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Synthesis of novel polyhydroxylated pyrrolidine–triazole/-isoxazole hybrid molecules

Cheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun, Wei-Chieh Cheng
2015 Organic and biomolecular chemistry  
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described.
doi:10.1039/c4ob01934b pmid:25525831 fatcat:r2uholxvszcjhge3byrmaa4mri

Optimization Method Based Mppt For Wind Power Generators

Chun-Yao Lee, Yi-Xing Shen, Jung-Cheng Cheng, Chih-Wen Chang, Yi-Yin Li
2009 Zenodo  
This paper proposes the method combining artificial neural network with particle swarm optimization (PSO) to implement the maximum power point tracking (MPPT) by controlling the rotor speed of the wind generator. With the measurements of wind speed, rotor speed of wind generator and output power, the artificial neural network can be trained and the wind speed can be estimated. The proposed control system in this paper provides a manner for searching the maximum output power of wind generator
more » ... n under the conditions of varying wind speed and load impedance.
doi:10.5281/zenodo.1078399 fatcat:2cxdnzvmfnbo7jjzjiq6jl7yse

Competing risk model to determine the prognostic factors and treatment strategies for elderly patients with glioblastoma

Zhuo-yi Liu, Song-shan Feng, Yi-hao Zhang, Li-yang Zhang, Sheng-chao Xu, Jing Li, Hui Cao, Jun Huang, Fan Fan, Li Cheng, Jun-yi Jiang, Quan Cheng (+1 others)
2021 Scientific Reports  
AbstractThe prognostic factors and optimal treatment for the elderly patient with glioblastoma (GBM) were poorly understood. This study extracted 4975 elderly patients (≥ 65 years old) with histologically confirmed GBM from Surveillance, Epidemiology and End Results (SEER) database. Firstly, Cumulative incidence function and cox proportional model were utilized to illustrate the interference of non-GBM related mortality in our cohort. Then, the Fine-Gray competing risk model was applied to
more » ... mine the prognostic factors for GBM related mortality. Age ≥ 75 years old, white race, size > 5.4 cm, frontal lobe tumor, and overlapping lesion were independently associated with more GBM related death, while Gross total resection (GTR) (HR 0.87, 95%CI 0.80–0.94, P = 0.010), radiotherapy (HR 0.64, 95%CI 0.55–0.74, P < 0.001), chemotherapy (HR 0.72, 95%CI 0.59–0.90, P = 0.003), and chemoRT (HR 0.43, 95%CI 0.38–0.48, P < 0.001) were identified as independently protective factors of GBM related death. Based on this, a corresponding nomogram was conducted to predict 3-, 6- and 12-month GBM related mortality, the C-index of which were 0.763, 0.718, and 0.694 respectively. The calibration curve showed that there was a good consistency between the predicted and the actual mortality probability. Concerning treatment options, GTR followed by chemoRT is suggested as optimal treatment. Radiotherapy and chemotherapy alone also provide moderate clinical benefits.
doi:10.1038/s41598-021-88820-5 pmid:33927308 fatcat:pjiwhp46jbhb7g6x3k4ncicwli

Effect of Clazosentan in Patients with Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of Randomized Controlled Trials

Xiang Wang, Yi-Ming Li, Wei-Qing Li, Cheng-Guang Huang, Yi-Cheng Lu, Li-Jun Hou, Robert Loch Macdonald
2012 PLoS ONE  
Cerebral vasospasm is the most important potentially treatable cause of mortality and morbidity following aneurysmal subarachnoid hemorrhage (aSAH). Clazosentan, a selective endothelinreceptor antagonist, has been suggested to help reduce the incidence of vasospasm in patients with aSAH. However, the results were controversial in previous trials. This meta-analysis attempts to assess the effect of clazosentan in patients with aSAH. Methodology/Principal Findings: We systematically searched
more » ... d, Embase, and the Cochrane Library from their inception until June, 2012. All randomized controlled trials (RCTs) related to the effect of clazosentan in aSAH were included. The primary outcomes included the incidence of angiographic vasospasm, new cerebral infarction (NCI), delayed ischemic neurological deficits (DIND), and vasospasm-related morbidity/mortality (M/M); the second outcomes included the occurrence of rescue therapy, all-cause-mortality, and poor outcome. 4 RCTs were included with a total of 2156 patients. The risk of angiographic vasospasm (relative risk [RR] = 0.58; 95% CI, 0.48 to 0.71), DIND (RR = 0.76; 95% CI, 0.62 to 0.92), and vasospasm-related M/M (RR = 0.80; 95% CI, 0.67 to 0.96) were statistically significantly reduced in the clazosentan group. Patients treated with clazosentan had a reduced occurrence of rescue therapy (RR = 0.62; 95% CI, 0.49 to 0.79). However, no statistically significant effects were observed in NCI (RR = 0.74; 95% CI, 0.52 to 1.04), mortality (RR = 1.03; 95% CI, 0.71 to 1.49), and poor outcome (RR = 1.12; 95% CI, 0.96 to 1.30). Conclusions/Significance: Our pooling data supports that clazosentan is probably effective in preventing the occurrence of angiographic vasospasm, vasospasm-related DIND, vasospasm related M/M, and rescue therapy. However, no evidence lends significant supports to the benefits of clazosentan in decreasing the occurrence of NCI, mortality or improving the functional outcome.
doi:10.1371/journal.pone.0047778 pmid:23082215 pmcid:PMC3474756 fatcat:vuvix6xjwja4fbks6xucox73re

GII.P16-GII.2 Recombinant Norovirus VLPs Polarize Macrophages Into the M1 Phenotype for Th1 Immune Responses

Ji Cheng Han, Qiu Xuan Li, Jin Bo Fang, Jin Yong Zhang, Yi Quan Li, Shan Zhi Li, Cheng Cheng, Chang Zhan Xie, Fu Long Nan, He Zhang, Zhuo Xin Li, Ning Yi Jin (+2 others)
2021 Frontiers in Immunology  
Norovirus (NoV) is a zoonotic virus that causes diarrhea in humans and animals. Outbreaks in nosocomial settings occur annually worldwide, endangering public health and causing serious social and economic burdens. The latter quarter of 2016 witnessed the emergence of the GII.P16-GII.2 recombinant norovirus throughout Asia. This genotype exhibits strong infectivity and replication characteristics, proposing its potential to initiate a pandemic. There is no vaccine against GII.P16-GII.2
more » ... t norovirus, so it is necessary to design a preventive vaccine. In this study, GII.P16-GII.2 type norovirus virus-like particles (VLPs) were constructed using the baculovirus expression system and used to conduct immunizations in mice. After immunization of mice, mice were induced to produce memory T cells and specific antibodies, indicating that the VLPs induced specific cellular and humoral immune responses. Further experiments were then initiated to understand the underlying mechanisms involved in antigen presentation. Towards this, we established co-cultures between dendritic cells (DCs) or macrophages (Mø) and naïve CD4+T cells and simulated the antigen presentation process by incubation with VLPs. Thereafter, we detected changes in cell surface molecules, cytokines and related proteins. The results indicated that VLPs effectively promoted the phenotypic maturation of Mø but not DCs, as indicated by significant changes in the expression of MHC-II, costimulatory factors and related cytokines in Mø. Moreover, we found VLPs caused Mø to polarize to the M1 type and release inflammatory cytokines, thereby inducing naïve CD4+ T cells to perform Th1 immune responses. Therefore, this study reveals the mechanism of antigen presentation involving GII.P16-GII.2 recombinant norovirus VLPs, providing a theoretical basis for both understanding responses to norovirus infection as well as opportunities for vaccine development.
doi:10.3389/fimmu.2021.781718 pmid:34868056 pmcid:PMC8637406 fatcat:tivucilllvgl3cn2quueljhwhi

Geometric Style Transfer [article]

Xiao-Chang Liu, Xuan-Yi Li, Ming-Ming Cheng, Peter Hall
2020 arXiv   pre-print
[26] provide one example in which the loss function is based on the statistical distribution of features; Li et al.  ... 
arXiv:2007.05471v1 fatcat:uo34uik5jff3rpgd4ki255mzgq

Rhinitis medicamentosa

Lok-Yee Joyce Li, Shin-Yi Wang, Cheng-Yu Tsai, Cheng-Jung Wu
2021 BMJ Case Reports  
ORCID iD Cheng-Jung Wu http:// orcid. org/ 0000-0002-7443-2119  ... 
doi:10.1136/bcr-2021-247051 pmid:34753736 pmcid:PMC8578967 fatcat:djwmos3ewnewrd37eiyecqyyzq


Yi-Min Hu, Yi-Zhi Li, Yan-Jie Li, Cheng-Jian Zhu, Yi Pan
2003 Acta Crystallographica Section E  
Hu, Yi-Zhi Li, Yan-Jie Li, Cheng-Jian Zhu and Yi Pan 3-Ethyl-1-(4-methylphenylsulfonyl)-4-phenethyl-4,5-dihydropyrrole Fractional atomic coordinates and isotropic or equivalent isotropic displacement  ...  R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger. 3-Ethyl-1-(4-methylphenylsulfonyl)-4-phenethyl-4,5-dihydropyrrole Yi-Min  ... 
doi:10.1107/s1600536803021342 fatcat:ydj3rjqf6nchncwpp4vddyfr5m

Cloning of Quantum Entanglement [article]

Li-Chao Peng, Dian Wu, Han-Sen Zhong, Yi-Han Luo, Yuan Li, Yi Hu, Xiao Jiang, Ming-Cheng Chen, Li Li, Nai-Le Liu, Kae Nemoto, William J. Munro (+3 others)
2020 arXiv   pre-print
Interest in this link between quantum cloning and entanglement lies not only in the extension from cloning of qubits to registers [19] ; profoundly, this link could reveal that entanglement, as a novel  ... 
arXiv:2010.01888v1 fatcat:ifn2cp6y6zgu7mutp4opkpavrm

Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis

Elliot Yi-Hsin Lin, Hsuan-Ju Lai, Yuan-Kai Cheng, Kai-Quan Leong, Li-Chieh Cheng, Yi-Chun Chou, Yu-Chun Peng, Yi-Hsuan Hsu, Hao-Sen Chiang
2020 Biomedicines  
Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter intestinal epithelium permeability during colitis remains elusive. Here, we demonstrated that NETs promote the breakdown in intestinal barrier function for the pathogenesis of intestinal inflammation in mouse models of colitis. NETs were abundant in the colon of mice with colitis
more » ... mentally induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid (TNBS). Analysis of the intestinal barrier integrity revealed that NETs impaired gut permeability, enabling the initiation of luminal bacterial translocation and inflammation. Furthermore, NETs induced the apoptosis of epithelial cells and disrupted the integrity of tight junctions and adherens junctions. Intravenous administration of DNase I, an enzyme that dissolves the web-like DNA filaments of NETs, during colitis restored the mucosal barrier integrity which reduced the dissemination of luminal bacteria and attenuated intestinal inflammation in both DSS and TNBS models. We conclude that NETs serve a detrimental factor in the gut epithelial barrier function leading to the pathogenesis of mucosal inflammation during acute colitis.
doi:10.3390/biomedicines8080275 pmid:32764411 fatcat:iu4ha4yaxjbr5m5grom52oo6ei


Qiang Li, Cheng-Jie Zhang, Ze-Di Cheng, Wenzheng Liu, Junfeng Wang, Feifei Yan, Zhihai Lin, Ya Xiao, Kai Sun, Yi-Tao Wang
2019 Figshare  
detailed information about single photon sources
doi:10.6084/m9.figshare.7450697.v1 fatcat:aglhzthzujesrc43qra3hhdm4u

Neural Networks And Particle Swarm Optimization Based Mppt For Small Wind Power Generator

Chun-Yao Lee, Yi-Xing Shen, Jung-Cheng Cheng, Yi-Yin Li, Chih-Wen Chang
2009 Zenodo  
Shen, Jung-Cheng Cheng, Yi-Yin Li and Chih-Wen Chang T World Academy of Science, Engineering and Technology International Journal of Electrical and Computer Engineering Vol:3, No:12, 2009 2222  ...  and Particle Swarm Optimization Based MPPT for Small Wind Power Generator International Science Index, Electrical and Computer Engineering Vol:3, No:12, 2009 Chun-Yao Lee, Yi-Xing  ... 
doi:10.5281/zenodo.1334614 fatcat:6aoadfzktbernnjom65xbitd5a


Xin CHEN, Kazuyoshi FUMOTO
2009 Journal of Architecture and Planning (Transactions of AIJ)  
doi:10.3130/aija.74.463 fatcat:ndacc62i6vg3fb2agwofkk6nmy

Behavioral Rhythms of Drosophila Suzukii and Drosophila Melanogaster

Qing-Cai Lin, Yi-Fan Zhai, Cheng-Gang Zhou, Li-Li Li, Qian-Ying Zhuang, Xiao-Yan Zhang, Frank G. Zalom, Yi Yu
2014 Florida Entomologist  
Drosophila suzukii and Drosophila melanogaster feed on various fruits, causing great economic losses. In order to find the optimum time for controlling D. suzukii and D. melanogaster, the daily rhythms of oviposition, egg hatch, pupation, adult eclosion, copulation, and feeding of these two pests were studied. We found the circadian rhythm of D. suzukii oviposition to have a single pattern with a peak from 20:00-24:00, while the peak oviposition of D. melanogaster was from 16:00-4:00 (the next
more » ... ay). Neither D. suzukii nor D. melanogaster showed a daily pattern of egg hatch; the single peak of egg hatch for D. suzukii occurred 24-32 h after oviposition, while that for D. melanogaster followed a bimodal pattern, with the first peak of egg hatch from 0-4 h after oviposition and the second from 32-36 h after oviposition. Pupation in D. suzukii showed a single peak from 8:00~16:00, while in D. melanogaster pupation followed a bimodal pattern, resumen Drosophila suzukii y Drosophila melanogaster se alimentan de varias especies de frutas, causando grandes pérdidas económicas. Con el fin de encontrar el momento óptimo para el control de D. suzukii y D. melanogaster, los ritmos diarios de la oviposición, la eclosión de los huevos, la fase de pupa, la eclosión de adultos, la cópula, y la alimentación de estas dos plagas fueron estudiados. Encontramos que el ritmo circadiano del la oviposición de D. suzukii tiene un patrón único con un pico de 20:00 a 24:00, mientras que el pico de oviposición de D. melanogaster fue de 16:00-4:00 (al día siguiente). Ni D. suzukii ni D. melanogaster mostraron un patrón diario de eclosión de los huevos; el único pico de eclosión de los huevos de D. suzukii ocurrió 24-32 horas (h) después de la oviposición, mientras que la de D. melanogaster siguieron un patrón bimodal, con el primer pico de eclosión de los huevos de 0-4 h después de la oviposición y el segundo 32-36 h después de la oviposición. La pupación en D. suzukii mostró un solo pico de 8:00 a 16: 00, mientras que la pupación en D. melanogaster siguió un patrón bimodal, con picos de 4:00-8:00 y 12:00-20:00. La eclosión de los adultos de D. suzukii siguió un patrón unimodal y en general se realizó entre 0:00-8:00, mientras que la de D. melanogaster también mostró un solo pico, generalmente entre 0:00-12:00. Mientras tanto, la cópula de D. suzukii, que mostró un patrón bimodal, se concentró entre 0:00-12:00 y 20:00-24:00 (al día siguiente), mientras que la copulación de D. melanogaster mostró un solo pico, generalmente entre 0:00-12:00. Tanto D. suzukii y D. melanogaster tenían una preferencia para alimentarse en la luz y en un fotoperiodo de 24 h el porcentaje de insectos alimentandose fue 80.8 y 81.1, respectivamente. Palabras Clave: ritmo circadiano, eclosión de los huevos, fase de pupa, eclosión de adultos, alimentación, cópula, oviposición
doi:10.1653/024.097.0417 fatcat:wcal3uo4z5bxjfljndy46q437e

Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans

Jun Tao, Qin-Yi Wu, Yi-Cheng Ma, Yuan-Li Chen, Cheng-Gang Zou
2017 Scientific Reports  
Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In the nematode Caenorhabditis elegans, the nuclear receptor DAF-12 acts as a dietary and environmental sensor to orchestrate diverse aspects of development, metabolism, and reproduction. Recently, we have reported that DAF-12 together with co-repressor DIN-1S is required for starvation tolerance by promoting fat mobilization. In this report, we
more » ... found that genetic inactivation of the DAF-12 signaling promoted the production of reactive oxygen species (ROS) during starvation. ROS mediated systemic necrosis, thereby inducing organismal death. The DAF-12/DIN-1S complex up-regulated the expression of antioxidant genes during starvation. The antioxidant enzyme GST-4 in turn suppressed ROS formation, thereby conferring worm survival. Our findings highlight the importance of antioxidant response in starvation tolerance and provide a novel insight into multiple organisms survive and adapt to periods of nutrient deprivation.
doi:10.1038/srep43547 pmid:28230214 pmcid:PMC5322524 fatcat:yor5raimkzdzreu5wvwjmxw3ua
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