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Cell Patterning with Mucin Biopolymers

T. Crouzier, H. Jang, J. Ahn, R. Stocker, K. Ribbeck
2013 Biomacromolecules  
However, this limitation can be overcome by coating glass with hydrophobic fluorosilane. We conclude that mucin biopolymers are attractive candidates to control cell adhesion on surfaces.  ...  These mucin coatings can be patterned with micrometer precision using a microfluidic device, and are stable enough to support myoblast differentiation over seven days.  ...  Here we seek to combine this relatively simple patterning technique with the use of mucin biopolymers to explore novel protocols for cell patterning.  ... 
doi:10.1021/bm400447z pmid:23980712 pmcid:PMC4076112 fatcat:7xvkjputhre2nmznvo5uv2kd4q

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

Lin Shu Liu, Joseph Kost, Fang Yan, Robert C. Spiro
2012 Polymers  
In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention.  ...  Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries.  ...  The mixtures of the three pectins with mucin were examined by rheological analysis.  ... 
doi:10.3390/polym4020997 fatcat:nbfhdghecvfcrijfuok2b4qomm

Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering

Jian Song, Benjamin Winkeljann, Oliver Lieleg
2020 Advanced Materials Interfaces  
assemblies with a patterned, aligned or random arrangement on the substrate on the other hand  ...  In comparison to other biopolymers, PLA has a better thermal processibility [41] but generates coatings with relatively high contact angles of ≈80°, which leads to low cell affinity.  ... 
doi:10.1002/admi.202000850 fatcat:yynzpdityjehrbvgmwns6ngsoy

Structure and function of epithelial mucins

I. I. Gout
1998 Biopolymers and Cell  
This progress was mainly associated with the isolation of the cDNA clones, encoding a family of epithelial mucins.  ...  To date, this family includes eight mucin genes (MUCJ-MUC8) and more await to be discovered.  ...  Polydispersity of the messenger RNA, which is a characteristic of most mucins, with the exception of MUC1, may also contribute to the regulation of their expression pattern [49] .  ... 
doi:10.7124/bc.0004e5 fatcat:6aejahw435bgzah26uk6hyjz2y

Interaction Between Chitosan and Mucin: Fundamentals and Applications

Collado-González, González Espinosa, Goycoolea
2019 Biomimetics  
Mucins are glycoprotein macromolecules that are the major components of mucus overlaying epithelia. CS interacts with mucin and adsorbs on and changes the rheology of mucus.  ...  However, CS and mucins denote families of polymers/macromolecules with highly variable chemical structure, properties, and behavior.  ...  the biopolymer [22, 48] .  ... 
doi:10.3390/biomimetics4020032 pmid:31105217 pmcid:PMC6631199 fatcat:7ozyjnjndzf6zahmy67hq6r45m

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery

Connor V. Duffy, Laurent David, Thomas Crouzier
2015 Acta Biomaterialia  
Along with previously-established anti-inflammatory, anti-viral, and hydrocarbonsolubilizing properties of mucin, the results of this study establish mucin as a readily-available, chemically-versatile,  ...  Mucin molecules are indeed equipped with an optimized and diverse chemistry: their protein backbone, rich in thiol groups, contains both hydrophobic and charged domains.  ...  Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery. Acta Biomater (2015), http://dx.doi.org/10.1016/j.actbio.2015.03.024.  ... 
doi:10.1016/j.actbio.2015.03.024 pmid:25818947 fatcat:jpzwlbflqrhqno7bb2n44t7mbi

Advancing Discovery of Snail Mucins Function and Application

Maxwell McDermott, Antonio R. Cerullo, James Parziale, Eleonora Achrak, Sharmin Sultana, Jennifer Ferd, Safiyah Samad, William Deng, Adam B. Braunschweig, Mandë Holford
2021 Frontiers in Bioengineering and Biotechnology  
Recently, snail mucins have also become a lucrative source of innovation with wide ranging applications across chemistry, biology, biotechnology, and biomedicine.  ...  This perspective describes the current research on secreted snail mucus, highlighting the potential of this biopolymer, and also outlines a research strategy to fulfill the unmet need of examining the  ...  Sialic acid mediates cell-to-cell interactions, along with being able to mask antigens from human macrophages (Yan et al., 2020).  ... 
doi:10.3389/fbioe.2021.734023 pmid:34708024 pmcid:PMC8542881 fatcat:le2sjrwwlncrpgvv65wuhzc2dq

Extracellular barriers in respiratory gene therapy

Niek Sanders, Carsten Rudolph, Kevin Braeckmans, Stefaan C. De Smedt, Joseph Demeester
2009 Advanced Drug Delivery Reviews  
In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid.  ...  The financial support of this institute is acknowledged with gratitude.  ...  Additionally, it has been found that the glycosylation pattern of these respiratory mucins is altered in CF patients [26] .  ... 
doi:10.1016/j.addr.2008.09.011 pmid:19146894 pmcid:PMC7103358 fatcat:hbb5iv3jkvbktaramqoprjrbre

Chemical Technologies for Probing Glycans

Jennifer A. Prescher, Carolyn R. Bertozzi
2006 Cell  
Cells treated with this compound express truncated mucin-type O-linked glycans (monosaccharide units shown in black).  ...  Similarly, mucin-type O-linked glycans were labeled with GalNAz and then reacted with a phosphine probe in vivo (Dube et al., 2006) .  ... 
doi:10.1016/j.cell.2006.08.017 pmid:16959565 fatcat:rlp5nkdpcvd4nkce44732x5tr4

Electrostatic Interactions Control the Permeability of Mucin Hydrogels

Oliver Lieleg, Ioana Vladescu, Katharina Ribbeck
2010 Biophysical Journal  
mucin hydrogel.  ...  It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria  ... 
doi:10.1016/j.bpj.2009.12.337 fatcat:i6n2lo2cdrh3jnektd6fbekh4q

Glycosaminoglycans in biomedicine

Rebecca A. Scott, Alyssa Panitch
2013 Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology  
Glycosaminoglycans (GAGs) compose one of four classes of mammalian biopolymers, and are arguably the most complex.  ...  Several studies have shown that the clustering of GAGs, as is often the case in proteoglycans, increases the affinity between GAGs and other biopolymers.  ...  good incorporation of the mucin mimics into the cell membrane of a mucin deficient ldlD CHO cell line.  ... 
doi:10.1002/wnan.1223 pmid:23606640 pmcid:PMC3683376 fatcat:o5fwzpnhpnbnfirdsq6c6rquae

Atomic Scale Description of Ionic Behavior in Polymer Nanopores

Eduardo Cruz, Klaus Schulten
2009 Biophysical Journal  
In small pores (<5 nm) the transport time of the biopolymer is determined by a balance of the electrical field and the frictional force resulting from interactions with the pore walls and hydrodynamic  ...  This coat is of vital biological importance for example in cell proliferation and migration, but also in diseases like osteoarthritis or with age. The PCC consists mainly of water.  ... 
doi:10.1016/j.bpj.2008.12.3835 fatcat:jw3wiliyofbrhksl2733yb4xiq

Fibrin Gel Ultrastructure

Massimiliano Papi, Giuseppe Maulucci, Giuseppe Arcovito, Mauro Missori, Andrea Bellelli, Giovanna Bumis, Marco De Spirito
2010 Biophysical Journal  
By dividing the simulation box into cells, we quantified local water density, diffusion coefficient, and water orientation at atomistic resolution.  ...  It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria  ...  mucin hydrogel.  ... 
doi:10.1016/j.bpj.2009.12.338 fatcat:spig6b4mqbfwvlcterw6x4pluq

Role of Water in Mediating the Interaction Between Collagens

Krishnakumar Mayuram Ravikumar, Wonmuk Hwang
2010 Biophysical Journal  
By dividing the simulation box into cells, we quantified local water density, diffusion coefficient, and water orientation at atomistic resolution.  ...  It regulates the uptake of nutrients from our gastrointestinal system, adjusts itself with the menstrual cycle to control the passage of sperm, and shields the underlying cells from pathogens such as bacteria  ...  mucin hydrogel.  ... 
doi:10.1016/j.bpj.2009.12.336 fatcat:iattp4k2ovgkvcvj6pjpu66kj4

Specific secretion of gel-forming mucins and TFF peptides in HT-29 cells of mucin-secreting phenotype

Valérie Gouyer, Antje Wiede, Marie-Pierre Buisine, Sophie Dekeyser, Odile Moreau, Thécla Lesuffleur, Werner Hoffmann, Guillemette Huet
2001 BBA - Molecular Cell Research  
Overlay assays indicated that HT-29 MTX mucins bound to secretory peptides of HT-29 MTX cells with relative molecular mass similar to TFF peptides.  ...  The differentiation of HT-29 MTX cells into the mucin-secreting phenotype was characterised by secretion of the gel-forming mucins MUC2, MUC5AC, and MUC5B, however, according to a different pattern in  ...  The question arises whether TFF peptides inter-act with mucins in the formation of a complex viscous mucus biopolymer as predicted in the past [16] .  ... 
doi:10.1016/s0167-4889(01)00092-1 pmid:11389969 fatcat:mqdhmxuvunc3viw5vs5ntajtva
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