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Author Response

Chang-Yi Yen, Kwan-Hwa Lin, Ming-Hsia Hu, Ruey-Meei Wu, Tung-Wu Lu, Chia-Hwa Lin
2011 Physical Therapy  
Author Response Chang-Yi Yen, Kwan-Hwa Lin, Ming-Hsia Hu, Ruey-Meei Wu, Tung-Wu Lu, Chia-Hwa Lin The commentary by Deutsch et al 1 focuses on the strengths and weaknesses of virtual reality (VR)augmented  ...  such as traffic auditory distraction and traffic light recognition, would be considered in future design of VR balance training with dual tasks. 7, 8 DOI: 10.2522/ptj.20100050.ar 16 Yen C-Y, Lin K-H, Hu  ... 
doi:10.2522/ptj.20100050.ar fatcat:xztez6npbrhtrlxzlaionh77ke

MSVA

Yin-Tzu Lin, Po-Nien Chen, Chia-Hu Chang, Ja-Ling Wu
2014 Proceedings of the ACM International Conference on Multimedia - MM '14  
Google Maps with Street View (GSV) provides ways to explore the world but it lacks efficient ways to present a journey. Hyperlapse provides another ways for quick glimpsing the street-views along the route; however, its viewing experience is also not comfortable and could be tedious when the route is long-distance. In this paper, we provide an efficient and enjoyable way to present street view sequences of long journey. Street view journey video accompanied with locally listened music will be
more » ... oduced by the proposed approach. During the move between locations, we use the speed control techniques for animation production to improve the viewing experience. User evaluation results show that the proposed method increases the satisfaction of users in viewing the street view sequences.
doi:10.1145/2647868.2654967 dblp:conf/mm/LinCCW14 fatcat:3q3usxsfwjhm7gxpjoilmny4wi

Fibreoptic fluorescence spectroscopy for monitoring fish freshness

Chi-Wu Wu, Tzu-Chien Hsiao, Shou-Chia Chu, Hung-Hsi Hu, Jyh-Cheng Chen, Robert R. Alfano, Stavros G. Demos
2012 Optical Biopsy X  
In this study, a portable Y-type fibreoptic fluorescence spectroscopy measurement system was used to evaluate the freshness of eight cobias (Rachycentron canadum). The results showed that the ratio of fluorescent intensity, which F 480 nm/F exci+50 nm was belong with the range of collagen type I and type V characteristic spectra, was positive correlated to the frozen time by hours. It was a strong approach to be a potential index for differentiating the fish freshness during delivery process.
more » ... sides, the different pattern results of dorsum and abdomen were shown in this study. In further, fibreoptic fluorescence spectroscopy could be a way not only to measure and quantify the freshness of different fish body but also to verify the level of taste.
doi:10.1117/12.910072 fatcat:xxm5hj7wnfgixmu33vgob2isuq

Continuous microfluidic assortment of interactive ligands (CMAIL)

Yi-Hsing Hsiao, Chao-Yang Huang, Chih-Yung Hu, Yen-Yu Wu, Chung-Hsiun Wu, Chia-Hsien Hsu, Chihchen Chen
2016 Scientific Reports  
Finding an interactive ligand-receptor pair is crucial to many applications, including the development of monoclonal antibodies. Biopanning, a commonly used technique for affinity screening, involves a series of washing steps and is lengthy and tedious. Here we present an approach termed continuous microfluidic assortment of interactive ligands, or CMAIL, for the screening and sorting of antigenbinding single-chain variable antibody fragments (scFv) displayed on bacteriophages (phages). Phages
more » ... arrying native negative charges on their coat proteins were electrophoresed through a hydrogel matrix functionalized with target antigens under two alternating orthogonal electric fields. During the weak horizontal electric field phase, phages were differentially swept laterally depending on their affinity for the antigen, and all phages were electrophoresed down to be collected during the strong vertical electric field phase. Phages of different affinity were spatially separated, allowing the continuous operation. More than 10 5 CFU (colony forming unit) antigen-interacting phages were isolated with ~100% specificity from a phage library containing 3 × 10 9 individual members within 40 minutes of sorting using CMAIL. CMAIL is rapid, sensitive, specific, and does not employ washing, elution or magnetic beads. In conclusion, we have developed an efficient and cost-effective method for isolating and sorting affinity reagents involving phage display.
doi:10.1038/srep32454 pmid:27578501 pmcid:PMC5006012 fatcat:34gbkonn5vfvjgthlfj4gin2yq

A Distributed Code Assignment Algorithm with High Code Reusability for CDMA-Based Ad Hoc Networks [chapter]

Chang Wu Yu, Tung-Kuang Wu, Rei-Heng Cheng, Chia Hu Wu
2006 Lecture Notes in Computer Science  
T We propose a dynamic and distributed CDMA code assignment protocol for ad hoc networks. By combining the TRTS/CTS dialogue, modified busy tone signaling and power control Tmechanisms with Tour specially designed CDMA code selection rules, our protocol can not only save precious battery energy of mobile nodes, but also increase CDAM code reusability.T TOur simulation indicates that the proposed protocol performs better than the static code assignment method and the on-demand code assignment
more » ... hod (with/without using power control)T Tin terms of successful transmission rate, code reusability andT number of successful code assignment.
doi:10.1007/11814856_32 fatcat:2xjutkhnnngm7ktks3qnofkyoa

Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes

Shih-Ho Wang, Chin-Hu Wu, Chin-Chuan Tsai, Tai-Yu Chen, Kuen-Jang Tsai, Chao-Ming Hung, Chia-Yi Hsu, Chia-Wei Wu, Tsung-Hua Hsieh
2022 Current Issues in Molecular Biology  
Taraxacum officinale (dandelion) is often used in traditional Chinese medicine for the treatment of cancer; however, the downstream regulatory genes and signaling pathways mediating its effects on breast cancer remain unclear. The present study aimed to explore the effects of luteolin, the main biologically active compound of T. officinale, on gene expression profiles in MDA-MB-231 and MCF-7 breast cancer cells. The results revealed that luteolin effectively inhibited the proliferation and
more » ... ity of the MDA-MB-231 and MCF-7 cells. The mRNA expression profiles were determined using gene expression array analysis and analyzed using a bioinformatics approach. A total of 41 differentially expressed genes (DEGs) were found in the luteolin-treated MDA-MB-231 and MCF-7 cells. A Gene Ontology analysis revealed that the DEGs, including AP2B1, APP, GPNMB and DLST, mainly functioned as oncogenes. The human protein atlas database also found that AP2B1, APP, GPNMB and DLST were highly expressed in breast cancer and that AP2B1 (cut-off value, 75%) was significantly associated with survival rate (p = 0.044). In addition, a Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that the DEGs were involved in T-cell leukemia virus 1 infection and differentiation. On the whole, the findings of the present study provide a scientific basis that may be used to evaluate the potential benefits of luteolin in human breast cancer. Further studies are required, however, to fully elucidate the role of the related molecular pathways.
doi:10.3390/cimb44050142 fatcat:ln7xtl4pxvakhjr2anksxkzivu

Photo navigator

Chi-Chang Hsieh, Wen-Huang Cheng, Chia-Hu Chang, Yung-Yu Chuang, Ja-Ling Wu
2008 Proceeding of the 16th ACM international conference on Multimedia - MM '08  
Nowadays, travel has become a popular activity for people to relax their body and mind. Taking photos is then often an inevitable and frequent event during one's trip for recording the enjoyable experience. To help people to relive the wonderful travel experience they had recorded in photos, this paper presents a system, Photo Navigator, for enhancing the photo browsing experience by creating a new browsing style with a realistic feel to users as being into the scenes and taking a trip back in
more » ... ime to revisit the place. The proposed system is characterized by two main features. First, it better reveals the spatial relations among photos and offers a strong sense of space by taking users to fly into the scenes. Second, it is fully automatic and makes plausible for novice users to utilize the 3D technologies that are traditionally complex to manipulate. The proposed system is compared with two other photo browsing tools, ACDSee's photo slideshow and Microsoft's PhotoStory. User studies show that people would comparatively favor the browsing style we offer and appreciate the ease to create such a style.
doi:10.1145/1459359.1459415 dblp:conf/mm/HsiehCCCW08 fatcat:gtdpcdk4lrhlxcfuqiodfnag7u

Applicability of the WHOQOL-BREF on early adolescence

Kun-Hu Chen, Chia-Huei Wu, Grace Yao
2005 Social Indicators Research  
The WHOQOL-BREF is one of the cross-cultural and widely used measures for assessing health-related quality of life (HRQOL). Previous studies of the HRQOL using the WHOQOL-BREF mainly focused on adult; however, there has been less work carried out on assessing the HRQOL on early adolescence. The goal of this study was to examine the applicability of the WHOQOL-BREF Taiwan version in early adolescent sample. A total of 365 junior high school students participated in this study. Participants
more » ... ted the WHOQOL-BREF Taiwan version and five visual-analogue items on HRQOL evaluation. The results supported the originally designed four-factor model, and also indicated good item discrimination, internal reliability, factorial validity (by using confirmatory factor analysis) and construct validity (e.g., predictive validity, discriminant and convergent validity) after deleting two physical health items (i.e.
doi:10.1007/s11205-005-0211-0 fatcat:jgezu2rhcnarngaoha262gp4gm

N-(6-Methyl-2-pyridyl)formamide

Hui-Ling Hu, Chia-Jun Wu, Pei-Chi Cheng, Jhy-Der Chen
2009 Acta Crystallographica Section E  
Key indicators: single-crystal X-ray study; T = 295 K; mean (C-C) = 0.003 Å; R factor = 0.050; wR factor = 0.148; data-to-parameter ratio = 13.3. organic compounds o180 Hu et al.  ...  E66, o180 [doi:10.1107/S1600536809053549] N-(6-Methyl-2-pyridyl)formamide Hui-Ling Hu, Chia-Jun Wu, Pei-Chi Cheng and Jhy-Der Chen Figure 1 4 14 Molecular structure of the title compound with atom labeling  ... 
doi:10.1107/s1600536809053549 pmid:21580065 pmcid:PMC2980114 fatcat:chcnyk6ftbhhzogt2bw2n6vfke

Long term outcome of Aldosteronism after target treatments

Vin-Cent Wu, Shuo-Meng Wang, Chia-Hui Chang, Ya-Hui Hu, Lian-Yu Lin, Yen-Hung Lin, Shih-Chieh Jeff Chueh, Likwang Chen, Kwan-Dun Wu
2016 Scientific Reports  
There exists a great knowledge gap in terms of long-term effects of various surgical and pharmacological treatments on outcomes among primary aldosteronism (PA) patients. Using a validated algorithm, we extracted longitudinal data for all PA patients diagnosed in 1997-2010 and treated in the Taiwan National Health Insurance. We identified 3362 PA patients for whom the mean length of follow-up was 5.75 years. PA has higher major cardiovascular events (MACE) than essential hypertension (23.3% vs
more » ... 9.3%, p = 0.015). Results from the Cox model suggest a strong effect of adrenalectomy on lowering mortality (HR = 0.23 with residual hypertension and 0.21 with resolved hypertension). While need for receptor antagonist (MRA) MRA after diagnosis suggests that a defined daily dose (DDD) of MRA between 12.5 and 50 mg may alleviate risk of death in a U-shape pattern. A specificity test identified patients who has aldosterone producing adenoma (HR = 0.50, p = 0.005) also confirmed adrenalectomy attenuated all-cause mortality. Adrenalectomy decreases long-term all-cause mortality independently from PA cure from hypertension. Prescription corresponding to a DDD between 12.5 and 50 mg may decrease mortality for patients needing MRA. It calls for more attention on early diagnosis, early treatment and prescription of appropriate dosage of MRA for PA patients. Although the role of primary aldosteronism (PA) in increasing cardiovascular risk and the potential of targeted therapy for PA have gained recognition 1,2 , there exists a great knowledge gap in terms of long-term effects of various surgical and pharmacological treatments on outcomes among PA patients 3 . For instance, it remains unclear whether certain targeted treatments for PA can yield everlasting elimination of high blood pressure and regression of the adverse cardiovascular changes 4,5 . A cohort study reported a higher risk of cardiovascular events in PA patients than in non-PA counterparts at diagnosis, and an indifferent risk level for PA patients in the follow-up after adrenalectomy or treatment with a mineralocorticoid receptor antagonist (MRA) 6 . While MRA treatment seems to produce a similar effect as adrenalectomy in terms of prevention of cardiovascular events 7 , it is unclear whether MRA treatment and adrenalectomy also grant a similar effect regarding all-cause mortality 3 . A recent nationwide epidemiological study in Japan showed that surgical treatment had a larger effect of on ameliorating hypertension and hypokalemia than medical treatment 8 . While normalization of blood pressure and correction of hypokalemia are important, there are other goals for effectively managing PA and preventing organ complications 9 . It calls for more effort into unearthing better treatment patterns for reducing risk of mortality over a long term. Furthermore, it is worthwhile to investigate how adrenalectomy may lessen threat from death for PA patients with different statuses of subsequent of cardiovascular accidents (CVA), a well-recognized risk factor for all-cause mortality. Claims databases comprehensively capturing information on episodes of care across healthcare settings could make disease outcomes research greatly more promising 10 .
doi:10.1038/srep32103 pmid:27586402 pmcid:PMC5009379 fatcat:qg24kz3iqzggnhtfka5h5vbmjq

Increasing the Performance of Vacuum Membrane Distillation Using Micro-Structured Hydrophobic Aluminum Hollow Fiber Membranes

Chia-Chieh Ko, Chien-Hua Chen, Yi-Rui Chen, Yu-Hsun Wu, Soon-Chien Lu, Fa-Chun Hu, Chia-Ling Li, Kuo-Lun Tung
2017 Applied Sciences  
This study develops a micro-structured hydrophobic alumina hollow fiber with a high permeate flux of 60 Lm −2 h −1 and salt rejection over 99.9% in a vacuum membrane distillation process. The fiber is fabricated by phase inversion and sintering, and then modified with fluoroalkylsilanes to render it hydrophobic. The influence of the sintering temperature and feeding temperature in membrane distillation (MD) on the characteristics of the fiber and MD performance are investigated. The vacuum
more » ... ane distillation uses 3.5 wt% NaCl aqueous solution at 70 • C at 0.03 bar. The permeate flux of 60 Lm −2 h −1 is the highest, compared with reported data and is higher than that for polymeric hollow fiber membranes.
doi:10.3390/app7040357 fatcat:rcvxnmrozje5lezcyf55mtdxya

Application of flexible ureterorenoscopy for upper urinary tract disease

Yin-Ting Liu, Chi-Yun Lan, Kai-Yi Tzou, Su-Wei Hu, Chia-Chang Wu
2016 Urological Science  
Abstracts / Urological Science 27 (2016) S53eS83 S83 NDP118: APPLICATION OF FLEXIBLE URETERORENOSCOPY FOR UPPER URINARY TRACT DISEASE Yin-Ting Liu, Chi-Yun Lan, Kai-Yi Tzou, Su-Wei Hu, Chia-Chang Wu.  ...  NDP120: MESH MIGRATION INTO THE URINARY BLADDER AFTER INGUINAL HERNIA REPAIR: A RARE CASE REPORT Chian-Shiung Lin 1,2 , Chih-Cheng Lu 1 , Chia-Ho Lin 1 , Eric W.  ... 
doi:10.1016/j.urols.2016.05.311 fatcat:3ju6kb4rjjd5xiyvhwrjxy5jwq

Methyl 4-[(pyrimidin-2-yl)carbamoyl]benzoate

Chun-Hsiang Lu, Chia-Jun Wu, Chun-Wei Yeh, Hui-Ling Hu, Jhy-Der Chen
2011 Acta Crystallographica Section E  
Experimental The title compound was prepared according to a published procedure (Wu et al., 2011) .  ...  Related literature For related metal complexes of the title compound, see: Wu et al. (2011 Table 1 Hydrogen-bond geometry (Å , ).  ... 
doi:10.1107/s1600536811025190 pmid:21837223 pmcid:PMC3151977 fatcat:gy6he5esanhctkwrzp273nrueq

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Chia-Hui Chang, Ya-Hui Hu, Yao-Chou Tsai, Che-Hsiung Wu, Shuo-Meng Wang, Lian-Yu Lin, Yen-Hung Lin, Fumitoshi Satoh, Kwan-Dun Wu, Vin-Cent Wu
2017 OncoTarget  
The aim of this study was to show the effect of KCNJ5 mutational status on arterial stiffness in aldosterone-producing adenomas after adrenalectomy. Between February 2008 and January 2010, we prospectively enrolled 108 aldosterone-producing adenoma patients undergoing adrenalectomy. We conducted repeated measurements of pulse wave velocity at baseline, 6 months, and 12 months after adrenalectomy, grouped by KCNJ5 mutational status. Prognostic factors of arterial stiffness and risk for
more » ... on at 12 months after adrenalectomy were analyzed after propensity score matching in a 1:1 ratio. After matching for age, sex and body mass index, 88 patients were divided equally into KCNJ5-mutant and non-mutant groups. KCNJ5 mutational status was not an independent variable in either the generalized estimating equation model (p = 0.147) or the percentage change of brachial-ankle pulse wave velocity (p = 0.106). The generalized additive model smoothing plot showed that aldosterone-producing adenoma patients who carried the KCNJ5 mutation and were aged between 37 and 60 may have a hypertension recovery advantage. According to our observations during a 12-month follow-up after adrenalectomy, KCNJ5 mutational status was not associated with improvement in arterial stiffness.
doi:10.18632/oncotarget.16269 pmid:28415786 pmcid:PMC5444719 fatcat:tfdqyue5hrft3flr56ifssbe6q

Differential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer

Oluwaseun Adebayo Bamodu, Kai-Yi Tzou, Chia-Da Lin, Su-Wei Hu, Yuan-Hung Wang, Wen-Ling Wu, Kuan-Chou Chen, Chia-Chang Wu
2021 Cancers  
Testosterone plays a critical role in prostate development and pathology. However, the impact of the molecular interplay between testosterone-associated genes on therapy response and susceptibility to disease relapse in PCa patients remains underexplored. Objective: This study investigated the role of dysregulated or aberrantly expressed testosterone-associated genes in the enhanced dissemination, phenoconversion, and therapy response of treatment-resistant advanced or recurrent PCa. Methods:
more » ... ploying a combination of multi-omics big data analyses, in vitro, ex vivo, and in vivo assays, we assessed the probable roles of HSD17B2, HSD17B3, SHBG, and SRD5A1-mediated testosterone metabolism in the progression, therapy response, and prognosis of advanced or castration-resistant PCa (CRPC). Results: Our bioinformatics-aided gene expression profiling and immunohistochemical staining showed that the aberrant expression of the HSD17B2, HSD17B3, SHBG, and SRD5A1 testosterone metabolic tetrad characterize androgen-driven PCa and is associated with disease progression. Reanalysis of the TCGA PRAD cohort (n = 497) showed that patients with SRD5A1-dominant high expression of the tetrad exhibited worse mid-term to long-term (≥5 years) overall survival, with a profoundly shorter time to recurrence, compared to those with low expression. More so, we observed a strong association between enhanced HSD17B2/SRD5A1 signaling and metastasis to distant lymph nodes (M1a) and bones (M1b), while upregulated HSD17B3/SHBG signaling correlated more with negative metastasis (M0) status. Interestingly, increased SHBG/SRD5A1 ratio was associated with metastasis to distant organs (M1c), while elevated SRD5A1/SHBG ratio was associated with positive biochemical recurrence (BCR) status, and shorter time to BCR. Molecular enrichment and protein–protein connectivity network analyses showed that the androgenic tetrad regulates testosterone metabolism and cross-talks with modulators of drug response, effectors of cell cycle progression, proliferation or cell motility, and activators/mediators of cancer stemness. Moreover, of clinical relevance, SHBG ectopic expression (SHBG_OE) or SRD5A1 knockout (sgSRD5A1) induced the acquisition of spindle fibroblastoid morphology by the round/polygonal metastatic PC-3 and LNCaP cells, attenuated their migration and invasion capability, and significantly suppressed their ability to form primary or secondary tumorspheres, with concomitant downregulation of stemness KLF4, OCT3/4, and drug resistance ABCC1, ABCB1 proteins expression levels. We also showed that metronomic dutasteride synergistically enhanced the anticancer effect of low-dose docetaxel, in vitro, and in vivo. Conclusion: These data provide proof of concept that re-reprogramming of testosterone metabolism through "SRD5A1 withdrawal" or "SHBG induction" is a workable therapeutic strategy for shutting down androgen-driven oncogenic signals, reversing treatment resistance, and repressing the metastatic/recurrent phenotypes of patients with PCa.
doi:10.3390/cancers13143478 fatcat:feqr2k3lwrb7nhom4u62zioc7y
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