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Channel Responses for the Molecule Release from Spherical Homogeneous Matrix Carriers [article]

Maximilian Schäfer, Yolanda Salinas, Alexander Ruderer, Franz Enzenhofer, Oliver Brüggemann, Ramón Martínez-Máñez, Rudolf Rabenstein, Robert Schober, Werner Haselmayr
2021 arXiv   pre-print
In a matrix carrier, the drug molecules are dispersed in the matrix core and diffuse from the inner to the outer layers of the carrier once immersed in a dissolution medium.  ...  Finally, we investigate the channel responses for the release of common therapeutic drugs, e.g., doxorubicin, from a diblock copolymer micelle acting as drug carrier.  ...  CHANNEL RESPONSE FOR SPHERICAL MATRIX In Section III, the gradual and instantaneous release of molecules from a spherical matrix have been analyzed, assuming a perfect sink condition at the matrix boundary  ... 
arXiv:2106.08392v1 fatcat:esomm6uzefh2to732cwrflrqcy


A N Jyothsna Sree
2021 International Journal of Research in Ayurveda and Pharmacy  
This article is a cumulation of structure, types, composition, formulation methodologies, drug release from NLCs, various applications of NLCs.  ...  The key aspects for promising drug delivery systems are biocompatibility, drug loading capacity, ease of preparation, non-toxicity, and stability  ...  SLNs possess a solid lipid core matrix that can solubilize lipophilic molecules whereas nanostructured lipid carriers are the colloidal nanocarriers that uses both solid and liquid lipids.  ... 
doi:10.7897/2277-4343.1204130 fatcat:ixtfaqmzzzabljzjp3afqrp2zy

Perspectives and Prospective on Solid Lipid Nanoparticles as Drug Delivery Systems

Osama A. Madkhali
2022 Molecules  
Combating multiple drug resistance necessitates the delivery of drug molecules at the cellular level.  ...  of large quantities of the carrier systems.  ...  This system has increased potential for improving drug stability and controlling drug release from the matrix over time.  ... 
doi:10.3390/molecules27051543 pmid:35268643 pmcid:PMC8911793 fatcat:s6o27ktg6zhrrm4vie7hmoz57m

Microfluidic Devices for Drug Delivery Systems and Drug Screening

Samar Damiati, Uday Kompella, Safa Damiati, Rimantas Kodzius
2018 Genes  
In this system, the reactions between carrier materials and molecules are controlled by the channel length and flow rate.  ...  Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening.  ...  For example, in the hydrogel-supported 3D cell cultures, the gel matrix may prevent the cells from culturing at a high enough density, resulting in the formation of interstitial spaces.  ... 
doi:10.3390/genes9020103 pmid:29462948 pmcid:PMC5852599 fatcat:lg3s33u5a5gb7ay5irtz4yg4ym

On designing particulate carriers for encapsulation and controlled release applications

Wenjie Liu, Winston Duo Wu, Cordelia Selomulya, Xiao Dong Chen
2013 Powder Technology  
These outcomes demonstrated the capability to tune the particle response(s) from the knowledge of material properties, with the understanding of release mechanisms elucidated from monodisperse particles  ...  Having lactose distributed homogeneously in the matrix resulted in significantly faster and almost complete release due to enhanced swelling of the polymeric matrix with the dissolution of lactose.  ...  response(s) from the knowledge of material properties.  ... 
doi:10.1016/j.powtec.2012.02.012 fatcat:6ouffqttx5gv7kkatfx653nbbi

Improved Skin Delivery of Voriconazole with a Nanostructured Lipid Carrier-Based Hydrogel Formulation

Seh Hyon Song, Kyung Min Lee, Jong Boo Kang, Sang Gon Lee, Myung Joo Kang, Young Wook Choi
2014 Chemical and pharmaceutical bulletin  
In order to develop topical preparations of voriconazole (VRC) for the treatment of mycotic infections of the skin, a nanostructured lipid carrier-based hydrogel (NLC-gel) formulation was developed and  ...  The lipid nanoparticles in the hydrogel were approximately 210 nm in size, with a spherical shape and zeta potential of 30 mV.  ...  The authors declare no conflict of interest. # These authors contributed equally to this work. Acknowledgment This study was supported by Seoul R & BD program (SS100001).  ... 
doi:10.1248/cpb.c14-00202 pmid:25087631 fatcat:6z3u2qtombd7vkopxb5d2z73fe

Elaborate Design Strategies Toward Novel Microcarriers for Controlled Encapsulation and Release

Tae Soup Shim, Shin-Hyun Kim, Seung-Man Yang
2012 Particle & particle systems characterization  
Acknowledgements This work was supported by a grant from the Creative Research Initiative Program of the Ministry of Education, Science and Technology for "Complementary Hybridization of Optical and Fluidic  ...  Devices for Integrated Optofl uidic Systems."  ...  Hydrogels can be used as drug carriers only for drug molecules that chemically bond to or are strongly adsorbed to the gel matrix.  ... 
doi:10.1002/ppsc.201200044 fatcat:ddtbe4mm35hoxj4yw36t5zsqma


2021 International Journal of Applied Pharmaceutics  
Conclusion: These results clearly illustrated that the developed KA intercalated polymeric microbeads are potential drug carriers for the controlled release of CUR.  ...  Objective: The objective of this study is to fabricate sodium alginate (SA)/gum ghatti (GG) microbeads intercalated with Kaolin (KA) nano clay for the sustained release of curcumin (CUR).  ...  For spherical drug carriers, if n<0.43, the drug diffuses from the polymer matrix according to Fickian diffusion; if 0.43<n<0.85, anomalous or non-Fickian type drug diffusion occurs; if n = 0.85, Case-II  ... 
doi:10.22159/ijap.2021v13i1.39963 fatcat:udbcj2ooabhtreg2dujl2epu2a

Nanostructured Mesoporous Silicas for Bone Tissue Regeneration

Isabel Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
2008 Journal of Nanomaterials  
Finally, a deep discussion about the influence of the textural parameters and organic modification of mesoporous silicas on molecules adsorption and controlled release is performed.  ...  In this review, the last advances in nanochemistry aimed at designing and tailoring the chemical and textural properties of mesoporous silicas for biomedical applications are described.  ...  Release profiles from both mesoporous carriers into the delivery medium (NaCl 0.9%, pH 7.4) exhibited an initial burst effect when ca. 20% and ca. 50% of alendronate loaded were quickly released from MCM  ... 
doi:10.1155/2008/106970 fatcat:75fowpt6bbgexbetxryuw35oxu

Silica Materials for Medical Applications

María Vallet-Regí, Francisco Balas
2008 Open Biomedical Engineering Journal  
The adequate combination of the synthesis techniques, template systems and additives leads to the development of materials that merge the bioactive behavior with the drug carrier ability.  ...  These systems could be excellent candidates as materials for the development of devices for tissue engineering.  ...  ACKNOWLEDGEMENTS Authors would like to express their thanks to all the coworkers and colleagues that have contributed over the years with their effort and thinking to these studies.  ... 
doi:10.2174/1874120700802010001 pmid:19662110 pmcid:PMC2701070 fatcat:qab3ap4a3ves7lst6njyamo74a

Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

László Janovák, Árpád Turcsányi, Éva Bozó, Ágota Deák, László Mérai, Dániel Sebők, Ádám Juhász, Edit Csapó, Mohamed M. Abdelghafour, Eszter Farkas, Imre Dékány, Ferenc Bari
2018 European Journal of Pharmaceutical Sciences  
The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d=5.2 ± 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker  ...  condition) but at pH <6.5 which is typical for seriously ischemic brain tissue, 93.6% of the available 0.14 mg/ml NIMO was released into the buffer solution under 8 h release time.  ...  Acknowledgements The authors are very thankful for the financial support from the Hungarian Scientific  ... 
doi:10.1016/j.ejps.2018.07.031 pmid:30026092 fatcat:zaeku67ko5f6hjpvdginszurqi

Novel approach to improve bioavailability and factors affecting to stability of nanoformulaiton

Vikrant K. Nikam, Ankita Ugale, Jyoti Khapare
2020 Asian Journal of Pharmacy and Pharmacology  
of health in USA as, "Formulation of a device that enables the introduction of therapeutic substances in to the body and improves efficiency and safety by controlling the rate, time and place of release  ...  The chemical and physical properties of nanoparticles make then efficient Drug delivery system that have the potential to improve the bioavailability, drug carrying capacity, stability for the drugs within  ...  Acknowledgement Authors are thankful to Amrutvahini College of Pharmacy, Sangamner for providing necessary facility to carry out the work.  ... 
doi:10.31024/ajpp.2020.6.6.1 fatcat:s62uehh2rnarrk53hmmvff6bdi

Novel Bioactive Extraction and Nano-Encapsulation

Shaba Noore, Navin Kumar Rastogi, Colm O'Donnell, Brijesh Tiwari
2021 Encyclopedia  
An extraction technology works on the principle of two consecutive steps that involves mixture of solute with solvent and the movement of soluble compounds from the cell into the solvent and its consequent  ...  The conventional extraction techniques are mostly based on the use of mild/high temperatures (50–90 °C) that can cause thermal degradation, are dependent on the mass transfer rate, being reflected on long  ...  Conflicts of Interest: The authors declare no conflict of interest. Entry Link on the Encyclopaedia Platform: The link to the entry published on the encyclopedia platform.  ... 
doi:10.3390/encyclopedia1030052 fatcat:xwb4iv7mr5gwvjvevfuwmgtbqq

Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled

Chandrakantsing Pardeshi, Pravin Rajput, Veena Belgamwar, Avinash Tekade, Ganesh Patil, Kapil Chaudhary, Abhijeet Sonje
2012 Acta Pharmaceutica  
The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical  ...  approach in the early nineties.  ...  molecules from stretched to coiled.  ... 
doi:10.2478/v10007-012-0040-z pmid:23333884 fatcat:st4vcjirpfenrggiqdzv6v7ybq

Silica-based mesoporous nanoparticles for controlled drug delivery

Sooyeon Kwon, Rajendra K Singh, Roman A Perez, Ensanya A Abou Neel, Hae-Won Kim, Wojciech Chrzanowski
2013 Journal of Tissue Engineering  
Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner.  ...  This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles  ...  The authors declare that there is no conflict of interest.  ... 
doi:10.1177/2041731413503357 pmid:24020012 pmcid:PMC3764983 fatcat:xwizt6j67rdn7fhccw5zzu3unm
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