cancer have barely been investigated to date. This study included 579 patients with prostate cancer who received
more » ... obotic-assisted radical prostatectomy at Taichung Veterans General Hospital from 2012 to 2017. Three SNPs of MALAT1 were analyzed to identify the impacts of SNPs on the clinicopathologic features in Taiwanese prostate cancer. Our results show that patients with a polymorphic G allele at rs619586 had a significantly higher risk of being in an advanced Gleason grade group (AOR: 1.764; 95% CI: 1.011–3.077; p = 0.046). Moreover, individuals with at least one polymorphic A allele at MALAT1 rs1194338 in the PSA >10 ng/mL group were positively associated with node-positive prostate cancer. In conclusion, MALAT1 SNPs are significantly associated with the susceptibility to both advanced Gleason grade and nodal metastasis in prostate cancer. The presence of MALAT1 SNPs rs619586 and rs1194338 seems to enhance oncogenesis in prostate cancer.
doi:10.3390/diagnostics11091692 pmid:34574033 fatcat:kdqhjzg7obfcfkly3x43qjcnyu

Synthesis of Apolipoprotein B Lipoparticles to Deliver Hydrophobic/Amphiphilic Materials

Hsueh-Liang Chu, Tsai-Mu Cheng, Hung-Wei Chen, Fu-Hsuan Chou, Yu-Chuan Chang, Hsin-Yu Lin, Shih-Yi Liu, Yu-Chuan Liang, Ming-Hua Hsu, Dian-Shyeu Wu, Hsing-Yuan Li, Li-Ping Ho (+8 others)
2013 ACS Applied Materials and Interfaces  
.; Li, H.; Glickson, J. D. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 17757−17762. (7) Segrest, J. P.; Jones, M. K.; De Loof, H.; Dashti, N. J. Lipid Res. 2001, 42, 1346−1367.  ... 
doi:10.1021/am401808e pmid:23834261 pmcid:PMC3744920 fatcat:2nanxpkkg5alheqxbsznd5gxuu

Proactive Identification Of False Alert For Drug-Drug Interaction

Hsuan-Chia Yang, Yan-Jhih Haung, Yu-Chuan Li
2010 Zenodo  
Proactive Identification of False Alert for Drug-Drug Interaction Hsuan-Chia Yang, Yan-Jhih Haung, Yu-Chuan Li International Scholarly and Scientific Research & Innovation 4(8) 2010  ...  Yan-Jhih Haung. is with the institute of Biomedical Informatics, National Yang-Ming University, Address: No. 155, Sec. 2, Linong St., Beitou District, Taipei City 112, Taiwan Yu-Chuan Li is with the institute  ... 
doi:10.5281/zenodo.1328316 fatcat:yangcurj4bg5ncjcgizmdw5sjq

Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold

Chia-Yu Fan, Chuan-Chuan Huang, Wei-Chun Chiu, Chun-Chieh Lai, Gunn-Guang Liou, Hsiu-Chuan Li, Min-Yuan Chou
2008 The FASEB Journal  
A class of multivalent protein binders was designed to overcome the limitations of low-affinity therapeutic antibodies. These binders, termed "collabodies," use a triplex-forming collagen-like peptide to drive the trimerization of a heterologous target-binding domain. Different forms of collabody, consisting of the human single-chain variable fragment (scFv) fused to either the N or C terminus of the collagen-like peptide scaffold (Gly-Pro-Pro) 10 , were stably expressed as soluble secretory
more » ... teins in mammalian cells. The collabody consisting of scFv fused to the N terminus of collagen scaffold is present as a homotrimer, whereas it exhibited a mixture of trimer and interchain disulfidebonded hexamer when cysteine residues were introduced and flanked the scaffold. The collagenous motif in collabody is prolyl-hydroxylated, with remarkable thermal and serum stabilities. The collabody erb_scFv-Col bound to the extracellular domain of epidermal growth factor receptor with a binding strength ϳ20and 1000-fold stronger than the bivalent and monovalent counterparts, respectively. The trimeric collagen scaffold does not compromise the functionality of the binding moieties of parental immunoglobulin G (IgG); therefore, it could be applied to fuse other protein molecules to acquire significantly improved targetingbinding strengths.
doi:10.1096/fj.08-111484 pmid:18635738 fatcat:yu2sd5jxczhq5aodstq4cq5x4q

Portal venous velocity affects liver regeneration after right lobe living donor hepatectomy

Chen-Tai Hou, Yao-Li Chen, Chia-Cheng Lin, Chen-Te Chou, Kuo-Hua Lin, Ping-Yi Lin, Ya-Lan Hsu, Chia-Bang Chen, Hui-Chuan Lin, Chih-Jan Ko, Su-Han Wang, Li-Chueh Weng (+2 others)
2018 PLoS ONE  
Author Contributions Conceptualization: Chen-Tai Hou, Yao-Li Chen, Chia-En Hsieh. Data curation: Ya-Lan Hsu, Chia-Bang Chen, Hui-Chuan Lin.  ...  Writing -review & editing: Chia-Cheng Lin, Li-Chueh Weng, Chia-En Hsieh.  ... 
doi:10.1371/journal.pone.0204163 pmid:30222781 pmcid:PMC6141071 fatcat:aktzi3hlrnhg5bmqgziodv7uea

Clinical outcomes in castration resistant prostate cancer patients treated with docetaxel

Shian-Shiang Wang, Yen-Chuan Ou, Chen-Li Cheng, Hao-Chung Ho, Kun-Yuan Chiu, Chuan-Shu Chen, Jian-Ri Li, Cheng-Kuang Yang, Cheng-Che Chen, Chia-Yen Lin
2016 Urological Science  
doi:10.1016/j.urols.2016.05.069 fatcat:e3s33i5ikfhuxigjapxlu5cpv4

Atrial Fibrillation and Coronary Artery Disease as Risk Factors of Retinal Artery Occlusion: A Nationwide Population-Based Study

Ju-Chuan Yen, Hsiu-Li Lin, Chia-An Hsu, Yu-Chuan (Jack) Li, Min-Huei Hsu
2015 BioMed Research International  
We use Taiwanese national health insurance research database (NHIRD) to investigate whether thrombolism (carotid artery disease (CAD) as a surrogate) or embolism (atrial fibrillation (AF) as a surrogate) plays roles in later retinal artery occlusion (RAO) development and examine their relative weights. The relative risks of RAO between AF and CAD patients and controls were compared by estimating the crude hazard ratio with logistic regression. Kaplan-Meier analysis was used to calculate the
more » ... lative incidence rates of developing RAO, and a log-rank test was used to analyze the differences between the survival curves. Separate Cox proportional hazard regressions were done to compute the RAO-free rate after adjusting for possible confounding factors such as age and sex. The crude hazard ratios were 7.98 for the AF group and 5.27 for the CAD group, and the adjusted hazard ratios were 8.32 and 5.34 for the AF and CAD groups, respectively. The observation time with RAO-free was shorter for AF compared with CAD group (1490 versus 1819 days). AF and CAD were both risk factors for RAO with different hazard ratios. To tackle both AF and CAD is crucial for curbing RAO.
doi:10.1155/2015/374616 pmid:26558268 pmcid:PMC4628970 fatcat:ryqfounjcbfzrdahwe6n7hgply

Leptospirosis and Peripheral Artery Occlusive Disease

Chun-Hsiang Chiu, Cheng-Li Lin, Feng-You Lee, Ying-Chuan Wang, Chia-Hung Kao
2016 Medicine  
Data on the association between peripheral artery occlusive disease (PAOD) and leptospirosis are limited. We conducted a retrospective cohort study for determining whether leptospirosis is one of the possible risk factors for PAOD. Patients diagnosed with leptospirosis by using 2000 to 2010 data from the Taiwan National Health Insurance Research Database. Patients with leptospirosis without a history of PAOD were selected. For each leptospirosis patient, 4 controls without a history of
more » ... osis and PAOD were randomly selected and frequency-matched for sex, age, the year of the index date, and comorbidity diseases. The follow-up period was from the time of the initial diagnosis of leptospirosis to the diagnosis date of PAOD, or December 31, 2011. The Cox proportional hazard regression models were used for analyzing the risk of PAOD. During the follow-up period, the cumulative incidence of PAOD was higher among the patients from the leptospirosis cohort than among the nonleptospirosis cohort (log-rank test, P < 0.001). In total, 29 patients with PAOD from the leptospirosis cohort and 81 from the nonleptospirosis cohort were observed with the incidence rates of 2.1 and 1.3 per 1000 person-years, respectively, yielding a crude hazards ratio (HR) of 1.62 (95% confidence interval [CI] ¼ 1.44-1.81) and adjusted HR (aHR) of 1.75 (95% CI ¼ 1.58-1.95). The risk of PAOD was 1.75-fold higher in the patients with leptospirosis than in the general population. (Medicine 95(11):e3127) Abbreviations: aHR = adjusted hazard ratio,
doi:10.1097/md.0000000000003127 pmid:26986166 pmcid:PMC4839947 fatcat:5z3t4eudxnch5czzycig4gcrhm

Contemporary trends in robot-assisted laparoscopic partial nephrectomy in Taiwanese patients

Chia-yen Lin, Cheng-kuang Yang, Yen-chuan Ou, Kun-yuan Chiu, Chen-li Cheng, Hao-chung Ho, Chung-kuang Su, Shian-shiang Wang, Chuan-shu Chen, Jian-ri Li, Chi-feng Hung, Cheng-che Chen
2015 Urological Science  
Su, Shian-shiang Wang, Chuan-shu Chen, Jian-ri Li, Chi-feng Hung, Cheng-che Chen.  ...  NDP053: CONTEMPORARY TRENDS IN ROBOT-ASSISTED LAPAROSCOPIC PARTIAL NEPHRECTOMY IN TAIWANESE PATIENTS Chia-yen Lin, Cheng-kuang Yang, Yen-chuan Ou * , Kun-yuan Chiu, Chen-li Cheng, Hao-chung Ho, Chung-kuang  ... 
doi:10.1016/j.urols.2015.06.086 fatcat:lbyrxadu75czbahqscjjxwwbmy

Antidepressants and Valvular Heart Disease

Chia-Hui Lin, Fei-Yuan Hsiao, Yen-Bin Liu, Susan Shur-Fen Gau, Chi-Chuan Wang, Li-Jiuan Shen
2016 Medicine  
Empirical evidence regarding the association between antidepressants and valvular heart disease (VHD) is scarce. Using Taiwan's National Health Insurance Research database, this nested case-control study assessed the association between antidepressants and VHD in a Chinese population. Among a cohort of patients who used at least 3 prescription antidepressants, 874 cases with VHD and 3496 matched controls (1:4 ratio) were identified. Conditional logistic regression models were used to examine
more » ... timing, duration, dose and type of antidepressants use, and the risk of VHD. Current use of antidepressants was associated with a 1.4-fold increase in the risk of VHD (adjusted odds ratio [aOR] 1.44; 95% confidence interval [CI] 1.17-1.77). Among current users, a doseresponse association was observed in terms of the cumulative duration and the cumulative antidepressant dose. Significantly higher risks of VHD were observed among the current users of tricyclic antidepressants (aOR 1.40 [1.05-1.87]). We found that the use of antidepressants was associated with a greater risk of VHD and that the risks varied according to different antidepressants. (Medicine 95(14):e3172) Abbreviations: AOR = adjusted odds ratio, CI = confidence interval, DDD = defined daily dose, ICD-9-CM = International Classification of Disease-Ninth edition-Clinical Modification, LHID = Longitudinal Health Insurance Database, NHI = National Health Insurance, NHIRD = National Health Insurance Research Database, SNRIs = serotonin-norepinephrine reuptake inhibitors, SSRIs = selective serotonin reuptake inhibitors, TCAs = tricyclic antidepressants, VHD = valvular heart disease. Editor: Leonardo Roever.
doi:10.1097/md.0000000000003172 pmid:27057841 pmcid:PMC4998757 fatcat:fej4rhaurrbq7c2z5v57zyc3ka

Propranolol Reduces Cancer Risk

Ping-Ying Chang, Wen-Yen Huang, Cheng-Li Lin, Tzu-Chuan Huang, Yi-Ying Wu, Jia-Hong Chen, Chia-Hung Kao
2015 Medicine  
b-Blockers have been reported to exhibit potential anticancer effects in cancer cell lines and animal models. However, clinical studies have yielded inconsistent results regarding cancer outcomes and cancer risk when b-blockers were used. This study investigated the association between propranolol and cancer risk. A propranolol cohort (propranolol usage >6 months) and nonpropranolol cohort were matched using a propensity score. Cox proportional hazard models were used to estimate the hazard
more » ... o (HR) and 95% confidence intervals (CIs) of cancer associated with propranolol treatment. The study sample comprised 24,238 patients. After a 12-year follow-up period, the cumulative incidence for developing cancer was low in the propranolol cohort (HR: 0.75; 95% CI: 0.67-0.85; P < 0.001). Patients with propranolol treatment exhibited significantly lower risks of cancers in head and neck (HR: 0.58; 95% CI: 0.35-0.95), esophagus (HR: 0.35; 95% CI: 0.13-0.96), stomach (HR: 0.54; 95% CI: 0.30-0.98), colon (HR: 0.68; 95% CI: 0.49-0.93), and prostate cancers (HR: 0.52; 95% CI: 0.33-0.83). The protective effect of propranolol for head and neck, stomach, colon, and prostate cancers was most substantial when exposure duration exceeded 1000 days. This study supports the proposition that propranolol can reduce the risk of head and neck, esophagus, stomach, colon, and prostate cancers. Further prospective study is necessary to confirm these findings. (Medicine 94 (27):e1097) Abbreviations: CI = confidence interval, b-AR = b-adrenergic receptor, NHI = the National Health Insurance, HR = hazard ratio,
doi:10.1097/md.0000000000001097 pmid:26166098 pmcid:PMC4504645 fatcat:ce4mtvjidjgg7pb4rgaqumwx7y

Docetaxel Rechallenge Improves Survival in Patients With Metastatic Castration-resistant Prostate Cancer: A Retrospective Study

2021 In Vivo  
Docetaxel has been widely used in metastatic Castration-resistant Prostate Cancer (mCRPC) patients for decades. The purpose of the study was to evaluate the efficacy of docetaxel rechallenge in patients with mCRPC. We retrospectively compared patients who had received either first-line docetaxel and rechallenge after Androgen Receptor-axis Targeted therapies (ARAT), to those without rechallenge docetaxel. Multivariate cox-regression analysis was used to evaluate survival. Out of the 204
more » ... with mCRPC enrolled in the study, 24 patients received docetaxel rechallenge and 180 did not. The median overall survival was 50.11 months in the rechallenge group, as compared to 26.36 months in the non-rechallenge group (p of log rank=0.044). In the multivariate model, doxetaxel rechallenge was an independent risk factor for overall survival [hazard ratio (HR)=0.59, 95% confidence interval (CI)=0.32-0.99], together with the performance status score 2 (HR=2.46, 95%CI=1.32-4.58), hormone-sensitive state duration (HR=0.99, 95%CI=0.99-0.999), liver (HR=1.90, 95%CI=1.04-3.47) and brain metastases (HR=2.23, 95%CI=1.26-5.46). The advantage of rechallenge was addressed in the androgen receptor-axis-targeted (ARAT) non-responsive patients (HR=0.36, 95%CI=0.17-0.78). Adverse events were at 29.17% with Grade 3/4 neutropenia and at 20.83% with Grade 1/2 neutropenia in the docetaxel rechallenge group. The docetaxel rechallenge improved survival in patients with mCRPC failure of first-line docetaxel and subsequent abiraterone acetate or enzalutamide. Independent predictive factors for overall survival included i) the performance status, ii) hormone-sensitive state duration, iii) liver and iv) brain metastases. Patients non-responsive to ARATs will benefit from docetaxel rechallenge with regards to overall survival.
doi:10.21873/invivo.12653 pmid:34697189 pmcid:PMC8627717 fatcat:get2wvsucba3bb6lt5tdeowm6u

Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics

Chia-Yen Lin, Shian-Shiang Wang, Cheng-Kuang Yang, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Kun-Yuan Chiu, Chen-Li Cheng, Yen-Chuan Ou, Shun-Fa Yang
2019 International Journal of Medical Sciences  
Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579 prostate cancer patients who underwent robot-assisted radical prostatectomy and 579 healthy controls were included. The frequency of the allele del of rs145204276 were compared between the patients
more » ... nd the controls to evaluate the impact of tumor susceptibility and the correlation of clinicopathological variables. The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins. In the subgroup analysis of age, more significant risk reduction effects were noted over lymph node metastasis disease (OR=0.426, p=0.032) and lymphovascular invasion (OR=0.521, p=0.025). In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis.
doi:10.7150/ijms.38080 pmid:31673232 pmcid:PMC6818208 fatcat:r7gon6qwx5g23j2ckp4otzterm
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