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An improvement on a spernerity proof of Horrocks

Szu-En Cheng, Ko-Wei Lih
2001 Theoretical Computer Science  
In Horrocks' proof (Horrocks, European Journal of Combinatorics 20 (1999) 131-148) of Lih's conjecture about the Spernerity of ÿlters in a Boolean algebra generated by 2-subsets, there are 116 exceptional graphs to be checked case by case. The details of the analysis could not be published in its entirety. In this paper we carry Horrocks' method much further to reduce the exceptional cases to a manageable number. A complete examination can thus be exhibited. : S 0 3 0 4 -3 9 7 5 ( 0 0 ) 0 0 2 5 5 -3
doi:10.1016/s0304-3975(00)00255-3 fatcat:z27rpgy5qfhjvhe6ahu4v6x27a

Platinum-graphene counter electrodes for dye-sensitized solar cells

Cheng-En Cheng, Chi-Yuan Lin, Chien-Hsun Shan, Shang-Yi Tsai, Ko-Wei Lin, Chen-Shiung Chang, Forest Shih-Sen Chien
2013 Journal of Applied Physics  
doi:10.1063/1.4812498 fatcat:nwwp3smtyve4zhzci2e5n5663m

Effects of depression and antidepressant medications on hip fracture

Bi-Hua Cheng, Pau-Chung Chen, Yao-Hsu Yang, Chuan-Pin Lee, Ko-En Huang, Vincent C. Chen
2016 Medicine  
0.573 Sertraline 0.80 0.52-1.22 0.303 Fluvoxamine 1.02 0.42-2.48 0.962 Escitalopram 0.60 0.22-1.62 0.317 TCA (ref: none) 0.80 0.52-1.23 0.299 SNRI (ref: none) 1.18 0.70-2.00 0.532 Cheng  ...  SSRI 12,669 (45.5%) 683 (0.6%) 13,352 <0.001 TCA 2012 (7.2%) 889 (0.8%) 2901 <0.001 SNRI 2498 (9.0%) 53 (0.0%) * 2551 <0.001 Others † 5465 (19.6%) 395 (0.4%) 5860 <0.001 * Cheng  ... 
doi:10.1097/md.0000000000004655 pmid:27603358 pmcid:PMC5023880 fatcat:ztnbctvimbhhjnkluvopvya4cu

Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice

Caroline Jung, Sabine Christiansen, Michael Gerhard Kaul, Eva Koziolek, Rudolph Reimer, Jörg Heeren, Gerhard Adam, Markus Heine, Harald Ittrich, Xianwu Cheng
2017 PLoS ONE  
face preparation evaluated in ApoE KO mice.  ...  The aim of the study was to quantify atherosclerotic plaque burden by volumetric assessment and T1 relaxivity measurement at 7T MRI using Gadospin F (GDF) in comparison to en face based measurements.  ...  Strongest correlation of r = 0.85; p<0.001 is detectable for the estimated TPV at MRI and 3D en face. Estimation of atherosclerosis in ApoE KO mice with  ... 
doi:10.1371/journal.pone.0180407 pmid:28771481 pmcid:PMC5542445 fatcat:s46mjeys4fbofags6nfkgsqgju

Determinants of Treatment Modification in Hypercholesterolemic Patients

Ko-Fan Wang, Cheng-Hsueh Wu, Chun-Chin Chang, Lung-Ching Chen, Kang-Ling Wang, Tse-Min Lu, Shing-Jong Lin, Chern-En Chiang
2017 Acta Cardiologica Sinica  
Ko-Fan Wang et al. * Data are in numbers (%) unless noted otherwise. # Abdominal obesity (waist > 90 cm in men or > 80 cm in women); abnormal triglyceride (³ 150 mg/dL); low HDL-C (< 40 mg/dL in men or  ... 
pmid:28344419 pmcid:PMC5364157 fatcat:3k2ra4fucve27kyvpghf32xvyq

3-D neurohistology of transparent tongue in health and injury with optical clearing

Tzu-En Hua, Tsung-Lin Yang, Wen-Chan Yang, Ko-Jiunn Liu, Shiue-Cheng Tang
2013 Frontiers in Neuroanatomy  
Research Program (102N2758E1) to Shiue-Cheng Tang.  ...  This work was supported in part by grants from the Department of Health, Taiwan (DOH100-TD-I-111-TM016) to Ko-Jiunn Liu and Taiwan National Science Council (NSC 102-2628-B-007-002-MY2) and NTHU-NHRI Joint  ... 
doi:10.3389/fnana.2013.00036 pmid:24155698 pmcid:PMC3805177 fatcat:k4fb5av5cnahlhrgovr4b76pum

Lipedematous alopecia with mucinosis: report of the first case in Taiwan

Jui-Hung Ko, Yi-Chin Shih, Cheng Hong Toh, Hua-En Lee, Tseng-tong Kuo, Rosaline Chung-Yee Hui
2011 Zhōnghuá Pífūkē Yīxué Zázhì  
Ko et al. / Dermatologica Sinica 29 (2011) 25e28  ... 
doi:10.1016/j.dsi.2011.01.003 fatcat:mgichi52evdwlkwxmmaimmhqd4

High Spatial Resolution Ambient Ionization Mass Spectrometry Imaging Using Microscopy Image Fusion [article]

Chih-Lin Chen, Li-En Lin, Ying-Chen Huang, Hsin-Hsiang Chung, Ko-Chien Chen, Yu-Ju Peng, Chiao-Wei Lin, Shih-Torng Ding, Tang-Long Shen, Cheng-Chih Hsu
2019 bioRxiv   pre-print
Mass spectrometry imaging (MSI) using ambient ionization technique enables a direct chemical investigation of biological samples with minimal sample pretreatment. However, detailed morphological information of the sample is often lost due to its limited spatial resolution. We demonstrated that the fusion of ambient ionization MSI with optical microscopy of routine hematoxylin and eosin (H&E) staining produces predictive, high-resolution molecular imaging. In this study, desorption electrospray
more » ... onization (DESI) and nanospray desorption electrospray ionization (nanoDESI) mass spectrometry were employed to visualize lipid and protein species on mouse tissue sections. The resulting molecular distributions obtained by ambient ionization MSI-microscopy fusion were verified with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) MSI and routine immunohistochemistry (IHC) staining on the adjacent sections. Label-free molecular imaging with 5-um spatial resolution can be achieved using DESI and nanoDESI, whereas the typical spatial resolution of ambient ionization MSI is ~100 um. In this regard, sharpened molecular histology of tissue sections was achieved, providing complementary references to the pathology. Such multi-modality integration enabled the discovery of potential tumor biomarkers. After image fusion, we identified about 70% more potential biomarkers that could be used to determine the tumor margins on a lung tissue section with metastatic tumors.
doi:10.1101/657494 fatcat:bdjrlx3fwzbofp6743iyupljkq

Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint

Jai-Hong Cheng, Ke-Tien Yen, Wen-Yi Chou, Shun-Wun Jhan, Shan-Ling Hsu, Jih-Yang Ko, Ching-Jen Wang, Chun-En Aurea Kuo, Szu-Ying Wu, Tsai-Chin Hsu, Chieh-Cheng Hsu
2021 Pharmaceuticals  
Adipose-derived mesenchymal stem cells (ADSCs) and shockwave (SW) therapy have been shown to exert a chondroprotective effect for osteoarthritis (OA). The results of this study demonstrated that autologous ADSCs had dose-dependent and synergistic effects with SW therapy (0.25 mJ/mm2 with 800 impulses) in OA rat knee joint. Autologous, high-dose 2 × 106 ADSCs (ADSC2 group) combined with SW therapy significantly increased the bone volume, trabecular thickness, and trabecular number among in the
more » ... eatment groups. ADSC2 combined with SW therapy significantly reduced the synovitis score and OARSI score in comparison with other treatments. In the analysis of inflammation-induced extracellular matrix factors of the articular cartilage in OA, the results displayed that ADSC2 combined with SW therapy had a greater than other treatments in terms of reducing tumor necrosis factor-inducible gene (TSG)-6 and proteoglycan (PRG)-4, in addition to increasing tissue inhibitor matrix metalloproteinase (TIMP)-1 and type II collagen. Furthermore, ADSC2 combined with SW therapy significantly reduced the expression of inflammation-induced bone morphogenetic protein (BMP)-2 and BMP-6. Therefore, the results demonstrated that ADSC2 combined with SW therapy had a synergistic effect to ameliorate osteoarthritic pathological factors in OA joints.
doi:10.3390/ph14040318 pmid:33916108 fatcat:u4odtkane5gczint4kcduvxkqu

Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis

Po-Ming Chen, Cheng-Hsueh Tsai, Chieh-Cheng Huang, Hau-Hsuan Hwang, Jian-Rong Li, Chun-Chi Liu, Hsin-An Ko, En-Pei Isabel Chiang
2022 International Journal of Molecular Sciences  
Detailed procedures on the establishment of cell models and the characteristics of these cell-lines will be submitted elsewhere (Ko et al. manuscript in preparation).  ...  In gnmt-KO mice developed steatosis, fibrosis, and HCC, the methylation of RASSF1 and SOCS2 promoters and H3K27, which may result in epigenetic modulation of critical HCC carcinogenic pathways [21] .  ... 
doi:10.3390/ijms23010481 pmid:35008908 pmcid:PMC8745498 fatcat:el6kl75prbhkhb3cwmadgb24yq

Impact of microRNA-34a and polymorphism of its target gene CA9 on susceptibility to uterine cervical cancer

Shun-Fa Yang, Yu-Fan Liu, Chao-Wen Cheng, Wei-En Yang, Wea-Lung Lin, Jiunn-Liang Ko, Po-Hui Wang
2017 OncoTarget  
Copyright: Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT The purposes of this study were to associate the genetic polymorphisms in carbonic anhydrase (CA) 9 with uterine cervical cancer and identify the clinical implications. Three single-nucleotide polymorphisms (SNPs),
more » ... s2071676 (+201, G/A), rs3829078 (+1081, A/G), and rs1048638 (+1584, C/A), and an 18-base-pair deletion/insertion (376del393) in CA9 were examined. We used the Boyden chamber assay to evaluate the influence of CA9 on the migration of cervical cancers. Tissue microarrays were used to evaluate CAIX immunoreactivity and determine its clinical significance. The results revealed that the CA9 SNP rs1048638 is the only significant polymorphism that increases the risk of cervical cancer in Taiwanese women. We discovered that the CA9 SNP rs1048638 influences the expression of CA9 through the interaction between the 3′-untranslated region (UTR) of exon 11, where the SNP is located, and miR-34a, and influences the migration of cervical cancer cells. Moreover, we demonstrated that CAIX immunoreactivity is related to the occurrence of cervical cancer, and elevated CAIX immunoreactivity is associated with a more advanced stage. In conclusion, the finding that the CA9 SNP rs1048638 exerts its action through duplexes of the miR-34a and CA9 3′-UTRs and plays a vital role in cervical cancer in Taiwanese women may be applicable to translational medicine.
doi:10.18632/oncotarget.20842 pmid:29100431 pmcid:PMC5652820 fatcat:4v6wmtmhrveafmwygtmpcajmai

Effects of standardized phytoestrogen on Taiwanese menopausal women

Tzay-Shing Yang, Sung-Yuan Wang, Yu-Cheng Yang, Chu-Hui Su, Fa-Kung Lee, Su-Chee Chen, Chao-Yang Tseng, Hei-Jen Jou, Jian-Pei Huang, Ko-En Huang
2012 Taiwanese Journal of Obstetrics & Gynecology  
Objective: To investigate the effects of standardized soy extract on climacteric symptoms, lipid profiles, bone markers, and serum isoflavone concentration in healthy Taiwanese postmenopausal women. Materials and Methods: A multicenter, open-labeled, randomized, prospective, comparative study design was used. A total of 130 outpatients who had undergone natural menopause were randomly administered either 70 mg or 35 mg soy extract daily for 24 weeks. Results: The evidence suggests that the soy
more » ... xtract treatment that was administered to both groups for 1 month could help reduce climacteric scores (reductions of 19.66% [p < 0.01] and 18.85% [p < 0.01] in the 35 mg and 70 mg groups compared with baseline, respectively), and the efficacy was more potent after 6 months of treatment. Soy isoflavone significantly reduced the total cholesterol (reductions of 4.50% [p < 0.01] and 3.06% [p < 0.05] in the 35 mg and 70 mg groups, respectively) and low density lipoprotein cholesterol levels (reductions of 4.67% [p < 0.05] and 5.09% [p < 0.05] in the 35 mg and 70 mg groups, respectively) in patients with total cholesterol > 200 mg/dL after 6 months of treatment. In patients with high bone turnover (urinary deoxypyridinoline/creatinine > 7.4 nM/mM), soy extract treatment reduced the deoxypyridinoline /creatinine level by 10.53% ( p < 0.05) and 11.58% ( p < 0.05) in the 35 mg and 70 mg groups, respectively. Serum levels of isoflavone increased in both groups after 6 months of treatment. Conclusion: Soy extract is highly efficacious at relieving menopausal symptoms and demonstrates a positive effect on the cardiovascular system and skeleton.
doi:10.1016/j.tjog.2012.04.011 pmid:22795099 fatcat:d4i6biwujfevtpekcrh5ikadfe

Pathogenesis of partial tear of the rotator cuff: A clinical and pathologic study

Jih-Yang Ko, Chung Cheng Huang, Wei-Jen Chen, Chin-En Chen, Sung-Hsiung Chen, Ching-Jen Wang
2006 Journal of shoulder and elbow surgery  
Ko etal 277 The authors thank Ryuji Yamamoto, MD, PhD, Katsuya Nobuhara, MD, PhD, Kai-Nan An, PhD, Sheng-Nan Lu, MD, C.F.  ...  Reprint requests: Jih-Yang Ko, MD, Department of Orthopaedic Surgery, Chang Gung Memorial Hospital at Kaohsiung, 123, Ta-Pei Rd., Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan (e-mail:  ... 
doi:10.1016/j.jse.2005.10.013 pmid:16679225 fatcat:4sz2prqnxff5hollg7un44nu5m

Predictors of intra-abdominal coagulopathic hemorrhage after living donor liver transplantation

Man-Ling Kao, Ping-Yi Lin, Chia-En Heish, Chen-Te Chou, Kuo-Hua Lin, Chih-Jan Ko, Chia-Cheng Lin, Yao-Li Chen
2013 International Journal of Surgery  
Author contribution Man-Ling Kao, Chia-En Heish, Kuo-Hua Lin and Yao-Li Chen designed and performed the research. Chen-Te Chou and Chih-Jan Ko collected data.  ... 
doi:10.1016/j.ijsu.2013.10.004 pmid:24161418 fatcat:lcwrm2ckrnefbnsqoj7sp7noka

Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome

Ming-En Lin, Hsin-An Hou, Cheng-Hong Tsai, Shang-Ju Wu, Yuan-Yeh Kuo, Mei-Hsuan Tseng, Ming-Chih Liu, Chia-Wen Liu, Wen-Chien Chou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao (+6 others)
2018 Clinical Epigenetics  
DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain controversial. Results: In this study, DNMT3A mutation was identified in 7.9% of 469 de novo MDS patients. DNMT3A-mutated patients had higher platelet counts at diagnosis, and patients with ring sideroblasts had the highest incidence of DNMT3A mutations, whereas those with multilineage
more » ... ia had the lowest incidence. Thirty-one (83.8%) of 37 DNMT3A-mutated patients had additional molecular abnormalities at diagnosis, and DNMT3A mutation was highly associated with mutations of IDH2 and SF3B1. Patients with DNMT3A mutations had a higher risk of leukemia transformation and shorter overall survival. Further, DNMT3A mutation was an independent poor prognostic factor irrespective of age, IPSS-R, and genetic alterations. The sequential study demonstrated that the original DNMT3A mutations were retained during follow-ups unless allogeneic hematopoietic stem cell transplantation was performed, while DNMT3A mutation was rarely acquired during disease progression. Conclusions: DNMT3A mutation predicts unfavorable outcomes in MDS and was stable during disease evolutions. It may thus be a potential biomarker to predict prognosis and monitor the treatment response.
doi:10.1186/s13148-018-0476-1 pmid:29619119 pmcid:PMC5879939 fatcat:i335glf76vfzdmnrkz3kddmrau
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