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Chemical Entities of Biological Interest: an update

Paula de Matos, Rafael Alcántara, Adriano Dekker, Marcus Ennis, Janna Hastings, Kenneth Haug, Inmaculada Spiteri, Steve Turner, Christoph Steinbeck
2009 Nucleic Acids Research  
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds.  ...  ChEBI includes an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified.  ...  ACKNOWLEDGEMENTS The authors would like to acknowledge the contribution of the following people to the success of the project: Michael  ... 
doi:10.1093/nar/gkp886 pmid:19854951 pmcid:PMC2808869 fatcat:phtdfvxygrhczfberkbzgmyvyy

DrugCentral 2018: an update

Oleg Ursu, Jayme Holmes, Cristian G Bologa, Jeremy J Yang, Stephen L Mathias, Vasileios Stathias, Dac-Trung Nguyen, Stephan Schürer, Tudor Oprea
2018 Nucleic Acids Research  
Since the 2016 release, 103 new approved drugs were updated.  ...  New and existing entries have been updated with the latest information from scientific literature, drug labels and external databases.  ...  ., for contributions to the front-end website development of DrugCentral. FUNDING  ... 
doi:10.1093/nar/gky963 pmid:30371892 pmcid:PMC6323925 fatcat:adbxxj73trgpph4k4f5wnubuvy

FlavorDB2: An Updated Database of Flavor Molecules [article]

Nishant Grover, Mansi Goel, Devansh Batra, Neelansh Garg, Rudraksh Tuwani, Apuroop Sethupathy, Ganesh Bagler
2022 arXiv   pre-print
FlavorDB2 (https://cosylab.iiitd.edu.in/flavordb2/) is an updated database of flavor molecules with an user-friendly interface.  ...  Knowing the utility of flavor molecules in food and fragrances, it is valuable to add a comprehensive repository of flavor compounds characterizing their flavor profile, chemical properties, regulatory  ...  Flavor perception is an emergent property of the complex biological system, the complete understanding of which still eludes us [1] - [5] .  ... 
arXiv:2205.05451v1 fatcat:zuqdkya7ivg37bka5lhnlpycxy

Drug-induced lupus: an update

S Vasoo
2006 Lupus  
This review discusses the clinical presentation, diagnosis of DILE as well as provides an update on postulated pathogenic mechanisms and an overview of implicated drugs. Lupus (2006) 15, 757-761.  ...  Drug-induced lupus erythematosus (DILE) is a lupus-like illness that has been recognized as an entity under environmentally-induced lupus erythematosus, where other agents such as physical (ultra-violet  ...  This review discusses the clinical presentation, diagnosis of DILE as well as provides an update on postulated pathogenic mechanisms and an overview of implicated drugs.  ... 
doi:10.1177/0961203306070000 pmid:17153847 fatcat:47rbzemspfhwxaqfmcoi52xuxa

The ChEMBL bioactivity database: an update

A. Patrícia Bento, Anna Gaulton, Anne Hersey, Louisa J. Bellis, Jon Chambers, Mark Davies, Felix A. Krüger, Yvonne Light, Lora Mak, Shaun McGlinchey, Michal Nowotka, George Papadatos (+2 others)
2013 Nucleic Acids Research  
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue.  ...  Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource.  ...  This information allows users of the bioactivity data to assess whether a compound of interest is an approved drug and is, therefore, likely to have an advantageous safety/pharmacokinetic profile or be  ... 
doi:10.1093/nar/gkt1031 pmid:24214965 pmcid:PMC3965067 fatcat:ndvcr7h2d5grdntilmpuyxrks4

Application of fullerenes in nanomedicine: an update

Anthony Dellinger, Zhiguo Zhou, James Connor, AB Madhankumar, Sarala Pamujula, Christie M Sayes, Christopher L Kepley
2013 Nanomedicine  
Furthermore, the spherical configuration of the planar benzene rings imposes an  ...  potentially beneficial biologic properties.  ...  The FDA requires that every new chemical entity must be evaluated separately; extrapolating toxicity (or nontoxicity) by categorizing compound mixtures and making generalizations about classes of compounds  ... 
doi:10.2217/nnm.13.99 pmid:23837857 fatcat:ivau6qorobhwlak6oae4d6pmji

An update on prodrugs from natural products

Sekar Vinoth Kumar, Devarajan Saravanan, Balasubramanian Kumar, Annamalai Jayakumar
2014 Asian Pacific Journal of Tropical Medicine  
Acknowledgements The authors are thankful to the authorities of Ratnam Institute of Pharmacy for providing support to the study and other facilities.  ...  In the future, further study claims an open area of research for sound consideration for development of new prodrugs. Conflict of interest statement We declare that we have no conflict of interest.  ...  The value of natural products in this regard can be assessed using three criteria such as the rate of introduction of new chemical entities of wide structural diversity, including serving as templates  ... 
doi:10.1016/s1995-7645(14)60203-0 pmid:25312180 fatcat:iq5aj7sdd5gu3ce2qyar624eym

Quantum Biology: An Update and Perspective

Youngchan Kim, Federico Bertagna, Edeline M. D'Souza, Derren J. Heyes, Linus O. Johannissen, Eveliny T. Nery, Antonio Pantelias, Alejandro Sanchez-Pedreño Jimenez, Louie Slocombe, Michael G. Spencer, Jim Al-Khalili, Gregory S. Engel (+10 others)
2021 Quantum Reports  
biological functions.  ...  Remarkable advances in observation techniques allow us to investigate a broad range of complex and dynamic biological processes in which living systems could exploit quantum behaviour to enhance and regulate  ...  This is the first report of a step-wise hydride transfer in enzyme catalysis, rather than as a single chemical entity, which has only been possible to observe It has been proposed that the role of light  ... 
doi:10.3390/quantum3010006 fatcat:352kibsylbeerfryx3dmxdj56q

Carum Carvi- An Updated Review

Munish Goyal, Vivek Kumar Gupta, Navjeet Singh, Mrinal .
2018 Indian Journal of Pharmaceutical and Biological Research  
It contained a wide range of chemical constituents like essential oils, volatile oils, flavonoids, proteins, carbohydrates, vitamins and trace elements.  ...  This review is a step to open insight for therapeutic efficacy of Carum carvi.  ...  Abbrevations Conflict of Interest: None : i.p.-Interaparetonial p.o.  ... 
doi:10.30750/ijpbr.6.4.4 fatcat:2rdie3vnqbaq3icvadrqxau6am

Bioactive-Based Cosmeceuticals: An Update on Emerging Trends

Anju Goyal, Aditya Sharma, Jasanpreet Kaur, Sapna Kumari, Madhukar Garg, Rakesh K. Sindhu, Md. Habibur Rahman, Muhammad Furqan Akhtar, Priti Tagde, Agnieszka Najda, Barbara Banach-Albińska, Katarzyna Masternak (+10 others)
2022 Molecules  
Mainly, the utilization of phytoconstituents as cosmetic-containing herbals in the care of skin and hair, such as dryness of skin, acne, eczema, inflammation of the skin, aging, hair growth, and dandruff  ...  The name is a combination of "cosmetics" and "pharmaceuticals".  ...  The authors also grateful to Chitkara college of pharmacy, Chitkara university, Punjab, for providing institutional resources for data compilation.  ... 
doi:10.3390/molecules27030828 pmid:35164093 pmcid:PMC8837976 fatcat:anlkqaggnzb3lkrv4dlmgi23wm

Gastritis: An Update in 2020

Massimo Rugge, Kentaro Sugano, Diana Sacchi, Marta Sbaraglia, Peter Malfertheiner
2020 Current treatment options in gastroenterology  
This review illustrates the updated criteria applied in the taxonomy of gastritis (Kyoto classification), elucidates the biological rationale for endoscopy biopsy sampling (heterogeneity of gastric mucosa  ...  Purpose of review The gastritis constellation includes heterogeneous clinicopathological entities, among which long-standing, non-self-limiting gastritis, mainly due to Helicobacter pylori infection, has  ...  There is an update on the (sub)types of functional dyspepsia at the Rome IV conference [1, 2] .  ... 
doi:10.1007/s11938-020-00298-8 fatcat:wxcntvkzb5alrowqbn234xzxuq

Dietary and health biomarkers—time for an update

Lars O. Dragsted, Qian Gao, Giulia Praticò, Claudine Manach, David S. Wishart, Augustin Scalbert, Edith J. M. Feskens
2017 Genes & Nutrition  
These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health.  ...  This current paper outlines the needs and serves as an introduction to this thematic issue of Genes & Nutrition on dietary and health biomarkers.  ...  Councils; the work was funded in part by a grant from the Danish Innovation Foundation (#4203-00002B) and a Semper Ardens grant from the Carlsberg Foundation to LOD, a postdoc grant from the University of  ... 
doi:10.1186/s12263-017-0578-y pmid:28974991 pmcid:PMC5622518 fatcat:hu3v2lakg5cldb6ujgacalfspi

Drug delivery systems: An updated review

Gaurav Tiwari, Ruchi Tiwari, SaurabhK Bannerjee, L Bhati, S Pandey, P Pandey, Birendra Sriwastawa
2012 International Journal of Pharmaceutical Investigation  
forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable  ...  Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against  ...  in the introduction of new chemical entities since the late 1950s.  ... 
doi:10.4103/2230-973x.96920 pmid:23071954 pmcid:PMC3465154 fatcat:zprwhlfdp5aixip74xzwk6uhja

Nanoparticle Exposure and Hormetic Dose–Responses: An Update

Ivo Iavicoli, Veruscka Leso, Luca Fontana, Edward Calabrese
2018 International Journal of Molecular Sciences  
The concept of hormesis, as an adaptive response of biological systems to moderate environmental challenges, has raised considerable nano-toxicological interests in view of the rapid pace of production  ...  Therefore, the aim of this review is to provide an update of the current knowledge concerning the biphasic dose-responses induced by nanoparticle exposure.  ...  Conflicts of Interest: The authors declare no conflicts of interest.  ... 
doi:10.3390/ijms19030805 pmid:29534471 pmcid:PMC5877666 fatcat:rczpym6qxzatlac3xb33vkv7zy

1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update

Harigopal S. Sawarkar, Mahavir Singh, Birendra Shrivastav, R. L. Bakal
2021 Journal of Pharmaceutical Research International  
One of important heterocycle is five-membered 1,3,4-thiadiazole with unique bioisosteric properties displaying unusually wide spectrum of biological activities.  ...  Persistent and uncontrolled use of antibiotics results in development of bacterial resistant.  ...  The hybrid technique is an innovative and strong synthetic tool for the synthesis of two or more different entities in one molecule with novel biological functions, according to the review study.  ... 
doi:10.9734/jpri/2021/v33i62a35203 fatcat:4vb3ykzgpve6dgzcp7ifu3dkva
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