Filters








43 Hits in 1.5 sec

Monolayer 1T-NbSe2 as a 2D correlated magnetic insulator [article]

Mengke Liu, Joshua Leveillee, Shuangzan Lu, Jia Yu, Hyunsue Kim, Keji Lai, Chendong Zhang, Feliciano Giustino, Chih-Kang Shih
2021 arXiv   pre-print
1T/2H NbSe2 heterostructure, we find evidence of exchange interactions between the localized magnetic moments in 1T phase and the metallic/superconducting phase, as manifested by Kondo resonances and Yu-Shiba-Rusinov  ...  Supplementary Materials for Monolayer 1T-NbSe2 as a 2D correlated magnetic insulator Mengke Liu 1 , Joshua Leveillee 1,2 , Shuangzan Lu 3 , Jia Yu 1 , Hyunsue Kim 1 , Keji Lai 1 , Chendong Zhang 3 , Feliciano  ...  Our STS measurements on this heterostructure reveal Kondo resonances (32, 33) and Yu-Shiba-Rusinov bound states (34-36), which are clear fingerprints of the exchange interaction between localized magnetic  ... 
arXiv:2103.12948v1 fatcat:pogmg2ytsnb53fd2j76q2upbyq

An Indoor Localization System Using Residual Learning with Channel State Information

Chendong Xu, Weigang Wang, Yunwei Zhang, Jie Qin, Shujuan Yu, Yun Zhang
2021 Entropy  
With the increasing demand of location-based services, neural network (NN)-based intelligent indoor localization has attracted great interest due to its high localization accuracy. However, deep NNs are usually affected by degradation and gradient vanishing. To fill this gap, we propose a novel indoor localization system, including denoising NN and residual network (ResNet), to predict the location of moving object by the channel state information (CSI). In the ResNet, to prevent overfitting,
more » ... replace all the residual blocks by the stochastic residual blocks. Specially, we explore the long-range stochastic shortcut connection (LRSSC) to solve the degradation problem and gradient vanishing. To obtain a large receptive field without losing information, we leverage the dilated convolution at the rear of the ResNet. Experimental results are presented to confirm that our system outperforms state-of-the-art methods in a representative indoor environment.
doi:10.3390/e23050574 pmid:34067056 pmcid:PMC8151952 fatcat:2qfhxrl7wnfolnzgp4u52lph4a

Disruption of cholesterol homeostasis by plant sterols

Chendong Yang, Liqing Yu, Weiping Li, Fang Xu, Jonathan C. Cohen, Helen H. Hobbs
2004 Journal of Clinical Investigation  
The ABC transporters ABCG5 and ABCG8 limit absorption and promote excretion of dietary plant sterols. It is not known why plant sterols are so assiduously excluded from the body. Here we show that accumulation of plant sterols in mice lacking ABCG5 and ABCG8 (G5G8 -/mice) profoundly perturbs cholesterol homeostasis in the adrenal gland. The adrenal glands of the G5G8 -/mice were grossly abnormal in appearance (brown, not white) due to a 91% reduction in cholesterol content. Despite the very low
more » ... cholesterol levels, there was no compensatory increase in cholesterol synthesis or in lipoprotein receptor expression. Moreover, levels of ABCA1, which mediates sterol efflux, were increased 10-fold in the G5G8 -/adrenals. Adrenal cholesterol levels returned to near-normal levels in mice treated with ezetimibe, which blocks phytosterol absorption. To determine which plant sterol(s) caused the metabolic changes, we examined the effects of individual plant sterols on cholesterol metabolism in cultured adrenal cells. Addition of stigmasterol, but not sitosterol, inhibited SREBP-2 processing and reduced cholesterol synthesis. Stigmasterol also activated the liver X receptor in a cellbased reporter assay. These data indicate that selected dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism. Nonstandard abbreviations used: ACAT, acyl-CoA:cholesterol acyltransferase; FPPS, farnesyl diphosphate synthase; G5G8 -/mice, mice lacking ABCG5 and ABCG8; HMGCR, HMG-CoA reductase; HMGCS, HMG-CoA synthase; HSL, hormone-sensitive lipase; LDLR, LDL receptor; LXR, liver X receptor; LXR-α, liver X receptor ligand binding site; NCLPPS, newborn calf lipoprotein-poor serum; SR-BI, scavenger receptor class B type I. Conflict of interest: The authors have declared that no conflict of interest exists. Citation for this article:
doi:10.1172/jci200422186 fatcat:d7fheyt4unhnvkp267n5mpmyte

Disruption of cholesterol homeostasis by plant sterols

Chendong Yang, Liqing Yu, Weiping Li, Fang Xu, Jonathan C. Cohen, Helen H. Hobbs
2004 Journal of Clinical Investigation  
The ABC transporters ABCG5 and ABCG8 limit absorption and promote excretion of dietary plant sterols. It is not known why plant sterols are so assiduously excluded from the body. Here we show that accumulation of plant sterols in mice lacking ABCG5 and ABCG8 (G5G8 -/mice) profoundly perturbs cholesterol homeostasis in the adrenal gland. The adrenal glands of the G5G8 -/mice were grossly abnormal in appearance (brown, not white) due to a 91% reduction in cholesterol content. Despite the very low
more » ... cholesterol levels, there was no compensatory increase in cholesterol synthesis or in lipoprotein receptor expression. Moreover, levels of ABCA1, which mediates sterol efflux, were increased 10-fold in the G5G8 -/adrenals. Adrenal cholesterol levels returned to near-normal levels in mice treated with ezetimibe, which blocks phytosterol absorption. To determine which plant sterol(s) caused the metabolic changes, we examined the effects of individual plant sterols on cholesterol metabolism in cultured adrenal cells. Addition of stigmasterol, but not sitosterol, inhibited SREBP-2 processing and reduced cholesterol synthesis. Stigmasterol also activated the liver X receptor in a cellbased reporter assay. These data indicate that selected dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism. Nonstandard abbreviations used: ACAT, acyl-CoA:cholesterol acyltransferase; FPPS, farnesyl diphosphate synthase; G5G8 -/mice, mice lacking ABCG5 and ABCG8; HMGCR, HMG-CoA reductase; HMGCS, HMG-CoA synthase; HSL, hormone-sensitive lipase; LDLR, LDL receptor; LXR, liver X receptor; LXR-α, liver X receptor ligand binding site; NCLPPS, newborn calf lipoprotein-poor serum; SR-BI, scavenger receptor class B type I. Conflict of interest: The authors have declared that no conflict of interest exists. Citation for this article:
doi:10.1172/jci22186 pmid:15372105 pmcid:PMC516266 fatcat:fwcs4lvhmjepxgt5iwrkddirmi

SICD: Novel Single-Access-Point Indoor Localization Based on CSI-MIMO with Dimensionality Reduction

Yunwei Zhang, Weigang Wang, Chendong Xu, Jie Qin, Shujuan Yu, Yun Zhang
2021 Sensors  
In [7] , Yu et al. proposed a stable CSI fingerprint extraction method to achieve indoor localization.  ... 
doi:10.3390/s21041325 pmid:33668436 pmcid:PMC7918435 fatcat:cmwzpns4frh45cmm5q3yoy7qne

Comparative proteomic analysis of okra (Abelmoschus esculentus L.) seedlings under salt stress

Yihua Zhan, Qingfei Wu, Yue Chen, Mengling Tang, Chendong Sun, Junwei Sun, Chenliang Yu
2019 BMC Genomics  
Salinization seriously threatens land use efficiency and crop yields across the world. Understanding the mechanisms plants use to protect against salt stress will help breeders develop salt-tolerant vegetable crops. Okra (Abelmoschus esculentus L.) is an important vegetable crop of the mallow family, which is now cultivated in warm regions worldwide. To understand the effects of salt stress on the protein level of okra, a comparative proteomic analysis of okra seedlings grown in the presence of
more » ... 0 or 300 mmol L − 1 NaCl treatment was performed using an integrated approach of Tandem Mass Tag labeling and LC-MS/MS integrated approach. Results: A total of 7179 proteins were identified in this study, for which quantitative information was available for 5774 proteins. In the NaCl/control comparison group, there were 317 differentially expressed proteins (DEPs), of which 165 proteins were upregulated and 152 proteins downregulated in the presence of NaCl. Based on the above data, we carried out a systematic bioinformatics analysis of proteins with information, including protein annotation, domain characteristics, functional classification, and pathway enrichment. Enriched gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the DEPs were most strongly associated with "response to stress" and "protein processing in endoplasmic reticulum". Furthermore, several heat shock proteins were identified as DEPs. Conclusions: This information provides a reference direction for further research on the okra proteome in the downstream of the salt stress response, with our data revealing that the responses of okra to salt stress involves by various pathways.
doi:10.1186/s12864-019-5737-7 fatcat:ta7r3n3cdnhk3if2dpsdsv32qm

The Phosphoproteomic Response of Okra (Abelmoschus esculentus L.) Seedlings to Salt Stress

Chenliang Yu, Qinqfei Wu, Chendong Sun, Mengling Tang, Junwei Sun, Yihua Zhan
2019 International Journal of Molecular Sciences  
Soil salinization is a major environmental stresses that seriously threatens land use efficiency and crop yields worldwide. Although the overall response of plants to NaCl has been well studied, the contribution of protein phosphorylation to the detoxification and tolerance of NaCl in okra (Abelmoschus esculentus L.) seedlings is unclear. The molecular bases of okra seedlings' responses to 300 mM NaCl stress are discussed in this study. Using a combination of affinity enrichment, tandem mass
more » ... (TMT) labeling and high-performance liquid chromatography–tandem mass spectrometry analysis, a large-scale phosphoproteome analysis was performed in okra. A total of 4341 phosphorylation sites were identified on 2550 proteins, of which 3453 sites of 2268 proteins provided quantitative information. We found that 91 sites were upregulated and 307 sites were downregulated in the NaCl/control comparison group. Subsequently, we performed a systematic bioinformatics analysis including gene ontology annotation, domain annotation, subcellular localization, and Kyoto Encyclopedia of Genes and Genomes pathway annotation. The latter revealed that the differentially expressed proteins were most strongly associated with 'photosynthesis antenna proteins' and 'RNA degradation'. These differentially expressed proteins probably play important roles in salt stress responses in okra. The results should help to increase our understanding of the molecular mechanisms of plant post-translational modifications in response to salt stress.
doi:10.3390/ijms20061262 fatcat:x6fgsnmeenbxlm5wgl74dxq5ua

Two 'braking mechanisms' for Tin phthalocyanine molecular rotor on dipolar oxide iron surface

Shuangzan Lu, Min Huang, Guodong Huang, Qinmin Guo, Hongxing Li, Jinghao Deng, Chendong Zhang, Yinghui Yu
2022 Nanoscale Advances  
Chendong Zhang: resources, supervision, writingoriginal dra. Yinghui Yu: conceptualization, methodology, data curtion, writingoriginal dra, writingreview & editing.  ... 
doi:10.1039/d1na00588j fatcat:tdex4n4xunf4fkofvc2aqqmdv4

Comparison Research on Different Injection Control Strategy of CI Free Piston Linear Generator in One-time Starting Process

Yu Song, Huihua Feng, Zhengxing Zuo, Mengqiu Wang, Chendong Guo
2014 Energy Procedia  
In one-time starting process of CI free piston linear generator, the starting energy in one cylinder always influence the combustion process in the other cylinder. And the ignition delay has a great influence on the performance of the system running in the process. Based on this influence, two strategies of injection controlling are proposed, which are triggered by displacement signal and velocity signal, respectively. With the strategy of injection triggered by displacement signal, the
more » ... e of injection position to MEP, compression radio and other performance parameters of two cylinders are discussed. The velocity injection strategy utilizes the same model and the kinetic energy of piston assembly in different key position is considered as the impact indicator. This parameter and the injection time are interacted with each other, and they can influence the combustion performance of two cylinders. Finally, this paper describes the applicability of two strategies and concludes that the strategy of injection triggered by velocity is more suitable for CI free piston linear generator in process of starting.
doi:10.1016/j.egypro.2014.12.180 fatcat:7xxswj3rincyrlr634wbbu6v4q

Research on the Combustion Characteristics of a Free-Piston Gasoline Engine Linear Generator during the Stable Generating Process

Yuxi Miao, Zhengxing Zuo, Huihua Feng, Chendong Guo, Yu Song, Boru Jia, Yuyao Guo
2016 Energies  
Chendong Guo and Yuyao Guo performed the experiments. Huihua Feng analysed the data. Yu Song contributed analysis tools. Yuxi Miao wrote the paper.  ...  Chendong Guo and Boru Jia helped revise the paper. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/en9080655 fatcat:bamgcmifirc37ckce2pyyavobq

Study of the Injection Control Strategies of a Compression Ignition Free Piston Engine Linear Generator in a One-Stroke Starting Process

Huihua Feng, Yuyao Guo, Yu Song, Chendong Guo, Zhengxing Zuo
2016 Energies  
Yu Song and Chendong Guo revised the paper. Zhengxing Zuo made many useful comments and experimental suggestions. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/en9060453 fatcat:w4lezpdnk5cpjbwcirnuacoib4

Endovascular thrombectomy for acute ischemic stroke in elderly patients with atrial fibrillation

Jincheng Jiao, Sheng Liu, Chang Cui, Yuezhou Cao, Zhenyu Jia, Hailei Liu, Chendong Wang, Yu Hang, Heng Ni, Minglong Chen, Mingfang Li, Haibin Shi
2022 BMC Neurology  
Background To assess the clinical outcomes after endovascular thrombectomy (EVT) in elderly large vessel occlusion (LVO)-related acute ischemic stroke (AIS) patients with atrial fibrillation (AF). Methods Between January 2019 and December 2020, consecutive AF patients who received EVT due to anterior-circulation stroke were enrolled. The primary outcome was modified Rankin scale (mRS) score at 90 days. Secondary outcomes included all-cause mortality, the recanalization status after EVT
more » ... using modified thrombolysis in cerebral infarction scale, mTICI) and any intracranial hemorrhage (ICH). A multivariate logistic regression model was performed to identify predictors of the functional outcome. Results A total of 148 eligible patients were finally enrolled. Among them, 42 were ≥ 80 years old. Compared to their younger counterparts, patients aged ≥80 years had lower likelihood of good functional outcome (mRS score 0–2) at 90 days (26.2% vs. 48.1%, P = 0.015), less satisfied recanalization (mTICI, 2b-3) (78.6% vs. 94.3%, P = 0.004) and higher all-cause mortality rate (35.7% vs. 14.2%, P = 0.003). A multivariable logistic regression analysis showed that age ≥ 80 years at baseline were the significant predictors for a poor functional outcome (OR: 3.72, 95% CI: 1.17–11.89, p = 0.027). Intravenous thrombolysis (IVT) prior to EVT and longer time intervals from onset of symptoms to EVT tended to be associated with poor functional outcome in patients ≥80 years old. Conclusions Age ≥ 80 years was a significant predictor of unfavorable outcomes after EVT for AIS patients with AF. An increased risk of adverse events must be balanced against the benefit from EVT in elderly patients with AF.
doi:10.1186/s12883-022-02631-3 pmid:35300621 pmcid:PMC8928604 fatcat:3llto22mh5g33lotfhe2k5vhbq

Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway

Chendong Yang, Aihua Hou, Chunfeng Yu, Lingling Dai, Wen Wang, Kangle Zhang, Hongmin Shao, Jinghua Ma, Wenjuan Xu
2018 OncoTargets and Therapy  
Multidrug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in patients diagnosed with hepatocellular carcinoma (HCC). Revealing the molecular mechanism of MDR is indispensable for the development of effective chemotherapeutic drugs. Purpose: Due to the low-toxicity modulators to inhibit MDR, we considered that Kanglaite (KLT) is a potential agent for reversing MDR in HCC. Materials and Methods: BEL-7402/5-fluorouracil (5-FU) and HepG2/adriamycin (ADM) were
more » ... alyzed for cell viability, colony formation assay, cell scratch assay, and cell cycle analysis and apoptosis assay by flow cytometry. The expression of PARP, caspase-3, Bax, Bcl-2, CDC25C, Cyclin B1 and phosphorylation of PTEN, PI3K, and AKT in HepG2/ADM cells were detected by western blotting. Results: The proliferation of drug-resistant cell lines BEL-7402/5-FU and HepG2/ADM pretreated with KLT was significantly inhibited when compared with drug alone. KLT could increase the accumulation of ADM in HepG2/ADM cells. In this study, we found that KLT treatment notably reduced cell viability, induced apoptosis and cell cycle arrest in human HepG2/ ADM and BEL-7402/5-FU cells, and effectively reversed the MDR by p-glycoprotein (P-gp) inhibition. Moreover, KLT decreased the phosphorylation of AKT and PI3K in KLT-treated HepG2/ADM cells. These data together implied that KLT might reverse drug resistance in HCC by blocking the PI3K/AKT signaling. Conclusion: We demonstrated that KLT reversed MDR of human HCC by inducing apoptosis and cell cycle arrest via the PI3K/AKT signaling pathway.
doi:10.2147/ott.s153814 pmid:29520149 pmcid:PMC5833758 fatcat:5do2otchsjbixddum2twf3hjmi

Identification and Expression Profiling of the Auxin Response Factors in Capsicum annuum L. under Abiotic Stress and Hormone Treatments

Chenliang Yu, Yihua Zhan, Xuping Feng, Zong-An Huang, Chendong Sun
2017 International Journal of Molecular Sciences  
Yihua Zhan and Xuping Feng performed the experiments; Chendong Sun analysed the data; Chenliang Yu and Zong-An Huang contributed to writing the manuscript.  ...  Author Contributions: Chenliang Yu conceived and designed the research.  ... 
doi:10.3390/ijms18122719 pmid:29244768 pmcid:PMC5751320 fatcat:ay74xfmjjvfmxoqlon3vng3zou

Genome-Wide Analysis of SRNF Genes in Gossypium hirsutum Reveals the Role of GhSRNF18 in Primary Root Growth

Li Yu, Shuojun Zhang, Hailun Liu, Yufei Wang, Yiting Wei, Xujiao Ren, Qian Zhang, Junkang Rong, Chendong Sun
2021 Frontiers in Plant Science  
All cotton genome databases were downloaded from CottonGen 2 (Yu et al., 2014) . Then, the conserved amino acid residues were explored by SMART 3 (Letunic et al., 2015) .  ...  Chromosomal Mapping and Synteny Analysis Chromosomal position information for all GhSRNFs was obtained from annotation files downloaded from the CottonGen (see footnote 2) website (Yu et al., 2014) .  ... 
doi:10.3389/fpls.2021.731834 pmid:34630480 pmcid:PMC8494181 fatcat:rc6lu5etebcarasb4gkf3dmp5m
« Previous Showing results 1 — 15 out of 43 results