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Cell Patterning with Mucin Biopolymers
2013
Biomacromolecules
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However, this limitation can be overcome by coating glass with hydrophobic fluorosilane. We conclude that mucin biopolymers are attractive candidates to control cell adhesion on surfaces. ...
These mucin coatings can be patterned with micrometer precision using a microfluidic device, and are stable enough to support myoblast differentiation over seven days. ...
Here we seek to combine this relatively simple patterning technique with the use of mucin biopolymers to explore novel protocols for cell patterning. ...
doi:10.1021/bm400447z
pmid:23980712
pmcid:PMC4076112
fatcat:7xvkjputhre2nmznvo5uv2kd4q
Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications
2012
Polymers
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In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. ...
Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. ...
The mixtures of the three pectins with mucin were examined by rheological analysis. ...
doi:10.3390/polym4020997
fatcat:nbfhdghecvfcrijfuok2b4qomm
Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering
2020
Advanced Materials Interfaces
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assemblies with a patterned, aligned or random arrangement on the substrate on the other hand ...
In comparison to other biopolymers, PLA has a better thermal processibility [41] but generates coatings with relatively high contact angles of ≈80°, which leads to low cell affinity. ...
doi:10.1002/admi.202000850
fatcat:yynzpdityjehrbvgmwns6ngsoy
Structure and function of epithelial mucins
1998
Biopolymers and Cell
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This progress was mainly associated with the isolation of the cDNA clones, encoding a family of epithelial mucins. ...
To date, this family includes eight mucin genes (MUCJ-MUC8) and more await to be discovered. ...
Polydispersity of the messenger RNA, which is a characteristic of most mucins, with the exception of MUC1, may also contribute to the regulation of their expression pattern [49] . ...
doi:10.7124/bc.0004e5
fatcat:6aejahw435bgzah26uk6hyjz2y
Interaction Between Chitosan and Mucin: Fundamentals and Applications
2019
Biomimetics
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Mucins are glycoprotein macromolecules that are the major components of mucus overlaying epithelia. CS interacts with mucin and adsorbs on and changes the rheology of mucus. ...
However, CS and mucins denote families of polymers/macromolecules with highly variable chemical structure, properties, and behavior. ...
the biopolymer [22, 48] . ...
doi:10.3390/biomimetics4020032
pmid:31105217
pmcid:PMC6631199
fatcat:7ozyjnjndzf6zahmy67hq6r45m
Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery
2015
Acta Biomaterialia
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Along with previously-established anti-inflammatory, anti-viral, and hydrocarbonsolubilizing properties of mucin, the results of this study establish mucin as a readily-available, chemically-versatile, ...
Mucin molecules are indeed equipped with an optimized and diverse chemistry: their protein backbone, rich in thiol groups, contains both hydrophobic and charged domains. ...
Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery. Acta Biomater (2015), http://dx.doi.org/10.1016/j.actbio.2015.03.024. ...
doi:10.1016/j.actbio.2015.03.024
pmid:25818947
fatcat:jpzwlbflqrhqno7bb2n44t7mbi
Advancing Discovery of Snail Mucins Function and Application
2021
Frontiers in Bioengineering and Biotechnology
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Recently, snail mucins have also become a lucrative source of innovation with wide ranging applications across chemistry, biology, biotechnology, and biomedicine. ...
This perspective describes the current research on secreted snail mucus, highlighting the potential of this biopolymer, and also outlines a research strategy to fulfill the unmet need of examining the ...
Sialic acid mediates cell-to-cell interactions, along with being able to mask antigens from human macrophages (Yan et al., 2020). ...
doi:10.3389/fbioe.2021.734023
pmid:34708024
pmcid:PMC8542881
fatcat:le2sjrwwlncrpgvv65wuhzc2dq
Extracellular barriers in respiratory gene therapy
2009
Advanced Drug Delivery Reviews
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In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid. ...
The financial support of this institute is acknowledged with gratitude. ...
Additionally, it has been found that the glycosylation pattern of these respiratory mucins is altered in CF patients [26] . ...
doi:10.1016/j.addr.2008.09.011
pmid:19146894
pmcid:PMC7103358
fatcat:hbb5iv3jkvbktaramqoprjrbre
Chemical Technologies for Probing Glycans
2006
Cell
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Cells treated with this compound express truncated mucin-type O-linked glycans (monosaccharide units shown in black). ...
Similarly, mucin-type O-linked glycans were labeled with GalNAz and then reacted with a phosphine probe in vivo (Dube et al., 2006) . ...
doi:10.1016/j.cell.2006.08.017
pmid:16959565
fatcat:rlp5nkdpcvd4nkce44732x5tr4
Electrostatic Interactions Control the Permeability of Mucin Hydrogels
2010
Biophysical Journal
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mucin hydrogel. ...
It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria ...
doi:10.1016/j.bpj.2009.12.337
fatcat:i6n2lo2cdrh3jnektd6fbekh4q
Glycosaminoglycans in biomedicine
2013
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
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Glycosaminoglycans (GAGs) compose one of four classes of mammalian biopolymers, and are arguably the most complex. ...
Several studies have shown that the clustering of GAGs, as is often the case in proteoglycans, increases the affinity between GAGs and other biopolymers. ...
good incorporation of the mucin mimics into the cell membrane of a mucin deficient ldlD CHO cell line. ...
doi:10.1002/wnan.1223
pmid:23606640
pmcid:PMC3683376
fatcat:o5fwzpnhpnbnfirdsq6c6rquae
Atomic Scale Description of Ionic Behavior in Polymer Nanopores
2009
Biophysical Journal
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In small pores (<5 nm) the transport time of the biopolymer is determined by a balance of the electrical field and the frictional force resulting from interactions with the pore walls and hydrodynamic ...
This coat is of vital biological importance for example in cell proliferation and migration, but also in diseases like osteoarthritis or with age. The PCC consists mainly of water. ...
doi:10.1016/j.bpj.2008.12.3835
fatcat:jw3wiliyofbrhksl2733yb4xiq
Fibrin Gel Ultrastructure
2010
Biophysical Journal
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By dividing the simulation box into cells, we quantified local water density, diffusion coefficient, and water orientation at atomistic resolution. ...
It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria ...
mucin hydrogel. ...
doi:10.1016/j.bpj.2009.12.338
fatcat:spig6b4mqbfwvlcterw6x4pluq
Role of Water in Mediating the Interaction Between Collagens
2010
Biophysical Journal
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By dividing the simulation box into cells, we quantified local water density, diffusion coefficient, and water orientation at atomistic resolution. ...
It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria ...
mucin hydrogel. ...
doi:10.1016/j.bpj.2009.12.336
fatcat:iattp4k2ovgkvcvj6pjpu66kj4
Specific secretion of gel-forming mucins and TFF peptides in HT-29 cells of mucin-secreting phenotype
2001
BBA - Molecular Cell Research
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Overlay assays indicated that HT-29 MTX mucins bound to secretory peptides of HT-29 MTX cells with relative molecular mass similar to TFF peptides. ...
The differentiation of HT-29 MTX cells into the mucin-secreting phenotype was characterised by secretion of the gel-forming mucins MUC2, MUC5AC, and MUC5B, however, according to a different pattern in ...
The question arises whether TFF peptides inter-act with mucins in the formation of a complex viscous mucus biopolymer as predicted in the past [16] . ...
doi:10.1016/s0167-4889(01)00092-1
pmid:11389969
fatcat:mqdhmxuvunc3viw5vs5ntajtva
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