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Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain

Mark G. MacAskill, Catriona Wimberley, Timaeus E. F. Morgan, Carlos J. Alcaide-Corral, David E. Newby, Christophe Lucatelli, Andrew Sutherland, Sally L. Pimlott, Adriana A. S. Tavares
2021 European Journal of Nuclear Medicine and Molecular Imaging  
Quantification of [18F]LW223 uptake kinetics in the brain and heart required the use of different outcome measures, with BPTC more stable in the heart and VT more stable in the brain.  ...  Conclusion Modelling of [18F]LW223 PET showed the use of simplified IDIF is acceptable in the rat and the minimum scan duration for quantification of TSPO expression in rats using kinetic modelling with  ...  Introduction Quantification of the 18 kDa translocator protein (TSPO) expression in vivo using positron emission tomography (PET) imaging has proven challenging due to sub-optimal physicochemical properties  ... 
doi:10.1007/s00259-021-05482-1 pmid:34338808 pmcid:PMC8712302 fatcat:qgyqb2esvndd5c6kyk3acv2aby

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

[18F]Fluoromisonidazole PET in rectal cancer

Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge, Tim Maughan
2017 EJNMMI Research  
The study explores [ 18 F]fluoromisonidazole ([ 18 F]FMISO) positron emission tomography (PET) scans for predicting clinical response in rectal cancer patients receiving neoadjuvant CRT.  ...  Conclusions: This pilot study with small number of datasets revealed significant challenges in delivery and interpretation of [ 18 F]FMISO PET scans of rectal cancer.  ...  Acknowledgements Thank you to the patients who took part in the RHYTHM-I study and the Oxford University Hospitals Foundation NHS Trust. This  ... 
doi:10.1186/s13550-017-0324-x pmid:28933018 pmcid:PMC5607050 fatcat:ogjejtqf7vecpoojvm2kdk2j2q

Quantitative in vivo Imaging of Adenosine A2A Receptors in the Human Brain Using 11C-SCH442416 PET: A Pilot Study

Igor Grachev, Miroslava Doder, David Brooks, Rainer Hinz
2014 Journal of Diagnostic Imaging in Therapy  
tomography (PET).  ...  11 C-SCH442416 was reported in preclinical studies with rodents and primates to be the first nonxanthine radioligand suitable for the in vivo imaging of adenosine A 2A receptors with positron emission  ...  , UK for the determination of specific binding potentials in the ROI, and the onsite manufacturing of  ... 
doi:10.17229/jdit.2014-0620-001 fatcat:g6cnr7ftgngyvoq6cxmupxjlbq

Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease [article]

Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Nymann Petersen, Annesofie Videbæk, Jens Damsgaard Mikkelsen, Patrick MacDonald Fisher, Pontus Plavèn-Sigray, Gitte Moos Knudsen, Mikael Palner
2021 bioRxiv   pre-print
Individuals with PD have both lower synaptic density and changes in neuronal metabolic function in the basal ganglia, as measured using [11C]UCB-J and [18F]FDG positron emission tomography (PET), respectively  ...  In conclusion, [11C]UCB-J and [18F]FDG PET can detect divergent changes following a dopaminergic lesion in rats, especially in cortical regions that are not directly affected by the neurotoxin.  ...  The authors would also like to thank the Department of Clinical Physiology, Nuclear Medicine and PET for their continuous support in imaging.  ... 
doi:10.1101/2021.05.27.444950 fatcat:aroyghznfbatjfwkcqy6kutdkq

Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging

Victor W. Pike
2016 Current Medicinal Chemistry  
The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET  ...  This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.  ...  Shuiyu Lu (NIMH) for critical reading of the manuscript. The author is also grateful to numerous coauthors for their contributions to research cited by the author in this article.  ... 
doi:10.2174/0929867323666160418114826 pmid:27087244 pmcid:PMC5579844 fatcat:v35marvaz5bg7lpycwfvwtjobi

PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging

Stefaan Vandenberghe, Paul K Marsden
2015 Physics in Medicine and Biology  
The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) has been an ongoing research topic for the last 20 years.  ...  This paper gives an overview of the different developments and the technical problems associated with combining PET and MRI in one system.  ...  Acknowledgments The authors would like to thank P Mollet for providing input for the pictures on the PET-MRI systems designs and V Keereman for providing input on the section on attenuation correction  ... 
doi:10.1088/0031-9155/60/4/r115 pmid:25650582 fatcat:jo5wn77bzzcurazvcmehiffq64

Evaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry

L Dubois, W Landuyt, K Haustermans, P Dupont, G Bormans, P Vermaelen, P Flamen, E Verbeken, L Mortelmans
2004 British Journal of Cancer  
The relationship found between [ 18 F]FMISO-PET and PIMO-and additionally CA IX-derived hypoxic volumes in rat rhabdomyosarcomas indicates the value of the noninvasive imaging method to measure hypoxia  ...  Syngeneic rhabdomyosarcoma (R1) tumour pieces were transplanted subcutaneously in the flanks of WAG/Rij rats. Tumours were analysed at volumes between 0.9 and 7.3 cm 3 .  ...  F-fluorinated tracers and Positron Emission Tomography -a Autoradiography images of a large (A: 4.36 cm 3 ) and a small (B: 0.92 cm 3 ) tumour.  ... 
doi:10.1038/sj.bjc.6602219 pmid:15520822 pmcid:PMC2409764 fatcat:dc5ublrcibh5dbje5irelrhuvu

Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats

Sujata Sridharan, Francois-Xavier Lepelletier, William Trigg, Samuel Banister, Tristan Reekie, Michael Kassiou, Alexander Gerhard, Rainer Hinz, Hervé Boutin
2016 Molecular Imaging and Biology  
The translocator protein (TSPO) has proven a reliable NI biomarker for positron emission tomography (PET) imaging.  ...  A cerebellar reference region and novel data-driven input to the SRTM were unable to distinguish differences in tracer BP ND .  ...  Positron emission tomography (PET) studies of neuroinflammation have been conducted for over 30 years.  ... 
doi:10.1007/s11307-016-0984-3 pmid:27481358 pmcid:PMC5209405 fatcat:sb2rkcce7raxri2scw7nfhjd2q

Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

Rodrigo Teodoro, Daniel Gündel, Winnie Deuther-Conrad, Lea Ueberham, Magali Toussaint, Guy Bormans, Peter Brust, Rareş-Petru Moldovan
2021 International Journal of Molecular Sciences  
Aiming at the development of a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we herein describe the radiosynthesis of cis-[  ...  Its further evaluation by PET in a well-established rat model of CB2R overexpression demonstrated its ability to selectively image the CB2R in the brain and its potential as a tracer to further investigate  ...  Acknowledgments: We thank the staff of the Institute of Analytical Chemistry, Department of Chemistry and Mineralogy of Universität Leipzig (Leipzig, Germany), for NMR and HRFT-MS measurements, Karsten  ... 
doi:10.3390/ijms22158051 pmid:34360817 pmcid:PMC8347709 fatcat:oe2ioe7fxngrjotiugnz7gzsse

Instrumentation and Methodology for Quantitative Pre-Clinical Imaging Studies

Steven Meikle, Stefan Eberl, Hidehiro Iida
2001 Current pharmaceutical design  
Recent developments in instrumentation and imaging methodology make it possible to image and quantify the kinetics of radiolabelled pharmaceuticals in a wide range of animal models from rodents to non-human  ...  This article reviews the developments which have led to the current state-of-the-art, including advances in detector technologies, image reconstruction and tracer kinetic modelling.  ...  Providing appropriate correction for the physical processes (attenuation, scatter and partial volume effects) described above are applied, emission tomography can non-invasively provide images of regional  ... 
doi:10.2174/1381612013396961 pmid:11772359 fatcat:fwqpf7oa5nbpzgzqymdranndqe

Deriving physiological information from PET images: from SUV to compartmental modelling

Alessandra Bertoldo, Gaia Rizzo, Mattia Veronese
2014 Clinical and translational imaging  
Positron emission tomography (PET) imaging has made it possible to detect the in vivo concentration of positron-emitting compounds accurately and non-invasively.  ...  This review provides a complete overview of the semi-quantitative and quantitative methods used in PET analysis. The pros and cons of each method are evaluated and discussed.  ...  Introduction Positron emission tomography (PET) imaging, ever since its introduction, has played an important role in the medical imaging field.  ... 
doi:10.1007/s40336-014-0067-x fatcat:szhb4hp3wjbjzltt3rbj4zscme

Huntington's Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers

Klaudia Cybulska, Lars Perk, Jan Booij, Peter Laverman, Mark Rijpkema
2020 Molecules  
A review of Positron Emission Tomography (PET) studies relating to HD was performed, including clinical and preclinical data.  ...  the brain.  ...  Positron Emission Tomography PD Parkinson's disease  ... 
doi:10.3390/molecules25030482 pmid:31979301 pmcid:PMC7038198 fatcat:bwhvj3moyvb7dlucjrlservu3a

Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling

Richa Gandhi, Charalampos Tsoumpas
2019 Contrast Media & Molecular Imaging  
Thirty-five relevant in vivo imaging studies are included, of which most made use of magnetic resonance imaging or positron emission tomography, whilst various optical modalities were also utilised.  ...  A systematic search of the PubMed® and Elsevier's Scopus databases identified studies that were conducted between 2008 and 2018 to explore postischaemic neurovascular remodelling in small animal models  ...  Methods to correct for partial volume effects in PET imaging represent an active field of research [65] [66] [67] . e biggest advantage of using these nuclear medicine techniques despite the poor anatomical  ... 
doi:10.1155/2019/3128529 pmid:30863220 pmcid:PMC6378027 fatcat:qybsfz5panfd7kzjum2kmfltni

Digital data repository and automatic analysis framework for FDOPA PET neuroimaging [article]

Giovanna Nordio, Rubaida Easmin, Alessio Giacomel, Ottavia Dipasquale, Daniel Martins, Steven Williams, Federico Turkheimer, Oliver Howes, Mattia Veronese
2022 bioRxiv   pre-print
than men, while the effects of weight, age, injected radioactivity, and scanner, varied by brain region and parameter of interest.ConclusionsCombining information from different neuroimaging studies has  ...  ABSTRACTIntroductionFDOPA PET has been used extensively to image the human brain in many clinical disorders and has the potential to be used for patient stratification and individualized treatment.  ...  The limbic subdivision is a small region, more susceptible to motion artefacts and partial volume effects, and this can affect the amount of activity measured (Mawlawi et al. 2001 ).  ... 
doi:10.1101/2022.04.14.488129 fatcat:hno4yvlxxfderlerkq5wr2drxe
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