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Changes in the intracranial volume from early adulthood to the sixth decade of life: A longitudinal study
[article]
2019
bioRxiv
pre-print
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In conclusion, human intracranial volume does not stay constant during adulthood but instead shows small increases during young adulthood and decreases from the fourth decade of life. ...
We report statistically significant increases in the ICV in adulthood until the fourth decade of life (average change +0.03%/y, or about 0.5 ml/y, at age 20), and decreases in the ICV afterward (-0.09% ...
values from young adulthood to the sixth decade of life. ...
doi:10.1101/677898
fatcat:ezueg36nb5entob2inrbcdxcku
Changes in the intracranial volume from early adulthood to the sixth decade of life: A longitudinal study
2020
NeuroImage
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In conclusion, human intracranial volume does not stay constant during adulthood but instead shows small increase during young adulthood and a decrease thereafter from the fourth decade of life. ...
We report statistically significant increases in the ICV in adulthood until the fourth decade of life (average change +0.03%/y, or about 0.5 ml/y, at age 20), and decreases in the ICV afterward (-0.09% ...
Acknowledgments The authors would like to thank Hakim Achterberg, Marcel Koek, Adriaan Versteeg, Thomas Phil, Thomas Kroes, Baldur van Lew, Marcel Zwiers and Seyed Mostafa Kia for a collaboration within ...
doi:10.1016/j.neuroimage.2020.116842
pmid:32339774
fatcat:gfg5aalixnaqlcrtlr5ln46y7m
Ophthalmologic complications of meningomyelocele: a longitudinal study
1990
Transactions of the American Ophthalmological Society
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Children with spina bifida should have frequent examinations by an ophthalmologist who is familiar with the diagnosis and management of the defects recorded in this study. ...
Most of the problems are related to the hydrocephalus, which is caused by the coexisting Arnold-Chiari malformation. ...
If hydrocephalus is present early in life, the head will enlarge. If glaucoma occurs early in life the eye will enlarge, and become buphthalmic. ...
pmid:2095031
pmcid:PMC1298598
fatcat:piyt4a6lnbbjpgn5ckiug4wosu
Life-Span Changes of the Human Brain White Matter: Diffusion Tensor Imaging (DTI) and Volumetry
2009
Cerebral Cortex
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Although the volumetric data supported protracted growth into the sixth decade, DTI indices plateaued early in the fourth decade across all tested regions and then declined slowly into late adulthood followed ...
Tractwise and voxel-based analyses yielded regional differences in development and aging but did not provide ample evidence in support of a simple last-in-firstout hypothesis of life-span changes. ...
28.6 Note: The FA values were computed as mean values in regions encompassing both the TBSS skeleton and the atlas-based tract. t 5 t value, F 5 F value, R 2 5 adjusted R 2 , age at maxima 5 age at LOESS ...
doi:10.1093/cercor/bhp280
pmid:20032062
fatcat:genhrhvwzvdobfa4dlkcy62tsi
Coupled changes in hippocampal structure and cognitive ability in later life
2018
Brain and Behavior
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Methods: In a longitudinal study of community-dwelling adults, we investigated whether there were coupled changes in hippocampal structure and verbal memory, working memory, and processing speed between ...
Hippocampal structure was indexed by hippocampal volume, hippocampal volume as a percentage of intracranial volume (H_ICV), fractional anisotropy (FA), mean diffusivity (MD), and longitudinal relaxation ...
A previous study showed that T1 declines throughout adolescence and early adulthood, achieving a minimum value in the fourth to sixth decade of life, and then T1 begins increasing (Cho, Jones, Reddick ...
doi:10.1002/brb3.838
pmid:29484252
pmcid:PMC5822578
fatcat:v4vkqkwqhzdatoha2if6wss2rm
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
2019
Lancet Neurology
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High and increasing blood pressure from early adulthood into midlife seems to be associated with increased WMHV and smaller brain volumes at 69-71 years of age. ...
Participants were from Insight 46, a neuroscience substudy of the ongoing longitudinal Medical Research Council National Survey of Health and Development, a birth cohort that initially comprised 5362 individuals ...
Acknowledgments We are very grateful to those study members who helped in the design of the study through focus groups, and to the participants both for their contributions to Insight 46 and for their ...
doi:10.1016/s1474-4422(19)30228-5
pmid:31444142
pmcid:PMC6744368
fatcat:edrx63jygbakjjnjuw7xbw4sc4
The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study
2018
Neurobiology of Aging
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These results suggest that increasing and persistent inflammation in the decades spanning middle-to late-life may promote WM disease in older adults. ...
Compared to the group with low CRP at all three visits, the group which transitioned from low to elevated CRP during midlife demonstrated greatest WMH volume and poorest WM microstructural integrity, after ...
Acknowledgments The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C ...
doi:10.1016/j.neurobiolaging.2018.03.031
pmid:29702373
pmcid:PMC6010227
fatcat:oggkimhkszdlnlibjbtw7g5vgi
Corticolimbic Circuit Structure Moderates an Association Between Early Life Stress and Later Trait Anxiety
2019
NeuroImage: Clinical
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These structural properties of the corticolimbic circuit may capture a neural profile of relative resiliency to early life stress, especially against the negative effects of childhood adversity on later ...
Here, we examined how individual variability in structural features of the corticolimbic circuit, which plays a key role in emotional reactivity, moderates the association between childhood adversity and ...
Acknowledgments We thank the Duke Neurogenetics Study participants as well as the staff of the Laboratory of NeuroGenetics. ...
doi:10.1016/j.nicl.2019.102050
pmid:31677585
pmcid:PMC6838553
fatcat:tui3sbr27raohkuqprmeegw27e
Correlations among Brain Gray Matter Volumes, Age, Gender, and Hemisphere in Healthy Individuals
2011
PLoS ONE
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Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region. ...
Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant ...
Acknowledgments We would like to thank Drs. Kentaro Inoue and Ken Okada for collecting the data.
Author Contributions ...
doi:10.1371/journal.pone.0022734
pmid:21818377
pmcid:PMC3144937
fatcat:fq7ngozuj5gwhmaecvgk6af6cm
Hominin life history: reconstruction and evolution
2008
Journal of Anatomy
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In this review we attempt to reconstruct the evolutionary history of hominin life history from extant and fossil evidence. ...
We compare the life history variables of modern great apes and identify traits that are likely to be shared by the last common ancestor of Pan-Homo and those likely to be derived in hominins. ...
Acknowledgements We thank Matthew Skinner for several of the figures and illustrations, and Robin Bernstein, Sarah Elton, Kristen Hawkes, Earl Keefe, and James O'Connell for helpful comments. ...
doi:10.1111/j.1469-7580.2008.00867.x
pmid:18380863
fatcat:u3y4ankb35bpnmscxobjdv6e2y
Brain Morphometry and Cognitive Performance in Normal Brain Aging: Age- and Sex-Related Structural and Functional Changes
2022
Frontiers in Aging Neuroscience
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It is challenging to segregate normal brain aging from the accelerated one.ObjectiveTo work out a descriptive model of brain structural and functional changes in normal aging.Materials and MethodsBy using ...
They should be viewed as signs of a disease. There is a sex difference in the speed and/or in the onset of the gray matter atrophy. It either starts earlier or goes faster in males. ...
A steep increase in the volume of ventricles began in the fifth decade in men and in the sixth decade in women. ...
doi:10.3389/fnagi.2021.713680
pmid:35153713
pmcid:PMC8826453
fatcat:det7xklw6rgk3e3pni7gdkyala
Entorhinal Cortex Thickness across the Human Lifespan
2015
Journal of Neuroimaging
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Here, we sought to fill this gap in knowledge by quantifying the ERC thickness in a very large cohort of subjects spanning nine decades of life. ...
of ERC thickness in 1660 healthy controls ranging from 2 to 94 years of age. ...
Acknowledgements This work is funded by the National Institutes of Health (NIH/NINDS R01-NS052505-04) and the Dunn Research Fund to K.M.H., NS046565 to R.E.F, NIMH Grant R01 MH 085667 and the Pat Rutherford ...
doi:10.1111/jon.12297
pmid:26565394
pmcid:PMC4826319
fatcat:m4pvo2y6u5hxhcyocrxncfo32y
Is Autosomal Dominant Polycystic Kidney Disease Becoming a Pediatric Disorder?
2017
Frontiers in Pediatrics
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As renal cyst formation and expansion begins early in life, frequently in utero, ADPKD should no longer be considered an adult-onset disease. ...
Autosomal dominant polycystic kidney disease (ADPKD) affects 1 in 400 to 1,000 live births, making it the most common monogenic cause of renal failure. ...
Importantly, mathematical models computing volume changes of solitary and multiple cysts in function of time show that cysts formed early in life, are the main contributors to the final total cyst volume ...
doi:10.3389/fped.2017.00272
pmid:29326910
pmcid:PMC5742347
fatcat:r6qcpt2gebdebmi5bxdyejjyqa
White Matter Changes of Neurite Density and Fiber Orientation Dispersion during Human Brain Maturation
2015
PLoS ONE
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after the fourth decade of life. ...
Our results suggest that the rise of FA during the first two decades of life is dominated by increasing NDI, while the fall in FA after the fourth decade is driven by the exponential rise of ODI that overcomes ...
Acknowledgments We are grateful to all of the families at the participating Simons Variation in Individuals Project (Simons VIP) sites, as well as the Simons VIP working group (Simons VIP Consortium, Neuron ...
doi:10.1371/journal.pone.0123656
pmid:26115451
pmcid:PMC4482659
fatcat:khyfuld3bbgrdfemsnjhfqxjkm
Childhood self-control forecasts the pace of midlife aging and preparedness for old age
2021
Proceedings of the National Academy of Sciences of the United States of America
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We studied the association between self-control and midlife aging in a population-representative cohort of children followed from birth to age 45 y, the Dunedin Study. ...
The ability to control one's own emotions, thoughts, and behaviors in early life predicts a range of positive outcomes in later life, including longevity. Does it also predict how well people age? ...
WMH volume is measured in Montreal Neurological Institute space, removing the influence of differences in brain volume and intracranial volume on WMH volume. ...
doi:10.1073/pnas.2010211118
pmid:33397808
pmcid:PMC7826388
fatcat:6l4mn7s5ojaw5e6bautgle4jwa
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