A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Filters
Characterizing the Scope of Exposome Research Through Topic Modeling and Ontology Analysis
2019
Studies in Health Technology and Informatics
Preserved Fulltext
In this work, we characterize the exposome research landscape and update our previous study of formal knowledge representation approaches to this field. ...
We applied a deductive analysis using the National Center for Biomedical Ontology Recommender for comparability of the results generated from a literature dataset and newly available ontologies with our ...
Hawthorne is funded by a Northern Ireland Department for the Economy (DfE) postgraduate studentship Award. ...
doi:10.3233/shti190519
pmid:31438216
fatcat:5rryojxs4rbdvoga2g5ov767om
Human Exposome Assessment Platform - Data Management Plan
2020
Zenodo
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
This deliverable is the Data Management Plan (DMP) of the Human Exposome Assessment Platform (HEAP), which aims to create a technical research platform to assess the impact of the internal and external ...
collection study The plan sets out a governance framework and strategy to cover the full data management lifecycle for all of the above-mentioned data cohorts and projects. ...
The sequencing analysis of specimens together with metadata aims to identify and characterize risk factors that may impact risk for having disease or being healthy. ...
doi:10.5281/zenodo.4043110
fatcat:wiq4jptomjdtfhdpzxw72klaqu
The exposome – a new approach for risk assessment
2020
ALTEX: Alternatives to Animal Experimentation
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Considering the complexity of exposures and, in addition, the reactions of the body to exposures - i.e., the exposome - reverses classical exposure science where the precise measurement of single or few ...
Technological developments and synergies between approaches, quality assurance (ultimately as Good Exposome Practices), and the integration of mechanistic thinking will advance this approach. ...
The mentioned work on computational toxicology was mainly executed by Thomas Luechtefeld during ...
doi:10.14573/altex.2001051
pmid:31960937
fatcat:gdjlg7c2czgchdn2cvr6upiube
4549 Reproducible Informatics for Reproducible Translational Research
2020
Journal of Clinical and Translational Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
A scoping review of scoping reviews: advancing the approach and enhancing the consistency. ...
The Sequence Ontology: a tool for the unification of genome annotations. ...
A scoping review of scoping reviews: advancing the approach and enhancing the consistency. ...
doi:10.1017/cts.2020.221
fatcat:zy6wnxciinbrpa2xptw7cpdou4
Information Technology for Clinical, Translational and Comparative Effectiveness Research
2014
IMIA Yearbook of Medical Informatics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Two other papers exemplify the growing role of formal representation of clinical data -in metadata repositories -and knowledge -in ontologies -for supporting the process of reusing data for clinical research ...
Objective: To select and summarize key contributions to current research in the field of Clinical Research Informatics (CRI). ...
Acknowledgement We would like to acknowledge the support of Martina Hutter and the reviewers in the selection process of the IMIA Yearbook. ...
doi:10.15265/iy-2014-0040
pmid:25123747
pmcid:PMC4287061
fatcat:dgf5qqmvbfd5rfk6j3y2kjuvgm
Computational resources associating diseases with genotypes, phenotypes and exposures
2018
Briefings in Bioinformatics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
He is interested in understanding transcriptional and translational regulation through the integrative analysis of multi-omics data. ...
Haiyue Zhang is a research assistant in Zhongshan School of Medicine at Sun Yat-sen University. Her research is focused on building and applying ontologies for phenotypes and diseases. ...
Table 5 . 5 Summary of different biomedical data and analysis web platforms ZFin, MGI and RGD in total 17 resources Scope refers to the major focus of the web platform. ...
doi:10.1093/bib/bby071
pmid:30102366
fatcat:63ijmbhgxbf6pousquyuhl3s3a
Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes
2020
Frontiers in Public Health
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
The exposome represents the totality of exogenous (external) and endogenous (internal) exposures from conception onwards, simultaneously distinguishing, characterizing, and quantifying etiologic, mediating ...
The exposome is a measure of all the exposures of an individual across the life course and the relationship of those exposures to health effects. ...
Most of the studies pertaining to development of transcriptomic biomarkers have been carried out in animal models, which we have not addressed here as it is beyond the scope of this review. ...
doi:10.3389/fpubh.2020.00379
pmid:32903514
pmcid:PMC7437454
fatcat:avxm7oaehbhy7jsvpcszsc6une
Integrative concepts and practices of health in transdisciplinary social ecology
2019
Socio-Ecological Practice Research
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Through a semi-systematic evaluation of knowledge generation in scientific publications (comprised of literature reviews, conceptual models and analyses of communities of practice), we show how integrative ...
, expanding their scope and linking them better. ...
To characterize the development of concepts and their uses, we employed conceptual models, drew on the previous literature, and evaluated the development of knowledge empirically by coupled bibliometric ...
doi:10.1007/s42532-019-00038-y
fatcat:quxpvnoqunf7zgfxiponsmorea
Charting a future for epidemiologic training
2015
Annals of Epidemiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Purpose-To identify macro level trends that are changing the needs of epidemiologic research and practice and to develop and disseminate a set of competencies and recommendations for epidemiologic training ...
Conclusion-Addressing these issues through curricular change is needed to allow the field of epidemiology to more fully reach and sustain its full potential to benefit population health and remain a scientific ...
Acknowledgments The authors are grateful for the input of Ms. Anna Hardy and Pam Hipp and Drs. David Celentano, Steve Goodman, Kim Johnson, and Andy Olshan. ...
doi:10.1016/j.annepidem.2015.03.002
pmid:25976024
pmcid:PMC4646613
fatcat:fhk5dwdq6bhkzmamevepmmjgfi
The informational stance: Philosophy and logic. Part I. The basic theories
2013
Logic and Logical Philosophy
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
In Part II [WuB14], we develop the relation between information and social value as a basis for the ethical development of the emerging Information Society. ...
In the 80's, Wu Kun proposed a "The Basic Theory of the Philosophy of Information", which became available in English only in 2010. ...
structure of its related ontology, • a two-level framework of relational analysis. ...
doi:10.12775/llp.2013.019
fatcat:q2ajarkz3zhotbizqj4czy466i
Biomarker discovery in mass spectrometry-based urinary proteomics
2016
PROTEOMICS - Clinical Applications
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Urinary proteomics has become one of the most attractive topics in disease biomarker discovery. ...
Mass spectrometry (MS)-based proteomic analysis has advanced continuously and emerged as a prominent tool in the field of clinical bioanalysis. ...
Acknowledgments The authors would like to thank National Institutes of Health funding through Grants P20 DK097826; R01 DK093690; and U54 DK104310. ...
doi:10.1002/prca.201500102
pmid:26703953
pmcid:PMC4888976
fatcat:adao77gznvb5bc5a7q57wkb6nq
Embracing microbes in exposure science
2018
Journal of Exposure Science and Environmental Epidemiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Emerging knowledge creates a major opportunity to expand the scope of exposure science to incorporate the human microbiome as a target and modulator of exposure. ...
A study committee of the National Academies of Sciences, Engineering, and Medicine has defined a research strategy to address health risks that pertain to the interaction of environmental chemicals with ...
Interactions with the Human Microbiome, National Academy of Sciences, Engineering and Medicine. ...
doi:10.1038/s41370-018-0075-4
pmid:30254254
fatcat:qe3oypzijbc4vcnpir256yezae
European Landscape Of Tdm Applications Report
2016
Zenodo
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
(mostly in terms of funded projects), the research output (in terms of scientific publications produced), the resources and tools available for TDM as well as the commercial activity (in terms of companies ...
In this report, after a brief introduction to the different stakeholders and parameters involved in TDM, we focus on TDM in the European Union and try to paint the landscape of TDM research, development ...
Each topic t (in our analysis) is represented by a small set of words; the ones that are more likely to belong to t according to the estimated LDA probabilities (word-topic distribution). ...
doi:10.5281/zenodo.1240758
fatcat:ie25jfzuqne3bc37dc5qotcyyi
Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine
2020
Metabolites
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Besides, we will elucidate the potential involvement of machine learning and demonstrate that the need for automated data mining algorithms to improve the quality of future research is undeniable. ...
Our discussion reflects the current obstacles and potential solutions toward the progressing trend of utilizing metabolomics in clinical research to create the next-generation healthcare system. ...
The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. ...
doi:10.3390/metabo10020051
pmid:32013105
pmcid:PMC7074059
fatcat:xwbqomk26jg7fn6rgnwwq267oe
Precision Medicine Informatics: Principles, Prospects, and Challenges
[article]
2019
arXiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Recent advances in technological innovations and genetics, and the growing availability of health data have set a new pace of the research and imposes a set of new requirements on different stakeholders ...
Furthermore, the paper provides some guidelines for future research for seamless implementation and wide-scale deployment of PM based on identified open issues and associated challenges. ...
The research emphasized on the need of extending the scope of the existing standards rather to invent a new. ...
arXiv:1911.01014v1
fatcat:vnmzgn5jknhjtf5hhhwzvx3gki
« Previous
Showing results 1 — 15 out of 35 results