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In Horrocks' proof (Horrocks, European Journal of Combinatorics 20 (1999) 131-148) of Lih's conjecture about the Spernerity of ÿlters in a Boolean algebra generated by 2-subsets, there are 116 exceptional graphs to be checked case by case. The details of the analysis could not be published in its entirety. In this paper we carry Horrocks' method much further to reduce the exceptional cases to a manageable number. A complete examination can thus be exhibited. : S 0 3 0 4 -3 9 7 5 ( 0 0 ) 0 0 2 5 5 -3doi:10.1016/s0304-3975(00)00255-3 fatcat:z27rpgy5qfhjvhe6ahu4v6x27a
0.573 Sertraline 0.80 0.52-1.22 0.303 Fluvoxamine 1.02 0.42-2.48 0.962 Escitalopram 0.60 0.22-1.62 0.317 TCA (ref: none) 0.80 0.52-1.23 0.299 SNRI (ref: none) 1.18 0.70-2.00 0.532 Cheng ... SSRI 12,669 (45.5%) 683 (0.6%) 13,352 <0.001 TCA 2012 (7.2%) 889 (0.8%) 2901 <0.001 SNRI 2498 (9.0%) 53 (0.0%) * 2551 <0.001 Others † 5465 (19.6%) 395 (0.4%) 5860 <0.001 * Cheng ...doi:10.1097/md.0000000000004655 pmid:27603358 pmcid:PMC5023880 fatcat:ztnbctvimbhhjnkluvopvya4cu
face preparation evaluated in ApoE KO mice. ... The aim of the study was to quantify atherosclerotic plaque burden by volumetric assessment and T1 relaxivity measurement at 7T MRI using Gadospin F (GDF) in comparison to en face based measurements. ... Strongest correlation of r = 0.85; p<0.001 is detectable for the estimated TPV at MRI and 3D en face. https://doi.org/10.1371/journal.pone.0180407.g005 Estimation of atherosclerosis in ApoE KO mice with ...doi:10.1371/journal.pone.0180407 pmid:28771481 pmcid:PMC5542445 fatcat:s46mjeys4fbofags6nfkgsqgju
Ko-Fan Wang et al. * Data are in numbers (%) unless noted otherwise. # Abdominal obesity (waist > 90 cm in men or > 80 cm in women); abnormal triglyceride (³ 150 mg/dL); low HDL-C (< 40 mg/dL in men or ...pmid:28344419 pmcid:PMC5364157 fatcat:3k2ra4fucve27kyvpghf32xvyq
Research Program (102N2758E1) to Shiue-Cheng Tang. ... This work was supported in part by grants from the Department of Health, Taiwan (DOH100-TD-I-111-TM016) to Ko-Jiunn Liu and Taiwan National Science Council (NSC 102-2628-B-007-002-MY2) and NTHU-NHRI Joint ...doi:10.3389/fnana.2013.00036 pmid:24155698 pmcid:PMC3805177 fatcat:k4fb5av5cnahlhrgovr4b76pum
Ko et al. / Dermatologica Sinica 29 (2011) 25e28 ...doi:10.1016/j.dsi.2011.01.003 fatcat:mgichi52evdwlkwxmmaimmhqd4
Mass spectrometry imaging (MSI) using ambient ionization technique enables a direct chemical investigation of biological samples with minimal sample pretreatment. However, detailed morphological information of the sample is often lost due to its limited spatial resolution. We demonstrated that the fusion of ambient ionization MSI with optical microscopy of routine hematoxylin and eosin (H&E) staining produces predictive, high-resolution molecular imaging. In this study, desorption electrospraydoi:10.1101/657494 fatcat:bdjrlx3fwzbofp6743iyupljkq
more »... onization (DESI) and nanospray desorption electrospray ionization (nanoDESI) mass spectrometry were employed to visualize lipid and protein species on mouse tissue sections. The resulting molecular distributions obtained by ambient ionization MSI-microscopy fusion were verified with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) MSI and routine immunohistochemistry (IHC) staining on the adjacent sections. Label-free molecular imaging with 5-um spatial resolution can be achieved using DESI and nanoDESI, whereas the typical spatial resolution of ambient ionization MSI is ~100 um. In this regard, sharpened molecular histology of tissue sections was achieved, providing complementary references to the pathology. Such multi-modality integration enabled the discovery of potential tumor biomarkers. After image fusion, we identified about 70% more potential biomarkers that could be used to determine the tumor margins on a lung tissue section with metastatic tumors.
Adipose-derived mesenchymal stem cells (ADSCs) and shockwave (SW) therapy have been shown to exert a chondroprotective effect for osteoarthritis (OA). The results of this study demonstrated that autologous ADSCs had dose-dependent and synergistic effects with SW therapy (0.25 mJ/mm2 with 800 impulses) in OA rat knee joint. Autologous, high-dose 2 × 106 ADSCs (ADSC2 group) combined with SW therapy significantly increased the bone volume, trabecular thickness, and trabecular number among in thedoi:10.3390/ph14040318 pmid:33916108 fatcat:u4odtkane5gczint4kcduvxkqu
more »... eatment groups. ADSC2 combined with SW therapy significantly reduced the synovitis score and OARSI score in comparison with other treatments. In the analysis of inflammation-induced extracellular matrix factors of the articular cartilage in OA, the results displayed that ADSC2 combined with SW therapy had a greater than other treatments in terms of reducing tumor necrosis factor-inducible gene (TSG)-6 and proteoglycan (PRG)-4, in addition to increasing tissue inhibitor matrix metalloproteinase (TIMP)-1 and type II collagen. Furthermore, ADSC2 combined with SW therapy significantly reduced the expression of inflammation-induced bone morphogenetic protein (BMP)-2 and BMP-6. Therefore, the results demonstrated that ADSC2 combined with SW therapy had a synergistic effect to ameliorate osteoarthritic pathological factors in OA joints.
Detailed procedures on the establishment of cell models and the characteristics of these cell-lines will be submitted elsewhere (Ko et al. manuscript in preparation). ... In gnmt-KO mice developed steatosis, fibrosis, and HCC, the methylation of RASSF1 and SOCS2 promoters and H3K27, which may result in epigenetic modulation of critical HCC carcinogenic pathways  . ...doi:10.3390/ijms23010481 pmid:35008908 pmcid:PMC8745498 fatcat:el6kl75prbhkhb3cwmadgb24yq
Copyright: Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT The purposes of this study were to associate the genetic polymorphisms in carbonic anhydrase (CA) 9 with uterine cervical cancer and identify the clinical implications. Three single-nucleotide polymorphisms (SNPs),doi:10.18632/oncotarget.20842 pmid:29100431 pmcid:PMC5652820 fatcat:4v6wmtmhrveafmwygtmpcajmai
more »... s2071676 (+201, G/A), rs3829078 (+1081, A/G), and rs1048638 (+1584, C/A), and an 18-base-pair deletion/insertion (376del393) in CA9 were examined. We used the Boyden chamber assay to evaluate the influence of CA9 on the migration of cervical cancers. Tissue microarrays were used to evaluate CAIX immunoreactivity and determine its clinical significance. The results revealed that the CA9 SNP rs1048638 is the only significant polymorphism that increases the risk of cervical cancer in Taiwanese women. We discovered that the CA9 SNP rs1048638 influences the expression of CA9 through the interaction between the 3′-untranslated region (UTR) of exon 11, where the SNP is located, and miR-34a, and influences the migration of cervical cancer cells. Moreover, we demonstrated that CAIX immunoreactivity is related to the occurrence of cervical cancer, and elevated CAIX immunoreactivity is associated with a more advanced stage. In conclusion, the finding that the CA9 SNP rs1048638 exerts its action through duplexes of the miR-34a and CA9 3′-UTRs and plays a vital role in cervical cancer in Taiwanese women may be applicable to translational medicine. www.impactjournals.com/oncotarget
Objective: To investigate the effects of standardized soy extract on climacteric symptoms, lipid profiles, bone markers, and serum isoflavone concentration in healthy Taiwanese postmenopausal women. Materials and Methods: A multicenter, open-labeled, randomized, prospective, comparative study design was used. A total of 130 outpatients who had undergone natural menopause were randomly administered either 70 mg or 35 mg soy extract daily for 24 weeks. Results: The evidence suggests that the soydoi:10.1016/j.tjog.2012.04.011 pmid:22795099 fatcat:d4i6biwujfevtpekcrh5ikadfe
more »... xtract treatment that was administered to both groups for 1 month could help reduce climacteric scores (reductions of 19.66% [p < 0.01] and 18.85% [p < 0.01] in the 35 mg and 70 mg groups compared with baseline, respectively), and the efficacy was more potent after 6 months of treatment. Soy isoflavone significantly reduced the total cholesterol (reductions of 4.50% [p < 0.01] and 3.06% [p < 0.05] in the 35 mg and 70 mg groups, respectively) and low density lipoprotein cholesterol levels (reductions of 4.67% [p < 0.05] and 5.09% [p < 0.05] in the 35 mg and 70 mg groups, respectively) in patients with total cholesterol > 200 mg/dL after 6 months of treatment. In patients with high bone turnover (urinary deoxypyridinoline/creatinine > 7.4 nM/mM), soy extract treatment reduced the deoxypyridinoline /creatinine level by 10.53% ( p < 0.05) and 11.58% ( p < 0.05) in the 35 mg and 70 mg groups, respectively. Serum levels of isoflavone increased in both groups after 6 months of treatment. Conclusion: Soy extract is highly efficacious at relieving menopausal symptoms and demonstrates a positive effect on the cardiovascular system and skeleton.
Ko etal 277 The authors thank Ryuji Yamamoto, MD, PhD, Katsuya Nobuhara, MD, PhD, Kai-Nan An, PhD, Sheng-Nan Lu, MD, C.F. ... Reprint requests: Jih-Yang Ko, MD, Department of Orthopaedic Surgery, Chang Gung Memorial Hospital at Kaohsiung, 123, Ta-Pei Rd., Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan (e-mail: firstname.lastname@example.org ...doi:10.1016/j.jse.2005.10.013 pmid:16679225 fatcat:4sz2prqnxff5hollg7un44nu5m
Author contribution Man-Ling Kao, Chia-En Heish, Kuo-Hua Lin and Yao-Li Chen designed and performed the research. Chen-Te Chou and Chih-Jan Ko collected data. ...doi:10.1016/j.ijsu.2013.10.004 pmid:24161418 fatcat:lcwrm2ckrnefbnsqoj7sp7noka
DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain controversial. Results: In this study, DNMT3A mutation was identified in 7.9% of 469 de novo MDS patients. DNMT3A-mutated patients had higher platelet counts at diagnosis, and patients with ring sideroblasts had the highest incidence of DNMT3A mutations, whereas those with multilineagedoi:10.1186/s13148-018-0476-1 pmid:29619119 pmcid:PMC5879939 fatcat:i335glf76vfzdmnrkz3kddmrau
more »... ia had the lowest incidence. Thirty-one (83.8%) of 37 DNMT3A-mutated patients had additional molecular abnormalities at diagnosis, and DNMT3A mutation was highly associated with mutations of IDH2 and SF3B1. Patients with DNMT3A mutations had a higher risk of leukemia transformation and shorter overall survival. Further, DNMT3A mutation was an independent poor prognostic factor irrespective of age, IPSS-R, and genetic alterations. The sequential study demonstrated that the original DNMT3A mutations were retained during follow-ups unless allogeneic hematopoietic stem cell transplantation was performed, while DNMT3A mutation was rarely acquired during disease progression. Conclusions: DNMT3A mutation predicts unfavorable outcomes in MDS and was stable during disease evolutions. It may thus be a potential biomarker to predict prognosis and monitor the treatment response.
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