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Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences

Nathalie Just, Lijing Xin, Hanne Frenkel, Rolf Gruetter
2013 NeuroImage  
In the present study, the rat barrel cortex was reliably and reproducibly activated through sustained trigeminal nerve (TGN) stimulation.  ...  These results allow demonstrating the feasibility of fMRS measurements during prolonged barrel cortex activation in rats.  ...  Acknowledgments This study was supported by the Centre d'Imagerie BioMédicale (CIBM) of Ecole Polytechnique Fédérale de Lausanne (EPFL), the University of Lausanne (UNIL) and the Foundations Leenards et  ... 
doi:10.1016/j.neuroimage.2013.02.042 pmid:23473934 fatcat:xwi3oqfx7nhstcombbtc2xkfdi

Quantitative activity-induced manganese-dependent MRI for characterizing cortical layers in the primary somatosensory cortex of the rat

Matthieu Auffret, Idrees Samim, Mario Lepore, Rolf Gruetter, Nathalie Just
2014 Brain Structure and Function  
Pixel-by-pixel T 1 data were investigated using histogram distributions in the barrel cortex (BC) and the thalamus before and after Mn 2?  ...  In the present study, a precise follow-up of physiological parameters during MnCl 2 and mannitol infusions improved the reproducibility of AIM-MRI allowing in-depth evaluation of the technique.  ...  ROIs of identical volumes were drawn in the rat barrel cortex and the thalamus.  ... 
doi:10.1007/s00429-014-0933-3 pmid:25366973 fatcat:pvlvttvl4faexjxyixeriaaevq

Evaluation of BOLD effects in the rat cortex [article]

Nathalie Just
2021 bioRxiv   pre-print
Purpose: This study aimed to characterize Blood oxygen level-dependent (BOLD) effects in 1H- MR spectra obtained during optogenetic activation of the rat forelimb cortex for the correction and estimation  ...  STEAM acquisitions at 9.4T in rats (n=8) upon optogenetic stimulation of the primary somatosensory cortex were used.  ...  Neuroimage 93(Pt 1):138-145. 28 31 33 35 1 barrel cortex and neurochemical consequences. Neuroimage.2013;74:343-51.  ... 
doi:10.1101/2021.05.12.443862 fatcat:pktsxrmqkfhibmf72p6y5lg77i

Optical imaging of the rat brain suggests a previously missing link between top-down and bottom-up nervous system function

Susan A. Greenfield, Antoine-Scott Badin, Giovanni Ferrati, Ian M. Devonshire
2017 Neurophotonics  
The strategy of voltage-sensitive dye imaging is therefore as powerful as it is versatile and as such can now be applied to the evaluation of neurochemical signaling systems and the screening of related  ...  and, in vivo, depths of anesthesia.  ...  Science Foundation, the Arete Initiative at the University of Chicago, the James Martin 21st Century School, and the European Society of Anesthesiology.  ... 
doi:10.1117/1.nph.4.3.031213 pmid:28573153 pmcid:PMC5443969 fatcat:fr5jy2dlbnaxffutlmozgrpvwm

Cocaine Activation Discriminates Dopaminergic Projections by Temporal Response: An fMRI Study in Rat

John J.A. Marota, Joseph B. Mandeville, Robert M. Weisskoff, Michael A. Moskowitz, Bruce R. Rosen, Barry E. Kosofsky
2000 NeuroImage  
We applied a sensitive new functional magnetic resonance imaging technique to identify the pattern and determinants of cocaine-induced brain activation in drug-naive rats.  ...  At doses greater than 0.1 mg/kg iv, cocaine produced robust activation throughout cortex with the largest magnitude increase in frontal neocortex.  ...  Despite rats being both drug naive and anesthetized, the similarity in activation patterns implies that some components of cocaineinduced brain activation are a direct consequence of dopaminergic mechanisms  ... 
doi:10.1006/nimg.1999.0520 pmid:10686113 fatcat:ztl2oxdshfetfebuhrlty6g2nq

Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in rat forebrain [article]

Jeeun Kang, Shilpa D Kadam, Joshua S Elmore, Brennan J Sullivan, Heather Valentine, Adarsha P Malla, Maged M Harraz, Arman Rahmim, Jin U. Kang, Leslie M Loew, Michael Baumann, Anthony A Grace (+3 others)
2018 bioRxiv   pre-print
The technique previously distinguished global seizure activity from control neural activity in groups of rats.  ...  activities in two distinct circuits with differential response profiles, i.e., sensorimotor cortex and hippocampus.  ...  The alignment of outlets was focused specifically at 20 mm depth. The PA probe was 187 positioned in the sagittal plane to cover the barrel cortex and hippocampus at the same time.  ... 
doi:10.1101/308585 fatcat:cjwevxcwnbb23fdnpkfhcdnesi

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Pierre J. Magistretti, Igor Allaman
2015 Neuron  
Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity  ...  Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity.  ...  The authors wish to thank Ivan Gromiko and Heno Hwang for their support in drawing figures and Virginia Unkefer for editorial review, all of the academic writing services at KAUST.  ... 
doi:10.1016/j.neuron.2015.03.035 pmid:25996133 fatcat:xhmeqeifpjglhf6a3lkmn4f54u

Understanding behavioral effects of early life stress using the reactive scope and allostatic load models

Brittany R. Howell, Mar M. Sanchez
2011 Development and Psychopathology  
In this review we examine the mechanisms underlying the behavioral consequences of early life stress in the context of both these models.  ...  The mechanisms through which early life stress leads to psychopathology are thought to involve allostatic load, the "wear and tear" an organism is subjected to as a consequence of sustained elevated levels  ...  Acknowledgments This work was supported by NIH Grants MH078105 and HD055255 (to M.M.S.) and NRSA MH086203 (to B.R.H.).  ... 
doi:10.1017/s0954579411000460 pmid:22018078 pmcid:PMC4593415 fatcat:sb63rmtifrdgpbmfok4y3tmyki

Dynamic adaptation of large-scale brain networks in response to acute stressors

Erno J. Hermans, Marloes J.A.G. Henckens, Marian Joëls, Guillén Fernández
2014 Trends in Neurosciences  
Corticosteroids: steroid hormones produced in the adrenal cortex (cortisol in humans, corticosterone in rodents). Corticosteroids bind centrally to MRs and GRs.  ...  Blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI): neuroimaging technique that uses BOLD contrast to infer changes in neuronal activity from hemodynamic changes.  ...  LC stimulation furthermore decreases phasic discharge of thalamic and barrel cortex neurons in response to sensory stimuli, while increasing their spontaneous activity [65] .  ... 
doi:10.1016/j.tins.2014.03.006 pmid:24766931 fatcat:okkdek4pzfg7lbijtmesrge4ki

Abstracts of the Tenth Annual Meeting of the Israel Society for Neurosciences

2001 Neural Plasticity  
Incorrect responses, indicating processing of both the word meaning and the color (e.g., 'rblue' in response to the word "RED" written in blue), were typical in the incongrue.nt condition.  ...  The studied coupling is between the input level of the motor system controlling handwritten response (Margo in, Quarterly Journal of Experim.ental Psychology, 34A: 459_-489 [1984]), and the lingual levels  ...  The BOLD technique measures the changes in the oxy/dioxy-hemoglobin ratio during rest represents the basal level activity. We measured the BOLD signal in six urethane-anesthetized rats during rest.  ... 
doi:10.1155/np.2001.157 pmid:11783444 pmcid:PMC2565376 fatcat:ybrait32srfhbaddpozdxlwvcu

Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

D. J. Chandler, W.-J. Gao, B. D. Waterhouse
2014 Proceedings of the National Academy of Sciences of the United States of America  
Specifically, cells that communicate with the prefrontal cortex, a region involved in cognition and executive function, are characterized by properties that allow for independent and asynchronous modulation  ...  of operations in this area, compared with those that project to the motor cortex and regulate movement generation.  ...  Devilbiss DM, Waterhouse BD (2004) The effects of tonic locus ceruleus output on sensory-evoked responses of ventral posterior medial thalamic and barrel field cortical neurons in the awake rat.  ... 
doi:10.1073/pnas.1320827111 pmid:24753596 pmcid:PMC4020069 fatcat:tmq6pleabranth6r3jvvcer6tm

Abstracts of the 12th Annual Meeting of Israel Society for Neuroscience

2003 Neural Plasticity  
The phosphorylation of both proteins is specific to the taste cortex. In addition, eEF2 phosphorylation during memory consolidation is detected in a synaptosomal fraction made from taste cortex.  ...  Administration of a CB2, but not CB1 antagonist significantly reversed the effect of PRS-211,375 in both the inflammatory and visceral pain models suggesting that the analgesic activity of PRS-211,375  ...  In this study we examined the BOLD-fMRI response in the rat barrel field cortex as a result of multiple whisker deflection.  ... 
doi:10.1155/np.2003.179 pmid:14712829 pmcid:PMC2565426 fatcat:4midzhgcurdejakjjwizqvpguq

Abstracts of the 11th Annual Meeting of the Israel Society for Neuroscience

2002 Neural Plasticity  
We relate these results also to the differentiated function of the anterior cingulated cortex in the verbal and motor domain.  ...  Objectives: To examine error-correcting activity and correction of brrors in the verbal and motor domain in these patients.  ...  In this study we found that, the ability to resist the consequences of CNS axonal injury is characterized bythe early activation of site-specific phagocytic activity and MHC class II expression.  ... 
doi:10.1155/np.2002.65 pmid:12516548 pmcid:PMC2565399 fatcat:6o7uzh2mtfawdao4mzwue32m2y

Olfactory input is critical for sustaining odor quality codes in human orbitofrontal cortex

Keng Nei Wu, Bruce K Tan, James D Howard, David B Conley, Jay A Gottfried
2012 Nature Neuroscience  
changes in odor-evoked fMRI activity in piriform cortex and orbitofrontal cortex (OFC).  ...  Our findings suggest that transient changes in these key olfactory brain regions are instrumental in sustaining odor perception integrity in the wake of disrupted sensory input. npg  ...  AcknowledgmenTS The authors would like to thank M. Cahill for assistance in nasal endoscopy and acoustic rhinometry measurements, N. Sandalow and K.  ... 
doi:10.1038/nn.3186 pmid:22885850 pmcid:PMC3431433 fatcat:aztqqwvvwvfmdm65dhr7w2jaci

A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

Mei-Fang Xiao, Seung-Eon Roh, Jiechao Zhou, Chun-Che Chien, Brendan P. Lucey, Michael T. Craig, Lindsay N. Hayes, Jennifer M. Coughlin, F. Markus Leweke, Min Jia, Desheng Xu, Weiqiang Zhou (+10 others)
2021 Science Advances  
Weinberger and the Lieber Institute for access to human brain tissue and helpful discussions.  ...  .; NIH National Center for Advancing Translational Sciences (UL1 TR000448 and KL2  ...  We examined behavior-linked NPTX2-SEP in barrel fields of the primary sensory cortex in male mice.  ... 
doi:10.1126/sciadv.abf6935 pmid:34818031 pmcid:PMC8612534 fatcat:zrb36xgearfqtoq5fmnyqqv4mi
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