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However, Chan et al.  show that images captured by on-wrist camera are significantly different from images in ImageNet. ...arXiv:1710.07477v1 fatcat:apq4uszvzbfyzbxl2oyknjyoli
A case of right branch retinal artery occlusion (BRAO) due to cholesterol-containing embolus following transfemoral cardiac catheterization is reported. It is extremely rare, however, cardiologists should be alert to any thromboembolic complications during and following cardiac catheterization and choose the suitable approach (either upper extremity or transfemoral). (Jpn Heart J 2002; 43: 193-196) Key words: Branch retinal artery occlusion, Cardiac catheterization DIAGNOSTIC coronarydoi:10.1536/jhj.43.193 pmid:12025907 fatcat:4fgbyzft7jftxgyejtxys7o5wa
more »... ation may result in complications, such as neurologic events (stroke, transient ischemic attack, 0.1%), arrythmias (0.3%), local vascular problems (1.6%), vasovagal reactions (2.1%), and allergy (0.1~2%). 1) The incidence of systemic cholesterol emboli after a percutaneous transluminal coronary angioplasty was reported to be 1.4-3%. 2) However, ocular complications are extremely rare after simple diagnostic cardiac catheterization. We report a case of branch retinal artery occlusion following transfemoral cardiac catheterization. CASE REPORT A 79-year-old Taiwanese female was admitted because of a sudden onset of chest tightness, which was responsive to sublingual nitroglycerin. She had hypertension for more than 10 years with regular treatment. She had no history of diabetes mellitus, hyperlipidemia, or smoking. Echocardiography revealed a calcified aortic valve and normal left ventricular function. No obvious intracardiac vegetation or thrombus was seen. Tl-201 stress/redistribution myocardial perfusion single photon emission computed tomography revealed possible mild From the
The rapid growth of protein-protein interaction (PPI) data has led to the emergence of PPI network analysis. Despite advances in high-throughput techniques, the interactomes of several model organisms are still far from complete. Therefore, it is desirable to expand these interactomes with ortholog-based and other methods. Results: Orthologous pairs of 18 eukaryotic species were expanded and merged with experimental PPI datasets. The contributions of interologs from each species were evaluated.doi:10.1186/1471-2105-9-s12-s11 pmid:19091010 pmcid:PMC2638151 fatcat:cay755v5wjf5fngc7r3g3msgvq
more »... The expanded orthologous pairs enable the inference of interologs for various species. For example, more than 32,000 human interactions can be predicted. The same dataset has also been applied to the prediction of host-pathogen interactions. PPIs between P. falciparum calmodulin and several H. sapiens proteins are predicted, and these interactions may contribute to the maintenance of host cell Ca 2+ concentration. Using comparisons with Bayesian and structure-based approaches, interactions between putative HSP40 homologs of P. falciparum and the H. sapiens TNF receptor associated factor family are revealed, suggesting a role for these interactions in the interference of the human immune response to P. falciparum. Conclusion: The PPI datasets are available from POINT http://point.bioinformatics.tw/ and POINeT http://poinet.bioinformatics.tw/. Further development of methods to predict hostpathogen interactions should incorporate multiple approaches in order to improve sensitivity, and should facilitate the identification of targets for drug discovery and design.
Sheng-Ta Hsieh et al. ... detection and removal mechanism Before the global best position Gbest is updated to move the macrocell to a new position, the proposed floorplanner should detect if the current macrocell overlaps with any Sheng-Ta ...doi:10.1155/2008/514879 fatcat:vjubln54uzg53g5uwt6nwwghz4
Fermented broth has a long history of applications in the food, pharmaceutical and cosmetic industries. Recently, the use of fermented broth in skin care products is in ascendance. This review investigates the efficacy of fermented broth in inhibiting tyrosinase and melanogenesis. Possible active ingredients and hypopigmentation mechanisms of fermented broth are discussed, and potential applications of fermented broth in the cosmetic industry are also addressed. Keywords: microorganisms;doi:10.3390/molecules190913122 pmid:25255749 fatcat:prnuulnehrepflj5aphveg4i6u
more »... ed broth; melanogenesis with lighter skin tones over those with darker complexions  . Another study indicated that tan skin indicates a blue collar socioeconomic status, whereas pale skin represents a white collar status  . Therefore, numerous skin care products labeled skin "whitening" or "lightening" comprise the best-selling product lines in the Asian cosmetics market  . Scientists have proved that numerous skin-whitening agents added to products effectively reduce melanin, which is the main source of skin color  . When humans are exposed to unlimited UV light, melanogenesis causes hyperpigmentation through the overproduction of melanin, which causes the skin to tan  . Tyrosinase is the key enzyme in the melanin biosynthesis pathway  . Hydroxylated L-tyrosine produces L-3,4-dihydroxyphenylalanine (L-DOPA), which is oxidized to the corresponding o-quinone  . Tyrosinase inhibitors can be categorized into competitive, uncompetitive, and noncompetitive inhibitors  . Although most methods for skin lightening involve inhibiting tyrosinase  , skin lightening can be achieved using other methods, such as epidermal turnover enhancement [14-17] and antioxidation agents  . Enhancers of epidermal turnover reduce melanin by accelerating epidermal turnover time [19, 20] , and antioxidants reduce reactive oxygen species that induce melanogenesis caused by UV irradiation  . Tyrosinase inhibitors such as L-ascorbic acid    , kojic acid [25-27], ellagic acid [28-30], tranexamic acid [31-33], and hydroquinone [34-36] have been used as skin-whitening agents, albeit not without problems. For example, L-ascorbic acid is heat sensitive and degrades easily ; kojic acid can trigger allergic reactions such as contact dermatitis and sensitization  and has carcinogenic potential [39,40]; ellagic acid is insoluble and has poor bioavailability ; the melanogenesis inhibition pathway of tranexamic acid remains undetermined ; and long-term use of hydroquinone causes exogenous ochronosis [42,43]. Epidermal turnover enhancers only remove the melanin in the uppermost layer of the epidermis , and antioxidants, such as various botanical extracts, induce contact dermatitis . Because of these problems, scientists have endeavored to develop alternative skin-whitening techniques. Mushroom tyrosinase has been used for prescreening hypopigmentation agents because it is commercially available. However, it was found that many melanogenesis inhibitors didn't exhibit inhibitory effects on mushroom tyrosinase activity     . Mushroom tyrosinase is a secreted form which doesn't resemble mammalian tyrosinase    . Cytosolic mammalian tyrosinase is an inactive form which will be glycosylated in the Golgi complex. Then, glycosylated mammalian tyrosinase is delivered to melanosomes wherein the enzyme is membrane-bound form and phosphoactivated by PKCβ [50, 53, 54] . In addition, melanogenesis involves sophisticated signal pathways (Figure 1 )     . For example, UV radiation (UVR), the most important extrinsic factor of melanogenesis, increases α-melanocyte-stimulating hormone (α-MSH) binding to melanocortin 1 receptor (MC1R) followed by activating adenylate cyclase, increasing cAMP levels, activating the enzyme protein kinase A (PKA), and inducing gene transcription of microphthalmia-associated transcription factor (MITF), leading to transcription of the melanogenic enzyme tyrosinase [53, 54,      . Norepinephrine/α1 or β2 adrenergic receptor and UV radiation induce diacylglycerol (DAG) release from the cell membrane. DAG activates protein kinase C-β (PKC-β), which then phosphorylates serine residues on tyrosinase and activates the enzyme [53, 54] . Binding stem cell factor (SCF) to c-kit results in dimerization of receptors followed by activating mitogen-activated protein kinase (MAPK) cascade [53, 62] . The MAPK family proteins, including p38, ERK, and JNK, are known to play crucial roles in melanogenesis [56,62,63]. The ERK and JNK pathways cause downregulation (−) of melanin
Particle Swarm Optimization
How to reference In order to correctly reference this scholarly work, feel free to copy and paste the following: Tsung-Ying Sun, Chan-Cheng Liu, Chun-Ling Lin, Sheng-Ta Hsieh and Cheng-Sen Huang (2009 ...doi:10.5772/6763 fatcat:7qb57i6v6vde3mo2gps47dk3ye
The case of a 43-year-old Taiwanese man who presented with spinal epidural hematoma following intravenous administration of recombinant tissue plasminogen activator (rTPA) and heparin therapy for acute myocardial infarction (AMI) is reported. Upper back pain and progressive neurological dysfunction ensued, secondary to spinal epidural hematoma with spinal cord compression. The patient did not recover neurologic function postsurgically, possibly because the operation was delayed. In conclusion,doi:10.1536/jhj.43.417 pmid:12227717 fatcat:bocrbdgmuvdyvj7x2ohhw35yke
more »... ardiologists should be alert to this rare, severe complication of rTPA and should perform early laminectomy (in ≤36 hours for those with complete deficit and in ≤48 hours for those with incomplete deficit) if possible.
Chan et al.  recently propose to wear a camera on hand webbings to recognize hand gestures and context-aware interactions such as events triggered by object recognition. ...arXiv:1512.01881v3 fatcat:a5nx4ggazrayjmhwgcs4lixzgm
A multi-electrolyte-step (MES) anodic aluminum oxide (AAO) method was used to achieve nanochannel arrays with good circularity and periodic structure. The nano-channel array fabrication process included immersion in a phosphoric acid solution with a 120–150 bias voltage. Bowl-shaped structures were then formed by removing the walls of the nano-channel arrays. The nano-channel arrays were grown from the bottom of the bowl structure in an oxalic solution using a 50 V bias voltage. A comparison ofdoi:10.1155/2013/784927 fatcat:63i33pcjqvh57jgbrcqnui6ghq
more »... this new MES process with the one-step and five-step AAO process showed a 50% improvement in the circularity over the one-step process. The standard deviation of the average period in the MES array was 25 nm which is less than that of one-step process. This MES method also took 1/4 of the growing time of the five-step process. The orderliness of the nano-channel arrays for the five-step and MES process was similar. Finally, Cu nanoparticle arrays with a 200 nm period were grown using an electroplating process inside the MES nano-channel arrays on fluorine doped tin oxide glass. Stronger surface plasmon resonance absorption from 550 nm to 750 nm was achieved with the MES process than was possible with the one-step process.
Significantly higher cytotoxic and thrombogenic human electronegative low-density lipoprotein (LDL), or L5, has been found in patients with stable coronary artery disease and acute coronary syndrome. We hypothesized that the statin-benefit groups (SBGs) defined by the new cholesterol guideline were of higher electronegative L5. In total, 62 hyperlipidemia patients (mean age 59.4 ± 10.5, M/F 40/22) were retrospectively divided into SBGs (n = 44) and N-SBGs (n = 18). The levels of complete basicpmid:27899853 pmcid:PMC5126444 fatcat:brf36kzfsver3bqavlouw7bchm
more »... ipid panel, biochemical profile and electronegative L5 of each individual were obtained before and after rosuvastatin 10 mg/day for 3 months. After 3 months' statin therapy, significant reduction of total cholesterol, LDL-C and triglyceride were demonstrated (all p-values < 0.05), with 38.4% LDL-C reduction. The percentage of L5 was significantly reduced by 40.9% (from 4.4% to 2.6%) after statin therapy (p = 0.001). Regarding absolute L5 concentration, derived from L5% multiplied by LDL-C, there was approximate 63.8% reduction (from 6.3 mg/dL to 2.3 mg/dL) of absolute L5 (p < 0.001) after statin treatment. Notably, while plasma LDL-C levels were similar between SBGs and N-SBGs (152.8 ± 48.6 vs. 146.9 ± 35.0 mg/dL), the SBGs had significantly elevated L5% (5.2 ± 7.4% vs. 2.6 ± 1.9%, p = 0.031) and higher absolute L5 concentration (7.4 ± 10.4 vs. 3.7 ± 3.1 mg/dL, p = 0.036). Linear regression showed the significantly positive correlation between the plasma L5 concentration and the 10-year cardiovascular risk by pooled cohort equation (r = 0.297, p < 0.05). The four SBGs defined by the 2013 ACC/AHA new cholesterol guideline tend to have increased atherogenic electronegative L5. Statin therapy can effectively reduce the electronegative L5 of these four major SBGs.
The purpose of the current study was to investigate the long-term outcomes of radial head arthroplasty in complex elbow injuries through radiographic analysis and functional correlation. We evaluated 24 radial head arthroplasties in 24 consecutive patients with complex elbow fracture dislocation. All patients were treated with a single type of modular monopolar prosthesis containing smooth stem in press-fit implantation. Clinical survey using the Mayo Elbow Performance Score (MEPS),doi:10.3390/jcm10163488 pmid:34441783 pmcid:PMC8397011 fatcat:iddetiukt5hyfjzjnknxrrvu5a
more »... d scales of shortened Disabilities of the Arm, Shoulder, and Hand (QuickDASH) and the visual analog scale (VAS) at more than 10-year follow-up were reported and compared to 2-year outcomes. Periprosthetic osteolysis was measured in the 10 zones of prosthesis-cortical interface with a modified radiolucency score, which was calibrated by each prosthesis size. Pearson correlation analysis was performed to detect the association between periprosthetic radiolucency and clinical assessment. At the final follow-up, MEPS, QuickDASH score and VAS score averaged 82.5 ± 15, 14.1 ± 14.3 and 1.6 ± 1.2 respectively. A decline in functional status was noted, with decreased mean MEPS and increased mean QuickDASH and VAS scores as compared to the 2-year results while the difference was insignificant. Periprosthetic osteolysis was more prevalent around stem tip of zone 3 and zone 8. The final and 2-year radiolucency scores averaged 7.4 ± 4.2 and 2.6 ± 2.3 respectively with significant difference. Pearson correlation analysis indicated that the difference between radiolucency scores and clinical outcomes in MEPS/QuickDASH/VAS was −0.836, 0.517 and 0.464. Progression of periprosthetic osteolysis after postoperative 10 years is more prevalent around the stem tip with moderate to high correlation to clinical outcomes. Sustained follow-up is warranted to justify subsequent surgery for revision or implant removal.
CIG precursors were deposited on the glass from the Cu-Ga alloy and Indium targets by co-sputtering method. The results show that when the sputtering pressure was increased, the surface morphology was changed from a roughness island-crystalline (RMS=165 nm) to a smaller pellet-crystalline (RMS=54.4 nm). At the same time the Cu/(In+Ga) ratio was increased. So, the crystallization of Cu 11 In 9 phase was increasing and CuIn 2 phase was decreasing in the CIG precursor. Then, a layer of seleniumdoi:10.1016/j.proeng.2012.03.008 fatcat:kyuwyq6rzzgddnc342wlsubuja
more »... coated on the precursor and the precursor was selenized using RTA selenization of 600 C. The results show a good stoichiometric and crystallization under the parameters of the sputtering pressure at 4.2 mTorr of CIG precursors.
Authors' contributions SHC (Chan) designed the study and wrote the paper. JWC, HSW, MCL, and HBC analyzed the data. SHC (Chen), CCL, and CCK are advisors. ...doi:10.1186/1556-276x-9-581 pmid:25364316 pmcid:PMC4214604 fatcat:vx5sluu4fnacflzyrksw5ntrue
Clinical experience and animal studies have suggested that positron emission tomography (PET) using fluorine-18-labeled fluorodeoxyglucose ( 18 F-FDG) may be promising for imaging of bone infections. In this study, we aimed to establish the accuracy of 18 F-FDG PET scanning for monitoring the response to poly(lactide-co-glycolide) (PLGA) vancomycin beads for treatment of bone infection. Methods: PLGA was mixed with vancomycin and hot-compress molded to form antibiotic beads. In vitro, elutiondoi:10.1186/s13018-016-0386-x pmid:27121956 pmcid:PMC4848784 fatcat:jkjelbzm6rayjkucubavd5e2xm
more »... says and bacterial inhibition tests were employed to characterize the released antibiotics. In vivo, cylindrical cavities were made in six adult male New Zealand white rabbits, and Staphylococcus aureus or saline was injected into the cavity to create a bone infection. After 2 weeks, the infection was confirmed by bacterial cultures, and the defect was filled with PLGA vancomycin beads. The treatment response was monitored by 18 F-FDG PET. Results: The biodegradable beads released high concentrations of vancomycin (well above the breakpoint sensitivity concentration) for treatment of bone infection. In bacterial inhibition tests, the diameter of the sample inhibition zone ranged from 6.5 to 10 mm, which was equivalent to 12.5-100 % relative activity. 18 F-FDG PET results showed that uncomplicated bone healing was associated with a temporary increase in 18 F-FDG uptake at 2 weeks, with return to near baseline at 6 weeks. In the infected animals, localized infection resulted in intense continuous uptake of 18 F-FDG, which was higher than that in uncomplicated healing bones. Bone infection was confirmed with positive bacterial cultures. In vancomycin-treated animals, data showed rapidly decreasing amounts of 18 F-FDG uptake after treatment. Conclusions: In vitro and in vivo analyses showed that the use of biodegradable PLGA vancomycin beads successfully eradicated S. aureus infection in damaged bone.
This study was aimed at investigating the antioxidant, whitening, and moisture-retention properties of Lactobacillus rhamnosus spent culture supernatant (Lr-SCS) in cosmetic applications. Results reveal that Lr-SCS effectively and gradually scavenges 1,1-diphenyl-2-picrylhydrazyl as well as 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cations, and increases reducing power in a dose-dependent manner. Additionally, Lr-SCS can also suppress tyrosinase activity in vitro anddoi:10.3390/molecules181114161 pmid:24248144 fatcat:m6uilyrbebanxn5hfbnyew3c3m
more »... vely promote moisture retention. Heat treatment at 100 °C for 30 min does not influence the functions of Lr-SCS. We conclude that Lr-SCS can be used effectively in skin care cosmetics.
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