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Cerebral Blood Flow Increases Across Early Childhood [article]

Dmitrii Paniukov, R. Marc Lebel, Gerald Giesbrecht, Catherine Lebel
2019 bioRxiv   pre-print
early childhood.Highlights*We mapped cerebral blood flow development longitudinally in 96 typically developing children aged 2-7 years*Cerebral blood flow increased over the full age range*No significant  ...  AbstractAdequate cerebral blood flow (CBF) is essential to proper brain development and function.  ...  The copyright holder for this preprint . http://dx.doi.org/10.1101/587139 doi: bioRxiv preprint first posted online Mar. 24, 2019; CEREBRAL BLOOD FLOW INCREASES ACROSS EARLY CHILDHOOD 4 2004b), and therefore  ... 
doi:10.1101/587139 fatcat:4tkd7wjn4zfkjokm4nb6s6ah3u

Fetal umbilical, cerebral and pulmonary blood flow patterns in relation to lung function and asthma in childhood. The Generation R Study

Marjolein N. Kooijman, Evelien R. van Meel, Eric. A.P. Steegers, Irwin K. Reiss, Johan de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts
2019 Pediatric Allergy and Immunology  
We examined the associations of fetal umbilical, cerebral, and pulmonary blood flow with wheezing patterns, lung function, and asthma in childhood.  ...  Fetal growth restriction is associated with higher risks of childhood respiratory morbidity. Fetal blood flow adaptations might contribute to these associations.  ...  Although the effects of fetal umbilical and cerebral blood flow adaptations on fetal and childhood growth are well known, it is unknown whether fetal blood flow adaptations affect childhood respiratory  ... 
doi:10.1111/pai.13044 pmid:30801809 pmcid:PMC6563472 fatcat:vsmyfku6fzhxbdh4q53dabdjhm

Sex differences in the developing brain: insights from multimodal neuroimaging

Antonia N. Kaczkurkin, Armin Raznahan, Theodore D. Satterthwaite
2018 Neuropsychopharmacology  
Youth (including both childhood and adolescence) is a period when the brain undergoes dramatic remodeling and is also a time when neuropsychiatric conditions often emerge.  ...  Results demonstrated that gray matter cerebral blood flow showed a rapid decline in late childhood and early adolescence and then plateaued in mid-adolescence before showing a slight increase in early  ...  Thus, in general, cerebral gray matter volumes increase with increasing brain volumes in early childhood, followed by a decrease during later development, while cerebral white matter volume tends to increase  ... 
doi:10.1038/s41386-018-0111-z pmid:29930385 pmcid:PMC6235840 fatcat:k3ryjbhi5zcqfgqc6nkx5ztl2e

Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study

MN Kooijman, R Gaillard, IKM Reiss, A Hofman, EAP Steegers, VWV Jaddoe
2016 BJOG: an International Journal of Obstetrics and Gynaecology  
Methods-We measured umbilical and cerebral artery blood flow at a gestational age of 30.3 weeks (95%range 28.5-32.6).  ...  Influence of fetal blood flow redistribution on fetal and childhood growth and fat distribution: the Generation R Study.  ...  To our knowledge, thus far this is the largest study, which examined the effects of fetal blood flow distribution on early growth trajectories.  ... 
doi:10.1111/1471-0528.13933 pmid:26936012 pmcid:PMC5427172 fatcat:s6btiq62hrfz5dlexdc6nebxba

Childhood determinants of arterial dysfunction central and peripheral blood pressure

Renate Oberhoffer
2018 Artery Research  
cerebral blood flow, particularly in the elderly, measures of pulsatile phenomena, such as arterial stiffness affecting wave propagation have been shown to be strong independent predictors of overall  ...  Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure.  ... 
doi:10.1016/j.artres.2018.10.014 fatcat:dxqyvziydzgdjg2eynzec3hcje

The neurodevelopmental implications of hypoplastic left heart syndrome in the fetus

David F. A. Lloyd, Mary A. Rutherford, John M. Simpson, Reza Razavi
2016 Cardiology in the Young  
blood flow and substrate delivery, disordered brain development, and an increased potential for neurological injury.  ...  These susceptibilities are present before any intervention, and are almost certainly substantial contributors to adverse neurodevelopmental outcomes in later childhood.  ...  resistance ratios in patients with hypoplastic left heart syndrome, 37, 38 suggesting activation of brain-sparing mechanisms in an attempt to increase cerebral blood flow.  ... 
doi:10.1017/s1047951116001645 pmid:27821206 pmcid:PMC7611403 fatcat:moqnd2dy4bcx3heoqbmldizn3y

Arterial stiffness as a risk factor for cerebral vascular lesions

Dariusz Gasecki
2018 Artery Research  
cerebral blood flow, particularly in the elderly, measures of pulsatile phenomena, such as arterial stiffness affecting wave propagation have been shown to be strong independent predictors of overall  ...  Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure.  ... 
doi:10.1016/j.artres.2018.10.013 fatcat:rgw2hsidanforjq3xzs67a43pm

Age-related differences in cerebral blood flow underlie the BOLD fMRI signal in childhood

Pamela Moses, Leanna M. Hernandez, Elizabeth Orient
2014 Frontiers in Psychology  
One critical component of the BOLD signal that has been noted to change with age is cerebral blood flow (CBF).  ...  In contrast, the relative increase of CBF above baseline, expressed as percent of CBF change, was comparable across groups. The percent of BOLD signal change was also stable across age groups.  ...  However, in association with neural activity, CBF increases, cerebral blood volume increases, and the cerebral metabolic rate of oxygen increases only modestly.  ... 
doi:10.3389/fpsyg.2014.00300 pmid:24795666 pmcid:PMC3997021 fatcat:zs7xjdgsarbfbd7igxzpaq2mqm

Are central hemodynamic parameters better prognostic markers than peripheral blood pressure in stroke?

Alberto Avolio, Ernesto L. Schiffrin
2018 Artery Research  
cerebral blood flow, particularly in the elderly, measures of pulsatile phenomena, such as arterial stiffness affecting wave propagation have been shown to be strong independent predictors of overall  ...  Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure.  ... 
doi:10.1016/j.artres.2018.10.015 fatcat:hhfodbnaszb75imwlwefscje6e

The Life Cycle of the Kidney: Implications for CKD

R. L. Chevalier
2014 Journal of the American Society of Nephrology  
An increased fetal umbilical/cerebral blood flow ratio was associated with smaller childhood kidney volume and lower GFR. 9 These physiologic and morphometric observations are the first to be performed  ...  GFR. 7 In the second study of 923 pregnant women and their children, fetal growth, kidney volume, and umbilical and cerebral artery blood flow were measured in the third trimester. 9 These were followed  ... 
doi:10.1681/asn.2014040380 pmid:24812166 pmcid:PMC4214540 fatcat:ov2vcbx7qjes7iay3snhjgogma

Vasoactivity of the major intracranial arteries in newborn infants

M R Drayton, R Skidmore
1987 Archives of Disease in Childhood  
While blood flow to the head and arms remained substantially constant in both groups over the first 48 hours of life (60 ml/100 g brain weight/min), blood velocity doubled in both cerebral arteries in  ...  Blood flow to the head and arms was measured by a new volumetric Doppler technique in 30 preterm infants and 10 full term infants. At least 80% of this blood flow is considered to perfuse the brain.  ...  As blood flow is the product of velocity and cross-sectional area the likely explanation of the constant cerebral blood flow with increasing velocities is that the major arteries have altered calibre,  ... 
doi:10.1136/adc.62.3.236 pmid:3551849 pmcid:PMC1778318 fatcat:mkynwp7znfd6vidlsrebs4x46y

Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction

A. A. Baschat
2011 Ultrasound in Obstetrics and Gynecology  
While these findings predominate in early-onset FGR, cerebral vascular impedance changes become important in late onset FGR.  ...  of infant and childhood neurodevelopment.  ...  Neurodevelopment is affected by umbilical artery and aortic blood flow impedance in early-onset FGR and by cerebral artery blood flow dynamics in late-onset disease.  ... 
doi:10.1002/uog.9008 pmid:21520312 fatcat:sl4mto3m2vaknlpu4uccbge654

Individualised brain development and cognitive outcome in infants with congenital heart disease

Alexandra F Bonthrone, Ralica Dimitrova, Andrew Chew, Christopher J Kelly, Lucilio Cordero-Grande, Olivia Carney, Alexia Egloff, Emer Hughes, Katy Vecchiato, John Simpson, Joseph V Hajnal, Kuberan Pushparajah (+6 others)
2021 Brain Communications  
Interventions to improve cerebral oxygen delivery may promote early brain growth and improve cognitive outcomes in infants with Congenital Heart Disease.  ...  Negative atypicality indices in deep grey matter were associated with both reduced neonatal cerebral oxygen delivery and poorer cognitive abilities at 22 months across the whole sample.  ...  Flow was extracted and summed across the vessels to estimate total cerebral blood flow.  ... 
doi:10.1093/braincomms/fcab046 pmid:33860226 pmcid:PMC8032964 fatcat:xo4tfkw26zephfm6kmh4frfyxq

The haemodynamic genesis of hypertension

Phil Chowienczyk
2018 Artery Research  
cerebral blood flow, particularly in the elderly, measures of pulsatile phenomena, such as arterial stiffness affecting wave propagation have been shown to be strong independent predictors of overall  ...  Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure.  ... 
doi:10.1016/j.artres.2018.10.016 fatcat:usiek4y2dneedb4agjecpjeyne

How do Adverse Childhood Experiences get under the skin to promote cardiovascular disease? A focus on vascular health

Nathaniel D M Jenkins, Austin T Robinson
2022 Function  
In the present study, the ACEs group demonstrated reduced mPFC blood flow.  ...  A Perspective on "The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature The question now is, what are the mechanisms and are they targetable?  ... 
doi:10.1093/function/zqac032 pmid:35859580 pmcid:PMC9279110 fatcat:rzmdpgvyjjab3h74oputtkhz3e
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