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CentrosomeDB: a new generation of the centrosomal proteins database forHumanandDrosophila melanogaster

Joao Miguel da Conceiçao Alves-Cruzeiro, Rubén Nogales-Cadenas, Alberto Domingo Pascual-Montano
2013 Nucleic Acids Research  
We present the second generation of centrosomeDB, available online at, with a significant expansion of 1357 human and drosophila centrosomal genes and their corresponding  ...  This was our first motivation to introduce CentrosomeDB in NAR database issue in 2009, collecting a set of human centrosomal proteins that were reported in the literature and other sources.  ...  In comparison with the first edition of the database, that contained 470 human centrosomal genes (8) , CentrosomeDB now owns 1053 centrosomal genes for the Homo sapiens and 304 for Drosophila melanogaster  ... 
doi:10.1093/nar/gkt1126 pmid:24270791 pmcid:PMC3964966 fatcat:bawr4ihogjalrflqojuneaomlm

MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle

Zhengnan Huang, Lili Ma, Yongbo Wang, Zhicheng Pan, Jian Ren, Zexian Liu, Yu Xue
2014 Nucleic Acids Research  
The primary references of experimentally identified localizations were provided and the fluorescence microscope figures for the localizations of human proteins were shown.  ...  We reported an updated database of MiCroKiTS 4.0 ( for proteins temporally and spatially localized in distinct subcellular positions including midbody, centrosome, kinetochore  ...  For example, the Cildb database was developed by Arnaiz et al. for centrosome and cilia proteins (35) , while Nogales-Cadenas et al. constructed the CentrosomeDB database for human centrosomal proteins  ... 
doi:10.1093/nar/gku1125 pmid:25392421 pmcid:PMC4383938 fatcat:zjdd4zftlbb5hitt4wlz2bfyky

CLERC and centrosomal leucine-rich repeat proteins

Yoshinori Muto, Yukio Okano
2010 Open Life Sciences  
Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein.  ...  The bibliography as well as database searches provided evidence that the human proteome contains at least seven centrosomal leucine-rich repeat proteins including CLERC.  ...  Ishikawa of Ehime University for introducing him to the field of centrosome biology.  ... 
doi:10.2478/s11535-009-0061-x fatcat:4fuhing5zzecbd3h57pd4mh75i

Cildb: a knowledgebase for centrosomes and cilia

Olivier Arnaiz, Agata Malinowska, Catherine Klotz, Linda Sperling, Michal Dadlez, France Koll, Jean Cohen
2009 Database: The Journal of Biological Databases and Curation  
The web interface of Cildb comprises three tools, BioMart for complex queries, BLAST for sequence homology searches and GBrowse for browsing the human genome in relation to OMIM information for human diseases  ...  High throughput studies have revealed several hundred proteins that are involved in the composition, function or biogenesis of cilia.  ...  Acknowledgements The authors are grateful to Anne Laurençon who spent time testing Cildb and participated in its improvement and to the INRA MIGALE bioinformatics platform for providing computational resources  ... 
doi:10.1093/database/bap022 pmid:20428338 pmcid:PMC2860946 fatcat:j5lwb7h65ncatmzxyidstdvx3u

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is altered in Townes-Brocks Syndrome [article]

Laura Bozal-Basterra, María Gonzalez-Santamarta, Aitor Bermejo-Arteagabeitia, Carolina Da Fonseca, Olatz Pampliega, Ricardo Andrade, Natalia Martín-Martín, Tess C Branon, Alice Y Ting, Arkaitz Carracedo, Jose A Rodriguez, Felix Elortza (+2 others)
2019 bioRxiv   pre-print
We show that the leucine-zipper protein LUZP1 localizes to the pericentriolar material and actin cytoskeleton.  ...  Cilia arise from the centrosome and their formation is governed by numerous regulatory factors.  ...  CentrosomeDB: a 871 new generation of the centrosomal proteins database for Human and Drosophila 872 melanogaster.  ... 
doi:10.1101/721316 fatcat:43b7qmjxtfagdgekzs4xud3eli

Characterization of POC16/WDR90 Proteins in Centriole Integrity

Emmanuelle Steib, Paul Guichard, Virginie Hamel
In particular, the central core region is defined by the presence of a macromolecular helical inner scaffold where the four proteins POC1B, FAM161A, POC5 and Centrin-2 form a complex and localize.  ...  In this thesis, we undertake a functional and structural analysis of POC16 in Chlamydomonas reinhardtii and Paramecium tetraurelia as well as the characterization of its human ortholog WDR90.  ...  In the end, it will be long, emotional and a bit encrypted.  ... 
doi:10.13097/archive-ouverte/unige:137536 fatcat:hccjiy3ia5cqtg4hmbwqqtyyfa