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Maximal frustration as an immunological principle

F. V. de Abreu, P Mostardinha
2009 Journal of the Royal Society Interface  
A fundamental problem in immunology is that of understanding how the immune system selects promptly which cells to kill without harming the body. This problem poses an apparent paradox.  ...  This study strongly suggests that a principle of maximal frustration could be used to build artificial immune systems.  ...  Much remains to be studied in the context of how cellular frustrated systems can help to understand adaptive immune responses.  ... 
doi:10.1098/rsif.2008.0280 pmid:18715844 pmcid:PMC2659376 fatcat:l7t3qefgozan7mxo4e2p6elhry

Frustration in biomolecules

Diego U. Ferreiro, Elizabeth A. Komives, Peter G. Wolynes
2014 Quarterly Reviews of Biophysics (print)  
The energy landscape theory of protein folding provides a framework for quantifying frustration in large systems and has been implemented at many levels of description.  ...  In this review, we also emphasize that frustration, far from being always a bad thing, is an essential feature of biomolecules that allows dynamics to be harnessed for function.  ...  The principle of minimal frustration provides a framework for practical engineering questions (Onuchic et al. 1997) .  ... 
doi:10.1017/s0033583514000092 pmid:25225856 pmcid:PMC4256721 fatcat:xgc25cb5abfitf3k67mwzspxnq

Interview: Maria Carla Saleh

Maria Carla Saleh
2019 Cellular Microbiology  
For this second diploma, in addition to biology, I studied the conceptual and methodological frameworks of pedagogy and didactics and their application to the study of Biology according to different learning  ...  response for human ailments.  ... 
doi:10.1111/cmi.13061 pmid:31112322 pmcid:PMC6617764 fatcat:auvwosccq5cuvmqsuveat7fg7m

Genome Informatics: The Role of DNA in Cellular Computations

James A. Shapiro
2006 Biological Theory  
Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales.  ...  An interactive informatic conceptualization of the genome allows us to understand the functional importance of DNA that does not code for protein or RNA structure, clarifies the essential multidirectional  ...  Although prodigiously useful in terms of technology development, such "classical" molecular genetics has not proved particularly helpful in producing a conceptual framework for interpreting the expanding  ... 
doi:10.1162/biot.2006.1.3.288 fatcat:5lun7qryoreq5oyasd6tfbvddq

On the backroads to cellular asymmetry

J. Knoblich
2007 Development  
In other words, why does a particular growth factor mediate a mitogenic response in one cell, but a survival effect in another, or a migratory effect in another, or a change in fate in yet another.  ...  The negative side is that understanding the roles of even one of these signals can be challenging; it seems that new functions and components are discovered every day.  ... 
doi:10.1242/dev.014886 fatcat:jneuspqkcfdopccpukul7iiq7m

Studying Cellular Signal Transduction with OMIC Technologies

Benjamin D. Landry, David C. Clarke, Michael J. Lee
2015 Journal of Molecular Biology  
These systems use a relatively limited parts list to respond to a much longer list of extracellular, environmental, and/or mechanical cues with rapidity and specificity.  ...  In this review, we discuss common OMIC and modeling approaches for studying signaling, emphasizing the philosophical and practical considerations for effectively merging these two types of approaches to  ...  ACKNOWLEDGEMENTS MJL and DCC would like to thank the personnel and leadership of the MIT Center for Cell Decision Processes (CDP) and the MIT Integrative Cancer Biology Program (ICBP) for funding and intellectual  ... 
doi:10.1016/j.jmb.2015.07.021 pmid:26244521 pmcid:PMC4818567 fatcat:l3h2zdvbabhilobwpbfjy235p4

Metal Nanozymes: New Horizons in Cellular Homeostasis Regulation

Hanna Lewandowska, Karolina Wójciuk, Urszula Karczmarczyk
2021 Applied Sciences  
Finally, we discuss the current challenges and future directions for developing nanozymes for applications in the regulation of the redox-dependent cellular processes and detection in the cellular redox  ...  This review discusses the use of nanozymes in the regulation of cellular homeostasis.  ...  Schematic of proposed mechanism for enhancing antigen-specific immune response by the CS-IONzyme-based influenza vaccine.  ... 
doi:10.3390/app11199019 fatcat:z4aowksyxvgp3b6hfsrfus6ddq

Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells

Emmet A. Francis, Volkmar Heinrich, Nir Gov
2022 PLoS Computational Biology  
To better assess the contribution of active cytoskeletal protrusion to immune-cell spreading during phagocytosis, we here develop a computational framework that allows us to optionally investigate both  ...  The dynamic interplay between cell adhesion and protrusion is a critical determinant of many forms of cell motility.  ...  Marc Herant for fruitful discussions on computational modeling of motile cells and Dr. Vasilios Morikis for his feedback on early versions of this manuscript.  ... 
doi:10.1371/journal.pcbi.1009937 pmid:36026476 pmcid:PMC9455874 fatcat:4fny5vaco5ekxfb2qsuupqec2e

Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells [article]

Emmet A Francis, Volkmar Heinrich
2022 bioRxiv   pre-print
To better assess the contribution of active cytoskeletal protrusion to immune-cell spreading during phagocytosis, we here develop a computational framework that allows us to optionally investigate both  ...  The dynamic interplay between cell adhesion and protrusion is a critical determinant of many forms of cell motility.  ...  Marc Herant for fruitful discussions on computational modeling of motile cells.  ... 
doi:10.1101/2022.03.01.482589 fatcat:3gt4mmbb4vgq5otn3bbuqpvqri

The Immune System and Its Ecology*

Alfred I. Tauber
2008 Philosophy of Science  
Moving from the first attempts at modeling the immune system as a closed network, immunologists have joined the general interest in systems analysis, and that move might portend a significant shift to  ...  In biology, the 'ecological orientation' rests on a commitment to examining systems, and the conceptual challenge of defining that system now employs techniques and concepts adapted from diverse disciplines  ...  In short, models based on systems analysis presumably will push immunology towards a larger ecological conceptualization for understanding immune regulation. 6. Formalizing Immunology.  ... 
doi:10.1086/590200 fatcat:knadrbvbqzegdnwcq677256a4i

The Strauss-Kahn Syndrome

Robert Skopec
2011 Nature Precedings  
Concerning the role of immune system in cancer, psychosocial influences on immune function provide a mechanism of association between psychosocial factors (like interpersonal aggression) and cancer prognosis  ...  strong emotional response in others.  ...  For our conceptual framework of the aggression stress is central the strategy of authoritarian Hawks, showing that inefficient management of allostasis mediators may lead to violent behavior, development  ... 
doi:10.1038/npre.2011.6456.1 fatcat:wrhb4j7fxjfltjhv47xpps43ne

PNAS Plus Significance Statements

2018 Proceedings of the National Academy of Sciences of the United States of America  
For influenza virus to release from the infected host cell, controlled viral budding must finalize with membrane scission of the viral envelope.  ...  The recent availability of large digitized art collections enables a shift in the scale of such analysis through the use of computational methods.  ...  We propose a general conceptual framework for emergence of complexity through competing interactions and frustrated states similar to those that yield patterns in striped glasses and cause self-organized  ... 
doi:10.1073/pnas.ss11537 fatcat:3ctjfjbmzfcpzlkvr7gb774t6m

Mechanistic classification of immune checkpoint inhibitor toxicity as a pointer to minimal treatment strategies of selected emergent autoimmune disease to further improve survival

Dennis McGonagle, Nicola Luigi Bragazzi, Howard Amital, Abdulla Watad
2019 Autoimmunity Reviews  
Herein, we highlight mechanistic insights on how tumour responses and certain types of autoimmunity appear to be inextricably linked around CD8+ T-cell mediated responses and that strategies that interfere  ...  We discuss the possible circumstances in which intensive immunosuppressive therapy for irAEs that occur with ICIs might blunt anti-tumour immunity.  ...  The conceptual framework and emerging evidence for refraining from vigorously and aggressively treating all ICIs related autoimmunity and why such strategies should be a key part of the research agenda  ... 
doi:10.1016/j.autrev.2019.102456 pmid:31838166 fatcat:42brz4yzpbbk7di6cfsz7zljzy

Roadmap on biology in time varying environments

Arvind Murugan, Kabir Husain, Michael Rust, Joseph T Bass, Chelsea Hepler, Julian M.J. Pietsch, P S Swain, Jared E. Toettcher, Siddhartha Jena, Arup K Chakraborty, Kayla G. Sprenger, Thierry Mora (+9 others)
2021 Physical Biology  
Our understanding is particularly poor in the intermediate regime with no separation of timescales, where the environment changes on the same timescale as the physiological or evolutionary response.  ...  Experiments to systematically characterize the response to dynamic environments are challenging since such environments are inherently high dimensional.  ...  Acknowledgments MJR was supported by NIH R01 GM135382 and a Howard Hughes Medical Institute Faculty Scholar award.  ... 
doi:10.1088/1478-3975/abde8d pmid:33477124 pmcid:PMC8652373 fatcat:d2m6vvklvrddtodpjbbchxtpme

Modulation of toll-like receptor signaling by antimicrobial peptides

Ernest Y. Lee, Michelle W. Lee, Gerard C.L. Wong
2018 Seminars in Cell and Developmental Biology  
In a broader scope, we discuss how this new conceptual framework allows for the prediction of immunomodulatory behavior in AMPs, how the discovery of hidden antimicrobial activity in known immune signaling  ...  However, recent work has shown that AMPs are pleiotropic, multifunctional molecules that can strongly modulate immune responses.  ...  The qualitative concept of clustering of immune ligands to drive immune responses is not a new concept [144] .  ... 
doi:10.1016/j.semcdb.2018.02.002 pmid:29432957 pmcid:PMC6087683 fatcat:oqmvnitwhbesndbgurvsrl4rea
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