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Gene-Expressing Liposomes as Synthetic Cells for Molecular Communication Studies

Giordano Rampioni, Francesca D'Angelo, Livia Leoni, Pasquale Stano
<span title="2019-01-17">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tkuhrcyiufdxtkdmjqvay6f2ua" style="color: black;">Frontiers in Bioengineering and Biotechnology</a> </i> &nbsp;
Here, we present a review focused on the exchange of chemical signals between liposome-based synthetic cells (operating by gene expression) and biological cells, as well as between two populations of synthetic  ...  The bottom-up branch of synthetic biology includes-among others-innovative studies that combine cell-free protein synthesis with liposome technology to generate cell-like systems of minimal complexity,  ...  between the bio-chem-ICT idea of exchanging chemical signals in a programmable way, and the bottom-up synthetic biology approach focused on the construction of cell-like systems based on gene expression  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2019.00001">doi:10.3389/fbioe.2019.00001</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30705882">pmid:30705882</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6344414/">pmcid:PMC6344414</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s6tpcobojfgzjfvpcqorwpxeo4">fatcat:s6tpcobojfgzjfvpcqorwpxeo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190217081404/http://pdfs.semanticscholar.org/0450/bb40817fcd4015f57eb9a621aa2d6c390dba.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/04/50/0450bb40817fcd4015f57eb9a621aa2d6c390dba.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2019.00001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344414" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Chemical communication between synthetic and natural cells: a possible experimental design

Giordano Rampioni, Luisa Damiano, Marco Messina, Francesca D'Angelo, Livia Leoni, Pasquale Stano
<span title="2013-09-30">2013</span> <i title="Open Publishing Association"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qzezkwolyvf33pglm2jldjklca" style="color: black;">Electronic Proceedings in Theoretical Computer Science</a> </i> &nbsp;
We firstly discuss how our research goal (based on the natural capabilities of biological systems to manipulate chemical signals) finds a proper place in the current scientific and technological contexts  ...  In the previous WIVACE (2012) we presented the state-of-the-art of semi-synthetic minimal cell (SSMC) technology and introduced, for the first time, the idea of chemical communication between synthetic  ...  Acknowledgements All authors greatly acknowledge Pier Luigi Luisi (University Roma Tre) for inspiring discussions on synthetic cells and autopoiesis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4204/eptcs.130.4">doi:10.4204/eptcs.130.4</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7axkqrooajec5bzmhd53vexk5a">fatcat:7axkqrooajec5bzmhd53vexk5a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191013162559/https://arxiv.org/pdf/1309.7687v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/71/66/716600b3b558c1246826cf43dd0973e93671cae1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4204/eptcs.130.4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Vesicle-based artificial cells: Materials, construction methods and applications

Yao Lu, Giulia Allegri, Jurriaan Huskens
<span title="2021-12-15">2022</span> <i title="Royal Society of Chemistry (RSC)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kcpwuad7gjdpbp46teydaxnjk4" style="color: black;">Materials Horizons</a> </i> &nbsp;
The construction of artificial cells with specific cell-mimicking functions helps to explore complex biological processes and cell functions in natural cell systems, and provides insight into the origins  ...  G.A. acknowledges the financial support by the University of Parma for the exchange visit at the University of Twente.  ...  Acknowledgements Y.L and J.H. acknowledge financial support by the Netherlands Organization for Scientific Research (NWO-NSFC grant no. 729001032 to J.H.).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/d1mh01431e">doi:10.1039/d1mh01431e</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34908080">pmid:34908080</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8900604/">pmcid:PMC8900604</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/aljeosnduffxlnk7zqadioho7y">fatcat:aljeosnduffxlnk7zqadioho7y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211128025155/https://pubs.rsc.org/en/content/articlepdf/2022/mh/d1mh01431e" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/b0/52b02ff8a2a0d7829bd81f6e2fab6187358e1dc5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/d1mh01431e"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900604" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Is Research on "Synthetic Cells" Moving to the Next Level?

Pasquale Stano
<span title="2018-12-26">2018</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gbzbhas4rfd5pkn6xglvth3dre" style="color: black;">Life</a> </i> &nbsp;
Here we summarize some technical and theoretical aspects of synthetic cells based on gene expression and other enzymatic reactions inside liposomes, and comment on the most recent trends.  ...  "Synthetic cells" research focuses on the construction of cell-like models by using solute-filled artificial microcompartments with a biomimetic structure.  ...  The structures called "synthetic cells", or "artificial cells", or "protocells" (sometimes with different nuances in meaning) are chemical or biochemical systems based on micro-compartments that enclose  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/life9010003">doi:10.3390/life9010003</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30587790">pmid:30587790</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6463193/">pmcid:PMC6463193</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/isd3kgjm65hdbhl4hvgj25tcjq">fatcat:isd3kgjm65hdbhl4hvgj25tcjq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190503114049/https://res.mdpi.com/life/life-09-00003/article_deploy/life-09-00003.pdf?filename=&amp;attachment=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/39/38/3938b01d3e0ea68f2f707b867100afa7e094698b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/life9010003"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463193" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Droplet-based microfluidics for artificial cell generation: a brief review

Chiara Martino, Andrew J. deMello
<span title="2016-06-17">2016</span> <i title="The Royal Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d7whzd2jibasbkf6j6dw5axlae" style="color: black;">Interface Focus</a> </i> &nbsp;
One contribution of 8 to a theme issue 'Sensors in technology and nature'.  ...  This study demonstrated the feasibility of encapsulating proteins, beads and cells in liposomes with diameters ranging from 27 to 55 mm, and facilitating ion exchange between the inner compartment and  ...  and synthetic chemical components, is able to mimic or substitute cellular functions [3, 4] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1098/rsfs.2016.0011">doi:10.1098/rsfs.2016.0011</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27499841">pmid:27499841</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4918832/">pmcid:PMC4918832</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7fsuktuiafepfadrtps6mecmvq">fatcat:7fsuktuiafepfadrtps6mecmvq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223002000/http://pdfs.semanticscholar.org/3cab/ca92261f90923acc1b25df4790429e2be275.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/ab/3cabca92261f90923acc1b25df4790429e2be275.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1098/rsfs.2016.0011"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918832" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Usual Suspects 2019: of Chips, Droplets, Synthesis, and Artificial Cells

Christoph Eilenberger, Sarah Spitz, Barbara Eva Maria Bachmann, Eva Kathrin Ehmoser, Peter Ertl, Mario Rothbauer
<span title="2019-04-27">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4clw6v34prcbvk2usotmbz6v3q" style="color: black;">Micromachines</a> </i> &nbsp;
Synthetic biology aims to understand fundamental biological processes in more detail than possible for actual living cells.  ...  This review critically highlights the latest updates in microfluidic cell-free and cell-based protein synthesis as well as the progress on chip-based artificial cells.  ...  Within this device, cell-sized liposomes were generated via octanol-assisted liposome assembly and subsequently flowed against a wedge-shaped splitter, resulting in two liposomes with a size of 6 µm.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi10050285">doi:10.3390/mi10050285</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31035574">pmid:31035574</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6562886/">pmcid:PMC6562886</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/h7yucbgw2ffozoyktobhnvj3fq">fatcat:h7yucbgw2ffozoyktobhnvj3fq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211060717/https://res.mdpi.com/d_attachment/micromachines/micromachines-10-00285/article_deploy/micromachines-10-00285-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ea/5d/ea5dd502ca974728928d4d09ba71bd2ce6714e96.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi10050285"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562886" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cell-Free Synthetic Biology Platform for Engineering Synthetic Biological Circuits and Systems

Jeong, Klocke, Agarwal, Kim, Choi, Franco, Kim
<span title="2019-05-14">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/26pa4o55qbcudfcimiw32nr32y" style="color: black;">Methods and Protocols</a> </i> &nbsp;
To streamline design processes and facilitate debugging of complex synthetic circuits, cell-free synthetic biology approaches has reached broad research communities both in academia and industry.  ...  By recapitulating gene expression systems in vitro, cell-free expression systems offer flexibility to explore beyond the confines of living cells and allow networking of synthetic and natural systems.  ...  Minimal cell systems can be designed to perform specified tasks autonomously, or they can network with native cells to increase sensing and actuation of biological systems.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mps2020039">doi:10.3390/mps2020039</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31164618">pmid:31164618</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6632179/">pmcid:PMC6632179</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tuoyrfi5bnespmmmkip5xec4ti">fatcat:tuoyrfi5bnespmmmkip5xec4ti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200305174721/http://oasis.postech.ac.kr/bitstream/2014.oak/99016/1/2019_MethodsProc.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/97/97/9797cf9c069ffb8c0250eaf96552915191a13e6a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mps2020039"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632179" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Development of Artificial Cell Models Using Microfluidic Technology and Synthetic Biology

Koki Kamiya
<span title="2020-05-30">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4clw6v34prcbvk2usotmbz6v3q" style="color: black;">Micromachines</a> </i> &nbsp;
Recent developments in microfluidic technologies and synthetic biology have enabled the development of well-defined artificial cell models with complex reactions based on the giant lipid vesicles.  ...  Giant lipid vesicles or liposomes are primarily composed of phospholipids and form a lipid bilayer structurally similar to that of the cell membrane.  ...  Synthetic cells containing mammalian transcriptional and translational machinery communicate with other synthetic cells via biological nanopores or by membrane fusion.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi11060559">doi:10.3390/mi11060559</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32486297">pmid:32486297</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7345299/">pmcid:PMC7345299</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vswe37v5hjgaffagbo43nwuqli">fatcat:vswe37v5hjgaffagbo43nwuqli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211208232945/https://mdpi-res.com/d_attachment/micromachines/micromachines-11-00559/article_deploy/micromachines-11-00559-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/23/3a/233a427adaeaf42216689d83e06d7c4e65e26240.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi11060559"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345299" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Designer cell signal processing circuits for biotechnology

Robert W. Bradley, Baojun Wang
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lz4pmajgdvhmhhibru6fyygj7e" style="color: black;">New Biotechnology</a> </i> &nbsp;
Up to now most examples of synthetic biological signal processing have been built based on digital information flow, though analogue computing is being developed to cope with more complex operations and  ...  Great progress has been made in expanding the categories of characterised biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally  ...  apoptosis is triggered with a chemical stimulus.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nbt.2014.12.009">doi:10.1016/j.nbt.2014.12.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25579192">pmid:25579192</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4571992/">pmcid:PMC4571992</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/l3lcf6xoyneblfhais4c7k3zme">fatcat:l3lcf6xoyneblfhais4c7k3zme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171118132135/https://core.ac.uk/download/pdf/28979620.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7c/27/7c276e4e3fc8f1f147fd69863bd7201a740efab6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.nbt.2014.12.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571992" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Creation of Artificial Cell-Like Structures Promoted by Microfluidics Technologies

Yusuke Sato, Masahiro Takinoue
<span title="2019-03-27">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4clw6v34prcbvk2usotmbz6v3q" style="color: black;">Micromachines</a> </i> &nbsp;
The progress of versatile biological research fields has clarified many biological phenomena, and various artificial cell models have been proposed in these fields.  ...  The creation of artificial cells is an immensely challenging task in science. Artificial cells contribute to revealing the mechanisms of biological systems and deepening our understanding of them.  ...  capable of controlling their function based on individual interactions, and "development of life like technology" [77] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi10040216">doi:10.3390/mi10040216</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30934758">pmid:30934758</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6523379/">pmcid:PMC6523379</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5dc5pj6qubhq5ey24hfuea5nsy">fatcat:5dc5pj6qubhq5ey24hfuea5nsy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209030050/https://res.mdpi.com/d_attachment/micromachines/micromachines-10-00216/article_deploy/micromachines-10-00216-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f9/f1/f9f1074a0f25fddacff8949f4d36e1680fba6dc7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/mi10040216"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523379" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mechanobiology of mRNA Localization in Breast Cancer Cells

Susan M. Hamilla, Stavroula Mili, Helim Aranda-Espinoza
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
Here, we examine methods to engineer coupled equilibria that are linked to the protein binding event, which result in protein variants that can be regulated reversibly, based on environmental conditions  ...  Using single domain (VHH) antibodies as model affinity reagents, along with combinatorial libraries, which provide a route to screen new and wild-type residues across a significant amount of interface  ...  In order to better elucidate this interaction, we designed a biomimetic robotic host platform comprised of an onboard synthetically engineered microbiome.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2014.11.3416">doi:10.1016/j.bpj.2014.11.3416</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ef6mtcnlfneh7gkv7wpz3jev2e">fatcat:ef6mtcnlfneh7gkv7wpz3jev2e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190416034931/https://core.ac.uk/download/pdf/82491913.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f8/dc/f8dc1fdd2562faa8c9efc712d3a296a8cc3693bc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2014.11.3416"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials

Qingming Ma, Yang Song, Wentao Sun, Jie Cao, Hao Yuan, Xinyu Wang, Yong Sun, Ho Cheung Shum
<span title="2020-02-11">2020</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ifj4v2fyuvegzgqkhtt4dthbna" style="color: black;">Advanced Science</a> </i> &nbsp;
Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and replicate the intracellular LLPS.  ...  structural proficiency and diversified biological functions.  ...  For instance, ATPS-based heterocellular culture systems that resemble embryonic development in terms of direct intercellular interactions and induce neural differentiation of embryonic stem cells have  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/advs.201903359">doi:10.1002/advs.201903359</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32274317">pmid:32274317</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7141073/">pmcid:PMC7141073</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/no2r7bnhfzgc7plotgi5jxqkme">fatcat:no2r7bnhfzgc7plotgi5jxqkme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200430124623/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7141073&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c3/a1/c3a153371e4dc31ab08671d97dbdd003d823da81.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/advs.201903359"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141073" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Biohybrid actuators for robotics: A review of devices actuated by living cells

Leonardo Ricotti, Barry Trimmer, Adam W. Feinberg, Ritu Raman, Kevin K. Parker, Rashid Bashir, Metin Sitti, Sylvain Martel, Paolo Dario, Arianna Menciassi
<span title="2017-11-29">2017</span> <i title="American Association for the Advancement of Science (AAAS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/n6i5zz3genavjbew2xq42udvji" style="color: black;">Science Robotics</a> </i> &nbsp;
By leveraging the performance of living cells and tissues and directly interfacing them with artificial components, it should be possible to exploit the intricacy and metabolic efficiency of biological  ...  Actuation is essential for artificial machines to interact with their surrounding environment and to accomplish the functions for which they are designed.  ...  A lack of a fundamental understanding of certain biological phenomena is missing, especially concerning the ultimate control of muscle size, shape, and interactions with other tissues.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1126/scirobotics.aaq0495">doi:10.1126/scirobotics.aaq0495</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33157905">pmid:33157905</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fvxjemw62zht3bitby7ic4g7na">fatcat:fvxjemw62zht3bitby7ic4g7na</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190429065049/https://robotics.sciencemag.org/content/robotics/2/12/eaaq0495.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/48/ef/48ef4083aff034d924eafd6c533cfcc0f5c2a21c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1126/scirobotics.aaq0495"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> sciencemag.org </button> </a>

A Survey of Molecular Communication in Cell Biology: Establishing a New Hierarchy for Interdisciplinary Applications [article]

Dadi Bi, Apostolos Almpanis, Adam Noel, Yansha Deng, Robert Schober
<span title="2020-08-31">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Molecular communication (MC) engineering is inspired by the use of chemical signals as information carriers in cell biology.  ...  The biological nature of chemical signaling makes MC a promising methodology for interdisciplinary applications requiring communication between cells and other microscale devices.  ...  In the following, we review some synthetic digital and analog circuits which are designed based on chemical reactions and synthetic biology.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2009.00090v1">arXiv:2009.00090v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5fhpk7dpmvc35b44ysr4srqbc4">fatcat:5fhpk7dpmvc35b44ysr4srqbc4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200903112239/https://arxiv.org/pdf/2009.00090v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2009.00090v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Nano-enabled synthetic biology

Mitchel J Doktycz, Michael L Simpson
<span title="2007-07-10">2007</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/oayrvwhnr5a2jm4pbva2dvz3ui" style="color: black;">Molecular Systems Biology</a> </i> &nbsp;
Attention to systems biology principles can lead to the practical development of nanoscale technologies with possible realization of synthetic systems with cell-like complexity.  ...  In natural systems, the cell is the elemental unit and efforts to emulate cells, their components, and organization have relied primarily on the use of bioorganic materials.  ...  Acknowledgements We gratefully acknowledge the staff of the Molecular-Scale Engineering and Nanoscale Technologies and the Biological and Nanoscale Systems research groups for contributions and critiques  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/msb4100165">doi:10.1038/msb4100165</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17625513">pmid:17625513</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1948103/">pmcid:PMC1948103</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lbmglqpd2valdonpaifrwb6t24">fatcat:lbmglqpd2valdonpaifrwb6t24</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170811141432/http://msb.embopress.org/content/msb/3/1/125.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/2a/d12a7e50753850e5baa4b43cf694aad6cad3dbbb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/msb4100165"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948103" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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